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1. New WHO guidelines for treating rhodesiense human African trypanosomiasis: expanded indications for fexinidazole and pentamidine

Author

Lindner, Andreas K, Lejon, Veerle, Barrett, Michael P, Blumberg, Lucille, Bukachi, Salome A, Chancey, Rebecca J, Edielu, Andrew, Matemba, Lucas, Mesha, Tihitina, Mwanakasale, Victor, Pasi, Christopher, Phiri, Tapunda, Seixas, Jorge, Akl, Elie A, Probyn, Katrin, Villanueva, Gemma, Simarro, Pere P, Kadima Ebeja, Augustin, Franco, Jose R, and Priotto, Gerardo

Published
2025
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2. Baylisascaris procyonis Roundworm Infection in Child with Autism Spectrum Disorder, Washington, USA, 2022

Author

Lipton, Beth A., Oltean, Hanna N., Capron, Roger B., Hamlet, Arran, Montgomery, Susan P., Chancey, Rebecca J., Konold, Victoria J.L., and Steffi, Katherine E.

Subjects
Pediatric research, Autistic children -- Case studies -- Health aspects, Ascariasis -- Case studies -- Causes of, Health
Abstract

Baylisascaris spp. are ascarid worms that parasitize the small intestines of multiple species. The primary definitive host for B. procyonis roundworms is the raccoon (Procyon lotor), although other carnivores, including [...]

Published
2023
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3. Contributors

