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9. Processing of Food Powders

Author

Ahrné, Lilia, Chamayou, Alain, Dewettinck, Koen, Depypere, Frederic, Dumoulin, Elisabeth, Fitzpatrick, John, Meesters, Gabrie, Aguilera, José Miguel, editor, and Lillford, Peter J., editor

Published
2008
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15. Comprehensive experimental investigation of mechanically induced 1,4-diazines synthesis in solid state

Author

F. M. オリヴェイラ, パウロ, F. M. Oliveira, Paulo, Haruta, Naoki, Chamayou, Alain, Guidetti, Brigitte, Baltas, Michel, Tanaka, Kazuyoshi, Sato, Tohru, Baron, Michel, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Graduate School of Engineering, Kyoto University, Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Unit of Element Strategy Initiative for Catalysts & Batteries, ESICB, Kyoto University, Kyoto University, Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Kyoto University [Kyoto], IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Reaction mechanism, 010405 organic chemistry, Concerted reaction, Diazines, Organic Chemistry, Phenazine, Reaction intermediate, 010402 general chemistry, Photochemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, Ball milling, [SPI]Engineering Sciences [physics], chemistry, Mechanochemistry, Diamine, Drug Discovery, Hemiaminal, Mechanosynthesis, Reaction intermediates
Abstract

International audience; Compared mechanosynthesis of two condensed 1,4-diazines were investigated in ball milling conditions from o-phenylenediamine. C-13 CP-MAS NMR revealed a hemiaminal intermediate for dibenzo[a,c] phenazine synthesis accumulated under mechanical action, as confirmed by calorimetry. Such intermediate, which is not detected in the case of 2,3-diphenylquinoxaline synthesis, provides experimental evidence of a concerted reaction between highly reactive mechanically-excited diamine and 9,10-phenanthrenequinone.

Published
2017

18. Engineering of nano-crystalline drug suspensions: Employing a physico-chemistry based stabilizer selection methodology or approach

Author

Authelin, Jean-Rene, Nakach, Mostafa, Authelin, Jean-René, Tadros, Tharwat, Galet, Laurence, Chamayou, Alain, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
Time Factors, Chemistry, Pharmaceutical, Drug Storage, Pharmaceutical Science, Nanotechnology, Dispersant, Top down process, Excipients, [SPI]Engineering Sciences [physics], chemistry.chemical_compound, Adsorption, Drug Stability, Suspensions, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Beads milling, Surface charge, Sodium dodecyl sulfate, Active ingredient, Chemistry, Temperature, Povidone, Sodium Dodecyl Sulfate, Dispersant agent, Wetting agent, Chemical engineering, Wettability, Nano-crystalline suspension, Nanoparticles, Wetting, Stabilizer, Nano crystalline, Stabilizer (chemistry)
Abstract

International audience; This paper describes a systematic approach to select optimum stabilizer for the preparation of nano-crystalline suspensions of an active pharmaceutical ingredient (API). The stabilizer can be either a dispersant or a combination of dispersant and wetting agent. The proposed screening method is a quick and efficient way to investigate a large number of stabilizers based on the principles of physical-chemistry and employs a stepwise approach. The methodology has been divided in two main parts; the first part being focused on the qualitative screening with the objective of selecting the best candidate(s) for further investigation, the second part has been focused on quantitative screening with the objective to optimize the ratio and amount of wetting and dispersing agents, based on wettability, surface charges measurement, adsorption evaluation, process-ability evaluation and storage stability. The results showed clearly that SDS/PVP 40/60% (w/w) (sodium dodecyl sulfate/poly(vinyl pyrrolidone)) at a total concentration of 1.2% was the optimum stabilizer composition, at which the resulting nanosuspensions were stable for more than 50 days at room temperature.

Published
2014

19. Lowering the Activation Energy under Mechanochemical Conditions: The Case of 2,3-diphenylquinoxaline

Author

F. M. オリヴェイラ, パウロ, F. M. Oliveira, Paulo, Baron, Michel, Chamayou, Alain, Baltas, Michel, Guidetti, Brigitte, Haruta, Naoki, Tanaka, Kazuyoshi, Sato, Tohru, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Graduate School of Engineering, Kyoto University, Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Green chemistry, Computational chemistry, Materials science, Kinetics, Thermodynamics, 02 engineering and technology, General Chemistry, Activation energy, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Arrhenius plot, 0104 chemical sciences, [SPI]Engineering Sciences [physics], Mechanochemistry, 0210 nano-technology, Powder mixture, Mechanical energy, Eutectic system
Abstract

International audience; The kinetics of 2,3-diphenylquinoxaline synthesis was investigated in mechanochemical conditions aiming to estimate the overall activation energy. Arrhenius plot revealed a change in the activation energy around the eutectic melting of the powder mixture under mechanical activation. Below this transition zone the reaction between solids prevails, where the mechanical effects lower the activation energy. Above it, part of the energy is used to induce the eutectic, and the apparent activation energy is higher. DFT calculations showed a reaction barrier similar to the experimental one for higher temperatures. This study is the first that demonstrates the effect of mechanical energy to lower an activation barrier for ball milled organic reaction.

