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10. Plasma neurofilament light-chain and phosphorylated tau as biomarkers of disease severity in Huntington's disease: Korean cohort data

Author

Hwang, Yun Su, Oh, Eungseok, Kim, Manho, Lee, Chan Young, Kim, Hyun Sook, Chung, Sun Ju, Sung, Young Hee, Yoon, Won Tae, Cho, Jin Hwan, Lee, Jae-Hyeok, Kim, Han-Joon, Chang, Hee Jin, Jeon, Beomseok, Woo, Kyung Ah., Ko, Seong Beom, Kwon, Kyum-Yil, Moon, Jangsup, Shin, Chaewon, Kim, Young Eun, and Lee, Jee-Young

Published
2023
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17. Establishment of a registry of clinical data and bioresources for rare nervous system diseases

Author

Kim, Dayoung, primary, Kim, Sooyoung, additional, Seok, Jin Myoung, additional, Shin, Kyong Jin, additional, Oh, Eungseok, additional, Jeon, Mi Young, additional, Park, Joungkyu, additional, Chang, Hee Jin, additional, Youn, Jinyoung, additional, Oh, Jeeyoung, additional, Sohn, Eunhee, additional, Park, Jinse, additional, Cho, Jin Whan, additional, and Kim, Byoung Joon, additional

Published
2024
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22. Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): 10-year follow-up of an open-label, non-inferiority, randomised controlled trial

Author

Park, Ji Won, Kang, Sung-Bum, Hao, Jie, Lim, Seok-Byung, Choi, Hyo Seong, Kim, Duck-Woo, Chang, Hee Jin, Kim, Dae Yong, Jung, Kyung Hae, Kim, Tae-You, Kang, Gyeong Hoon, Chie, Eui Kyu, Kim, Sun Young, Sohn, Dae Kyung, Kim, Jae-Sung, Lee, Hye Seung, Kim, Jee Hyun, Jeong, Seung-Yong, and Oh, Jae Hwan

Published
2021
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23. The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study.

Author

Nguyen, Linh Thi Dieu, Gunathilake, Madhawa, Lee, Jeonghee, Oh, Jae Hwan, Chang, Hee Jin, Sohn, Dae Kyung, Shin, Aesun, and Kim, Jeongseon

Subjects
KOREANS, COLORECTAL cancer, MAGNESIUM, DISEASE risk factors, GENETIC variation
Abstract

Magnesium may have a significant impact on the development of cancer. However, the relationship between magnesium intake and the risk of colorectal cancer (CRC) is unclear. Therefore, we evaluated the association between magnesium intake and the risk of CRC, and we investigated how the insulin receptor (INSR) rs1799817 variant impacts this relationship. Data from 1,420 CRC patients and 2,840 controls from the Korean National Cancer Centre were analysed. A higher intake of magnesium was associated with a reduced risk of CRC in the total population (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.52–0.81). We found that G + carriers of INSR rs1799817 with higher magnesium intake had a significantly lower risk of CRC (p for interaction = 0.003). Our findings indicated that high magnesium intake could be associated with a decreased risk of CRC, and this association could be modified by the INSR rs1799817 variant. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Caregiver burden of patients with Huntington’s disease in South Korea

Author

Lee, Chan Young, primary, Shin, Chaewon, additional, Hwang, Yun Su, additional, Oh, Eungseok, additional, Kim, Manho, additional, Kim, Hyun Sook, additional, Chung, Sun Ju, additional, Sung, Young Hee, additional, Yoon, Won Tae, additional, Cho, Jin Whan, additional, Lee, Jae-Hyeok, additional, Kim, Han-Joon, additional, Chang, Hee Jin, additional, Jeon, Beomseok, additional, Woo, Kyung Ah, additional, Koh, Seong-Beom, additional, Kwon, Kyum-Yil, additional, Moon, Jangsup, additional, Kim, Young Eun, additional, and Lee, Jee-Young, additional

Published
2023
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36. The development of collaborative learning practices in an online language course

