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To improve the efficiency of intelligent procurement of library literature and intelligence resources, the study conducts the design of literature and intelligence resources procurement model. The procurement model is constructed by using the support vector machine, and the optimal parameters of the support vector machine are obtained by using the genetic algorithm. The experimental results demonstrated that the mean square error of the proposed model was only 0.03, which was 40 % lower compared with the procurement models based on other optimization algorithms. The average accuracy of the proposed model was as high as 95.18 % and the prediction accuracy was 95.78 % compared to other methods. The accuracy was improved by 15.11 %, 24.57 % and 19.67 % respectively compared to other models. The results show that using genetic algorithm to optimize support vector machine can effectively improve the prediction speed and prediction efficiency of the model. The proposed hybrid procurement model based on genetic algorithm and support vector machine can effectively meet the needs of library literature and intelligence resources procurement construction. The model has positive application significance in library literature and intelligence resources procurement.

The work in this paper incorporated printed circuit board (PCB) technology into micro-direct methanol fuel cells (µDMFCs) and conjectured and verified the performance degradation factors of PCB current collectors in µDMFCs by testing different designed configuration µDMFCs. The experiment results showed that all kinds of PCB coating can benefit from the porous stainless-steel plates covering to a great extent. At the end of 48 h discharging, µDMFCs with porous stainless-steel plates between MEA and PCB coating achieved higher performance than those of the direct contacting series. It can be inferred from various types of experimental data that because of stainless-steel porous plate isolating, the impact of corrosion on the surface of the PCB electrode plate was reduced to a certain extent. The corrosion of the electrode plate was slowed down in the µDMFC discharging as a result of the passivation behavior on the iron surface and a decrease in corrosion current. Consequently, the attenuation of the PCB performance was delayed. The conclusion of this work explores a practical direction to enhance the cost-effectiveness of fuel cells, promoting the large-scale application of DMFCs in the future.

The increasing integration of artificial intelligence (AI) in art, particularly AI painting technology, has captivated significant attention and sparked debate. However, little is understood about the attitudes of Chinese students toward this technology and the factors influencing their perspectives. This study employed a mixed-methods approach to comprehensively appraise Chinese students’ attitudes toward AI painting technology and the reasons behind these viewpoints. Data was collected from five universities and three high schools in China through questionnaire surveys and semi-structured interviews. Quantitative analysis demonstrated clear trends in students’ attitudes toward AI painting technology, with gender, educational level, and background in art and design identified as significant influencing factors. Specifically, students with higher levels of education demonstrated more favorable attitudes toward AI painting technology. This was evidenced by a strong positive correlation coefficient of 0.644 (p0.05). In addition, regression analysis, with an R2 value of 0.419, suggests that these variables can account for 41.9% of the variance in student attitudes toward AI painting, emphasizing the significant effect of gender and education level on their perspectives. Qualitative findings further indicated that concerns about copyright ethics, job displacement anxieties, personal values and aesthetic viewpoints, and broader social and environmental implications all affected students’ attitudes toward AI painting technology. These findings offer valuable insights into the attitudes toward AI-generated technologies.

Natural fractures and cavities are the primary spaces for oil and gas accumulation in fracture-cavity carbonate reservoirs. Establishing the connection between these spaces and the wellbore through hydraulic fracturing treatment is important for oil and gas extraction from such reservoirs. Due to the discontinuity and heterogeneity of the existing natural fracture-cavity system, anticipating the viability of hydraulic fracturing treatment is troublesome. A new method to simulate the hydraulic fracturing propagation in fracture-cavity reservoirs is proposed based on the continuous damage theory. The method considers the random spatial distribution of fractures and cavities and can simulate the arbitrary expansion of hydraulic fractures in the three-dimensional direction. Based on this method, the influence of different geological and engineering factors on the propagation patterns of hydraulic fractures in the fracture-cavity reservoirs is investigated. It is found that the increase of reservoir burial depth significantly limits the propagation ranges of hydraulic fractures. The propagation modes of hydraulic fractures encountering natural fractures change with increasing burial depth, undergoing a transition from “penetrate and deflect” to ”defect” and then to ”penetrate”. The reduction of horizontal stress difference increases the complexity of hydraulic fractures, but it is not conducive for hydraulic fractures to connect more natural fractures and cavities. The increase in fracturing pump rate is significantly beneficial for hydraulic fractures to connect more natural fractures and cavities. The viscosity of fracturing fluid has a significant impact on the morphology of hydraulic fracture propagation, which undergoes a transition from simple to complex, and then to simple with the change of the fracturing fluid viscosity from low to high. either too high or too low viscosity of the fracturing fluid is not conducive to the connection of more natural fractures and cavities by hydraulic fractures. The obtained conclusions can provide a reference for the design of hydraulic fracturing treatment for fracture-cavity carbonate reservoirs.

