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4. Surface-Enhanced Raman Spectroscopy Monitoring of Enzymatic Domino Reactions on Ag Nanoshells for Sensitive Metabolite Detection.

Author

Park, Eungyeong, Heo, Eun Hae, Chung, Haejin, Jin, Sila, Guo, Shuang, Hahm, Eunil, Park, Yeonju, Chang, Hyejin, and Jung, Young Mee

Abstract

The reliable monitoring of metabolites in biofluids plays a pivotal role in the diagnosis, treatment, and long-term management of various diseases. Surface-enhanced Raman spectroscopy (SERS) is considered a promising tool for metabolite detection because of its unique advantages for detecting trace amounts of chemical and biological molecules without requiring extensive sample preprocessing. In this study, a SERS sensor is proposed, utilizing silver nanoshells in cooperation with enzymes and 4-mercaptobenzoic acid (4-MBA) as a bifunctional molecule, to monitor two distinct biological metabolites, lactate and cholesterol, at their respective levels. In our method, the enzymatic reactions between oxidases and their specific metabolites initiate a domino reaction, resulting in significant changes in the SERS signal of 4-MBA. Through systematic sensor optimization, the quantification of lactate (1.0 × 10–1 to 1.0 × 10–7 M) and cholesterol (1.0 × 10–2 to 1.0 × 10–6 M) in a buffer solution was successfully achieved using the SERS intensity as an indicator. The limits of detection for lactate and cholesterol were estimated to be 2.7 × 10–7 and 1.0 × 10–8 M, respectively. Our proposed SERS sensor precisely detected lactate concentrations in serum samples, with a high accuracy of over 91%, demonstrating high selectivity for compounds with similar structures and serum constituents. Our SERS sensor platform can be utilized as an efficient and versatile tool for measuring lactate concentrations in serum samples and is expected to have the potential to advance personalized healthcare solutions through rapid point-of-care testing. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Conclusion and Perspective

Author

Kim, Jaehi, Pham, Xuan-Hung, Chang, Hyejin, Lee, Sang Hun, Rho, Won-Yeop, Son, Byung Sung, Lee, Yoon-Sik, Jeong, Dae Hong, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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6. Carbon Nanomaterials for Biomedical Application

Author

Lee, Sang Hun, Rho, Won-Yeop, Chang, Hyejin, Lee, Jong Hun, Kim, Jaehi, Lee, Seung Hwan, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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7. Optical and Electron Microscopy for Analysis of Nanomaterials

Author

Kim, Hyoyeon, Murata, Michael M., Chang, Hyejin, Lee, Sang Hun, Kim, Jaehi, Lee, Jong Hun, Rho, Won-Yeop, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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8. Plasmonic Nanoparticles: Advanced Researches (II)

Author

Chang, Hyejin, Lee, Sang Hun, Kim, Jaehi, Rho, Won-Yeop, Pham, Xuan-Hung, Jeong, Dae Hong, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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9. Magnetic Nanoparticles

Author

Kyeong, San, Kim, Jaehi, Chang, Hyejin, Lee, Sang Hun, Son, Byung Sung, Lee, Jong Hun, Rho, Won-Yeop, Pham, Xuan-Hung, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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10. Luminescent Nanomaterials (II)

Author

Chang, Hyejin, Kim, Jaehi, Lee, Sang Hun, Rho, Won-Yeop, Lee, Jong Hun, Jeong, Dae Hong, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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11. Plasmonic Nanoparticles: Basics to Applications (I)

Author

Chang, Hyejin, Rho, Won-Yeop, Son, Byung Sung, Kim, Jaehi, Lee, Sang Hun, Jeong, Dae Hong, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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12. Silica Nanoparticles

Author

Chang, Hyejin, Kim, Jaehi, Rho, Won-Yeop, Pham, Xuan-Hung, Lee, Jong Hun, Lee, Sang Hun, Jeong, Dae Hong, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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13. Introduction of Nanobiotechnology

Author

Lee, Kwee-Yum, Pham, Xuan-Hung, Rho, Won-Yeop, Chang, Hyejin, Lee, Sang Hun, Kim, Jaehi, Hahm, Eunil, Lee, Jong Hun, Lee, Yoon-Sik, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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14. General in Colloidal Nanoparticles