Author

Abzug, Mark J., primary, Adderson, Elisabeth E., additional, Agarwal, Aastha, additional, Agwu, Allison L., additional, Albenberg, Lindsey, additional, Albert, Jonathan, additional, Alby, Kevin, additional, Aldrovandi, Grace M., additional, Allen, Upton D., additional, Alvarez-Hernndez, Gerardo, additional, Ampofo, Krow, additional, Anderson, Evan J., additional, Appiah, Grace D., additional, Ardura, Monica I., additional, Arnon, Stephen S., additional, Aronson, Naomi E., additional, Arvin, Ann M., additional, Ashkenazi, Shai, additional, Ashkenazi-Hoffnung, Liat, additional, Asturias, Edwin J., additional, Aukstuolis, Kestutis, additional, Badalyan, Vahe, additional, Baker, Carol J., additional, Balakrishnan, Karthik, additional, Barnett, Elizabeth D., additional, Bechtel, Kirsten, additional, Benitz, William E., additional, Berkovich, Rachel, additional, Berman, David M., additional, Bialek, Stephanie R., additional, Bijker, Else M., additional, Bizzarro, Matthew J., additional, Bloch, Karen C., additional, Bocchini, Joseph A., additional, Boyce, Thomas G., additional, Bradley, John S., additional, Bratcher, Denise F., additional, Braverman, Paula K., additional, Brook, Itzhak, additional, Brown, Kevin Edward, additional, Bryant, Kristina P., additional, Camacho-Gonzalez, Andres F., additional, Caete-Gibas, Connie F., additional, Cantey, Joseph B., additional, Cantey, Paul, additional, Cardemil, Cristina V., additional, Caserta, Mary T., additional, Castagnini, Luis A., additional, Cataldi, Jessica R., additional, Chadwick, Ellen Gould, additional, Chancey, Rebecca J., additional, Cherry, Cara C., additional, Chiang, Silvia S., additional, Choi, Mary, additional, Christenson, John C., additional, Coffin, Susan E., additional, Cohn, Amanda, additional, Contopoulos-Ioannidis, Despina G., additional, Conway, James H., additional, Cortese, Margaret M., additional, Creech, C. Buddy, additional, Crews, Jonathan D., additional, Curtis, Donna, additional, Curtis, Nigel, additional, Danziger-Isakov, Lara A., additional, Darville, Toni, additional, Dasch, Gregory A., additional, Daskalaki, Irini, additional, Davies, H. Dele, additional, Dawood, Fatimah S., additional, Day, J. Christopher, additional, Teresa de la Morena, M., additional, DeMuri, Gregory P., additional, Despommier, Dickson D., additional, Dodson, Daniel S., additional, Dolgner, Stephen J., additional, Dunn, Clinton, additional, Dyal, Jonathan, additional, Edwards, Kathryn M., additional, Edwards, Morven S., additional, Eichenfield, Dawn Z., additional, Eichenfield, Lawrence F., additional, Elston, Dirk M., additional, Emerson, Beth, additional, Enane, Leslie A., additional, Ephros, Moshe, additional, Erdem, Guliz, additional, Eremeeva, Marina E., additional, Esposito, Douglas H., additional, Farley, Monica M., additional, Feingold, Anat R., additional, Feja, Kristina N., additional, Finn, Adam, additional, Fischer, Marc, additional, Fisher, Brian T., additional, Fisher, Randall G., additional, Flynn, Patricia Michele, additional, Foster, Monique A., additional, Fox, LeAnne M., additional, Frank, Michael M., additional, Fredrick, Douglas R., additional, Frenck, Robert W., additional, Gaensbauer, James, additional, Gans, Hayley A., additional, Gauthier, Gregory M., additional, Gavigan, Patrick, additional, Gerber, Jeffrey S., additional, Gernez, Yael, additional, Gigliotti, Francis, additional, Gilger, Mark A., additional, Glaser, Carol A., additional, Gould, Jane M., additional, Graziano, James, additional, Green, Amanda M., additional, Green, Michael, additional, Griffin, Daniel, additional, Griffin, Patricia M., additional, Griffith, David C., additional, Gupta, Piyush, additional, Gutelius, Bruce J., additional, Gutman, Julie R., additional, Hall, Aron J., additional, Hamdy, Rana F., additional, Han, Jin-Young, additional, Handy, Lori K., additional, Hanisch, Benjamin, additional, Harper, Marvin B., additional, Harris, Aaron M., additional, Harrison, Christopher J., additional, Haslam, David B., additional, Haston, Julia C., additional, Hawkes, Sarah.J., additional, Heald-Sargent, Taylor, additional, Hendley, J. Owen, additional, Hersh, Adam L., additional, Hilinski, Joseph A., additional, Hills, Susan L., additional, Hong, David K., additional, Hotez, Peter J., additional, Hsu, Katherine K., additional, Huang, Felicia Scaggs, additional, Hunstad, David A., additional, Hunt, W. Garrett, additional, Hwang, Loris Y., additional, Ilboudo, Christelle M., additional, Jaggi, Preeti, additional, Jean, Sophonie, additional, Jhaveri, Ravi, additional, Jirk-Pomajbkov, Kateina, additional, Kadry, Nadia A., additional, Kamb, Mary L., additional, Kapadia, Ronak K., additional, Katz, Ben Z., additional, Katz, Sophie E., additional, Kaur, Ishminder, additional, Kersh, Gilbert J., additional, Khan, Muhammad Ali, additional, Khurana, Ananta, additional, Kimberlin, David W., additional, Klein, Bruce, additional, Kobayashi, Miwako, additional, Kociolek, Larry K., additional, Koh, Andrew Y., additional, Kotloff, Karen L., additional, Kroger, Andrew T., additional, Kronman, Matthew P., additional, Lalor, Leah, additional, Lauren, Christine T., additional, Leber, Amy, additional, Leshem, Eyal, additional, Lewis, David B., additional, Livingston, Robyn A., additional, Llata, Eloisa, additional, Lloyd, Kevin, additional, Loh, Katrina, additional, Long, Sarah S., additional, Lopman, Benjamin A., additional, Lucero, Yalda C., additional, Lugo, Debra J., additional, Lujn-Zilbermann, Jorge, additional, Maldonado, Yvonne A., additional, Manaloor, John J., additional, Manthiram, Kalpana, additional, Martin, Stacey W., additional, Mathew, Roshni, additional, Mazzulli, Tony, additional, McFarland, Elizabeth J., additional, McGann, Kathleen A., additional, McNamara, Lucy A., additional, Meislich, Debrah, additional, Meissner, H. Cody, additional, Mejias, Asuncion, additional, Mertsola, Jussi, additional, Messacar, Kevin, additional, Mhaissen, Mohammad Nael, additional, Michaels, Marian G., additional, Miller, Melissa B., additional, Miller-Handley, Hilary, additional, Mintz, Eric, additional, Mohan, Parvathi, additional, Montgomery, Susan P., additional, Montoya, Jose G., additional, Moorman, Anne C., additional, Moro, Pedro L., additional, Moscicki, Anna-Barbara, additional, Muller, William J., additional, Myers, Angela L., additional, Nadel, Simon, additional, Nayak, Jennifer Lynn, additional, Neely, Michael Noel, additional, Neil, Karen P., additional, Nelson, Christina A., additional, Nelson, Noele P., additional, Nichols, Megin, additional, Nicholson, William, additional, Nopper, Amy Jo, additional, Norton, Laura E., additional, Ochoa, Theresa J., additional, Olarte, Liset, additional, Onarecker, Timothy R., additional, Orenstein, Walter A., additional, ORyan, Miguel, additional, Otto, William R., additional, Ouellette, Christopher P., additional, Paddock, Christopher D., additional, Palazzi, Debra L., additional, Panuganti, Suresh Kumar, additional, Pappas, Diane E., additional, Paret, Michal, additional, Pastula, Daniel M., additional, Patterson, Thomas F., additional, Petersen, Brett W., additional, Petrosyan, Mikael, additional, Pickering, Larry K., additional, Pindyck, Talia, additional, Pinninti, Swetha, additional, Pittet, Laure F., additional, Planet, Paul J., additional, Pollard, Andrew J., additional, Posfay-Barbe, Klara M., additional, Poulsen, Casper S., additional, Poutanen, Susan M., additional, Powers, Ann M., additional, Prasanphanich, Nina Salinger, additional, Pritt, Bobbi S., additional, Prober, Charles G., additional, Puar, Neha, additional, Quilter, Laura A.S., additional, Ramilo, Octavio, additional, Rao, Suchitra, additional, Ratner, Adam J., additional, Rawstron, Sarah A., additional, Read, Jennifer S., additional, Relich, Ryan F., additional, Reller, Megan E., additional, Robinson, Candice L., additional, Romero, Jos R., additional, Rosen, David A., additional, Ross, Shannon A., additional, Rours, G. Ingrid J.G., additional, Rowe, Peter C., additional, Rowley, Anne H., additional, Rubin, Lorry G., additional, Ryan, Edward T., additional, Sacharok, Alexandra, additional, Sandora, Thomas J., additional, Sapp, Sarah G.H., additional, Sardana, Kabir, additional, Sauberan, Jason B., additional, Schaffzin, Joshua K., additional, Schillie, Sarah, additional, Schuster, Jennifer E., additional, Schwartz, Kevin L., additional, Sederdahl, Bethany K., additional, Serpa-Alvarez, Jose, additional, Shah, Kara N., additional, Shah, Samir S., additional, Shaikh, Nader, additional, Shane, Andi L., additional, Shapiro, Eugene D., additional, Shaw, Jana, additional, Shetty, Avinash K., additional, Shope, Timothy R., additional, Dairiki Shortliffe, Linda M., additional, Shulman, Stanford T., additional, Shust, Gail F., additional, Siberry, George Kelly, additional, Siegel, Jane D., additional, Siegel, Robert David, additional, Simonsen, Kari A., additional, Singh, Upinder, additional, Smith, Christiana, additional, Smith, Lauren L., additional, Song, Eunkyung, additional, Souder, Emily, additional, Spearman, Paul, additional, St. Geme, Joseph W., additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Starke, Jeffrey R., additional, Statler, Victoria A., additional, Steinbach, William J., additional, Stensvold, Christen Rune, additional, Stokes, Erin K., additional, Stoner, Bradley P., additional, Storch, Gregory A., additional, Straily, Anne, additional, Sullivan, Kathleen E., additional, Swanson, Douglas S., additional, Tanz, Robert R., additional, Taormina, Gillian, additional, Tate, Jacqueline E., additional, Taveras, Jeanette, additional, Tebruegge, Marc, additional, Teshale, Eyasu H., additional, Thompson, George R., additional, Thompson-Stone, Robert, additional, Thomsen, Isaac, additional, Thomson, Richard B., additional, Thorell, Emily A., additional, Tien, Vivian, additional, Tobin, Nicole H., additional, Toltzis, Philip, additional, Treat, James, additional, Troy, Stephanie B., additional, Van Dvke, Russell B., additional, Vaz, Louise Elaine, additional, Vijayan, Vini, additional, Vodzak, Jennifer, additional, Wagner, Thor A., additional, Wald, Ellen R., additional, Wallihan, Rebecca, additional, Wang, Huanyu, additional, Wangu, Zoon, additional, Washam, Matthew, additional, Waters, Valerie, additional, Watson, Joshua R., additional, Weatherhead, Jill E., additional, Weinberg, Geoffrey A., additional, Weng, Mark K., additional, Wiederhold, Nathan P., additional, Wiesenfeld, Harold C., additional, Williams, Cydni, additional, Williams, John V., additional, Willoughby, Rodney E., additional, Wittler, Robert R., additional, Wood, James B., additional, Woods, Charles Reece, additional, Workowski, Kimberly A., additional, Wright, Terry W., additional, Wu, Hsi-Yang, additional, Xu, Huan, additional, Yagupsky, Pablo, additional, Yi, Jumi, additional, Yoder, Jonathan, additional, Young, Edward J., additional, Zaenglein, Andrea L., additional, Zimmermann, Petra, additional, and Zong, Wenjing, additional