The asperity wear of rock joints significantly affects their shear behaviour. This study discusses the wear damage of the asperities on the joint surface, highlighting the roughness degradation characteristics during the shear process. The direct shear experiment of artificial specimens containing rock joints was conducted under different normal stresses based on three-dimensional scanning technology. These experimental results showed the contribution of joint wear to roughness degeneration, such as the height, zone, and volume of asperity degeneration. The wear coefficient of the rock joint was obtained based on the volume wear of asperities in the laboratory experiment. The functional relationship between the friction coefficient and wear coefficient is subsequently determined. To quantitatively analyse the wear damage of a joint surface, a calculation method for determining the wear depth of the rock joint after shearing was proposed based on wear theory. The relationship between the ultimate dilation and wear depth was analysed. A coefficient m, which can describe the damage degree of the joint surface, and a prediction method of joint surface roughness after shearing are established. Good agreement between analytical predictions and measured values demonstrates the capability of the developed model. Lastly, the sensitivity factors on the wear depth are explored.

In recent years, the rapid advancement of artificial intelligence technology has introduced novel tools for the realm of digital image creation.The use of AI tools for digital image creation has gradually become a common practice.In this context, this paper analyzed the methods and cases of AI-driven digital image art creation through interviews, surveys, and case analyses.The survey revealed that the majority of respondents believed that AI tools had a significant impact on their creative process, especially the widespread use of direct output from artificial intelligence methods in digital image art creation.By analyzing the cases in detail, this paper revealed the typical paradigms of AI-based digital image art creation and summarized them as the “AI art creation workflow”, which included AI direct output, AI assisted drawing, and ControlNet precision drawing.These methods can effectively replace repetitive steps in digital image creation and improve image output efficiency, assist in digital image drawing and break through the conventional drawing ideas, and achieve precise and controllable expression of digital image art content.

Abstract Organizational Ethical Self-Interest Climate (OESIC), a type of Organizational Ethical Climate (OEC) that exists widely in various organizations, plays an important role in unethical behaviours. Unfortunately, there is still little in-depth research on the effect of OESIC on Unethical Accounting Behaviour (UAB) and its related mechanism. This paper aims to explore the impact of OESIC on UAB with two different motivations i.e., Unethical Pro-Self Accounting Behaviour (UPSAB) and Unethical Pro-Organizational Accounting Behaviour (UPOAB). In addition, this paper studies the moderating effect of Confucian ShiZhong Thinking (CSZ Thinking), a typical characteristic of the Chinese people. In this paper, questionnaire data from 258 Chinese accountants at different professional levels were collected. A regression model was used to analyse and test the collected data. The results indicate that OESIC is positively correlated with UAB, and the effect of OESIC on UPSAB is more significant than the effect on UPOAB. CSZ Thinking weakens the positive impact of OESIC on UPSAB and UPOAB. This paper expands the research scope of OESIC into the accounting field and the Chinese context, which is helpful to better understand the relationship among OESIC, UAB and Confucian ShiZhong Thinking. This paper can enlighten organizational managers to consider the role of informal management control systems in restraining UAB and to pay attention to the two types of UAB with different motivations, especially UPOAB.