Author

Kim, Jaehi, Pham, Xuan-Hung, Chang, Hyejin, Son, Byung Sung, Hahm, Eunil, Lee, Sang Hun, Rho, Won-Yeop, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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15. Bioapplications of Nanomaterials

Author

Huynh, Kim-Hung, Lee, Kwee-Yum, Chang, Hyejin, Lee, Sang Hun, Kim, Jaehi, Pham, Xuan-Hung, Lee, Yoon-Sik, Rho, Won-Yeop, Jun, Bong-Hyun, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Jun, Bong-Hyun, editor

Published
2021
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19. Recent Studies on Metal-Embedded Silica Nanoparticles for Biological Applications.

Author

Cho, Hye-Seong, Noh, Mi Suk, Kim, Yoon-Hee, Namgung, Jayoung, Yoo, Kwanghee, Shin, Min-Sup, Yang, Cho-Hee, Kim, Young Jun, Yu, Seung-Ju, Chang, Hyejin, Rho, Won Yeop, and Jun, Bong-Hyun

Subjects
RAMAN scattering, SILICA nanoparticles, SURFACE plasmon resonance, RESONANCE Raman effect, SERS spectroscopy, PRECIOUS metals
Abstract

Recently, silica nanoparticles (NPs) have attracted considerable attention as biocompatible and stable templates for embedding noble metals. Noble-metal-embedded silica NPs utilize the exceptional optical properties of novel metals while overcoming the limitations of individual novel metal NPs. In addition, the structure of metal-embedded silica NPs decorated with small metal NPs around the silica core results in strong signal enhancement in localized surface plasmon resonance and surface-enhanced Raman scattering. This review summarizes recent studies on metal-embedded silica NPs, focusing on their unique designs and applications. The characteristics of the metal-embedded silica NPs depend on the type and structure of the embedded metals. Based on this progress, metal-embedded silica NPs are currently utilized in various spectroscopic applications, serving as nanozymes, detection and imaging probes, drug carriers, photothermal inducers, and bioactivation molecule screening identifiers. Owing to their versatile roles, metal-embedded silica NPs are expected to be applied in various fields, such as biology and medicine, in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Antibody‐Based Therapeutics: Ultrasensitive NIR‐SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation (Adv. Healthcare Mater. 4/2018)

Author

Kang, Homan, Jeong, Sinyoung, Jo, Ahla, Chang, Hyejin, Yang, Jin‐Kyoung, Jeong, Cheolhwan, Kyeong, San, Lee, Youn Woo, Samanta, Animesh, Maiti, Kaustabh Kumar, Cha, Myeong Geun, Kim, Taek‐Keun, Lee, Sukmook, Jun, Bong‐Hyun, Chang, Young‐Tae, Chung, Junho, Lee, Ho‐Young, Jeong, Dae Hong, and Lee, Yoon‐Sik

Published
2018
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28. Additional file 1 of Highly sensitive near-infrared SERS nanoprobes for in vivo imaging using gold-assembled silica nanoparticles with controllable nanogaps

Author

Bock, Sungje, Choi, Yun-Sik, Kim, Minhee, Yun, Yewon, Pham, Xuan-Hung, Kim, Jaehi, Seong, Bomi, Kim, Wooyeon, Jo, Ahla, Ham, Kyeong-Min, Lee, Sung Gun, Lee, Sang Hun, Kang, Homan, Choi, Hak Soo, Jeong, Dae Hong, Chang, Hyejin, Kim, Dong-Eun, and Jun, Bong-Hyun

Abstract

Additional file 1: Fig S1. TEM image of SiO2 NPs. Fig S2. TEM image of SiO2@Au used as a seed. Fig S3. TEM image of SiO2@Au@Au synthesized using 600 ��M gold(III) chloride hydrate. Fig S4. TEM image of SiO2@Au synthesized by directly attaching large-sized Au NPs (10���15 nm) to aminated silica (not a growth method). Fig S5. SERS intensities of SiO2@Au@Au-4-FBT synthesized using various concentrations of gold(III) chloride hydrate determined at (a) blue visible light (wavelength, 532 nm) and (b) red visible light (wavelength, 660 nm). Fig S6. Cytotoxicity test using HCT 116 cells incubated with different concentrations of SiO2@Au@Au500-4-FBT. Fig S7. (a) Optical image, SERS mapping image, and overlay image of human colon carcinoma (HCT 116) cells incubated with 50 ��g/mL SiO2@Au@Au500-4-FBT. (b) Raman intensities at different locations: outside the cell (i), on the cell surface (ii), and inside the cell (iii), corresponding to the overlay images shown in (a).

