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Your search keyword '"Chakrabarty, Ananda M."' showing total 243 results
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243 results on '"Chakrabarty, Ananda M."'

19. Cupredoxin-cancer interrelationship: Azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth

Author

Chaudhari, Anita, Mahfouz, Magdy, Fialho, Arsenio M., Yamada, Tohru, Granja, Ana Teresa, Yonghua Zhu, Hashimoto, Wataru, Schlarb-Ridley, Beatrix, Cho, Wonhwa, Das Gupta, Tapas K., and Chakrabarty, Ananda M.

Subjects
Tyrosine -- Chemical properties, Tyrosine -- Structure, Phosphorylation -- Research, Electron transport -- Analysis, Cancer cells -- Research, Biological sciences, Chemistry
Abstract

The research mainly deals with azurin, a metalloprotein called cupredoxins that along with being involved in the electron transfer, also enters cancer cells and induces apoptosis in them and is very much similar to the ligand called cphrinB2. The binding of azurin with the cognate receptor tyrosine kinase EphB2 initiates Eph/ephrin signaling and highly interferes with the tyrosine phosphorylation, thus facilitating the cancer cell growth inhibition.

Published
2007

25. Critical nucleotides in the interaction of CatR with the pheBA promoter: conservtion of the CatR-mediated regulation mechanisms between the pheBA and catBCA operons

Author

Tover, Andres, Zernant, Jana, Chugani, Sudha A., Chakrabarty, Ananda M., and Kivisaar, Maia

Subjects
Promoters (Genetics) -- Analysis, Genetic transcription -- Analysis, Operons -- Genetic aspects, Pseudomonas putida -- Research, Biological sciences
Abstract

Results show the activation binding site of CatR contains two G nucleotides important for promoter activity but not for CatR binding as indicated by the site-directed mutagenesis. Data also demonstrate a catR-mediated regulation mechanism conservation between the pheBA and the catBCA promoters.

Published
2000

28. Characterization of the alginate biosynthetic gene cluster in Pseudomonas syringae pv. syringae

Author

Penaloza-Vazquez, Alejandro, Kidambi, Saranga P., Chakrabarty, Ananda M., and Bender, Carol L.

Subjects
Gene expression -- Research, Pseudomonas syringae -- Research, Biosynthesis -- Research, Biological sciences
Abstract

Analysis of alginate biosynthesis is undertaken through the isolation and characterization of alginate-defective mutants of Pseudomonas syringae. Results show that the P. syringae had a Tn5 insertion in the alginate structural gene cluster. Alginate gene expression was evoked through the inclusion of ninionic solute sorbitol which also indicated the presence of osmolarity in such an expression.

Published
1997

30. Bacterial proteins and peptides in cancer therapy

Author

Chakrabarty, Ananda M, Bernardes, Nuno, and Fialho, Arsenio M

Subjects
Protein Conformation, Antibodies, Monoclonal, Antineoplastic Agents, Review, azurin, bacterial proteins, Drug Resistance, Neoplasm, tyrosine kinase inhibitors, Drug Discovery, cancer, monoclonal antibodies, therapeutic peptide/proteins, Transcriptome, Signal Transduction
Abstract

Cancer is one of the most deadly diseases worldwide. In the last three decades many efforts have been made focused on understanding how cancer grows and responds to drugs. The dominant drug-development paradigm has been the "one drug, one target." Based on that, the two main targeted therapies developed to combat cancer include the use of tyrosine kinase inhibitors and monoclonal antibodies. Development of drug resistance and side effects represent the major limiting factors for their use in cancer treatment. Nowadays, a new paradigm for cancer drug discovery is emerging wherein multi-targeted approaches gain ground in cancer therapy. Therefore, to overcome resistance to therapy, it is clear that a new generation of drugs is urgently needed. Here, regarding the concept of multi-targeted therapy, we discuss the challenges of using bacterial proteins and peptides as a new generation of effective anti-cancer drugs.