The unique characteristics, such as high magnetic moment, high Curie temperature, large magnetic crystalline anisotropy, and low cost, make the τ-phase MnAl a promising candidate as the market alternatives which could fill the gap between the rare earth magnets and ferrite magnets. Because at low temperatures the metal will become more brittle, the cryomilling technology may allow the τ-phase MnAl to be broken quickly and introduce few crystal defects, and then obtain better permanent magnetic properties. In this study, the cryomilling technology was used to grind the τ-phase MnAl, and the structural and magnetic properties of the obtained powder sample were investigated. It was found that compared to room-temperature ball milling, the morphology of cryomilled powders is granular and the powder agglomeration is dramatically suppressed at a low temperature, and as a result the larger particles tend to be broken down into smaller ones rather than being agglomerated to larger thin layers. The grain size D reduced continuously from 145 nm to 36 nm when the sample was milled for 120 minutes. The coercivity increased with increasing the cryo-milling time, while the saturation magnetization decreased. The maximum coercivity of up to 4.9 kOe was obtained by cryo-milling for 100 minutes. By the neutron diffraction analysis, it was confirmed that the decrease of the saturation magnetization with increasing milling time is mainly due to the migration of Mn atoms from 1a site to the 1d site and the decrease of Mn atomic magnetic moment.

Glioblastomas (GBMs) are the brain tumors with the highest malignancy and poorest prognoses. GBM is characterized by high heterogeneity and resistance to drug treatment. Organoids are 3-dimensional cultures that are constructed in vitro and comprise cell types highly similar to those in organs or tissues in vivo, thus simulating specific structures and physiological functions of organs. Organoids have been technically developed into an advanced ex vivo disease model used in basic and preclinical research on tumors. Brain organoids, which simulate the brain microenvironment while preserving tumor heterogeneity, have been used to predict patients’ therapeutic responses to antitumor drugs, thus enabling a breakthrough in glioma research. GBM organoids provide an effective supplementary model that reflects human tumors’ biological characteristics and functions in vitro more directly and accurately than traditional experimental models. Therefore, GBM organoids are widely applicable in disease mechanism research, drug development and screening, and glioma precision treatments. This review focuses on the development of various GBM organoid models and their applications in identifying new individualized therapies against drug-resistant GBM.

Accurate knowledge of gas flow within the reservoir and related controlling factors will be important for enhancing the production of coal bed methane. At present, most studies focused on the permeability evolution of dry coal under gas adsorption equilibrium, gas flow and gas diffusion within wet coal under the generally non-equilibrium state are often ignored in the process of gas recovery. In this study, an improved apparent permeability model is proposed which accommodates the water and gas adsorption, stress dependence, water film thickness and gas flow regimes. In the process of modeling, the water adsorption is only affected by water content while the gas adsorption is time and water content dependent; based on poroelastic mechanics, the effective fracture aperture and effective pore radius are derived; and then the variation in water film thickness for different pore types under the effect of water content, stress and adsorption swelling are modeled; the flow regimes are considered based on Beskok’s model. Further, after validation with experimental data, the proposed model was applied to numerical simulations to investigate the evolution of permeability-related factors under the effect of different water contents. The gas flow in wet coal under the non-equilibrium state is explicitly revealed.

The safe and efficient production of marine natural gas hydrates faces the challenges of seabed geological risk issues. Geological risk issues can be categorized from weak to strong threats in four aspects: sand production, wellbore instability, seafloor subsidence, and submarine landslides, with the potential risk of natural gas leakage, and the geological risk problems that can cause secondary disasters dominated by gas eruptions and seawater intrusion. If the gas in a reservoir is not discharged in a smooth and timely manner during production, it can build up inside the formation to form super pore pressure leading to a sudden gas eruption when the overburden is damaged. There is a high risk of overburden destabilization around production wells, and reservoirs are prone to forming a connection with the seafloor resulting in seawater intrusion under osmotic pressure. This paper summarizes the application of field observation, experimental research, and numerical simulation methods in evaluating the stability problem of the seafloor surface. The theoretical model of multi-field coupling can be used to describe and evaluate the seafloor geologic risk issues during depressurization production, and the controlling equations accurately describing the characteristics of the reservoir are the key theoretical basis for evaluating the stability of the seafloor geomechanics. It is necessary to seek a balance between submarine formation stability and reservoir production efficiency in order to assess the optimal production and predict the region of plastic damage in the reservoir. Prediction and assessment allow measures to be taken at fixed points to improve reservoir mechanical stability with the numerical simulation method. Hydrate reservoirs need to be filled with gravel to enhance mechanical strength and permeability, and overburden need to be grouted to reinforce stability.

