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1. Research progress of metabolomics in the diagnosis and treatment of severe injuries

Author

WEI Bin, DUAN Hongjie, CHAI Jiake

Subjects
metabolomics, trauma, burn, burn-blast combined injury, Medicine
Abstract

Metabolomics is a novel emerging technology recently applied in management of severe diseases and trauma, and has been widely used in gene analysis of disease metabolic disorders, clinical biomarker screening and disease diagnosis. This review comprehensively summarizes the latest research progress of the metabolomics in severe trauma and burns recently like traumatic brain injury(TBI), traumatic hemorrhagic shock, severe burns and so on. The paper elaborates the metabolomic technology which can quickly reflect the real-time metabolic changes of severely injured patients at different stages after injury, and uncovers new clinical biomarkers and potential drug targets of the patients with severe injuries thus improves the diagnosis and treatment strategies. Finally, we look forward to the current metabolomics research projects and tackling challenges on the burn-blast combined injuries, and the simultaneous development of multi-omics technology as well as artificial intelligence algorithms, which promotes the development of precision medicine.

Published
2024
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6. Epidemiology and first aid measures in pediatric burn patients in northern China during 2016–2020: A single‐center retrospective study.

Author

Liu, Tian, Qu, Yirui, Chai, Jiake, Liu, Xiangyu, Hu, Fangchao, Zhang, Dongliang, Duan, Hongjie, and Chi, Yunfei

Subjects
CHILD patients, BURN patients, FIRST aid in illness & injury, SCIENCE education, BURN care units, PRESCHOOL children, CHEMICAL burns
Abstract

Background and Aims: Burn and scald injuries are the fourth most common type of trauma. Pediatric burns account for a high proportion of the total number of burn patients and impose a high burden on public health. Understanding the epidemiology of pediatric burns can help improve science education and reduce the incidence of burn injuries. Methods: This study is a single‐center retrospective study. One thousand five hundred and twenty‐seven pediatric burn patients admitted to our burn center from January 2016 to December 2020 were included. Demographic and epidemiological data of included patients were extracted and analyzed. The correlations of categorical data were tested by the Chi‐square tests, and differences of continuous data were tested by the Kruskal–Wallis tests. A p‐value of less than 0.05 was considered to be statistically significant. Results: The results showed that children under 3 years of age were most susceptible to burn and scald injuries. Burn injuries were most likely to occur in the season of winter and at the place of home. 56.6% of included patients did receive first aid measures, while 1.8% received gold‐standard first aid. Clinical variables related to the severity of injuries were statistically different between patients with and without cooling measures in first aid. Linear regression models showed that emergency treatment of burns in children and adolescents was associated with outcome indicators, including number of operations, total operation duration per total burn surface area (TBSA), cost per TBSA, and length of stay per TBSA. Conclusions: This study summarized the epidemiology and outcomes of pediatric burn patients admitted to a burn center in northern China. Adopting cooling measures in first aid can reduce the severity of injuries and reduce the burden on the medical system. Education on burn prevention and first aid measures to caregivers of children, especially preschool children, should be strengthened. Key points: Understanding the epidemiology of pediatric burns can help improve science education and reduce the incidence of burn injuries.This study aimed to analyze epidemiological and clinical variables of pediatric burn patients in a burn center in northern China.Children under 3 years of age were most susceptible to burn and scald injuries.Burn injuries in pediatric patients were most likely to occur in the season of winter and at the place of home.Adopting cooling measures in first aid can reduce the severity of burn injuries. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Exosomes Derived from lncRNA-FGD5-AS1-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cells Promote Wound Healing by Inducing miR-17-5p/ATG5-Mediated Autophagy

Author

Chi, Yunfei, primary, Yin, Huinan, additional, Liu, Tian, additional, Qu, Yirui, additional, Liu, Xiangyu, additional, Chang, Yang, additional, Hu, Fangchao, additional, Bai, Hailiang, additional, Hao, Xingxia, additional, Wu, Yushou, additional, Han, Shaofang, additional, Duan, Hongjie, additional, and Chai, Jiake, additional

Published
2023
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14. List of Contributors

