Search

Your search keyword '"Chang, Gee-Chen"' showing total 851 results
Start Over Author "Chang, Gee-Chen"
851 results on '"Chang, Gee-Chen"'

2. Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor[FIGURE DASH]Resistant, EGFR–Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer

Author

Yang, James Chih-Hsin, Lee, Dae Ho, Lee, Jong-Seok, Fan, Yun, de Marinis, Filippo, Iwama, Eiji, Inoue, Takako, Rodríguez-Cid, Jerónimo, Zhang, Li, Yang, Cheng-Ta, de la Mora Jimenez, Emmanuel, Zhou, Jianying, Pérol, Maurice, Lee, Ki Hyeong, Vicente, David, Ichihara, Eiki, Riely, Gregory J., Luo, Yiwen, Chirovsky, Diana, Pietanza, M. Catherine, Bhagwati, Niyati, Lu, Shun, Joseph Boyer, Michael, Hui, Rina, Wong, Mark, Mant, Andrew, Parente, Phillip, John, Thomas, Parakh, Sagun, Castro, Gilberto, Jr, Werutsky, Gustavo, de Azevedo, Sergio Jobim, Andre Franke, Fabio, De Almeida Rego, Joilda Batista, Martins De Marchi, Pedro Rafael, Dix Junqueira, Gustavo, Maris Peria, Fernanda, Brust, Leandro, Cheema, Parneet, Doherty, Mark, Parmar, Ambika, Menjak, Ines B., Leighl, Natasha B., Agulnik, Jason, Lu, Shun, Han, Zhigang, Cui, Jiuwei, Zhang, Li, Cheng, Ying, Chen, Gongyan, Zhang, Helong, Yao, Yu, Hu, Chengping, Wang, Qiming, Zhang, Xin, Zhang, Yong, Zhou, Jianying, Ying, Kejing, Fan, Yun, Wang, Yan, Wang, Ziping, Feng, Jifeng, Du, YingYing, Wu, Lin, Huang, Cheng, Zhou, Xiangdong, Perol, Maurice, Domont, Julien, Lamour, Corinne, Dutilh, Julien, Oulkhouir, Youssef, Westeel, Virginie, Carmier, Delphine, Coudert, Bruno, Lagrange, Aurelie, Spaeth, Dominique, Ropert, Stanislas, Christoph, Daniel C., Kern, Jens, Kopp, Hans-Georg, Griesinger, Frank, Wiewrodt, Rainer, Wermke, Martin, Wesseler, Claas, Mueller, Annette, Vogel, Gunther, Lee, Victor, James Ho, Chung Man, Oscar Chan, Siu Hong, Hung Lo, Sing, Jonathan Nyaw, Shi Feng, Jacky Li, Yu Chung, Bar, Jair, Gottfried, Maya, Dudnik, Julia, Zer, Alona, Moskovitz, Mor, Wollner, Mirjana, Rotem, Ofer, Shamai, Sivan, Asna, Noam, Kamel, Mhameed, Novello, Silvia, Di Costanzo, Francesco, Doni, Laura, Mazzoni, Francesca, Ferrau, Francesco, de Marinis, Filippo, Tonini, Giuseppe, Galetta, Domenico, Piantedosi, Francovito, Vitiello, Fabiana, Kirita, Keisuke, Yoh, Kiyotaka, Takahashi, Toshiaki, Ohe, Yuichiro, Hattori, Yoshihiro, Okamoto, Isamu, Kurata, Takayasu, Yoshioka, Hiroshige, Saka, Hideo, Oki, Masahide, Kato, Terufumi, Tanaka, Hiroshi, Kumagai, Toru, Inoue, Takako, Hida, Toyoaki, Horio, Yoshitsugu, Teraoka, Shunsuke, Ichihara, Eiki, Kishi, Kazuma, Takaya, Hisashi, Takai, Daiya, Kozuki, Toshiyuki, Kasahara, Kazuo, Tambo, Yuichi, Hosomi, Yukio, Kondo, Masashi, Ichiki, Masao, Takeoka, Hiroaki, de la Mora Jimenez, Emmanuel, Hernandez, Carlos Alberto, Rodriguez Cid, Jeronimo Rafael, Rodriguez, Oscar Gerardo Arrieta, Han, Ji-Youn, Min, Young Joo, Kim, Dong-Wan, Park, Keunchil, Lee, Se-Hoon, Lee, Ki Hyeong, Lee, Jong-Seok, Kang, Jin Hyoung, Lee, Dae Ho, Cho, Eun Kyung, Carcereny, Enric, Lopez, Pilar Garrido, Tarruella, Margarita Majem, Rodriguez, Luis Paz-Ares, Vicente Baz, David, Font, Enriqueta Felip, Cobo-Dols, Manuel, Ekman, Simon, Bergman, Bengt, Ohman, Ronny, Vikstrom, Anders, Yang, Chih-Hsin, Chiu, Chao-Hua, Huang, Hsu-Ching, Yang, Cheng-Ta, Su, Jian, Chang, Gee-Chen, Yang, Tsung-Ying, Hsia, Te-Chun, Su, Wu-Chou, Wu, Shang-Yin, Wang, Chin-Chou, Lee, Kang-Yun, Lin, Sheng-Hao, Lin, Chih-Bin, Lee, Jih-Hsiang, Huang, Chun-Yao, Ahmed, Samreen, Newsom-Davis, Thomas, Baijal, Shobhit, Brock, Juliet, Zaki, Kam, Shamash, Jonathan, Papadatos-Pastos, Dionysis, Jain, Pooja, Jane Mackean, Melanie, Kendall, Stephan DiSean, Anderson, Ian, Costin, Dan, Hall, Richard, Campbell, Nicholas, Khan, Saad, Dowell, Jonathan, Mashru, Sandeep, Menon, Smitha, Raza, Ahmad, Ge, Li, Riely, Gregory J., Seetharamu, Nagashree, Stampleman, Laura, Subramanian, Janakiraman, Wender, Donald B., Natale, Ronald B., Zhu, Viola, Ignatius Ou, Sai-Hong, Sanborn, Rachel, and Evangelist, Makenzi C.