Abstract Background Myricetin (MYR) is a common plant flavonoid with antioxidant and anticancer properties. However, the anti-aging effect of MYR on nucleus pulposus cells (NPCs) is still unknown. The study aimed to explore the effect of MYR on the senescence of NPCs. Methods Methyl-thiazolyl tetrazolium assay was used to detect NPCs viability. Senescence level was evaluated by senescence-associated β-galactosidase (SA-β-Gal) staining and the expression levels of P21, P16, IL-6 and IL-8. RNA-Sequencing (RNA-seq) technology was used to identify differentially expressed genes (DEGs) between hydrogen peroxide + MYR (HO + MYR) group and HO group, and Gene Ontology (GO) functional was performed to analyze DEGs. A Venn diagram was generated to screen overlapping DEGs related to aging and inflammation, and the role of the promising validated DEG was selected for further investigation by gene functional assays. Results HO inhibited NPCs viability and stimulated the senescent phenotype of NPCs, whereas MYR treatment significantly reversed SA-β-gal activity in NPCs. MYR also reduced the expression of p21 and p16 and the secretion of IL-6 and IL-8 induced by HO. RNA-seq screened 421 DEGs. The GO enrichment results showed DEGs were mainly enriched in terms such as "sterol biosynthetic process". We also found SERPINE1 has the highest log2FC abs. Silence of SERPINE1 inhibited HO-induced NPCs senescence, and overexpression of SERPINE1 could limit the anti-aging effect of MYR. Conclusions MYR alleviated HO-induced senescence of NPCs by regulating SERPINE1 in vitro.

Drivers show different characteristics in traffic oscillations. These differences reflect the driver’s driving style, which is an important part of traffic uncertainty. This paper deeply explores the driving characteristics in asymmetric driving behaviour and its influence on traffic flow characteristics. The aim is to improve the understanding of safe driving. Continuous vehicle trajectories under various traffic flow conditions in an expressway merging area are obtained by aerial photography. Image processing technology is used to extract the basic parameters of traffic flow and vehicle operating characteristic data. Based on the measured data, the driver’s response mode is subdivided into multiple sub-modes. On the basis of this study, the types and distribution of traffic hysteresis and the impact of asymmetric behaviour on merging area capacity are further revealed. The results show that the response coefficient will increase for 58.72 % drivers during the process of experiencing oscillation disturbance to rebalance. The traffic hysteresis caused by driver’s asymmetric following behaviour in an expressway merging area is generally positive. This reduces the bottleneck outflow rate of the merging area by about 7 % on average. This study has important practical significance in analysing the formation mechanism of traffic congestion and adopting effective protective measures.

This study experimentally analyzes the nonlinear flow characteristics and channelization of fluid through rough-walled fractures during the shear process using a shear-flow-visualization apparatus. A series of fluid flow and visualization tests is performed on four transparent fracture specimens with various shear displacements of 1 mm, 3 mm, 5 mm, 7 mm and 10 mm under a normal stress of 0.5 MPa. Four granite fractures with different roughnesses are selected and quantified using variogram fractal dimensions. The obtained results show that the critical Reynolds number tends to increase with increasing shear displacement but decrease with increasing roughness of fracture surface. The flow paths are more tortuous at the beginning of shear because of the wide distribution of small contact spots. As the shear displacement continues to increase, preferential flow paths are more distinctly observed due to the decrease in the number of contact spots caused by shear dilation; yet the area of single contacts increases. Based on the experimental results, an empirical mathematical equation is proposed to quantify the critical Reynolds number using the contact area ratio and fractal dimension.

Although the slippage effect has been extensively studied, most of the previous studies focused on the impact of the slippage effect on apparent permeability within a low pore pressure range, resulting in the inability of matching the evolution of permeability in the remaining pressure range. In this paper, a new apparent permeability model that reveals the evolution of permeability under the combined action of effective stress and slippage in the full pore pressure range was proposed. In this model, both intrinsic permeability and slippage coefficient are stress dependent. Three experimental tests with pore pressure lower than 2 MPa and a test with pore pressure at about 10 MPa using cores from the same origin under constant confining stress and constant effective stress are conducted. By comparing experimental data and another apparent permeability model, we proved the fidelity of our newly developed model. Furthermore, the contribution factor of the slippage effect Rslip is used to determine the low pore pressure limit with significant slippage effect. Our results show that both narrow initial pore size and high effective stress increase the critical pore pressure. Finally, the evolutions of the slippage coefficient and the intrinsic permeability under different boundary conditions were analyzed.