Published
2016

20. High energy dry coating mixing: Elements on velocities, temperatures and melting

Author

Galet Laurence, Olivier Lecoq, Chamayou Alain, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
Work (thermodynamics), General Chemical Engineering, Mixing (process engineering), 02 engineering and technology, engineering.material, Dry coating, Purge, [SPI]Engineering Sciences [physics], Recirculation velocity, Temperature increase, 020401 chemical engineering, Coating, Hybridizer, 0204 chemical engineering, Composite material, chemistry.chemical_classification, Wax, Chromatography, Melting, Polymer, 021001 nanoscience & nanotechnology, Environmentally friendly, Solvent, chemistry, Mechanics of Materials, visual_art, visual_art.visual_art_medium, engineering, 0210 nano-technology
Abstract

Issu de : WCPT6 2010 - 6th World congress on particle technology, Nuremberg, GERMANY, 26-29 April 2010; International audience; In dry coating processes no liquid, solvent, binder or water, is required. This makes them advantageous compared to wet coating alternative: being low cost, no drying step required, environmentally friendly (no volatile organic compounds related problems) and simple in operation. But there is still a lack of fundamental knowledge of the implied mechanisms. Often the process itself has been empirically designed and is not always well characterized. In this work, some hydrodynamic elements are developed in a high energy mixer used for dry coating: the specific behavior of the Nara hybridizer NHS-0 is investigated. In the first part, recirculation velocities and temperatures are derived during the process, or when the purge is on. The effects of the pressure purge and of the rotor velocity on the purge and the effect of the rotation on the temperature increase are studied. In the second part, a simple experimental approach is carried out to derive qualitatively the local temperature inside the apparatus with the help of polymers with different melting temperatures. This approach illustrates a first step for dry coating application with waxes.

Published
2011

21. Mechanochemical Synthesis and Biological Evaluation of Novel Isoniazid Derivatives with Potent Antitubercular Activity

Author

Oliveira, Paulo, primary, Guidetti, Brigitte, additional, Chamayou, Alain, additional, André-Barrès, Christiane, additional, Madacki, Jan, additional, Korduláková, Jana, additional, Mori, Giorgia, additional, Orena, Beatrice, additional, Chiarelli, Laurent, additional, Pasca, Maria, additional, Lherbet, Christian, additional, Carayon, Chantal, additional, Massou, Stéphane, additional, Baron, Michel, additional, and Baltas, Michel, additional

Published
2017
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23. Apport de l’approche numérique DEM pour la compréhension de l’enrobage en voie sèche

Author

Sato, Akira, Chamayou, Alain, Galet, Laurence, Baron, Michel, Serris, Eric, Grosseau, Philippe, Thomas, Gérard, Laboratoire Georges Friedel (LGF-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département PROcédés Poudres, Interfaces, Cristallisation et Ecoulements (PROPICE-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-SPIN, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT), Fédération Française des Matériaux (FFM), Olivier ISNARD, Jérôme CREPIN, and Mines Albi-Carnaux

Subjects
mouvement de particule, DEM, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Enrobage
Abstract

National audience; Dans cette étude, l’intérêt est porté sur l’effet des conditions opératoires sur l’enrobage en voie sèche de grosses particules « hôtes » par de fines particules « invitées » et aussi sur la modélisation de cet enrobage selon la méthode par éléments discrets (DEM) afin de mieux comprendre les phénomènes mis en jeu. Dans ce travail, les matériaux choisis comme particules hôtes sont les Suglets® (des granules sphériques constituées principalement de sucre) et les particules invitées sont en stéarate de magnésium (StMg). Ces deux éléments sont introduits en poudre dans un mélangeur de 1L à fort taux de cisaillement, le Cyclomix. Les propriétés du produit final, comme la coulabilité, la mouillabilité et le degré d’avancement du revêtement, ont été caractérisées. La variation de l’indice de coulabilité est étudiée en fonction de la durée de traitement dans le Cyclomix pour diverses vitesses de rotation, taux de remplissage et rapport de taille de particules hôte et invitée. La coulabilité des produits a été améliorée en augmentant la durée du mélange ou la vitesse de rotation, tandis que le taux de remplissage de solide ne semble pas avoir d’importance. Le degré d’avancement présente une tendance semblable pour différentes conditions opératoires. La simulation des mouvements de particules dans le mélangeur par DEM a permis d’obtenir des informations sur la position, la vitesse des particules, et d’autres paramètres énergétiques, ainsi qu’une estimation du degré de mélange à tout instant. Les champs de vitesse réelle ou numérique liés aux mouvements de particules, analysés par PIV (Particule Image Velocimetry), sont analogues, cela permet de valider ces modélisations. Grâce à l’interprétation de ces mouvements de particules à l’intérieur du Cyclomix nous pouvons expliquer les différences de comportements déduites de l’analyse des propriétés physico-chimiques des produits composites obtenus.