Author

Ahuja, Rajeev B, primary, Aili Low, J F, additional, Arnoldo, Brett D., additional, Ayadi, Amina El, additional, Bache, Sarah E, additional, Barret, Juan P, additional, Barrow, Robert E, additional, Benjamin, Debra A, additional, Berger, Mette M, additional, Bernal, Eileen, additional, Bitz, Genevieve H, additional, Bohanon, Fredrick J, additional, Bojovic, Branko, additional, Branski, Ludwik, additional, Brownson, Elisha G, additional, Buffalo, Michael C, additional, Cambiaso-Daniel, Janos, additional, Campbell, Stephanie A, additional, Cancio, Leopoldo C, additional, Capek, Karel D, additional, Carmichael, Kelly D, additional, Carson, Joshua S, additional, Carter, Michele, additional, Celis, Mario M, additional, Chai, Jiake, additional, Chatterjee, Pallab, additional, Chilton, Linda, additional, Chung, Dai H, additional, Chung, Kevin K, additional, Clark, Audra T, additional, Cochran, Amalia, additional, Cowan, April, additional, Cox, Robert A, additional, Craft-Coffman, Beretta, additional, Culnan, Derek M, additional, Dannoun, Moayad, additional, Desmoulière, Alexis, additional, Donelan, Matthias B, additional, Dziewulski, Peter, additional, El-Muttardi, Naguib, additional, Enkhbaatar, Perenlei, additional, Fagan, Shawn P, additional, Fauerbach, James A, additional, Finnerty, Celeste C, additional, Gabriel, Christian, additional, Gallagher, James J, additional, Gibran, Nicole S, additional, Goodwin, Cleon W, additional, Goverman, Jeremy, additional, Guillory, Ashley N, additional, Haller, Herbert L, additional, Hassanpour, Houman K, additional, Hawkins, Hal K, additional, Herndon, David N, additional, Hollyoak, Maureen, additional, Huang, Ted T, additional, Hughes, Byron D, additional, Hundeshagen, Gabriel, additional, Ismail, Mohamed E., additional, Jaco, Mary, additional, Jeschke, Marc G, additional, Jimenez, Carlos, additional, Jokuszies, Andreas, additional, Kamolz, Lars-Peter, additional, Kemp-Offenberg, Jennifer, additional, Kinsky, Michael P, additional, Klein, Gordon L., additional, Kobayashi, Makiko, additional, Kramer, George C, additional, Kuhlmann-Capek, Maggie J, additional, Kwan, Peter, additional, Lee, Jong O, additional, Lee, Kwang Chear, additional, Leon-Villapalos, Jorge, additional, Levi, Benjamin, additional, Lineaweaver, William C, additional, Linticum, Kimberly M, additional, Lisiecki, Jeffrey, additional, Lopez, Omar Nunez, additional, Martinello, Caroline, additional, Martyn, J A Jeevendra, additional, Mason, Arthur D, additional, McLaughlin, Jillian M, additional, Merkley, Kevin H, additional, Meyer, Walter J, additional, Middelkoop, Esther, additional, Milner, Stephen M, additional, Mlcak, Ronald P, additional, Moiemen, Naiem S., additional, Morris, Stephen E, additional, Mozingo, David W, additional, Muller, Michael, additional, Mullins, Robert F, additional, Muthumalaiappan, Kuzhali, additional, Niederbichler, Andreas D, additional, Norbury, William B, additional, Ott, Sheila, additional, Peterlik, Christian, additional, Philp, Bruce, additional, Porter, Craig, additional, Pruitt, Basil A, additional, Radhakrishnan, Ravi S, additional, Rimmer, Ruth B, additional, Rosenberg, Laura, additional, Rosenberg, Marta, additional, Sanford, Arthur P, additional, Sarpong, Kwabena O, additional, Serghiou, Michael A, additional, Sheridan, Robert L, additional, Sherman, William C, additional, Sherwood, Edward R., additional, Smith, Lisa W, additional, Sousse, Linda E., additional, Spies, Marcus, additional, Suman, Oscar E, additional, Suzuki, Fujio, additional, Talon, Mark, additional, Thomas, Christopher R., additional, Toliver-Kinsky, Tracy, additional, Tredget, Edward E, additional, Trocmé, Stefan D, additional, Tropez-Arceneaux, Lisa L, additional, Vogt, Peter M, additional, Voigt, Charles D, additional, Voigt, David W, additional, Warden, Glen, additional, Wiechman, Shelley, additional, Willebrand, Mimmie, additional, Williams, Felicia N, additional, Williamson, Stephen, additional, Wolf, Steven E, additional, Woodson, Lee C., additional, Woodson, Sue M., additional, Wurzer, Paul, additional, Yngve, David, additional, and Zapata-Sirvent, Ramón L., additional