The shear behavior of the Bolt-Grout interface has a significant effect on the stability of a bolting system. In this paper, a series of shear tests were conducted on Bolt-Grout interfaces, and the effects of rib spacing, rib angles, and normal stress on the shear characteristics and failure modes of the Bolt-Grout interface were investigated. The results showed that the shear strength varied nonlinearly with an increase in rib spacing and angle, and also that it increased linearly with an increase in normal stress. With smaller rib spacings, the effect of rib spacing on peak shear strength was more apparent. The failure modes of the interface can be categorized as shear-slip failure, shear-break failure, and composite failure. The proportion of shear-slip failure and shear-break failure mainly depends on the rib spacing, rib face angle and normal stress.

The strip casting technique was first used in this work to prepare the Sm2Fe17 parent alloys. Next, the Sm2Fe17N3 powders were synthesized using a gas–solid reaction of Sm2Fe17 powders with N2. Then, the anisotropic Sm2Fe17N3 powders with high performance were prepared by a surfactant-assisted grinding method in gasoline solvent. It was found that the coercivity (iHc) of ground powders increases with decreasing the average particle size (Dm), while the saturation magnetization (Ms) decreases. The maximum value of iHc of 17.5 kOe was obtained at the Dm = 1.3 µm. The ground powders with Dm of 3.1 µm show a remanence ratio (Mr/Ms) over 95% and a maximum energy product [(BH)max] of 35 MGOe. The Sm2Fe17N3 powder exhibited a very high iHc of 36.1 kOe at 10 K. Above 300 K, Sm2Fe17N3 powders mixed with epoxy resin showed a low remanence temperature coefficient of α(RT-100°C) = −0.077% °C−1.

With the continuous development of communication technology, the microwave frequency used has been extended to 24∼30 GHz or even higher. Thus, for the research on microwave absorption materials, the commonly used 2∼18 GHz frequency range might no longer be enough. More studies of microwave absorption properties in a higher frequency band are necessary. In this work, we report the microwave absorption properties of several soft magnetic composites in frequency up to 40 GHz. Magnetic materials such as iron, Y2Fe16Si, Ce2Fe17N3−δ, and La2Fe4Co10B micron powders which display excellent microwave absorption properties in 2∼18 GHz, are investigated. Within 2∼40 GHz, the reflection loss (RL) of iron/paraffin, Y2Fe16Si/paraffin, Ce2Fe17N3−δ/paraffin and La2Fe4Co10B/paraffin composites could reach −46.2 dB, −71.4 dB, −49.1 dB, and −40.1 dB, respectively. Moreover, their effective absorption bandwidth (RL < −10 dB) could reach 16.9 GHz, 8.53 GHz, 10.08 GHz, and 8.03 GHz, respectively. Though the measurements are extended to 40 GHz, the absorption properties of these composites become weak when the frequency rises to around 40 GHz, which is restricted by the cutoff frequencies of the materials. The measured data shows that these soft magnetic composites are good candidates for high-frequency microwave absorption materials, while exploring magnetic materials with further higher cutoff frequencies may result in better performance.