Published
2014

27. Is sterilization by ionizing radiation detectable?

Author

Tilquin, Bernard, Talbi, Saad, Maquille, Aubert, Chamayou, Alain, Raffi, Jacques, Baron, Michel, Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[SPI]Engineering Sciences [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

28. Air jet milling

Author

Chamayou, Alain, Dodds, John A., Centre de recherche d'Albi en génie des procédés des solides divisés, de l'énergie et de l'environnement (RAPSODEE), Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[SPI]Engineering Sciences [physics], Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Experiment
Abstract

International audience; This chapter talks about air jet milling. The first versions, developed in the late 19th century, used a jet of compressed air to project solids against a target. Such devices have the severe disadvantage of target wear and subsequent contamination of the products but have lead to the development of other versions with opposed jets, tangential intersecting jets and more recently opposed jets in a fluidized bed. Air jet milling, or more correctly fluid energy milling, uses high velocity jets of gas to impart energy to particles for size reduction. Air jet mills have mainly been developed for producing fine particles of below 50 mm. Most models are available in many sizes from lab-size versions (as low as to 1 gram/h) up to industrial versions (up to 6 tonne/h), making for easy testing and scale-up. However, a disadvantage is that air jet mills require ancillary air compressors that can assure high flow rates at pressures up to about 10 bars. In addition, the chapter also discusses different types of air jet mills.

Published
2007

29. Pharmaceutical application of chemical engineering : Dimensionless analysis of a kneading process allowing complexation between eflucimibe et gamma-cyclodextrin

Author

Hutin, Séverine, Chamayou, Alain, Avan, J. L., Paillard, Bruno, Baron, Michel, Couarraze, Guy, Bougaret, Joël, IMT Mines Albi, IMT Mines Albi, Poudres et procédés - Ecole des Mines Albi-Carmaux, IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[SPI]Engineering Sciences [physics], [SPI] Engineering Sciences [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2004

30. Processing of Food Powders

Author

Ahrné, Lilia, primary, Chamayou, Alain, additional, Dewettinck, Koen, additional, Depypere, Frederic, additional, Dumoulin, Elisabeth, additional, Fitzpatrick, John, additional, and Meesters, Gabrie, additional

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32. Preface to the Special Edition of Powder Technology on the 9th European Symposium on Comminution

Author

Frances , C, Le Bolay , N, Chamayou , Alain, Dodds , John A., INPT ENSIACET LGC, Poudres et procédés - Ecole des Mines Albi-Carmaux, IMT École nationale supérieure des Mines d'Albi-Carmaux ( IMT Mines Albi ), IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[SPI]Engineering Sciences [physics], [ SPI ] Engineering Sciences [physics]
Abstract

Extrait de : 9th European Symposium on Comminution / sous la dir. de E. FORSSBERG. Ce numéro spécial de Powder Technology propose une sélection de communications présentées lors du 9th European Symposium on Comminution, 8-10 september 1998, Albi (FRANCE).; International audience; no abstract

Published
1999

40. Processing of Food Powders.

Author

Aguilera, José Miguel, Lillford, Peter J., Ahrné, Lilia, Chamayou, Alain, Dewettinck, Koen, Depypere, Frederic, Dumoulin, Elisabeth, Fitzpatrick, John, and Meesters, Gabrie

Abstract

The development of formulation engineering concepts in food manufacturing and the demand for diversity in food products has driven a substantial market increase for food ingredients. Most ingredients are supplied in powder form and therefore a better understanding of dispersed solid food systems is important both for food ingredient manufactures and food producers. [ABSTRACT FROM AUTHOR]

Published
2008
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42. Dry Coating of Talc Particles: Effect of Material and Process Modifications on Their Wettability and Dispersibility.

Author

Lefebvre, Guillaume, Galet, Laurence, and Chamayou, Alain

Subjects
TALC, HYDROPHOBIC surfaces, SILICA, COATING processes, DISPERSION (Chemistry)
Abstract

The article presents information on a study which examined the surface properties of talc particles modified by dry coating with hydrophobic silica properties. Variables studied included the concentration of silica properties and the dry coating processing time. It describes the talc powders and their characterization. The quantification of dispersion kinetics is detailed. A discussion on the findings of the study including surface morphology and wettability measurements is detailed.

Published
2011
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