Published
2023
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6. Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021

Author

Alford, Alexis, Baird, Samuel, Bankers, Laura, Bello, Jazmin, Bolcen, Shanna, Browning, Peter, Cook, Peter W., David, Ebenezer, Harcourt, Jennifer L., Hareland, Geir, Jr., Hetherington-Rauth, Molly C., Ir, Diana, Jain, Shilpi, Jia, Tao Lily, Johnson, Ralen, Kelleher, Anna, Kim, Gimin, Li, Yan, Lynch, Brian, Mallal, Daniel, Maniatis, Panagiotis, Marine, Rachel, Medrzycki, Magdalena, Metz, John M., Montmayeur, Anna Maria, Moss, Kimberly M., Justin Ng, Han Jia, Nyugen, Van, Ortiz, Kristina, Paden, Clinton R., Park, So Hee, Queen, Krista, Rossheim, Alexandria E.B., Semenova, Vera, Shepard, Samuel S., Tamin, Azaibi, Tao, Ying, Tejada-Strop, Alexandra, Wong, Phili, Zellner, Briana, Zhang, Jing, Waltenburg, Michelle A., Whaley, Melissa J., Chancey, Rebecca J., Donnelly, Marisa A.P., Chuey, Meagan R., Soto, Raymond, Schwartz, Noah G., Chu, Victoria T., Sleweon, Sadia, McCormick, David W., Uehara, Anna, Retchless, Adam C., Tong, Suxiang, Folster, Jennifer M., Petway, Marla, Thornburg, Natalie J., Drobeniuc, Jan, Austin, Brett, Hudziec, Meghan M., Stringer, Ginger, Albanese, Bernadette A., Totten, Sarah E., Matzinger, Shannon R., Staples, J. Erin, Killerby, Marie E., Hughes, Laura J., Matanock, Almea, Beatty, Mark, Tate, Jacqueline E., Kirking, Hannah L., and Hsu, Christopher H.

Published
2022
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7. Angiostrongylus cantonensisMeningoencephalitis in Three Pediatric Patients in Florida, USA

Author

Chance, Melinda D, Noel, Anniesha D, Thompson, Amelia B, Marrero, Natalie, Bula-Rudas, Fernando, Horvat, Christopher M, Green, Jerril, Armstrong, Jennifer E, Levent, Fatma, Dudas, Robert A, Shaffren, Serena, Samide, Aaron, Martinez, Katie, Stockdale, Kimberly, and Chancey, Rebecca J

Abstract

Eosinophilic meningoencephalitis caused by Angiostrongylus cantonensishas been reported in several southern U.S. states and Hawai‘i. We present the first locally acquired human cases of A. cantonensismeningoencephalitis in three children in Florida, occurring between June 2021 and January 2022. Clinicians should be attuned to this possible diagnosis in this region.Infection with Angiostrongylus cantonensiscauses eosinophilic meningoencephalitis. Here we present the first cases of locally acquired infection in Florida. Diagnosis requires a high degree of suspicion in a patient with consistent clinical and laboratory findings and potential epidemiologic exposure.