Rare-earth transition-metal (R-T) intermetallic compounds are emerging as competitive candidates for novel microwave absorption materials (MAMs) since they show high magnetization and tunable easy magnetization directions (EMDs). In this work, Y2(Co1−xFex)17 (0 ≤ x ≤ 0.3) compounds with the Th2Ni17 hexagonal structure were prepared with the purpose of tuning the EMDs. As x increases, the EMDs of the Y2(Co1−xFex)17 compounds change from the ab-plane (0 ≤ x < 0.0329) to the cone (0.0329 ≤ x ≤ 0.038) and then to the c-axis direction (0.038 < x ≤ 0.3). Furthermore, it was found that the extremely high cutoff frequencies of the uniaxial anisotropy materials give them considerably potential for microwave absorption applications above 10 GHz, despite their relatively low initial permeability compared to the planar anisotropic materials. By studying the high-frequency properties of Y2(Co1−xFex)17/paraffin composites, it is noted that uniaxial anisotropy compounds with x = 0.1 and x = 0.3 can possess higher permeability above 10 GHz as compared to both planar anisotropy and conical anisotropy compounds (x < 0.1) due to their high cutoff frequencies arising from large magnetocrystalline anisotropy fields. This can improve the impedance matching and thus lead to a better microwave absorption performance in the range of 10 to 40 GHz for materials with uniaxial anisotropy. Among all the compositions, the Y2(Co0.9Fe0.1)17/paraffin composite exhibits a minimum reflection loss (RL) of −50 dB at 6 GHz with a thickness of 2.5 mm and a wide qualified bandwidth (QB, RL < −10 dB) of 9.6 GHz at a center frequency of 30.3 GHz with a thickness of 0.6 mm, thus making it a promising candidate for MAMs above 10 GHz.

Microwave absorbers are increasingly being used to enhance shielding performance at higher frequencies. Great effort has been made to develop materials with superior reflection loss (RL), thin thickness, wide bandwidth, and low density to improve their performance in electromagnetic microwave absorption. In this work, the rare-earth intermetallics La2Fe4Co10B fine powders with planar magnetocrystalline anisotropy and high magnetization were prepared using the hydrogenation desorption (HD) technique. By heating the obtained magnetic powders in the air to slowly form an oxide layer on their surfaces, its complex permittivity can be tuned without changing its complex permeability, and its microwave absorption performance can be dramatically enhanced due to the improved impedance matching condition. For the La2Fe4Co10B/paraffin composite, the real part of the complex permittivity at 10 GHz can be reduced from 20.1 to 12.8, decreasing 36.3%. Before the oxidation, the RL of La2Fe4Co10B/paraffin composite is only −14.8 dB at 3.3 GHz under 3.4 mm thickness with an effective absorption bandwidth (EAB) of 0.9 GHz. However, after the 10-hour oxidation, the RL changes to −15.6 dB at 13.4 GHz under 1.4 mm thickness with an EAB of 6.2 GHz. As an efficient and lightweight absorber, La2Fe4Co10B/paraffin composite has potential application value in constructing a new microwave absorber.

Abstract We sought to investigate the outcomes of posterior-only approach using polyetheretherketone (PEEK) cage combined with single-segment instrumentation (modified-approach) for mono-segment lumbar tuberculosis in children. Between February 2008 and August 2017 in our hospital, 18 children with single-segment lumbar tuberculosis enrolled in this study were treated by modified-approach. Medical records and radiographs were retrospectively analyzed. Mean follow-up time was 54.6 ± 12.1 months. No severe complications were noted to have occurred. Measures indicated there was satisfactory bone fusion for all patients. Mean Cobb angles were significantly decreased from preoperative angle (19.8° ± 13.1°) to those both postoperatively (− 4.9° ± 7.6°) and at final follow-up (− 3.5° ± 7.3°) (both P

The glioma tumor microenvironment plays a crucial role in the development, occurrence, and treatment of gliomas. Glioma-associated macrophages (GAMs) are the most widely infiltrated immune cells in the tumor microenvironment (TME) and one of the major cell populations that exert immune functions. GAMs typically originate from two cell types-brain-resident microglia (BRM) and bone marrow-derived monocytes (BMDM), depending on a variety of cytokines for recruitment and activation. GAMs mainly contain two functionally and morphologically distinct activation types- classically activated M1 macrophages (antitumor/immunostimulatory) and alternatively activated M2 macrophages (protumor/immunosuppressive). GAMs have been shown to affect multiple biological functions of gliomas, including promoting tumor growth and invasion, angiogenesis, energy metabolism, and treatment resistance. Both M1 and M2 macrophages are highly plastic and can polarize or interconvert under various malignant conditions. As the relationship between GAMs and gliomas has become more apparent, GAMs have long been one of the promising targets for glioma therapy, and many studies have demonstrated the therapeutic potential of this target. Here, we review the origin and activation of GAMs in gliomas, how they regulate tumor development and response to therapies, and current glioma therapeutic strategies targeting GAMs.

