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Background: Plants have long been recognized as having a wide range of biological properties, including antibacterial, analgesic, anticancer, antipyretic, and antihypertensive action. They are also a significant source of several chemicals with biological activity. The Rutaceae family consists of a shrub Atalantia monophylla. It is available all over India. The extracts from its leaves have been reported to have antimicrobial and antiviral properties. Aims and Objectives: The objectives of the study were to evaluate the extraction protein content and antimicrobial activity of A. monophyla protein extract. The objective of the present study is to isolate protein extract from the aqueous extract of A. monophyla and to screen for antimicrobial activity. Materials and Methods: The A. monophylla protein isolate was prepared from aqueous extract. The protein isolate was done using the ammonium sulfate method and quantified using Lowry's method. Agar disc diffusion method and minimum inhibitory concentration were used to evaluate the antimicrobial activity of the extract. Results: The Lowry's method revealed 5.73 mg/mL protein isolate. The microbiological studies revealed significant inhibitions of microbes. Conclusion: The AM protein extract has significant microbiological action. [ABSTRACT FROM AUTHOR]

Background: Anxiety transcends a natural emotion, evolving into a pathological condition with the potential to trigger cascading cardiovascular and psychiatric disorders. Although conventional allopathic medicine offers treatment options, concerns regarding their side effects and long-term efficacy remain prevalent. Medicinal plants contain natural compounds that may be promising sources of therapeutic drugs. Aims and Objectives: This study aims to compare the anxiolytic potential of ethanolic and aqueous extracts of Ocimum sanctum (OS). The growing appeal of plant-based therapies for anxiety stems from perceived advantages in safety and tolerability compared to synthetic drugs. Materials and Methods: The anxiolytic activity of aqueous and ethanolic extract of OS is evaluated with an elevated plus maze test. A total of 36 Wistar albino rats (150-200 g) were used and randomly divided into six groups of six animals each. The effects of the test drug at different doses, 100 and 200 mg/kg, were compared with the standard anxiolytic drug diazepam at 2 mg/kg body weight and the control group using distilled water at 0.5 mL/kg body weight. Results: The behavioral changes suggested reduced anxiety and openarm exploration in plus-maze indicates reduced anxiety in animals treated with OS extracts. The changes are significantly (P < 0.001) comparable with the standard drug diazepam. Conclusion: The ethanolic extracts of OS are more significant than aqueous extracts for evaluating anti-anxiety activity in a dose-dependent manner. In addition, ethanolic extracts are more likely to contain a wider range of bioactive compounds, which are thought to be responsible for the anti-anxiety effects of OS. [ABSTRACT FROM AUTHOR]

This article presents a study conducted among undergraduate medical students in a South Indian hospital to assess their knowledge, attitude, and practices towards pharmacovigilance. The study reveals that the students possess a satisfactory level of knowledge on pharmacovigilance, but only a small percentage of them have actually reported adverse drug reactions (ADRs) during their clinical postings. The study suggests that educational interventions, such as continuous medical education and pharmacovigilance workshops, can enhance ADR reporting among medical students. [Extracted from the article]

Plants have been used as therapeutic agents in both un-ionized (Unani, Ayurveda) and unstructured forms since ancient times. Therefore, it is of interest to document the nootropic activity of methanolic extract from Evolvulus alsinoides Linn (Vishnukranthi) in mice with scopolamine-induced amnesia. Healthy male Swiss albino mice ranging between 25 and 30 g were used in the study. Scopolamine induced amnesia, the following two tests are performed, elevated plus maze test, passive avoidance test. The mean time spent in the open arm, closed arm, and central platform for each group of animals. The total transitions were 12.6±0.89 by GS group mice, 3.4±0.55 by GSP group mice, 7±0.71 by GSLD group mice and 10±0.71 by GSHD group mice. A significant difference was seen between GS and GSP group mice means. The mean time in the safe zone and shock zone for each group of animals when comparing to Group 2 Vs Group 3, 4 showed a statistical significance of p < 0.05. The findings of this study suggest that Evolvulus alsinoides may be a promising candidate for the development of new treatments for memory impairment and other cognitive disorders. It should be noted that more data is needed to confirm the safety and efficacy of Evolvulus alsinoides in humans and to investigate its long-term effects., Competing Interests: There are no conflicts of interest., (© 2023 Biomedical Informatics.)