Published
2024
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12. Characteristics and Adverse Events of Patients for Whom Nifurtimox Was Released Through CDC-Sponsored Investigational New Drug Program for Treatment of Chagas Disease--United States, 2001-2021

Author

Abbott, Andrew, Montgomery, Susan P., and Chancey, Rebecca J.

Subjects
United States. Food and Drug Administration, Chagas' disease -- Drug therapy -- Complications and side effects, Health
Abstract

Chagas disease, or American trypanosomiasis, is caused by the parasite Trypanosoma cruzi. Chagas disease is endemic in rural areas of Latin America, but T. cruzi, triatomine vectors, infected mammalian reservoir [...]

Published
2022

17. Household Transmission and Symptomology of Severe Acute Respiratory Syndrome Coronavirus 2 Alpha Variant among Children—California and Colorado, 2021

Author

Waltenburg, Michelle A., primary, Whaley, Melissa J., additional, Chancey, Rebecca J., additional, Donnelly, Marisa A.P., additional, Chuey, Meagan R., additional, Soto, Raymond, additional, Schwartz, Noah G., additional, Chu, Victoria T., additional, Sleweon, Sadia, additional, McCormick, David W., additional, Uehara, Anna, additional, Retchless, Adam C., additional, Tong, Suxiang, additional, Folster, Jennifer M., additional, Petway, Marla, additional, Thornburg, Natalie J., additional, Drobeniuc, Jan, additional, Austin, Brett, additional, Hudziec, Meghan M., additional, Stringer, Ginger, additional, Albanese, Bernadette A., additional, Totten, Sarah E., additional, Matzinger, Shannon R., additional, Staples, J. Erin, additional, Killerby, Marie E., additional, Hughes, Laura J., additional, Matanock, Almea, additional, Beatty, Mark, additional, Tate, Jacqueline E., additional, Kirking, Hannah L., additional, Hsu, Christopher H., additional, Alford, Alexis, additional, Baird, Samuel, additional, Bankers, Laura, additional, Bello, Jazmin, additional, Bolcen, Shanna, additional, Browning, Peter, additional, Cook, Peter W., additional, David, Ebenezer, additional, Harcourt, Jennifer L., additional, Hareland, Geir, additional, Hetherington-Rauth, Molly C., additional, Ir, Diana, additional, Jain, Shilpi, additional, Jia, Tao Lily, additional, Johnson, Ralen, additional, Kelleher, Anna, additional, Kim, Gimin, additional, Li, Yan, additional, Lynch, Brian, additional, Mallal, Daniel, additional, Maniatis, Panagiotis, additional, Marine, Rachel, additional, Medrzycki, Magdalena, additional, Metz, John M., additional, Montmayeur, Anna Maria, additional, Moss, Kimberly M., additional, Justin Ng, Han Jia, additional, Nyugen, Van, additional, Ortiz, Kristina, additional, Paden, Clinton R., additional, Park, So Hee, additional, Queen, Krista, additional, Rossheim, Alexandria E.B., additional, Semenova, Vera, additional, Shepard, Samuel S., additional, Tamin, Azaibi, additional, Tao, Ying, additional, Tejada-Strop, Alexandra, additional, Wong, Phili, additional, Zellner, Briana, additional, and Zhang, Jing, additional

Published
2022
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18. SARS-CoV-2 transmission in a Georgia school district — United States, December 2020–January 2021

Author

Gettings, Jenna R, Gold, Jeremy A W, Kimball, Anne, Forsberg, Kaitlin, Scott, Colleen, Uehara, Anna, Tong, Suxiang, Hast, Marisa, Swanson, Megan R, Morris, Elana, Oraka, Emeka, Almendares, Olivia, Thomas, Ebony S, Mehari, Lemlem, McCloud, Jazmyn, Roberts, Gurleen, Crosby, Deanna, Balajee, Abirami, Burnett, Eleanor, Chancey, Rebecca J, Cook, Peter, Donadel, Morgane, Espinosa, Catherine, Evans, Mary E, Fleming-Dutra, Katherine E, Forero, Catalina, Kukielka, Esther A, Li, Yan, Marcet, Paula L, Mitruka, Kiren, Nakayama, Jasmine Y, Nakazawa, Yoshinori, O'Hegarty, Michelle, Pratt, Caroline, Rice, Marion E, Rodriguez Stewart, Roxana M, Sabogal, Raquel, Sanchez, Emanny, Velasco-Villa, Andres, Weng, Mark K, Zhang, Jing, Rivera, Grant, Parrott, Tonia, Franklin, Rachel, Memark, Janet, Drenzek, Cherie, Hall, Aron J, Kirking, Hannah L, Tate, Jacqueline E, and Vallabhaneni, Snigdha

Subjects
AcademicSubjects/MED00290, Georgia, Schools, SARS-CoV-2, education, Major Article, COVID-19, Humans, Contact Tracing, physical distancing, Students, infection control
Abstract