Published
2024
Full Text
View/download PDF

3. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J, Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M, Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A, Kim, Jin Hee, Albanes, Demetrius, Wong, Jason YY, Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E, Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H, Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, and Kweon, Sun-Seog

Subjects
Genetics, Cancer, Clinical Research, Human Genome, Prevention, Lung, Lung Cancer, Tobacco, Tobacco Smoke and Health, 2.1 Biological and endogenous factors, Aetiology, Respiratory, Humans, Genome-Wide Association Study, Genetic Predisposition to Disease, Adenocarcinoma of Lung, Asia, Eastern, Lung Neoplasms, Polymorphism, Single Nucleotide
Abstract

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (Pinteraction = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.

Published
2023

5. Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP‐deficient lung cancer

Author

Chang, Wen‐Hsin, Chen, Yi‐Ju, Hsiao, Yi‐Jing, Chiang, Ching‐Cheng, Wang, Chia‐Yu, Chang, Ya‐Ling, Hong, Qi‐Sheng, Lin, Chien‐Yu, Lin, Shr‐Uen, Chang, Gee‐Chen, Chen, Hsuan‐Yu, Chen, Yu‐Ju, Chen, Ching‐Hsien, Yang, Pan‐Chyr, and Yu, Sung‐Liang

Subjects
Cancer, Lung Cancer, Lung, Aetiology, 2.1 Biological and endogenous factors, Humans, Lung Neoplasms, Protein-Arginine N-Methyltransferases, Purine-Nucleoside Phosphorylase, Vimentin, Methylproteome, Methylthioadenosine, Post-translational modification, Protein arginine methyltransferase 5, Symmetric dimethylarginine, Biochemistry and Cell Biology, Developmental Biology
Abstract

The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell-based model, we identified methylthioadenosine phosphorylase (MTAP) and confirmed its suppressive effects on tumorigenesis and metastasis. Patients with low MTAP expression display worse overall and progression-free survival. Mechanistically, accumulation of methylthioadenosine substrate in MTAP-deficient cells reduce the level of protein arginine methyltransferase 5 (PRMT5)-mediated symmetric dimethylarginine (sDMA) modification on proteins. We identify vimentin as a dimethyl-protein whose dimethylation levels drop in response to MTAP deficiency. The sDMA modification on vimentin reduces its protein abundance but trivially affects its filamentous structure. In MTAP-deficient cells, lower sDMA modification prevents ubiquitination-mediated vimentin degradation, thereby stabilizing vimentin and contributing to cell invasion. MTAP and PRMT5 negatively correlate with vimentin in lung cancer samples. Taken together, we propose a mechanism for metastasis involving vimentin post-translational regulation.

Published
2022

8. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chan, Chang-Chuan, Chan, Si-Wa, Chang, I-Shou, Chang, Jer-Hwa, Chao, Kun-San, Chen, Chi-Jen, Chen, Huei-Wen, Chiang, Chun-Ju, Chiou, Hung-Yi, Chou, Mei-Chun, Chung, Chi-Li, Chung, Ta-Jung, Guo, Yue Leon, Hsiao, Chin-Fu, Huang, Chien-Sheng, Ko, Sheung-Fat, Lee, Mei-Hsuan, Li, Yao-Jen, Liao, Yu-San, Lu, Yueh-Hsun, Ou, Hsin-You, Wu, Ping-An, Yang, Hwai-I, Yang, Shi-Yi, Yang, Szu-Chun, Chang, Gee-Chen, Chiu, Chao-Hua, Yu, Chong-Jen, Chang, Yeun-Chung, Chang, Ya-Hsuan, Hsu, Kuo-Hsuan, Wu, Yu-Chung, Chen, Chih-Yi, Hsu, Hsian-He, Wu, Ming-Ting, Yang, Cheng-Ta, Chong, Inn-Wen, Lin, Yu-Ching, Hsia, Te-Chun, Lin, Meng-Chih, Su, Wu-Chou, Lin, Chih-Bin, Lee, Kang-Yun, Wei, Yu-Feng, Lan, Gong-Yau, Chan, Wing P, Wang, Kao-Lun, Wu, Mei-Han, Tsai, Hao-Hung, Chian, Chih-Feng, Lai, Ruay-Sheng, Shih, Jin-Yuan, Wang, Chi-Liang, Hsu, Jui-Sheng, Chen, Kun-Chieh, Chen, Chun-Ku, Hsia, Jiun-Yi, Peng, Chung-Kan, Tang, En-Kuei, Hsu, Chia-Lin, Chou, Teh-Ying, Shen, Wei-Chih, Tsai, Ying-Huang, Tsai, Chun-Ming, Chen, Yuh-Min, Lee, Yu-Chin, Chen, Hsuan-Yu, Yu, Sung-Liang, Chen, Chien-Jen, Wan, Yung-Liang, Hsiung, Chao Agnes, and Yang, Pan-Chyr

Published
2024
Full Text
View/download PDF

10. Efficacy of Lorlatinib in Treatment-Naive Patients With ALK-Positive Advanced NSCLC in Relation to EML4::ALK Variant Type and ALK With or Without TP53 Mutations

Author

Bearz, Alessandra, Martini, Jean-François, Jassem, Jacek, Kim, Sang-We, Chang, Gee-Chen, Shaw, Alice T., Shepard, Deborah A., Dall’O’, Elisa, Polli, Anna, Thurm, Holger, Zalcman, Gerard, Garcia Campelo, Maria Rosario, Penkov, Konstantin, Hayashi, Hidetoshi, and Solomon, Benjamin J.