Published
2014

31. Contributors

Author

Bennardo, Francesco, Chow, Ming Fai, Engels, Jan Frederick, Goodsell, David S., Halpern, Georges M., Kayser, Oliver, Ullrich, Oliver, Bernhardt, Rita, Bornscheuer, Uwe, Cautherley, George, Chakrabarty, Ananda, Charpentier, Emmanuelle, Chow, King, Clark, David P., Demain, Arnold L., Dingermann, Theodor, Dübel, Stefan, Friedrich, Roland, Fromherz, Peter, Fuchs, Dietmar, Fukui, Saburo, Gänßler, Karla, Ghisalba, Oreste, Grunz, Horst, Halpern, Georges, Hempel, Albrecht, Hew, Choy-L., Hillenkamp, Franz, Hock, Bertold, Holtzhauer, Martin, Huntoon, Jon, Kempken, Frank, Kiderlen, Albrecht F., Klenz, Uwe, Law, Louiza, Lewen-Dörr, Inca, Lim, Hwa A., Ludwig-Müller, Jutta, Martin, Stephan, Matter, Alex, Meyer, Wolfgang, van Montagu, Marc, Müller-Esterl, Werner, Niessner, Reinhard, Pauly, Susanne, Polle, Jürgen, Rapoport, Tom A., Reuss, Matthias, Reski, Ralf, Sahm, Hermann, Scheller, Frieder W., Schmidt, Steffen, Schulz, Olaf, Sprenger, Georg, Stewart, Eric, Strobel, Gary, Stüber, Kurt, Tanaka, Atsuo, Trau, Dieter, Tuschl, Thomas, Wadsworth, Larry, Wan, Terence S.M., Wang, Zeng-yu, Wellmann, Eckhard, Wink, Michael, Wolf, Dieter, Zastrow, Leonhard, Aehle, Wolfgang, Arber, Werner, Barnum, Susan R., Beier, Hildburg, Ian, Billings, John, Chakrabarty, Ananda M., Chan, Cangel Pui Yee, Coutelle, Charles, Diamond, Jared M., Djerassi, Carl, Endo, Akira, Feldmeier, Herrmann, Fischer, Ernst Peter, Gänzle, Michael, Geißler, Erhard, Greenfield, Susan A., Guttmacher, Alan E., Haass, Christian, Hatzak, Frank, Jeffreys, Sir Alec, Kekulé, Alexander, Kinoshita, Shukuo, Korsman, Stephen, Larrick, James W., Ligler, Frances S., MacDiarmid, Alan, Paquet, Dominik, Perlitz, Uwe, Potrykus, Ingo, Preiser, Wolfgang, Rainer, Timothy H., Reich, Jens, Richardson, Michael K., Rokem, Stefan, Rossbach, Michael, Sankula, Sujatha, Schatz, Gottfried, Spelsberg, Gerd, Strobel, Gary A., Tautz, Jurgen, Wandrey, Christian, Wei, Fuwen, Whiteson, Katrine, Wilmut, Ian, Winterhalter, Christoph, Wolf, Eckhard, Woodruff, Boyd, Yang, Daichang, and Zinke, Holger

Published
2023
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36. Glioblastoma Multiforme: Novel Therapeutic Approaches

Author

Fialho, Arsenio M., Salunkhe, Prabhakar, Manna, Sunil, Mahali, Sidharth, and Chakrabarty, Ananda M.

Subjects
Article Subject
Abstract

The current therapy for glioblastoma multiforme involves total surgical resection followed by combination of radiation therapy and temozolomide. Unfortunately, the efficacy for such current therapy is limited, and newer approaches are sorely needed to treat this deadly disease. We have recently described the isolation of bacterial proteins and peptides with anticancer activity. In phase I human clinical trials, one such peptide, p28, derived from a bacterial protein azurin, showed partial and complete regression of tumors in several patients among 15 advanced-stage cancer patients with refractory metastatic tumors where the tumors were no longer responsive to current conventional drugs. An azurin-like protein called Laz derived from Neisseria meningitides demonstrates efficient entry and high cytotoxicity towards glioblastoma cells. Laz differs from azurin in having an additional 39-amino-acid peptide called an H.8 epitope, which allows entry and high cytotoxicity towards glioblastoma cells. Since p28 has been shown to have very little toxicity and high anti-tumor activity in advanced-stage cancer patients, it will be worthwhile to explore the use of H.8-p28, H.8-azurin, and Laz in toxicity studies and glioblastoma therapy in preclinical and human clinical trials.

Published
2012
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39. Intellectual Property Right Issues in Biotechnology: Some Recent Court Cases in the United States.

Author

Chakrabarty, Ananda M.

Subjects
*BIOTECHNOLOGY, *PHARMACOLOGY, *GENETIC engineering, *ERGONOMICS, *GENES
Abstract

There have been several court cases involving biotechnological patent eligibility issues in the United States during the last ten years. This review compiles the issues, the contentious court cases involving gene patents of plants, animals and humans and the outcome of the judicial decisions. [ABSTRACT FROM AUTHOR]

Published
2017

42. US Supreme Court's Decision on the Patent Ineligibility of Human Genes BRCA1/BRCA2 as Products of Nature.

Author

Chakrabarty, Ananda M.

Subjects
ASSOCIATION for Molecular Pathology v. Myriad Genetics Inc., PATENT law, LEGAL judgments, BRCA genes, DNA
Abstract

The article discusses the court case Association for Molecular Pathology, et al v. Myriad Genetics, Inc., et al. in which the U.S. Supreme Court decided on the patent eligibility issue of the isolated and purified DNA of the human BRCA1 and BRCA2 genes. The court held that the isolate genes are not eligible for patent due to its natural occurring DNA segments without any modifications.

Published
2015
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