To inform prevention strategies, we assessed the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and settings in which transmission occurred in a Georgia public school district.During 1 December 2020-22 January 2021, SARS-CoV-2-infected index cases and their close contacts in schools were identified by school and public health officials. For in-school contacts, we assessed symptoms and offered SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) testing; performed epidemiologic investigations and whole-genome sequencing to identify in-school transmission; and calculated secondary attack rate (SAR) by school setting (eg, sports, elementary school classroom), index case role (ie, staff, student), and index case symptomatic status.We identified 86 index cases and 1119 contacts, 688 (61.5%) of whom received testing. Fifty-nine of 679 (8.7%) contacts tested positive; 15 of 86 (17.4%) index cases resulted in ≥2 positive contacts. Among 55 persons testing positive with available symptom data, 31 (56.4%) were asymptomatic. Highest SARs were in indoor, high-contact sports settings (23.8% [95% confidence interval {CI}, 12.7%-33.3%]), staff meetings/lunches (18.2% [95% CI, 4.5%-31.8%]), and elementary school classrooms (9.5% [95% CI, 6.5%-12.5%]). The SAR was higher for staff (13.1% [95% CI, 9.0%-17.2%]) vs student index cases (5.8% [95% CI, 3.6%-8.0%]) and for symptomatic (10.9% [95% CI, 8.1%-13.9%]) vs asymptomatic index cases (3.0% [95% CI, 1.0%-5.5%]).Indoor sports may pose a risk to the safe operation of in-person learning. Preventing infection in staff members, through measures that include coronavirus disease 2019 vaccination, is critical to reducing in-school transmission. Because many positive contacts were asymptomatic, contact tracing should be paired with testing, regardless of symptoms.

Published
2021

21. A prospective cohort study in non-hospitalized household contacts with SARS-CoV-2 infection: symptom profiles and symptom change over time

Author

Yousaf, Anna R, Duca, Lindsey M, Chu, Victoria, Reses, Hannah E, Fajans, Mark, Rabold, Elizabeth M, Laws, Rebecca L, Gharpure, Radhika, Matanock, Almea, Wadhwa, Ash, Pomeroy, Mary, Njuguna, Henry, Fox, Garrett, Binder, Alison M, Christiansen, Ann, Freeman, Brandi, Gregory, Christopher, Tran, Cuc H, Owusu, Daniel, Ye, Dongni, Dietrich, Elizabeth, Pevzner, Eric, Conners, Erin E, Pray, Ian, Rispens, Jared, Vuong, Jeni, Christensen, Kim, Banks, Michelle, O'Hegarty, Michelle, Mills, Lisa, Lester, Sandra, Thornburg, Natalie J, Lewis, Nathaniel, Dawson, Patrick, Marcenac, Perrine, Salvatore, Phillip, Chancey, Rebecca J, Fields, Victoria, Buono, Sean, Yin, Sherry, Gerber, Susan, Kiphibane, Tair, Dasu, Trivikram, Bhattacharyya, Sanjib, Westergaard, Ryan, Dunn, Angela, Hall, Aron J, Fry, Alicia M, Tate, Jacqueline E, Kirking, Hannah L, and Nabity, Scott

Subjects
Adult, Young Adult, AcademicSubjects/MED00290, Fever, SARS-CoV-2, Major Article, community, COVID-19, Humans, Prospective Studies, Contact Tracing, Child, COVID-19 symptoms
Abstract

Improved understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spectrum of disease is essential for clinical and public health interventions. There are limited data on mild or asymptomatic infections, but recognition of these individuals is key as they contribute to viral transmission. We describe the symptom profiles from individuals with mild or asymptomatic SARS-CoV-2 infection.From 22 March to 22 April 2020 in Wisconsin and Utah, we enrolled and prospectively observed 198 household contacts exposed to SARS-CoV-2. We collected and tested nasopharyngeal specimens by real-time reverse-transcription polymerase chain reaction (rRT-PCR) 2 or more times during a 14-day period. Contacts completed daily symptom diaries. We characterized symptom profiles on the date of first positive rRT-PCR test and described progression of symptoms over time.We identified 47 contacts, median age 24 (3-75) years, with detectable SARS-CoV-2 by rRT-PCR. The most commonly reported symptoms on the day of first positive rRT-PCR test were upper respiratory (n = 32 [68%]) and neurologic (n = 30 [64%]); fever was not commonly reported (n = 9 [19%]). Eight (17%) individuals were asymptomatic at the date of first positive rRT-PCR collection; 2 (4%) had preceding symptoms that resolved and 6 (13%) subsequently developed symptoms. Children less frequently reported lower respiratory symptoms (21%, 60%, and 69% for18, 18-49, and ≥50 years of age, respectively; P = .03).Household contacts with laboratory-confirmed SARS-CoV-2 infection reported mild symptoms. When assessed at a single timepoint, several contacts appeared to have asymptomatic infection; however, over time all developed symptoms. These findings are important to inform infection control, contact tracing, and community mitigation strategies.

Published
2020

22. Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in a Georgia School District—United States, December 2020–January 2021