Published
2023
Full Text
View/download PDF

11. Low-Dose Computed Tomography Screening in Relatives With a Family History of Lung Cancer

Author

Wang, Chi-Liang, Hsu, Kuo-Hsuan, Chang, Ya-Hsuan, Ho, Chao-Chi, Chiang, Chun-Ju, Chen, Kun-Chieh, Cheung, Yun-Chung, Huang, Pei-Ching, Chen, Yu-Ruei, Chen, Chih-Yi, Hsu, Chung-Ping, Hsia, Jiun-Yi, Chen, Hsuan-Yu, Yang, Shi-Yi, Li, Yao-Jen, Yang, Tsung-Ying, Tseng, Jeng-Sen, Chuang, Cheng-Yen, Hsiung, Chao A., Chen, Yuh-Min, Huang, Ming-Shyan, Yu, Chong-Jen, Chen, Kuan-Yu, Su, Wu-Chou, Chen, Jeremy J.W., Yu, Sung-Liang, Chen, Chien-Jen, Yang, Pan-Chyr, Tsai, Ying-Huang, and Chang, Gee-Chen

Published
2023
Full Text
View/download PDF

12. Evaluation of combination treatment with DS-1205c, an AXL kinase inhibitor, and osimertinib in metastatic or unresectable EGFR-mutant non-small cell lung cancer: results from a multicenter, open-label phase 1 study

Author

Yang, James Chih-Hsin, Su, Wu-Chou, Chiu, Chao-Hua, Shiah, Her-Shyong, Lee, Kang-Yun, Hsia, Te-Chun, Uno, Makiko, Crawford, Nigel, Terakawa, Hiroshi, Chen, Wen-Chi, Takayama, Gensuke, Hsu, Ching, Hong, Ying, Saintilien, Carline, McGill, Joseph, and Chang, Gee-Chen

Published
2023
Full Text
View/download PDF

15. Asian Subgroup Analysis of the Randomized Phase 3 CROWN Study of First-Line Lorlatinib Versus Crizotinib in Advanced ALK-Positive NSCLC

Author

Zhou, Qing, Soo, Ross A., Chang, Gee-Chen, Chiu, Chao-Hua, Hayashi, Hidetoshi, Kim, Sang-We, Teraoka, Shunsuke, Goto, Yasushi, Zhou, Jianying, Ho-Fun Lee, Victor, Kim, Dong-Wan, Han, Baohui, Chung Man Ho, James, Lin, Chia-Chi, Lu, Shun, Polli, Anna, Calella, Anna Maria, Martini, Jean-François, Wong, Chew Hooi, Mok, Tony, Kim, Hye Ryun, and Wu, Yi-Long

Published
2023
Full Text
View/download PDF

16. Efficacy and Safety of Brigatinib Compared With Crizotinib in Asian vs. Non-Asian Patients With Locally Advanced or Metastatic ALK–Inhibitor-Naive ALK+ Non–Small Cell Lung Cancer: Final Results From the Phase III ALTA-1L Study

Author

Ahn, Myung J., Kim, Hye R., Yang, James C.H., Han, Ji-Yu, Li, Jacky Yu-Chung., Hochmair, Maximilian J., Chang, Gee-Chen, Delmonte, Angelo, Lee, Ki H., Campelo, Rosario G., Gridelli, Cesare, Spira, Alexander I., Califano, Raffaele, Griesinger, Frank, Ghosh, Sharmistha, Felip, Enriqueta, Kim, Dong-Wan, Liu, Yuyin, Zhang, Pingkuan, Popat, Sanjay, and Camidge, D. Ross

Published
2022
Full Text
View/download PDF

18. Osimertinib as Second- and ≥Third-Line Treatment in Advanced and Recurrence EGFR-Mutant NSCLC Patients Harboring Acquired T790M Mutation.

Author

Peng, Mu-Han, Huang, Yen-Hsiang, Hsu, Kuo-Hsuan, Tseng, Jeng-Sen, Lee, Po-Hsin, Chen, Kun-Chieh, Chang, Gee-Chen, and Yang, Tsung-Ying

Abstract

Simple Summary: The objective of this study was to compare the clinical outcomes of osimertinib as a 2nd-line treatment versus as a ≥3rd-line treatment in advanced and recurrent Epidermal Growth Factor Receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) patients with acquired T790M mutations. A total of 158 patients who received osimertinib as sequential treatment were enrolled for final analysis between September 2014 and March 2023. Among these, 99 patients (62.7%) received osimertinib as 2nd-line treatment, while 59 patients (37.3%) were treated with it as ≥3rd-line therapy. We found no significant difference in progression-free survival or overall survival between the two groups. Our findings suggest that osimertinib is not only effective as a 2nd-line therapy but also as a ≥3rd-line treatment, offering promising clinical benefits for advanced and recurrent EGFR-mutant NSCLC patients with acquired T790M mutations. Background/Objectives: Osimertinib is a standard sequential therapy for advanced and recurrent Epidermal Growth Factor Receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) patients with the T790M mutation, following treatment with first- or second-generation EGFR Tyrosine Kinase Inhibitors (TKIs). This study aims to investigate the differences in clinical outcomes between osimertinib as a 2nd-line treatment and as a ≥3rd-line treatment in this patient population. Methods: Between September 2014 and March 2023, we enrolled advanced and recurrent T790M + NSCLC patients who had received osimertinib as sequential treatment for analysis. All patients had previously been treated with gefitinib, erlotinib, or afatinib as first-line therapy. Results: A total of 158 patients who received osimertinib as sequential treatment were included in the final analysis. Of these, 99 patients (62.7%) received osimertinib as a 2nd-line treatment, while 59 patients (37.3%) were treated with osimertinib as ≥3rd-line therapy. The median progression-free survival (PFS) was 10.7 months for the 2nd-line group and 8.9 months for the ≥3rd-line group. The median overall survival (OS) from first-line treatment was 73.2 months in the 2nd-line group and 57.5 months in the ≥3rd-line group. No statistically significant differences in PFS or OS were observed between the two groups. Conclusions: Our research demonstrated that osimertinib is effective not only as a 2nd-line therapy but also as a ≥3rd-line treatment, offering promising clinical benefits for advanced and recurrent EGFR-mutant NSCLC patients with acquired T790M mutations who have developed resistance to first- and second-generation EGFR-TKI therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