Author

Chang, Hee-Jin

Subjects
418.00285
Abstract

The success or failure of a course is, to a great extent, dependent on the level of motivation and commitment of the learners. Such motivation and commitment are, however, difficult to establish and maintain, especially in an on-line course. Social relations within a class, and the willingness of learners to collaborate with each other, have an important role to play, but the constraints of time and distance are obstacles to fostering such social relations among students enrolled in on-line courses. It is not easy to encourage students to be collaborative when they are accessing the course at different times, from different locations. This thesis, however, seeks to demonstrate that the variety and complexity of the technologies used to deliver an on-line learning experience can help to overcome these challenges. When introduced and used in appropriate ways, the software, internet tools, even the data collection program used for statistical analysis can actually encourage and enhance participants' motivation to interact and learn in collaborative ways. This thesis is concerned with an on-line course created and delivered by the researcher, the aim of which was to foster a collaborative learning environment in which participants felt confident enough to share their work with others, and to offer and receive comments on their assignments. The primary aim was therefore not the direct teaching and learning of language, but the fostering of an environment in which the students felt comfortable working with the technology and with each other, as a pre-requisite for the acquisition of language through content-based activities. The study did not dwell on the effects of collaboration on language development but focused, rather, on how individual students collaborate in an online, e-learning course, what forms this collaboration takes, and how the pattern of collaboration changes as the course progresses. This focus allowed the researcher to look at ways collaboration affected the persistence and retention challenges of on-line learning experience. The course was designed for students learning EFL at a university in Korea. It lasts one semester, and is delivered using a virtual learning environment (VLE) program developed by the university. The course consists of 15 units to be completed at the rate of one a week. Each unit focuses on a different topic and consists of a reading passage and a listening exercise. This is followed by some writing activities, including a weekly written report, and recording assignments. The researcher was the instructor for this course, and made special interventions using appropriate technology (sometimes e-mail, other times Skype to make it more personal) to encourage students to work in pairs, and in group discussions, and to post their work in the VLE so that others could read and comment on it. The current study reports on the experience of running the course with one group of 47 Korean university students. Data was gathered from the learners‟ journals, their assignments, feedback and comments posted on the web board, and emails to the instructor. The VLE also recorded statistics showing the students‟ usage of the different components of the course, and how their use of these components changed and fluctuated as the course progressed. The results showed that in the process of completing the course the majority of the learners reported a strong sense of “belonging” to a learning community, developing a close rapport with other learners by sharing their work, exchanging comments and taking part in discussions. Students felt proud of their work as well as of the process of working together with other learners. In particular, the results suggest that opportunities for social interaction and feedback play a crucial role in developing the emotional connection which helps to create a collaborative learning environment and support an effective learning community. The evidence suggests that the appropriate use of technology when delivering an on-line course may, in fact, encourage collaboration because of two phenomena that are not always evident in a traditional, place-based classroom. These are anonymity and reciprocity. Anonymity makes it easier for students to share their work and ideas because, if a contribution is embarrassing, it may have less negative effect than in a face-to-face exchange. Reciprocity refers to the natural inclination of a student, having learned from others in the VLE, to give something back to the community.

Published
2012

42. The association of diet-dependent acid load with colorectal cancer risk: a case–control study in Korea.

Author

Tran, Tao Thi, Gunathilake, Madhawa, Lee, Jeonghee, Oh, Jae Hwan, Chang, Hee Jin, Sohn, Dae Kyung, Shin, Aesun, and Kim, Jeongseon

Subjects
CONFIDENCE intervals, VEGETABLES, MEAT, CARCINOGENESIS, DIET, CASE-control method, NUTRITIONAL requirements, COLORECTAL cancer, ACID-base imbalances, RISK assessment, COMPARATIVE studies, SEX distribution, QUESTIONNAIRES, DESCRIPTIVE statistics, FRUIT, RESEARCH funding, LOGISTIC regression analysis, ODDS ratio, ACID-base equilibrium, DISEASE risk factors
Abstract

Acid–base disequilibrium is a contributor to cancer development because it affects molecular activities such as insulin-like growth factor 1 levels and adiponectin production. However, evidence of an association of diet-induced acid–base imbalance with colorectal cancer (CRC) is limited. We examined whether colorectal carcinogenesis is attributable to a diet with a high acid load. We recruited a total of 923 CRC cases and 1846 controls at the National Cancer Center in Korea for inclusion in a case–control study. We collected information on nutrient intake and specific clinical parameters of CRC by using a semiquantitative FFQ and medical records, respectively. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) were used to estimate diet-dependent acid load. We used an unconditional logistic regression model to analyse the association. Dietary acid load scores had a positive association with the odds of CRC (OR = 2·31 (95 % CI 1·79, 2·99) and OR = 2·14 (95 % CI 1·66, 2·76) for PRAL and NEAP, respectively, P for trend < 0·001). A stronger positive association was observed for females (OR = 3·09, 95 % CI 1·93, 4·94) than for males (OR = 1·71, 95 % CI 1·27, 2·31). Furthermore, acidogenic diets appeared to affect rectal cancer more strongly than colon cancer in females. Our study contributes to reinforcing epidemiological evidence regarding a detrimental effect of acidogenic diets on colorectal carcinogenesis. Thus, it is important to pay attention to the balance of acidogenic (e.g. poultry and red meat) and alkalinogenic foods (e.g. fruits and vegetables) in CRC prevention, especially for females. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Stratification of rate of lymph node metastasis according to risk factors and oncologic outcomes in patients who underwent radical resection for rectal neuroendocrine tumors

Author

Jin, Myung Jae, primary, Park, Sung Sil, additional, Lee, Dong-Eun, additional, Park, Sung Chan, additional, Lee, Dong Woon, additional, Yu, Kiho, additional, Chang, Hee Jin, additional, Hong, Chang Won, additional, Sohn, Dae Kyung, additional, Han, Kyung Su, additional, Kim, Bun, additional, Kim, Byung Chang, additional, and Oh, Jae Hwan, additional

Published
2023
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47. Impact of primary tumor location and gene mutation on outcome after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal cancer peritoneal metastasis

Author

Kim, Min Chul, primary, Chan Park, Sung, additional, Oh, Jae Hwan, additional, Sohn, Dae Kyung, additional, Chang, Hee Jin, additional, Baek, Ji Yeon, additional, Lee, Dong Woon, additional, Park, Sung Sil, additional, Hong, Chang Won, additional, and Han, Kyung Su, additional

Published
2023
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