Author

Gettings, Jenna R, primary, Gold, Jeremy A W, additional, Kimball, Anne, additional, Forsberg, Kaitlin, additional, Scott, Colleen, additional, Uehara, Anna, additional, Tong, Suxiang, additional, Hast, Marisa, additional, Swanson, Megan R, additional, Morris, Elana, additional, Oraka, Emeka, additional, Almendares, Olivia, additional, Thomas, Ebony S, additional, Mehari, Lemlem, additional, McCloud, Jazmyn, additional, Roberts, Gurleen, additional, Crosby, Deanna, additional, Balajee, Abirami, additional, Burnett, Eleanor, additional, Chancey, Rebecca J, additional, Cook, Peter, additional, Donadel, Morgane, additional, Espinosa, Catherine, additional, Evans, Mary E, additional, Fleming-Dutra, Katherine E, additional, Forero, Catalina, additional, Kukielka, Esther A, additional, Li, Yan, additional, Marcet, Paula L, additional, Mitruka, Kiren, additional, Nakayama, Jasmine Y, additional, Nakazawa, Yoshinori, additional, O’Hegarty, Michelle, additional, Pratt, Caroline, additional, Rice, Marion E, additional, Rodriguez Stewart, Roxana M, additional, Sabogal, Raquel, additional, Sanchez, Emanny, additional, Velasco-Villa, Andres, additional, Weng, Mark K, additional, Zhang, Jing, additional, Rivera, Grant, additional, Parrott, Tonia, additional, Franklin, Rachel, additional, Memark, Janet, additional, Drenzek, Cherie, additional, Hall, Aron J, additional, Kirking, Hannah L, additional, Tate, Jacqueline E, additional, and Vallabhaneni, Snigdha, additional

Published
2021
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23. Symptoms and Transmission of SARS-CoV-2 Among Children — Utah and Wisconsin, March–May 2020

Author

Laws, Rebecca L., primary, Chancey, Rebecca J., additional, Rabold, Elizabeth M., additional, Chu, Victoria T., additional, Lewis, Nathaniel M., additional, Fajans, Mark, additional, Reses, Hannah E., additional, Duca, Lindsey M., additional, Dawson, Patrick, additional, Conners, Erin E., additional, Gharpure, Radhika, additional, Yin, Sherry, additional, Buono, Sean, additional, Pomeroy, Mary, additional, Yousaf, Anna R., additional, Owusu, Daniel, additional, Wadhwa, Ashutosh, additional, Pevzner, Eric, additional, Battey, Katherine A., additional, Njuguna, Henry, additional, Fields, Victoria L., additional, Salvatore, Phillip, additional, O’Hegarty, Michelle, additional, Vuong, Jeni, additional, Gregory, Christopher J., additional, Banks, Michelle, additional, Rispens, Jared, additional, Dietrich, Elizabeth, additional, Marcenac, Perrine, additional, Matanock, Almea, additional, Pray, Ian, additional, Westergaard, Ryan, additional, Dasu, Trivikram, additional, Bhattacharyya, Sanjib, additional, Christiansen, Ann, additional, Page, Lindsey, additional, Dunn, Angela, additional, Atkinson-Dunn, Robyn, additional, Christensen, Kim, additional, Kiphibane, Tair, additional, Willardson, Sarah, additional, Fox, Garrett, additional, Ye, Dongni, additional, Nabity, Scott A., additional, Binder, Alison, additional, Freeman, Brandi D., additional, Lester, Sandra, additional, Mills, Lisa, additional, Thornburg, Natalie, additional, Hall, Aron J., additional, Fry, Alicia M., additional, Tate, Jacqueline E., additional, Tran, Cuc H., additional, and Kirking, Hannah L., additional

Published
2021
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26. A Prospective Cohort Study in Nonhospitalized Household Contacts With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Symptom Profiles and Symptom Change Over Time

Author

Yousaf, Anna R, primary, Duca, Lindsey M, additional, Chu, Victoria, additional, Reses, Hannah E, additional, Fajans, Mark, additional, Rabold, Elizabeth M, additional, Laws, Rebecca L, additional, Gharpure, Radhika, additional, Matanock, Almea, additional, Wadhwa, Ashutosh, additional, Pomeroy, Mary, additional, Njuguna, Henry, additional, Fox, Garrett, additional, Binder, Alison M, additional, Christiansen, Ann, additional, Freeman, Brandi, additional, Gregory, Christopher, additional, Tran, Cuc H, additional, Owusu, Daniel, additional, Ye, Dongni, additional, Dietrich, Elizabeth, additional, Pevzner, Eric, additional, Conners, Erin E, additional, Pray, Ian, additional, Rispens, Jared, additional, Vuong, Jeni, additional, Christensen, Kim, additional, Banks, Michelle, additional, O’Hegarty, Michelle, additional, Mills, Lisa, additional, Lester, Sandra, additional, Thornburg, Natalie J, additional, Lewis, Nathaniel, additional, Dawson, Patrick, additional, Marcenac, Perrine, additional, Salvatore, Phillip, additional, Chancey, Rebecca J, additional, Fields, Victoria, additional, Buono, Sean, additional, Yin, Sherry, additional, Gerber, Susan, additional, Kiphibane, Tair, additional, Dasu, Trivikram, additional, Bhattacharyya, Sanjib, additional, Westergaard, Ryan, additional, Dunn, Angela, additional, Hall, Aron J, additional, Fry, Alicia M, additional, Tate, Jacqueline E, additional, Kirking, Hannah L, additional, and Nabity, Scott, additional

Published
2020
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27. Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in a Georgia School District—United States, December 2020–January 2021.