Published
2018
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24. Protective effect of restrictive resuscitation on vascular endothelial glycocalyx in pigs with traumatic hemorrhagic shock

Author

Chi, Yunfei, primary, Jiang, Xue, additional, Chai, Jiake, additional, Chang, Yang, additional, Liu, Tian, additional, Liu, Xiangyu, additional, Huang, Jianxiang, additional, Wei, Bin, additional, Zheng, Jinguang, additional, Hao, Xingxia, additional, Bai, Hailiang, additional, Qu, Yirui, additional, Hu, Fangchao, additional, Han, Shaofang, additional, and Wang, Qiushuang, additional

Published
2022
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31. A narrative review of changes in microvascular permeability after burn

Author

Chai Jiake, Xiangyu Liu, and Yunfei Chi

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, Endothelium, business.industry, Bradykinin, Vascular permeability, General Medicine, Review Article, Ulinastatin, Extravasation, Vascular endothelial growth factor, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Vascular resistance, medicine, business, Histamine
Abstract

Objective We aimed to review and discuss some of the latest research results related to post-burn pathophysiological changes and provide some clues for future study. Background Burns are one of the most common and serious traumas and consist of a series of pathophysiological changes of thermal injury. Accompanied by thermal damage to skin and soft tissues, inflammatory mediators are released in large quantities. Changes in histamine, bradykinin, and cytokines such as vascular endothelial growth factor (VEGF), metabolic factors such as adenosine triphosphate (ATP), and activated neutrophils all affect the body's vascular permeability. Methods We searched articles with subject words "microvascular permeability", "burn" "endothelium", and "endothelial barrier" in PubMed in English published from the beginning of database to Dec, 2020. Conclusions The essence of burn shock is the rapid and extensive fluid transfer in burn and non-burn tissue. After severe burns, the local and systemic vascular permeability increase, causing intravascular fluid extravasation, leading to a progressive decrease in effective circulation volume, an increase in systemic vascular resistance, a decrease in cardiac output, peripheral tissue edema, multiple organ failure, and even death. There are many cells, tissues, mediators and structures involved in the pathophysiological process of the damage to vascular permeability. Ulinastatin is a promising agent for this problem.

Published
2021

38. Preparation and evaluation of chitosan-polyvinyl alcohol/ polyhexamethylene guanidine hydrochloride antibacterial dressing to accelerate wound healing for infectious skin repair

Author

Yue, Xiaotong, primary, Liu, Lingying, additional, Wu, Yushou, additional, Liu, Xiangyu, additional, Li, Shaozeng, additional, Zhang, Zihao, additional, Han, Shaofang, additional, Wang, Xiaoteng, additional, Chang, Yang, additional, Bai, Hailiang, additional, Chai, Jiake, additional, Hu, Sen, additional, and Wang, Hongyu, additional

Published
2021
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41. Down-Regulation of miR-301a-3p Reduces Burn-Induced Vascular Endothelial Apoptosis by potentiating hMSC-Secreted IGF-1 and PI3K/Akt/FOXO3a Pathway

Author

Shaozeng Li, Shaofang Han, Wu Yushou, Hongjie Duan, Xingxia Hao, Bai Hailiang, Song Huifeng, Longlong Yang, Yin Huinan, Liu Lingying, Chi Yunfei, Qiong Wang, Yue Xiaotong, Xiuxiu Shi, Hongyu Wang, Chai Jiake, Wei Liu, Chang Yang, and Xiaoteng Wang

Subjects
0301 basic medicine, 02 engineering and technology, Umbilical vein, Article, Cell therapy, 03 medical and health sciences, Stem Cells Research, medicine, lcsh:Science, Protein kinase B, PI3K/AKT/mTOR pathway, Clinical Genetics, Multidisciplinary, business.industry, Organ dysfunction, Mesenchymal stem cell, 021001 nanoscience & nanotechnology, Cellular Therapy, Cell biology, 030104 developmental biology, Apoptosis, FOXO3, lcsh:Q, medicine.symptom, 0210 nano-technology, business
Abstract