Published
2022
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29. Tumor‐Associated Immune‐Cell‐Mediated Tumor‐Targeting Mechanism with NIR‐II Fluorescence Imaging

Author

Kang, Homan, primary, Shamim, Md, additional, Yin, Xiaoran, additional, Adluru, Eeswar, additional, Fukuda, Takeshi, additional, Yokomizo, Shinya, additional, Chang, Hyejin, additional, Park, Seung Hun, additional, Cui, Yanan, additional, Moy, Austin J., additional, Kashiwagi, Satoshi, additional, Henary, Maged, additional, and Choi, Hak Soo, additional

Published
2022
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30. Highly Sensitive Near-Infrared SERS Nanoprobes for in Vivo Imaging Using Gold-Assembled Silica Nanoparticles with Controllable Nanogaps

Author

Bock, Sungje, primary, Choi, Yun-Sik, additional, Kim, Minhee, additional, Yun, Yewon, additional, Pham, Xuan-Hung, additional, Kim, Jaehi, additional, Seong, Bomi, additional, Kim, Wooyeon, additional, Jo, Ahla, additional, Ham, Kyeong-Min, additional, Lee, Sung Gun, additional, Lee, Sang Hun, additional, Kang, Homan, additional, Choi, Hak Soo, additional, Jeong, Dae Hong, additional, Chang, Hyejin, additional, Kim, Dong-Eun, additional, and Jun, Bong-Hyun, additional

Published
2021
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35. Recent Advances in Surface-Enhanced Raman Scattering Magnetic Plasmonic Particles for Bioapplications

Author

Huynh, Kim-Hung, primary, Hahm, Eunil, additional, Noh, Mi Suk, additional, Lee, Jong-Hwan, additional, Pham, Xuan-Hung, additional, Lee, Sang Hun, additional, Kim, Jaehi, additional, Rho, Won-Yeop, additional, Chang, Hyejin, additional, Kim, Dong Min, additional, Baek, Ahruem, additional, Kim, Dong-Eun, additional, Jeong, Dae Hong, additional, Park, Seung-min, additional, and Jun, Bong-Hyun, additional

Published
2021
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42. Graphical and SERS dual-modal identifier for encoding OBOC library

Author

Kang, Homan, primary, Koh, Yul, additional, Jeong, Sinyoung, additional, Jeong, Chulhwan, additional, Cha, Myeong Geun, additional, Oh, Min-Hye, additional, Yang, Jin-Kyoung, additional, Lee, Hyunmi, additional, Jeong, Dae Hong, additional, Jun, Bong-Hyun, additional, Chang, Hyejin, additional, Kim, Yong-Kweon, additional, and Lee, Yoon-Sik, additional

Published
2020
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46. Ultrasensitive NIR-SERRS Probes with Multiplexed Ratiometric Quantification for In Vivo Antibody Leads Validation

Author

Kang, Homan, primary, Jeong, Sinyoung, additional, Jo, Ahla, additional, Chang, Hyejin, additional, Yang, Jin-Kyoung, additional, Jeong, Cheolhwan, additional, Kyeong, San, additional, Lee, Youn Woo, additional, Samanta, Animesh, additional, Maiti, Kaustabh Kumar, additional, Cha, Myeong Geun, additional, Kim, Taek-Keun, additional, Lee, Sukmook, additional, Jun, Bong-Hyun, additional, Chang, Young-Tae, additional, Chung, Junho, additional, Lee, Ho-Young, additional, Jeong, Dae Hong, additional, and Lee, Yoon-Sik, additional

Published
2017
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