20. Efficacy of Aumolertinib (HS-10296) in Patients With Advanced EGFR T790M+ NSCLC: Updated Post-National Medical Products Administration Approval Results From the APOLLO Registrational Trial

Author

Lu, Shun, Wang, Qiming, Zhang, Guojun, Dong, Xiaorong, Yang, Cheng-Ta, Song, Yong, Chang, Gee-Chen, Lu, You, Pan, Hongming, Chiu, Chao-Hua, Wang, Zhehai, Feng, Jifeng, Zhou, Jianying, Xu, Xingxiang, Guo, Renhua, Chen, Jianhua, Yang, Haihua, Chen, Yuan, Yu, Zhuang, Shiah, Her-Shyong, Wang, Chin-Chou, Yang, Nong, Fang, Jian, Wang, Ping, Wang, Kai, Hu, Yanping, He, Jianxing, Wang, Ziping, Shi, Jianhua, Chen, Shaoshui, Wu, Qiong, Sun, Changan, Li, Chuan, Wei, Hongying, Cheng, Ying, Su, Wu-Chou, Hsia, Te-Chun, Cui, Jiuwei, Sun, Yuping, Ou, Sai-Hong Ignatius, Zhu, Viola W., and Chih-Hsin Yang, James

Published
2022
Full Text
View/download PDF

24. Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia

Author

Blechter, Batel, Wong, Jason Y.Y., Agnes Hsiung, Chao, Hosgood, H.Dean, Yin, Zhihua, Shu, Xiao-Ou, Zhang, Han, Shi, Jianxin, Song, Lei, Song, Minsun, Zheng, Wei, Wang, Zhaoming, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Teresa Landi, Maria, Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chien, Li-Hsin, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Jie Seow, Wei, Bassig, Bryan A., Hu, Wei, Ji, Bu-Tian, Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Pik Wong, Maria, Lu, Daru, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, Chatterjee, Nilanjan, and Lan, Qing

Published
2021
Full Text
View/download PDF

26. Experience from Asian centers in a named-patient-use program for afatinib in patients with advanced non-small-cell lung cancer who had progressed following prior therapies, including patients with uncommon EGFR mutations

Author

Chang, Gee-Chen, Lam, David Chi-Leung, Tsai, Chun-Ming, Chen, Yuh-Min, Shih, Jin-Yuan, Aggarwal, Shyam, Wang, Shuhang, Kim, Sang-We, Kim, Young-Chul, Wahid, Ibrahim, Li, Rubi, Lim, Darren Wan-Teck, Sriuranpong, Virote, Chan, Raymond Tsz-Tong, Lorence, Robert M., Carriere, Philippe, Raabe, Christina, Cseh, Agnieszka, and Park, Keunchil

Published
2021
Full Text
View/download PDF

28. Safety, Efficacy, and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients With EGFR-Mutated Advanced NSCLC: A Multicenter, Open-label, Phase 1 Trial

Author

Yang, James Chih-Hsin, Camidge, D. Ross, Yang, Cheng-Ta, Zhou, Jianying, Guo, Renhua, Chiu, Chao-Hua, Chang, Gee-Chen, Shiah, Her-Shyong, Chen, Yuan, Wang, Chin-Chou, Berz, David, Su, Wu-Chou, Yang, Nong, Wang, Ziping, Fang, Jian, Chen, Jianhua, Nikolinakos, Petros, Lu, You, Pan, Hongming, Maniam, Ajit, Bazhenova, Lyudmila, Shirai, Keisuke, Jahanzeb, Mohammad, Willis, Maurice, Masood, Nehal, Chowhan, Naveed, Hsia, Te-Chun, Jian, Hong, and Lu, Shun

Published
2020
Full Text
View/download PDF

30. Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial

Author

Wu, Yi-Long, Liu, Xiaoqing, Liu, Zhe, Lu, Shun, Chen, Xi, Pan, Hongming, Wang, Mengzhao, Yu, Shiying, Zhang, Helong, Zhang, Yiping, Fang, Jian, Li, Wei, Zhou, Jianying, Zhao, Jun, Cheng, Ying, Yang, Chih-Hsin, Chang, Gee-Chen, Chen, Yuh-Min, Hsia, Te-Chun, Chian, Chih-Feng, Yang, Cheng-Ta, Wang, Chin-Chou, Kim, Sang-We, Park, Keunchil, Kim, Dong-Wan, Cho, Byoung Chul, Lee, Ki Hyeong, Kim, Young-Chul, An, Ho Jung, Woo, In Sook, Cho, Jae Yong, Shin, Sang Won, Lee, Jong-Seok, Kim, Joo-Hang, Yoo, Seung Soo, Kato, Terufumi, Shinagawa, Naofumi, Soo, Ross Andrew, Tan, Shao Weng Daniel, Ngo, Lynette Si-Mien, Ratnavelu, Kananathan, Ahmad, Azura Rozila, Liam, Chong Kin, de Marinis, Filippo, Tassone, Pierfrancesco, Molla, Amelia Insa, Calles Blanco, Antonio, Lazaro Quintela, Martin Emilio, Felip Font, Enriqueta, Dingemans, Anne-Marie, Bui, Lynne, Tan, Daniel Shao Weng, Bruns, Rolf, Straub, Josef, Johne, Andreas, Scheele, Jürgen, and Yang, James Chih-Hsin