Summary Vascular endothelium dysfunction plays a pivotal role in the initiation and progression of multiple organ dysfunction. The mesenchymal stem cell (MSC) maintains vascular endothelial barrier survival via secreting bioactive factors. However, the mechanism of human umbilical cord MSC (hMSC) in protecting endothelial survival remains unclear. Here, we found IGF-1 secreted by hMSC suppressed severe burn-induced apoptosis of human umbilical vein endothelial cells (HUVECs) and alleviated the dysfunction of vascular endothelial barrier and multiple organs in severely burned rats. Severe burn repressed miR-301a-3p expression, which directly regulated IGF-1 synthesis and secretion in hMSC. Down-regulation of miR-301a-3p decreased HUVECs apoptosis, stabilized endothelial barrier permeability, and subsequently protected against multiple organ dysfunction in vivo. Additionally, miR-301a-3p negatively regulated PI3K/Akt/FOXO3 signaling through IGF-1. Taken together, our study highlights the protective function of IGF-1 against the dysfunction of multiple organs negatively regulated by miR-301a-3p, which may provide the theoretical foundation for further clinical application of hMSC., Graphical Abstract, Highlights • IGF-1 secreted by hMSC suppressed severe burn-induced apoptosis of HUVECs • miR-301a-3p directly regulated IGF-1 synthesis and secretion in hMSC • DomiR-301a-3p protected against multiple organ dysfunction • miR-301a-3p regulated PI3K/Akt/FOXO3 signaling through hMSC-secreted IGF-1, Clinical Genetics; Cellular Therapy; Stem Cells Research

Published
2020

44. List of Contributors

Author

Aarsland, Asle, primary, Aikawa, Naoki, additional, Al-Mousawi, Ahmed M, additional, Arnoldo, Brett D, additional, Barret, Juan P, additional, Barrow, Robert E., additional, Benjamin, Debra A, additional, Blakeney, Patricia E, additional, Børsheim, Elisabet, additional, Branski, Ludwik K., additional, Buffalo, Michael C, additional, Chai, Jiake, additional, Chen, Xin, additional, Chung, Dai H, additional, Chung, Kevin K, additional, Cochran, Amalia, additional, Colon, Nadja, additional, Cowan, April, additional, Demling, Robert H, additional, Desmoulière, Alexis, additional, Dibildox, Manuel, additional, Donelan, Matthias B, additional, Dziewulski, Peter, additional, Elijah, Itoro E, additional, Enkhbaatar, Perenlei, additional, Evans, E Burke, additional, Fagan, Shawn P, additional, Fauerbach, James A, additional, Feldman, Michael J, additional, Finnerty, Celeste C, additional, Gabriel, Christian, additional, Gallagher, James J, additional, Gamelli, Richard L, additional, Gauglitz, Gerd G, additional, Gibran, Nicole S, additional, Goodwin, Cleon W., additional, Goverman, Jeremy, additional, Graves, Caran, additional, Haller, Herbert L, additional, Hartford, Charles E, additional, Hawkins, Hal K, additional, Hegde, Sachin D, additional, Heimbach, David M, additional, Herndon, David N, additional, Hollyoak, Maureen, additional, Huang, Ted, additional, Hunt, John L, additional, Jaco, Mary, additional, Jeschke, Marc, additional, Jimenez, Carlos J, additional, Jokuszies, Andreas, additional, Kagan, Richard J, additional, Kamolz, Lars-Peter, additional, Kinsky, Michael P, additional, Klein, Gordon L, additional, Koch, Eric, additional, Kramer, George C, additional, Kwan, Peter, additional, Lawrence, John, additional, Lee, Jong O, additional, Leon-Villapalos, Jorge, additional, Lewis, Giavonni M, additional, Liao, Eric C, additional, Low, JF Aili, additional, Mason, Arthur D, additional, Maybauer, Dirk M, additional, Maybauer, Marc O, additional, McCauley, Robert L, additional, McEntire, Serina J, additional, Meyer, Walter John, additional, Milner, Stephen M, additional, Mlcak, Ronald P, additional, Morris, Stephen E, additional, Morvant, Elise M, additional, Mozingo, David W, additional, Muller, Michael, additional, Murphey, Erle D, additional, Muthu, Kuzhali, additional, Niederbichler, Andreas D, additional, Norbury, William B, additional, Nugent, Nora, additional, Ott, Sheila, additional, Pereira, Clifford, additional, Peterlik, Rudolf C, additional, Porro, Laura J, additional, Posluszny, Joseph A, additional, Pruitt, Basil A, additional, Purdue, Gary F., additional, Qin, Fengjun, additional, Robb, Edward C, additional, Rodriguez, Noe A, additional, Rosenberg, Laura, additional, Rosenberg, Lior, additional, Rosenberg, Marta, additional, Saffle, Jeffrey R, additional, Sakurai, Hiroyuki, additional, Sanford, Arthur P, additional, Sayeed, Syed M, additional, Schlegel, Cameron, additional, Serghiou, Michael A, additional, Shankar, Ravi, additional, Shen, Yuming, additional, Sheridan, Robert L, additional, Sherwood, Edward R, additional, Spies, Marcus, additional, Sterling, Jose P, additional, Suman, Oscar E, additional, Talon, Mark, additional, Thomas, Christopher R, additional, Toliver-Kinsky, Tracy, additional, Tompkins, Ronald G, additional, Traber, Daniel L, additional, Tredget, Edward E, additional, Tropez-Arceneaux, Lisa L, additional, Tropez-Sims, Susanne, additional, Villarreal, Cynthia G, additional, Vogt, Peter M, additional, Warden, Glenn D, additional, Warner, Petra M, additional, Whitehead, Christopher C, additional, Wiechman, Shelley A, additional, Willebrand, Mimmie, additional, Williams, Felicia N, additional, Williams-Bouyer, Natalie M, additional, Winter, Robert, additional, Wolf, Steven E, additional, Woodson, Lee C, additional, and Yang, Jui-Yung, additional