Author

Gettings, Jenna R, Gold, Jeremy A W, Kimball, Anne, Forsberg, Kaitlin, Scott, Colleen, Uehara, Anna, Tong, Suxiang, Hast, Marisa, Swanson, Megan R, Morris, Elana, Oraka, Emeka, Almendares, Olivia, Thomas, Ebony S, Mehari, Lemlem, McCloud, Jazmyn, Roberts, Gurleen, Crosby, Deanna, Balajee, Abirami, Burnett, Eleanor, and Chancey, Rebecca J

Subjects
REVERSE transcriptase polymerase chain reaction, COVID-19, SEQUENCE analysis, CONFIDENCE intervals, SCHOOLS, DESCRIPTIVE statistics, POLYMERASE chain reaction
Abstract

Background To inform prevention strategies, we assessed the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and settings in which transmission occurred in a Georgia public school district. Methods During 1 December 2020–22 January 2021, SARS-CoV-2–infected index cases and their close contacts in schools were identified by school and public health officials. For in-school contacts, we assessed symptoms and offered SARS-CoV-2 reverse-transcription polymerase chain reaction (RT-PCR) testing; performed epidemiologic investigations and whole-genome sequencing to identify in-school transmission; and calculated secondary attack rate (SAR) by school setting (eg, sports, elementary school classroom), index case role (ie, staff, student), and index case symptomatic status. Results We identified 86 index cases and 1119 contacts, 688 (61.5%) of whom received testing. Fifty-nine of 679 (8.7%) contacts tested positive; 15 of 86 (17.4%) index cases resulted in ≥2 positive contacts. Among 55 persons testing positive with available symptom data, 31 (56.4%) were asymptomatic. Highest SARs were in indoor, high-contact sports settings (23.8% [95% confidence interval {CI}, 12.7%–33.3%]), staff meetings/lunches (18.2% [95% CI, 4.5%–31.8%]), and elementary school classrooms (9.5% [95% CI, 6.5%–12.5%]). The SAR was higher for staff (13.1% [95% CI, 9.0%–17.2%]) vs student index cases (5.8% [95% CI, 3.6%–8.0%]) and for symptomatic (10.9% [95% CI, 8.1%–13.9%]) vs asymptomatic index cases (3.0% [95% CI, 1.0%–5.5%]). Conclusions Indoor sports may pose a risk to the safe operation of in-person learning. Preventing infection in staff members, through measures that include coronavirus disease 2019 vaccination, is critical to reducing in-school transmission. Because many positive contacts were asymptomatic, contact tracing should be paired with testing, regardless of symptoms. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Performance of existing and novel surveillance case definitions for COVID-19 in household contacts of PCR-confirmed COVID-19.

Author

Reses, Hannah E., Fajans, Mark, Lee, Scott H., Heilig, Charles M., Chu, Victoria T., Thornburg, Natalie J., Christensen, Kim, Bhattacharyya, Sanjib, Fry, Alicia, Hall, Aron J., Tate, Jacqueline E., Kirking, Hannah L., Nabity, Scott A., The U.S. COVID-19 Household Investigation Team, Banks, Michelle, Battey, Katherine A., Binder, Alison M., Buono, Sean, Chancey, Rebecca J., and Christiansen, Ann

Subjects
CORONAVIRUS diseases, PUBLIC health surveillance, PANDEMICS, DIAGNOSIS, POLYMERASE chain reaction
Abstract

Background: Optimized symptom-based COVID-19 case definitions that guide public health surveillance and individual patient management in the community may assist pandemic control.Methods: We assessed diagnostic performance of existing cases definitions (e.g. influenza-like illness, COVID-like illness) using symptoms reported from 185 household contacts to a PCR-confirmed case of COVID-19 in Wisconsin and Utah, United States. We stratified analyses between adults and children. We also constructed novel case definitions for comparison.Results: Existing COVID-19 case definitions generally showed high sensitivity (86-96%) but low positive predictive value (PPV) (36-49%; F-1 score 52-63) in this community cohort. Top performing novel symptom combinations included taste or smell dysfunction and improved the balance of sensitivity and PPV (F-1 score 78-80). Performance indicators were generally lower for children (< 18 years of age).Conclusions: Existing COVID-19 case definitions appropriately screened in household contacts with COVID-19. Novel symptom combinations incorporating taste or smell dysfunction as a primary component improved accuracy. Case definitions tailored for children versus adults should be further explored. [ABSTRACT FROM AUTHOR]

Published
2021
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29. Notes from the Field: Cyclosporiasis Cases Associated with Dining at a Mediterranean-Style Restaurant Chain — Texas, 2017

Author

Keaton, Amelia A., primary, Hall, Noemi Borsay, additional, Chancey, Rebecca J., additional, Heines, Vivienne, additional, Cantu, Venessa, additional, Vakil, Varsha, additional, Long, Stephen, additional, Short, Kirstin, additional, Franciscus, Elya, additional, Wahab, Natasha, additional, Haynie, Aisha, additional, Gieraltowski, Laura, additional, and Straily, Anne, additional

Published
2018
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30. Patent Macracanthorhynchus ingens Infection in a 17-Month-Old Child, Ohio.

Author

Chancey, Rebecca J, Sapp, Sarah G H, Fox, Mark, Bishop, Henry S, Ndubuisi, MacKevin, Almeida, Marcos de, Montgomery, Susan P, and Congeni, Blaise

Subjects
*PATENTS, *INFECTION, *PARASITES, *EGGS
Abstract

Limited data exist on human Macracanthorhynchus infections. We report an asymptomatic 17-month-old who passed eggs and an adult Macracanthorhynchus ingens worm, indicating parasite maturation and reproduction. Macracanthorhynchus ingens may have a greater capacity to mature in humans versus Macracanthorhynchus hirudinaceus. [ABSTRACT FROM AUTHOR]

Published
2021
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31. Angiostrongylus cantonensis Meningoencephalitis in Three Pediatric Patients in Florida, USA.