Published
2020
Full Text
View/download PDF

31. Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

Author

Chen, Yi-Ju, Roumeliotis, Theodoros I., Chang, Ya-Hsuan, Chen, Ching-Tai, Han, Chia-Li, Lin, Miao-Hsia, Chen, Huei-Wen, Chang, Gee-Chen, Chang, Yih-Leong, Wu, Chen-Tu, Lin, Mong-Wei, Hsieh, Min-Shu, Wang, Yu-Tai, Chen, Yet-Ran, Jonassen, Inge, Ghavidel, Fatemeh Zamanzad, Lin, Ze-Shiang, Lin, Kuen-Tyng, Chen, Ching-Wen, Sheu, Pei-Yuan, Hung, Chen-Ting, Huang, Ke-Chieh, Yang, Hao-Chin, Lin, Pei-Yi, Yen, Ta-Chi, Lin, Yi-Wei, Wang, Jen-Hung, Raghav, Lovely, Lin, Chien-Yu, Chen, Yan-Si, Wu, Pei-Shan, Lai, Chi-Ting, Weng, Shao-Hsing, Su, Kang-Yi, Chang, Wei-Hung, Tsai, Pang-Yan, Robles, Ana I., Rodriguez, Henry, Hsiao, Yi-Jing, Chang, Wen-Hsin, Sung, Ting-Yi, Chen, Jin-Shing, Yu, Sung-Liang, Choudhary, Jyoti S., Chen, Hsuan-Yu, Yang, Pan-Chyr, and Chen, Yu-Ju

Published
2020
Full Text
View/download PDF

33. Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Author

Wong, Jason Y.Y., Zhang, Han, Hsiung, Chao A., Shiraishi, Kouya, Yu, Kai, Matsuo, Keitaro, Wong, Maria Pik, Hong, Yun-Chul, Wang, Jiucun, Seow, Wei Jie, Wang, Zhaoming, Song, Minsun, Kim, Hee Nam, Chang, I-Shou, Chatterjee, Nilanjan, Hu, Wei, Wu, Chen, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Seow, Adeline, Caporaso, Neil E., Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Yang, Yang, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Cai, Qiuyin, Yin, Zhihua, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Hosgood, H. Dean, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-ichi, Kubo, Michiaki, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Shi, Jianxin, Song, Lei, Hua, Xing, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wei, Fusheng, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Su, Wu-Chou, Chen, Yu-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Chien, Li-Hsin, Xiang, Yong-Bing, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Lee, Kyoung-Mu, Blechter, Batel, Li, Haixin, Gao, Yu-Tang, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Berndt, Sonja I., Wu, Wei, Pang, Herbert, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, C.H., Zhu, Meng, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Hsin, Michael, Sit, Ko-Yung, Ho, James, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho Il, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Wang, Yuzhuo, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Chen, Tzu-Yu, Jiang, Shih-Sheng, Liu, Jie, Yamaji, Taiki, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Yang, Kaiyun, Jiang, Gening, Fei, Ke, Wu, Guoping, Lin, Hsien-Chin, Chen, Hui-Ling, Fang, Yao-Huei, Tsai, Fang-Yu, Hsieh, Wan-Shan, Yu, Jinming, Stevens, Victoria L., Laird-Offringa, Ite A., Marconett, Crystal N., Rieswijk, Linda, Chao, Ann, Yang, Pan-Chyr, Shu, Xiao-Ou, Wu, Tangchun, Wu, Y.L., Lin, Dongxin, Chen, Kexin, Zhou, Baosen, Huang, Yun-Chao, Kohno, Takashi, Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2020
Full Text
View/download PDF

35. A Randomized-Controlled Phase 2 Study of the MET Antibody Emibetuzumab in Combination with Erlotinib as First-Line Treatment for EGFR Mutation–Positive NSCLC Patients

Author

Scagliotti, Giorgio, Moro-Sibilot, Denis, Kollmeier, Jens, Favaretto, Adolfo, Cho, Eun Kyung, Grosch, Heidrun, Kimmich, Martin, Girard, Nicolas, Tsai, Chun-Ming, Hsia, Te-Chun, Brighenti, Matteo, Schumann, Christian, Wang, Xuejing Aimee, Wijayawardana, Sameera R., Gruver, Aaron M., Wallin, Johan, Mansouri, Kambiz, Wacheck, Volker, and Chang, Gee-Chen

Published
2020
Full Text
View/download PDF

36. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Tobacco, Clinical Research, Urologic Diseases, Lung, Genetics, Rare Diseases, Lung Cancer, Human Genome, Hematology, Cancer, Tobacco Smoke and Health, Prevention, Lymphoma, Adult, Aged, Asian People, Bone Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Neoplasms, Osteosarcoma, Polymorphism, Single Nucleotide, Smoking, Testicular Neoplasms, Tissue Array Analysis, Urinary Bladder Neoplasms, White People, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

37. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Humans, Neoplasms, Osteosarcoma, Bone Neoplasms, Testicular Neoplasms, Lung Neoplasms, Kidney Neoplasms, Genetic Predisposition to Disease, Tissue Array Analysis, Smoking, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Urinary Bladder Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Oncology And Carcinogenesis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

41. Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Chu, Quincy, Cortot, Alexis, Pujol, Jean-Louis, Moro-Sibilot, Denis, Fabre, Elizabeth, Lamour, Corinne, Bischoff, Helge, Kollmeier, Jens, Reck, Martin, Kimmich, Martin, Engel-Riedel, Walburga, Hammerschmidt, Stefan, Schütte, Wolfgang, Syrigos, Konstantinos, Ho, James Chung Man, Au, Kwok-Hung, Novello, Silvia, Ardizzoni, Andrea, Pasello, Giulia, Gregorc, Vanessa, Del Conte, Alessandro, Galetta, Domenico, Takahashi, Toshiaki, Nakagawa, Kazuhiko, Nishio, Makoto, Yoh, Kiyotaka, Seto, Takashi, Imamura, Fumio, Kumagai, Toru, Hotta, Katsuyuki, Goto, Yasushi, Hosomi, Yukio, Sakai, Hiroshi, Takiguchi, Yuichi, Kim, Young Hak, Kurata, Takayasu, Yamaguchi, Hiroyuki, Daga, Haruko, Okamoto, Isamu, Satouchi, Miyako, Ikeda, Satoshi, Kasahara, Kazuo, Atagi, Shinji, Azuma, Koichi, Aoe, Keisuke, Horio, Yoshitsugu, Yamamoto, Nobuyuki, Tanaka, Hiroshi, Watanabe, Satoshi, Nogami, Naoyuki, Ozaki, Tomohiro, Koyama, Ryo, Hirashima, Tomonori, Kaneda, Hiroyasu, Tomii, Keisuke, Fujita, Yuka, Seike, Masahiro, Nishimura, Naoki, Kato, Terufumi, Ichiki, Masao, Saka, Hideo, Hirano, Katsuya, Nakahara, Yasuharu, Sugawara, Shunichi, Park, Keunchil, Kim, Sang-We, Min, Young Joo, Lee, Hyun Woo, Kang, Jin-Hyoung, An, Ho Jung, Lee, Ki Hyeong, Kim, Jin-Soo, Lee, Gyeong-Won, Lee, Sung Yong, Alexandru, Aurelia, Udrea, Anghel Adrian, Juan-Vidal, Óscar, Nadal-Alforja, Ernest, Gil-Bazo, Ignacio, Ponce-Aix, Santiago, Paz-Ares, Luis, Rubio-Viqueira, Belén, Alonso Garcia, Miriam, Felip Font, Enriqueta, Fuentes Pradera, Jose, Coves Sarto, Juan, Lin, Meng-Chih, Su, Wu-Chou, Hsia, Te-Chun, Chang, Gee-Chen, Wei, Yu-Feng, Chiu, Chao-Hua, Shih, Jin-Yuan, Su, Jian, Cicin, Irfan, Goksel, Tuncay, Harputluoglu, Hakan, Ozyilkan, Ozgur, Henning, Ivo, Popat, Sanjay, Hatcher, Olivia, Mileham, Kathryn, Acoba, Jared, Garon, Edward, Jung, Gabriel, Raj, Moses, Martin, William, Dakhil, Shaker, Garon, Edward B, Ponce Aix, Santiago, Nadal, Ernest, Au, Kwok Hung, Enatsu, Sotaro, Zimmermann, Annamaria, Frimodt-Moller, Bente, and Visseren-Grul, Carla