Published
2012
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46. Usage of Negative Pressure Wound Therapy in Pseudoepitheliomatous Hyperplasia Secondary to Burn Injury: A Case Series.

Author

Luo, Hongmin, Chi, Yunfei, Chen, Xin, and Chai, Jiake

Subjects
BURNS & scalds complications, DEBRIDEMENT, HYPERPLASIA, NEGATIVE-pressure wound therapy, EPITHELIAL cells, BACTERIAL diseases
Abstract

Pseudoepitheliomatous hyperplasia (PEH) is a reactive epithelial proliferation secondary to a wide range of stimuli, including traumatic injury, inflammation, infection, and tumors of the skin. PEH secondary to burn injury is rarely reported. We report three cases of PEH patients after burn injury. All three cases were confirmed with the existence of bacterial infection, and all these cases were second- or third-degree burns. All three patients were treated with negative pressure wound therapy after wound debridement or tangential excision. All the wounds healed without split-thickness skin grafting and recurrence. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Preparation and evaluation of chitosan-polyvinyl alcohol/ polyhexamethylene guanidine hydrochloride antibacterial dressing to accelerate wound healing for infectious skin repair

Author

Chai Jiake, Shaofang Han, Wu Yushou, Yue Xiaotong, Bai Hailiang, Hongyu Wang, Zhang Zihao, Liu Lingying, Sen Hu, Shaozeng Li, Liu Xiangyu, Xiaoteng Wang, and Chang Yang

Subjects
Skin repair, integumentary system, biology, Chemistry, Pseudomonas aeruginosa, 02 engineering and technology, General Medicine, 021001 nanoscience & nanotechnology, biology.organism_classification, medicine.disease_cause, Microbiology, Acinetobacter baumannii, 03 medical and health sciences, 0302 clinical medicine, Polyhexamethylene guanidine, Staphylococcus aureus, medicine, Original Article, 030212 general & internal medicine, 0210 nano-technology, Antibacterial activity, Candida albicans, Wound healing
Abstract

Background Wound infections, especially multidrug-resistant (MDR) bacterial infections, are a major challenge in clinical medicine. Methods In this study, a new type of antibacterial sponge was prepared from a solution containing a chitosan-polyvinyl alcohol (CTS-PVA) emulsion with added polyhexamethylene guanidine hydrochloride (PHMG) in a homogeneous medium using lyophilization technology. The antibacterial ability of and CTS-PVA/PHMG sponge against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and multidrug-resistant Acinetobacter baumannii in vitro. The structure and physical properties were characterized. The sponge dressing was tested in a Pseudomonas aeruginosa-infected full-thickness mouse skin wound defect model. The effects were evaluated by wound area measurement and histological analysis. Results The CTS-PVA/PHMG sponge showed broad-spectrum antibacterial ability, including for MDR bacterial stains from clinical sources, while maintaining excellent physicochemical properties, including a high swelling degree and good moisture retention capability. Scanning electron microscopy images displayed the surface morphology of the CTS-PVA/PHMG sponge dressing. The detection of the wound healing rate and histological analysis supported that the new dressing can alleviate the inflammation and accelerate the healing speed of infected wounds and in vivo. Conclusions CTS-PVA/PHMG sponge shows broad-spectrum antibacterial activity, which can provide a new pathway for clinical prevention and treatment of superbug-infected wounds.

Published
2021

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