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Your search keyword '"Chan, Tommy Chung Yan"' showing total 22 results
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22 results on '"Chan, Tommy Chung Yan"'

4. The association between altered intestinal microbiome, impaired systemic and ocular surface immunity, and impaired wound healing response after corneal alkaline-chemical injury in diabetic mice

Author

Bu, Yashan, primary, Shih, Kendrick Co, additional, Wong, Ho Lam, additional, Kwok, Sum Sum, additional, Lo, Amy Cheuk-Yin, additional, Chan, Joseph Yau-Kei, additional, Ng, Alex Lap-Ki, additional, Chan, Tommy Chung-Yan, additional, Jhanji, Vishal, additional, and Tong, Louis, additional

Published
2023
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12. A Systematic Review of Potential Therapeutic Use of Lycium Barbarum Polysaccharides in Disease

Author

Kwok, Sum Sum, Bu, Yashan, Lo, Amy Cheuk-Yin, Chan, Tommy Chung-Yan, So, Kwok Fai, Lai, Jimmy Shiu-Ming, and Shih, Kendrick Co

Subjects
Article Subject
Abstract

Objective. To evaluate the effect of Lycium barbarum polysaccharides in the treatment and/or prevention of diseases of different etiologies and systems. Methods. We performed an Entrez PubMed literature search using keywords “lycium”, “barbarum”, “polysaccharides”, “anti-fibrotic”, “anti-apoptotic”, “anti-oxidizing”, “anti-aging”, “neuroprotection”, “metabolism”, “diabetes”, “hyperlipidemia”, “neuroprotection”, and “immunomodulation” on the 14th of August 2018, resulting in 207 papers, of which 20 were chosen after filtering for ‘English language’ and ‘published within 10 years’ as well as curation for relevance by the authors. Results. The 20 selected papers included 2 randomized control trials (1 double-blinded RCT and 1 double-blinded placebo-controlled RCT), 11 in vivo studies, 5 in vitro studies, 1 study with both in vivo and in vitro results, and 1 chemical study. There is good evidence from existing studies on the antifibrotic, antioxidizing, neuroprotective, anticancer, and anti-inflammatory effects of Lycium barbarum polysaccharides. However, there is a need for further studies in the form of large-scale clinical trials to support its use in humans. There is also significant potential for LBP as a safe and effective topical treatment in ocular surface diseases, owing to promising in vitro results and a lack of demonstrated toxic effects to corneal epithelial cells. Conclusion. Results from existing studies suggest that LBP is a promising therapeutic agent, particularly in the management of liver disease, hyperlipidemia, and diabetes. One major limitation of current research is a lack of standardization and quality control for the LBP used. The availability of research-grade LBP will inevitably promote future research in this field worldwide.

Published
2019
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13. A sclerocornea-associated RAD21 variant induces corneal stroma disorganization

Author

Zhang, Bi Ning, primary, Wong, Thomas Chi Bun, additional, Yip, Yolanda Wong Ying, additional, Liu, Ziran, additional, Wang, Chengdong, additional, Wong, Janice Siu Chong, additional, He, Jing Na, additional, Chan, Tommy Chung Yan, additional, Jhanji, Vishal, additional, Pang, Chi Pui, additional, Zhao, Hui, additional, and Chu, Wai Kit, additional

Published
2019
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14. Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors

Author

Qin, Yong Jie, primary, Chu, Wai Kit, additional, Huang, Li, additional, Ng, Clara Hoi Yen, additional, Chan, Tommy Chung Yan, additional, Cao, Di, additional, Yang, Cheng, additional, Zhang, Liang, additional, Huang, Shao Ping, additional, Li, Juan, additional, Lin, Hong Liang, additional, Li, Wen Qian, additional, Chen, Li, additional, Schally, Andrew V., additional, Chan, Sun On, additional, Zhang, Hong Yang, additional, and Pang, Chi Pui, additional

Published
2018
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15. Analysis of multiple genetic loci reveals MPDZ-NF1B rs1324183 as a putative genetic marker for keratoconus