BackgroundPrevious studies have demonstrated that inflammation and impaired microcirculation are key factors in post-resuscitation syndromes. Here, we investigated whether methylprednisolone (MP) could improve myocardial function and microcirculation by suppressing the systemic inflammatory response following cardiopulmonary resuscitation (CPR) in a rat model of cardiac arrest (CA).MethodsSprague-Dawley rats were randomly assigned to (1) sham, (2) control, and (3) drug groups. Ventricular fibrillation was induced and then followed by CPR. The rats were infused with either MP or vehicle at the start of CPR. Myocardial function and microcirculation were assessed at baseline and after the restoration of spontaneous circulation. Blood samples were drawn at baseline and 60-min post-resuscitation to assess serum cytokine (TNF-α, IL-1β, and IL-6) levels.ResultsMyocardial function [estimated by the ejection fraction (EF), myocardial performance index (MPI), and cardiac output (CO)] improved post-ROSC in the MP group compared with those in the control group (p < 0.05). MP decreased the levels of the aforementioned pro-inflammatory cytokines and alleviated cerebral, sublingual, and intestinal microcirculation compared with the control (p < 0.05). A negative correlation emerged between the cytokine profile and microcirculatory blood flow.ConclusionMP treatment reduced post-resuscitation myocardial dysfunction, inhibited pro-inflammatory cytokines, and improved microcirculation in the initial recovery phase in a CA and resuscitation animal model. Therefore, MP could be a potential clinical target for CA patients in the early phase after CPR to alleviate myocardial dysfunction and improve prognosis.

To study the axial compression performance of precast circular semi-continuous concrete-filled steel tube (PCSCFST) column, a total of 17 specimens were prepared and tested, including 13 PCSCFST columns and 4 continuous CFST columns. This PCSCFST column is made up of upper and lower steel tubes and outer steel tubes connected by bolts, which has the advantages of easy factory production and convenient transportation. The results showed that shear failure occurred in continuous CFST columns, but not in PCSCFST columns, bolts had obvious influence on failure mode. Maintaining the consistency of the thickness of each steel tube on the specimen can not only improve the local buckling, but also avoid the short plate effect to give full play to the material performance. Moreover, with the increase of steel tube thickness, concrete strength, bolt diameter, reduction of specimen length and pure bolt connection instead of bolt and weld combination connection, the deformation resistance of bolts and axial compression performance of specimens had been enhanced. However, the increase of bolt diameter from 12 to 18 mm resulted in a better strength degradation rate, but worse bearing capacity and deformation resistance. Finally, the predictions of the ultimate bearing capacity of PCSCFST columns under axial compression agree well with the test results, the average value of N exp / N pre and the variance are 0.998 and 0.00111.

Abstract Background Melon is a very important horticultural crop produced worldwide with high phenotypic diversity. Fruit size is among the most important domestication and differentiation traits in melon. The molecular mechanisms of fruit size in melon are largely unknown. Results Two high-density genetic maps were constructed by whole-genome resequencing with two F2 segregating populations (WAP and MAP) derived from two crosses (cultivated agrestis × wild agrestis and cultivated melo × cultivated agrestis). We obtained 1,871,671 and 1,976,589 high quality SNPs that show differences between parents in WAP and MAP. A total of 5138 and 5839 recombination events generated 954 bins in WAP and 1027 bins in MAP with the average size of 321.3 Kb and 301.4 Kb respectively. All bins were mapped onto 12 linkage groups in WAP and MAP. The total lengths of two linkage maps were 904.4 cM (WAP) and 874.5 cM (MAP), covering 86.6% and 87.4% of the melon genome. Two loci for fruit size were identified on chromosome 11 in WAP and chromosome 5 in MAP, respectively. An auxin response factor and a YABBY transcription factor were inferred to be the candidate genes for both loci. Conclusion The high-resolution genetic maps and QTLs analyses for fruit size described here will provide a better understanding the genetic basis of domestication and differentiation, and provide a valuable tool for map-based cloning and molecular marker assisted breeding.