Published
2019
Full Text
View/download PDF

42. Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

Author

Batagelj, Emilio, Casarini, Ignacio, Pastor, Anea Viviana, Sena, Susana Noemi, Zarba, Juan Jose, Burghuber, Otto, Hartl, Sylvia, Hochmair, Maximilian J, Lamprecht, Bernd, Studnicka, Michael, Alberto Schlittler, Luis, Augusto Martinelli de Oliveira, Fabricio, Calabrich, Aknar, Colagiovanni Girotto, Gustavo, Dos Reis, Peo, Fausto Nino Gorini, Carlos, Rafael Martins De Marchi, Peo, Serodio da Rocha Baldotto, Clarissa, Sette, Claudia, Zukin, Mauro, Conev, Nikolay V, Dudov, Assen, Ilieva, Rumyana, Koynov, Krassimir, Krasteva, Rositsa, Tonev, Ivan, Valev, Spartak, Venkova, Violetka, Bi, Minghong, Chen, Chengshui, Chen, Yuan, Chen, Zhendong, Fang, Jian, Feng, Jifeng, Han, Zhigang, Hu, Jie, Hu, Yi, Li, Wei, Liang, Zongan, Lin, Zhong, Ma, Rui, Ma, Shenglin, Nan, Kejun, Shu, Yongqian, Wang, Kai, Wang, Mengzhao, Wu, Gang, Yang, Nong, Yang, Zhixiong, Zhang, Helong, Zhang, Wei, Zhao, Jun, Zhao, Yanqiu, Zhou, Caicun, Zhou, Jianying, Zhou, Xiangdong, Havel, Libor, Kolek, Vitezslav, Koubkova, Leona, Roubec, Jaromir, Skrickova, Jana, Zemanova, Milada, Chouaid, Christos, Hilgers, Werner, Lena, Hervé, Moro-Sibilot, Denis, Robinet, Gilles, Souquet, Pierre-Jean, Alt, Jürgen, Bischoff, Helge, Grohe, Christian, Laack, Eckart, Lang, Susanne, Panse, Jens, Reinmuth, Niels, Schulz, Christian, Bogos, Krisztina, Csánky, Eszter, Fülöp, Anea, Horváth, Zsolt, Kósa, Judit, Laczó, Ibolya, Losonczy, György, Pajkos, Gábor, Pápai, Zsuzsanna, Pápai Székely, Zsolt, Sárosi, Veronika, Somfay, Attila, Somogyiné Ezer, Éva, Telekes, Anás, Bar, Jair, Gottfried, Maya, Heching, Norman Isaac, Zer Kuch, Alona, Bartolucci, Roberta, Bettini, Anna Cecilia, Delmonte, Angelo, Garassino, Marina Chiara, Minelli, Mauro, Roila, Fausto, Verderame, Francesco, Atagi, Shinji, Azuma, Koichi, Goto, Hisatsugu, Goto, Koichi, Hara, Yu, Hayashi, Hidetoshi, Hida, Toyoaki, Hotta, Katsuyuki, Kanazawa, Kenya, Kanda, Shintaro, Kim, Young Hak, Kuyama, Shoichi, Maeda, Tadashi, Morise, Masahiro, Nakahara, Yasuharu, Nishio, Makoto, Nogami, Naoyuki, Okamoto, Isamu, Saito, Haruhiro, Shinoda, Masahiro, Umemura, Shigeki, Yoshida, Tatsuya, Claessens, Niels, Cornelissen, Robin, Heniks, Lizza, Hiltermann, Jeroen, Smit, Egbert, Staal van den Brekel, Agnes, Kazarnowicz, Andrzej, Kowalski, Dariusz, Mańdziuk, Slawomir, Mróz, Robert, Wojtukiewicz, Marek, Ciuleanu, Tudor, Ganea, Doina, Ungureanu, Anei, Dvorkin, Mikhail, Luft, Alexander, Moiseenko, Vladimir, Poltoratskiy, Artem, Sakaeva, Dina, Smolin, Alexey, Statsenko, Galina, Vasilyev, Alexander, Vladimirova, Lyubov, Anasina, Igor, Chovanec, Jozef, Demo, Pavol, Godal, Robert, Kasan, Peter, Stresko, Marian, Urda, Michal, Cho, Eun Kyung, Ji, Jun Ho, Kim, Joo-Hang, Kim, Sang-We, Lee, Gyeong-Won, Lee, Jong-Seok, Lee, Ki Hyeong, Lee, Kyung Hee, Lee, Yun Gyoo, Amelia Insa Molla, Maria, Domine Gomez, Manuel, Ignacio Delgado Mingorance, Juan, Isla Casado, Dolores, Lopez Brea, Marta, Majem Tarruella, Margarita, Morán Bueno, Teresa, Navarro Mendivil, Alejano, Paz-Ares Rodríguez, Luis, Ponce Aix, Santiago, Rosario Garcia Campelo, Maria, Chang, Gee-Chen, Chen, Yen-Hsun, Chiu, Chao-Hua, Hsia, Te-Chun, Lee, Kang-Yun, Li, Chien-Te, Wang, Chin-Chou, Wei, Yu-Feng, Wu, Shang-Yin, Alacacıoğlu, Ahmet, Çiçin, Irfan, Demirkazik, Ahmet, Erman, Mustafa, Göksel, Tuncay, Özgüroğlu, Mustafa, Adamchuk, Hryhoriy, Bondarenko, Igor, Kolesnik, Oleksii, Kryzhanivska, Anna, Ostapenko, Yuriv, Shevnia, Serhii, Shparyk, Yaroslav, Trukhin, Dmytro, Ursol, Grygorii, Voitko, Nataliia, Voitko, Oleksandr, Vynnychenko, Ihor, Babu, Sunil, Chen, Yuanbin, Chiang, Anne, Chua, Winston, Dakhil, Shaker, Dowlati, Afshin, Goldman, Jonathan W, Haque, Basir, Jamil, Rodney, Knoble, Jeanna, Lakhanpal, Shailena, Mi, Kailhong, Nikolinakos, Petros, Powell, Steven, Ross, Helen, Schaefer, Eric, Schneider, Jeffrey, Spahr, Joseph, Spigel, David, Stilwill, Joseph, Sumey, Christopher, Williamson, Michael, Paz-Ares, Luis, Ponce, Santiago, Armstrong, Jon, Byrne, Natalie, Shire, Norah, and Jiang, Haiyi

Published
2019
Full Text
View/download PDF

44. Primary tumor consolidative therapy improves the outcomes of patients with advanced EGFR-mutant lung adenocarcinoma treated with first-line osimertinib

Author

Wu, Jia-Jun, primary, Tseng, Jeng-Sen, additional, Zheng, Zhe-Rong, additional, Chu, Cheng-Hsiang, additional, Chen, Kun-Chieh, additional, Lin, Mong-Wei, additional, Huang, Yen-Hsiang, additional, Hsu, Kuo-Hsuan, additional, Yang, Tsung-Ying, additional, Yu, Sung-Liang, additional, Chen, Jin-Shing, additional, Ho, Chao-Chi, additional, and Chang, Gee-Chen, additional