Author

Wang, Yu Meng, primary, Ma, Li, additional, Lu, Shi Yao, additional, Chan, Tommy Chung Yan, additional, Yam, Jason C S, additional, Tang, Shu Min, additional, Kam, Ka Wai, additional, Tam, Pancy O S, additional, Tham, Clement C, additional, Young, Alvin L, additional, Jhanji, Vishal, additional, Pang, Chi Pui, additional, and Chen, Li Jia, additional

Published
2018
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21. Analysis of multiple genetic loci reveals MPDZ-NF1Brs1324183 as a putative genetic marker for keratoconus

Author

Wang, Yu Meng, Ma, Li, Lu, Shi Yao, Chan, Tommy Chung Yan, Yam, Jason C S, Tang, Shu Min, Kam, Ka Wai, Tam, Pancy O S, Tham, Clement C, Young, Alvin L, Jhanji, Vishal, Pang, Chi Pui, and Chen, Li Jia

Abstract

ObjectiveTo investigate the associations between 16 single-nucleotide polymorphisms (SNPs) in 14 genetic loci and keratoconus in an independent Chinese cohort.MethodsThis cross-sectional, case-control association study included a Chinese cohort of 133 patients with keratoconus and 371 control subjects. In a recent meta-analysis study, we identified association of 16 SNPs in 14 gene loci with keratoconus. In this study, we genotyped these 16 SNPs in all the patients and controls and analysed their association with keratoconus, its clinical severities and progression profiles. We also analysed the genotype-phenotype correlation between individual SNPs and steep keratometry, flat keratometry (Kf), average keratometry (Avg K) and best-fit sphere diameter (BFS) of the anterior and posterior corneal surface.ResultsAmong the 16 selected SNPs, rs1324183 in the MPDZ-NF1Blocus showed a significant association with keratoconus (OR=2.22; 95% CI 1.42 to 3.45, p=4.30×10–4), especially severe keratoconus (OR=5.10, 95% CI 1.63 to 15.93, p=0.005). The rs1324183 A allele was positively associated with anterior Kf (p=0.008), anterior Avg K (p=0.017), posterior Kf (p=0.01) and negatively associated with apex pachymetry (p=0.007) and anterior BFS (p=0.023) in keratoconus. The other 15 SNPs had no significant association with keratoconus or genotype-phenotype correlations.ConclusionsThis study confirmed the association of SNP rs1324183 in MPDZ-NF1Bwith keratoconus and revealed the association of this SNP with keratoconus severity and corneal parameters. It is thus a putative genetic marker for monitoring the progression of keratoconus to a severe form and facilitating early intervention.

Published
2018
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22. Role of tear film biomarkers in the diagnosis and management of dry eye disease.

Author

Fong PY, Shih KC, Lam PY, Chan TCY, Jhanji V, and Tong L

Abstract

In recent years, there has been increasing scientific interest in the use of tear film biomarkers in the diagnosis and management of dry eye disease (DED), owing to their potential important roles in the pathogenesis of ocular surface damage, as well as the technical feasibility of tear sample collection techniques. An Entrez PubMed search was conducted on March 2, 2019, to include papers investigating the use of tear film biomarkers in DED, and the results were classified according to whether the DED is associated with systemic inflammatory disease or not and further classified within each section according to the molecular nature of the biomarker for further discussion. A total of 58 relevant articles were reviewed. Certain cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha, IL-17, and IL-8, were found by a number of studies to consistently reflect disease severity well and had strong correlations with tear film metrics and tests for ocular surface damage in dry eye without systemic inflammatory disease. For dry eye with systemic inflammatory disease, IL-17, IL-8, and IL-1 receptor antagonists were shown to be consistently higher in affected eyes and correlated well with ocular surface disease severity in more than one type of inflammatory disease. With the advancement in technology and lowered costs in the future, tear film biomarker counts would allow better diagnosis and monitoring of DED, as well as facilitate personalized treatment strategies., Competing Interests: The authors declare that there are no conflicts of interests of this paper., (Copyright: © 2019 Taiwan J Ophthalmol.)

Published
2019
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