Author

Chance MD, Noel AD, Thompson AB, Marrero N, Bula-Rudas F, Horvat CM, Green J, Armstrong JE, Levent F, Dudas RA, Shaffren S, Samide A, Martinez K, Stockdale K, and Chancey RJ

Abstract

Eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis has been reported in several southern U.S. states and Hawai'i. We present the first locally acquired human cases of A. cantonensis meningoencephalitis in three children in Florida, occurring between June 2021 and January 2022. Clinicians should be attuned to this possible diagnosis in this region., (Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society 2024. This work is written by (a) US Government employee(s) and is in the public domain in the US.)

Published
2024
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32. A Prospective Cohort Study in Nonhospitalized Household Contacts With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Symptom Profiles and Symptom Change Over Time.

Author

Yousaf AR, Duca LM, Chu V, Reses HE, Fajans M, Rabold EM, Laws RL, Gharpure R, Matanock A, Wadhwa A, Pomeroy M, Njuguna H, Fox G, Binder AM, Christiansen A, Freeman B, Gregory C, Tran CH, Owusu D, Ye D, Dietrich E, Pevzner E, Conners EE, Pray I, Rispens J, Vuong J, Christensen K, Banks M, O'Hegarty M, Mills L, Lester S, Thornburg NJ, Lewis N, Dawson P, Marcenac P, Salvatore P, Chancey RJ, Fields V, Buono S, Yin S, Gerber S, Kiphibane T, Dasu T, Bhattacharyya S, Westergaard R, Dunn A, Hall AJ, Fry AM, Tate JE, Kirking HL, and Nabity S

Subjects
Adult, Child, Contact Tracing, Fever, Humans, Prospective Studies, Young Adult, COVID-19, SARS-CoV-2
Abstract

Background: Improved understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spectrum of disease is essential for clinical and public health interventions. There are limited data on mild or asymptomatic infections, but recognition of these individuals is key as they contribute to viral transmission. We describe the symptom profiles from individuals with mild or asymptomatic SARS-CoV-2 infection., Methods: From 22 March to 22 April 2020 in Wisconsin and Utah, we enrolled and prospectively observed 198 household contacts exposed to SARS-CoV-2. We collected and tested nasopharyngeal specimens by real-time reverse-transcription polymerase chain reaction (rRT-PCR) 2 or more times during a 14-day period. Contacts completed daily symptom diaries. We characterized symptom profiles on the date of first positive rRT-PCR test and described progression of symptoms over time., Results: We identified 47 contacts, median age 24 (3-75) years, with detectable SARS-CoV-2 by rRT-PCR. The most commonly reported symptoms on the day of first positive rRT-PCR test were upper respiratory (n = 32 [68%]) and neurologic (n = 30 [64%]); fever was not commonly reported (n = 9 [19%]). Eight (17%) individuals were asymptomatic at the date of first positive rRT-PCR collection; 2 (4%) had preceding symptoms that resolved and 6 (13%) subsequently developed symptoms. Children less frequently reported lower respiratory symptoms (21%, 60%, and 69% for <18, 18-49, and ≥50 years of age, respectively; P = .03)., Conclusions: Household contacts with laboratory-confirmed SARS-CoV-2 infection reported mild symptoms. When assessed at a single timepoint, several contacts appeared to have asymptomatic infection; however, over time all developed symptoms. These findings are important to inform infection control, contact tracing, and community mitigation strategies., (Published by Oxford University Press for the Infectious Diseases Society of America 2020.)

Published
2021
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33. Learners' Experiences During Rapid Cycle Deliberate Practice Simulations: A Qualitative Analysis.

Author

Chancey RJ, Sampayo EM, Lemke DS, and Doughty CB

Subjects
Clinical Competence, Educational Measurement, Emotions, Female, Formative Feedback, Group Processes, Humans, Male, Patient Care Team organization & administration, Perception, Problem-Based Learning, Qualitative Research, Self Efficacy, Attitude of Health Personnel, Emergency Medicine education, Internship and Residency organization & administration, Nursing Staff, Hospital psychology, Pediatrics education, Simulation Training organization & administration
Abstract

Introduction: Rapid Cycle Deliberate Practice (RCDP) is a team-based simulation method, emphasizing repetitive practice over reflective debriefing, with progressively more challenging rounds, frequent starts and stops, and direct coaching. Although some studies have shown improved performance, no study has evaluated learners' perceptions. We aimed to explore learners' experiences during RCDP., Methods: This was a qualitative study of participants' perceptions regarding RCDP during their pediatric emergency medicine rotation. Participants completed surveys about RCDP learning. A purposive sample of residents and nurses were interviewed. Two coders analyzed all interview transcripts to identify emerging themes. Constant comparison analysis was performed until thematic saturation was achieved., Results: Forty-four participants completed surveys. Participants found RCDP interruptions beneficial and felt that they learned most during interruptions. Participants who were able to compare traditional and RCDP simulations felt that RCDP allowed more focused correction of mistakes, acquisition of new skills, and timely practice of team behaviors. Fourteen participants were interviewed. Three themes emerged. (1) The real-time corrections during RCDP allowed for learning and creation of new skills through repetition and practice. (2) The RCDP allowed learners to gain confidence, decrease anxiety, and learn in a safe environment. (3) By introducing new information in smaller chunks, participants maximized learning without cognitive overload., Conclusions: Rapid Cycle Deliberate Practice is well received by learners. Because of frequent interruptions, learners noted early error correction, a safe learning environment, and skill improvement during RCDP. Learners recognized that the progressive advancement of RCDP helped prevent cognitive overload. Future studies should measure cognitive load and skills retention.

Published
2019
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