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984 results on '"Chang, Full-Young"'

13. Estrogen rapidly modulates mustard oil-induced visceral hypersensitivity in conscious female rats: a role of CREB phosphorylation in spinal dorsal horn neurons

Author

Lu, Ching-Liang, Hsieh, Jen-Chuen, Tsaur, Meei-Ling, Huang, Yn-Ho, Wang, Paulus S., Wu, Learn-Long, Liu, Pei-Yi, Chang, Full-Young, and Lee, Shou-Dong

Subjects
Cyclic adenosine monophosphate response element-binding protein -- Research, Irritable bowel syndrome -- Research, Estrogen -- Research, Biological sciences
Abstract

This study investigated the effect of sex hormones on mustard oil (MO)induced visceral hypersensitivity in female rats and analyzed possible involved signaling pathways. Female rats, either intact or ovariectomized (OVX), were prepared for abdominal muscle electromyography in response to colorectal distension after intracolonic instillation of MO. The effect of MO intracolonic sensitization was evaluated in intact rats, OVX rats, and OVX rats pretreated with a single injection of 17[beta]-estradiol (E), progesterone (P), E+P, or vehicle, cAMPresponsive element-binding protein (CREB) and phosphorylated CREB (pCREB) were detected in the superficial dorsal horn of L6 and [S.sub.1] in MO or mineral oil-treated OVX rats with/without colorectal distension and estrogen replacement. The distal colorectum was removed for histological evaluation of inflammatory severity in MOtreated intact or OVX rats. The MO-treated rats had significantly higher visceromotor reflex than controls (enhanced visceral hypersensitivity), whereas OVX eliminated this hypersensitivity. After a single injection of E or E+P, the rats rapidly restored MO-induced viscera/ hypersensitivity within 2 h. Estrogen also rapidly induced a dosedependent increase in pCREB expression in the superficial dorsal horn neurons in MO-treated, but not mineral oil-treated, OVX rats. The present study suggests that estrogen can rapidly modulate visceral hypersensitivity induced by MO intracolonic instillation in conscious female rats, which may involve spinal activation of the cAMP response element-mediated gene induction pathway. irritable bowel syndrome; spinal cord; cAMP-response element binding protein; gender

Published
2007

20. Tumor necrosis factor-[alpha] stimulates gastric epithelial cell proliferation

Author

Luo, Jiing Chyuan, Shin, Vivian Yvonne, Yang, Ying Hua, Wu, William Ka Kei, Ye, Yi Ni, So, Wallace Hau Leung, Chang, Full Young, and Cho, Chi Hin

Subjects
COX-2 inhibitors -- Research, Tumors -- Research, Biological sciences
Abstract

TNF-[alpha] is a cytokine produced during gastric mucosal injury. We examined whether TNF-[alpha] could promote mucosal repair by stimulation of epithelial cell proliferation and explored further the underlying mechanisms in a rat gastric mucosal epithelial cell line (RGM-1). TNF-[alpha] treatment (1-10 ng/ml) for 12 or 24 h significantly increased cell proliferation but did not induce apoptosis in RGM-1 cells. TNF-[alpha] treatment significantly increased cytosolic phospholipase [A.sub.2] and cyclooxygenase-2 (COX-2) protein expression and PG[E.sub.2] level but did not affect the protein levels of EGF, basic fibroblast growth factor, and COX-1 in RGM-1 cells. The mRNA of TNF receptor (TNF-R) 2 but not of TNF-R1 was also increased. Dexamethasone dose dependently inhibited the stimulatory effect of TNF-[alpha] on cell proliferation, which was associated with a significant decrease in cellular COX-2 expression and PG[E.sub.2] level. A selective COX-2 inhibitor 3-(3-fluorophenyl)-4-[4-(methylsulfonyl)phenyl] -5,5-dimethyl-[sup.5]H-furan-2-one (DFU) by itself had no effect on basal cell proliferation but significantly reduced the stimulatory effect of TNF-[alpha] on RMG-1 cells. Combination of dexamethasone and DFU did not produce an additive effect. PG[E.sub.2] significantly reversed the depressive action of dexamethasone on cell proliferation. These results suggest that TNF-[alpha] plays a regulatory role in epithelial cell repair in the gastric mucosa via the TNF-[alpha] receptor and activation of the arachidonic acid/PG pathway. cyclooxygenase; dexamethasone; phospholipase [A.sub.2]; prostaglandin [E.sub.2]

Published
2005

43. Asian consensus report on functional dyspepsia

Author

Miwa, Hiroto, Ghoshal, Uday Chand, Fock, Kwong Ming, Gonlachanvit, Sutep, Gwee, Kok-Ann, Ang, Tiing-Leong, Chang, Full-Young, Hongo, Michio, Hou, Xiaohua, Kachintorn, Udom, Ke, Meiyun, Lai, Kwok-Hung, Lee, Kwang Jae, Lu, Ching-Liang, Mahadeva, Sanjiv, Miura, Soichiro, Park, Hyojin, Rhee, Poong-Lyul, Sugano, Kentaro, Vilaichone, Ratha-korn, Wong, Benjamin C Y, and Bak, Young-Tae

Published
2012
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49. Asian consensus on irritable bowel syndrome

Author

Gwee, Kok-Ann, Bak, Young-Tae, Ghoshal, Uday Chand, Gonlachanvit, Sutep, Lee, Oh Young, Fock, Kwong Ming, Boon Chua, Andrew Seng, Lu, Ching-Liang, Goh, Khean-Lee, Kositchaiwat, Chomsri, Makharia, Govind, Park, Hyo-Jin, Chang, Full-Young, Fukudo, Shin, Choi, Myung-Gyu, Bhatia, Shobna, Ke, Meiyun, Hou, Xiaohua, and Hongo, Michio

Published
2010
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