Published
2024
Full Text
View/download PDF

45. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Zhaoming, Zhu, Bin, Zhang, Mingfeng, Parikh, Hemang, Jia, Jinping, Chung, Charles C, Sampson, Joshua N, Hoskins, Jason W, Hutchinson, Amy, Burdette, Laurie, Ibrahim, Abdisamad, Hautman, Christopher, Raj, Preethi S, Abnet, Christian C, Adjei, Andrew A, Ahlbom, Anders, Albanes, Demetrius, Allen, Naomi E, Ambrosone, Christine B, Aldrich, Melinda, Amiano, Pilar, Amos, Christopher, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Arici, Cecilia, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Beane Freeman, Laura E, Berg, Christine D, Berndt, Sonja I, Bertazzi, Pier Alberto, Biritwum, Richard B, Black, Amanda, Blot, William, Boeing, Heiner, Boffetta, Paolo, Bolton, Kelly, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brennan, Paul, Brinton, Louise A, Brotzman, Michelle, Bueno-de-Mesquita, H Bas, Buring, Julie E, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Cao, Guangwen, Caporaso, Neil E, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chang, Gee-Chen, Chang, I-Shou, Chang-Claude, Jenny, Che, Xu, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chung-Hsing, Chen, Constance, Chen, Kuan-Yu, Chen, Yuh-Min, Chokkalingam, Anand P, Chu, Lisa W, Clavel-Chapelon, Francoise, Colditz, Graham A, Colt, Joanne S, Conti, David, Cook, Michael B, Cortessis, Victoria K, Crawford, E David, Cussenot, Olivier, Davis, Faith G, De Vivo, Immaculata, Deng, Xiang, Ding, Ti, Dinney, Colin P, Di Stefano, Anna Luisa, Diver, W Ryan, Duell, Eric J, Elena, Joanne W, Fan, Jin-Hu, Feigelson, Heather Spencer, Feychting, Maria, Figueroa, Jonine D, Flanagan, Adrienne M, Fraumeni, Joseph F, Freedman, Neal D, Fridley, Brooke L, Fuchs, Charles S, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, and Garcia-Closas, Montserrat

Subjects
Biological Sciences, Genetics, Human Genome, Cancer, Prevention, 2.1 Biological and endogenous factors, Alleles, Chromosomes, Human, Pair 5, Computational Biology, DNA Methylation, Epigenesis, Genetic, Female, Gene Expression Regulation, Neoplastic, Gene Frequency, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Membrane Proteins, Neoplasm Proteins, Neoplasms, Odds Ratio, Polymorphism, Single Nucleotide, Risk, Telomerase, Medical and Health Sciences, Genetics & Heredity
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

46. Real-world osimertinib pretreatment experience in patients with epidermal growth factor receptor T790M mutation-positive locally advanced or metastatic non-small cell lung cancer.

Author

Chang, Gee-Chen, Shih, Jin-Yuan, Yu, Chong-Jen, Chao, Heng-Sheng, Yang, Cheng-Ta, Lin, Chien-Chung, Hung, Jen-Yu, Hsiao, Sheng-Yen, Wang, Chin-Chou, Chian, Chih-Feng, Hsia, Te-Chun, and Chen, Yuh-Min

Subjects
*EPIDERMAL growth factor receptors, *NON-small-cell lung carcinoma, *PATIENT experience, *OSIMERTINIB, *PATIENTS' attitudes, *PROTEIN-tyrosine kinase inhibitors
Abstract

Osimertinib has demonstrated efficacy in patients with epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer (NSCLC) in clinical trials. However, real-world data on its effectiveness remain scarce. Taiwanese patients with T790M-positive locally advanced or metastatic NSCLC and progressive disease following treatment with at least one EGFR tyrosine kinase inhibitor (TKI) were enrolled from the osimertinib early access program. Of the 419 patients (mean age, 63 years; female, 67%), 53% were heavily pretreated (≥ third-line [3L]), making osimertinib a fourth-line (4L) intervention. The median progression-free survival (PFS) was 10.5 months (95% confidence interval [CI]: 8.95–11.41); the 18-month PFS rate was 26.5%. The median overall survival (OS) was 19.0 months (95% CI: 16.30–20.95); the 24-month OS rate was 40.9%. The objective response rate was 32.46%, and the disease control rate was 86.38%. The median time to treatment discontinuation of osimertinib monotherapy was 11.9 months (95% CI: 10.49–13.11). Subgroup analyses of median PFS and OS in the chemotherapy combination group vs. the osimertinib monotherapy group yielded no difference. Central nervous system (CNS) metastasis, number of prior lines of therapy, and types of initial EGFR-TKIs did not significantly impact outcomes. The median PFS values were 9.0 (95% CI: 5.18–11.34) and 10.9 (95% CI: 9.18–11.90) months with and without CNS metastasis, respectively, and 10.8 (95% CI: 8.59–12.69), 13.6 (95% CI: 10.89–16.3), and 9.2 (95% CI: 7.8–10.62) months for second-line (2L), 3L, and ≥4L therapy, respectively. In patients who received osimertinib as 2L therapy, the median PFS values in response to prior afatinib, erlotinib and gefitinib treatment were 11.2 (95% CI: 4.85–4.79), 10.5 (95% CI: 8.59–20.26) and 8.7 (95% CI: 7.21–16.79) months, respectively. Overall, real-world data from Taiwan support the clinical benefits of osimertinib in EGFR T790M -positive NSCLC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

49. Polygenic Risk Score, Environmental Tobacco Smoke, and Risk of Lung Adenocarcinoma in Never-Smoking Women in Taiwan

Author

Blechter, Batel, primary, Chien, Li-Hsin, additional, Chen, Tzu-Yu, additional, Chang, I-Shou, additional, Choudhury, Parichoy Pal, additional, Hsiao, Chin-Fu, additional, Shu, Xiao-Ou, additional, Wong, Jason Y. Y., additional, Chen, Kuan-Yu, additional, Chang, Gee-Chen, additional, Tsai, Ying-Huang, additional, Su, Wu-Chou, additional, Huang, Ming-Shyan, additional, Chen, Yuh-Min, additional, Chen, Chih-Yi, additional, Hung, Hsiao-Han, additional, Hu, Jia-Wei, additional, Shi, Jianxin, additional, Zheng, Wei, additional, Rositch, Anne F., additional, Chen, Chien-Jen, additional, Chatterjee, Nilanjan, additional, Yang, Pan-Chyr, additional, Rothman, Nathaniel, additional, Hsiung, Chao Agnes, additional, and Lan, Qing, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results