To study the shear deformation and failure characteristics of a wellbore and the interaction mechanism with its surrounding rocks induced by a layer slip during natural gas hydrates (NGHs) extraction, this paper conducted a numerical simulation study of wellbore shear induced by a layer slip using ABAQUS software and carried out a laboratory experiment of wellbore shear to verify the accuracy of the numerical model. The results show that the shear force–displacement curves obtained from the laboratory experiments and numerical simulations are consistent with five stages, including the compaction stage, linear stage, plastic stage, strain-softening stage and residual stage. The wellbore shows a “Z”-shaped deformation characteristic after its shear breakage. The shear force of the wellbore is maximum at the shear surface, and it is distributed in an approximate “M” shape along the shear surface. The axial force of the wellbore is small and uniformly distributed in the initial stage of the shear. The wellbore bending moment is minimum at the shear surface, with a value of 0, and it is distributed in a skew–symmetric wave shape along the shear surface. During the shearing, the evolution of the wellbore axial force and shear force can be classified into the distribution pattern along the radial direction on the shear surface and the pattern along the axial direction. The combination of the wellbore axial force and shear force causes the tensile–shear compound failure of the wellbore. During shearing, the wellbore and rock body gradually enter the plastic state with the increase in the shear displacement. When the entire cross-section of the wellbore is in the plastic state, a “necking” phenomenon of the wellbore begins to appear. During the shearing, the frictional dissipation energy and plastic dissipation energy increase constantly. In addition, the elastic strain energy increases to a peak and then decreases to a certain value, which remains unchanged along with the work conducted by the shear force.

Anisotropic discontinuity exists widely in rock masses of mines, tunnels, slopes, water conservancy and hydropower projects. The shear characteristics of bolted anisotropic rock joints are extremely important for the stability design of engineering rock mass. However, few scholars have studied the bolted anisotropic rock joint. The different rock properties on both sides of the rock joint, especially the different rock strengths, will greatly affect the deformation characteristics and failure mode of the rock mass. Based on this, a series of shear tests were carried out on the bolted anisotropic rock joint under different normal stresses, and the characteristics of shear stress–shear displacement curve, shear strength, failure characteristics of the rock joint and deformation characteristics of the bolt are discussed. λ is defined as the strength ratio of upper and lower rock on the structural surface. The results show that the effect of λ on the shear stress–shear displacement curve is not obvious at the pre-fracture stage. The shear stress–shear displacement curve at the pre-breaking stage of the bolt presents a softening stage when the normal stress is equal to 0.5 MPa, tends to be horizontal when the normal stress is equal to 1 MPa and presents a hardening stage when the normal stress is greater than 1 MPa. After the bolt is broken, the shear stress–shear displacement curve presents a stepped-down descent. With the increase in λ, the breaking shear stress of the bolt increases. Elliptic failure occurs on the surface of the bolted anisotropic rock joint, and the length of the major axis of the ellipse decreases with the increase in λ value and normal stress. The bolts with different λ values of anisotropic rock joint show “Z-shaped” tensile bending deformation characteristics after shear fracture, and the horizontal and vertical components of the bolt deformation decrease with the increase in λ value and normal stress. The fracture shear displacement of the bolt increases with the increase in normal stress and decreases with the increase in λ value. The research results are helpful to further understand the shear mechanical characteristics and differences of bolted rock joints and provide a reference for solving the engineering problems of the composite layered rock mass.

Background and ObjectiveAcute kidney injury (AKI), the common complication after cardiopulmonary resuscitation (CPR), seriously affects the prognosis of cardiac arrest (CA) patients. However, there are limited studies on post-resuscitation AKI. In addition, it has been demonstrated that N-acetylcysteine (N-AC) as an ROS scavenger, has multiorgan-protective effects on systemic and regional ischaemia-reperfusion injuries. However, no studies have reported its protective effects against post-resuscitation AKI and potential mechanisms. This study aimed to clarify the protective effects of N-AC on post-resuscitation AKI and investigate whether its potential mechanism was mediated by activating Nrf-2/HO-1 pathway in the kidney.MethodsWe established cardiac arrest models in rats. All animals were divided into four groups: the sham, control, N-AC, and ZnPP groups. Animals in each group except for the ZnPP group were assigned into two subgroups based on the survival time: 6 and 48 h. The rats in the control, N-AC, and ZnPP groups underwent induction of ventricular fibrillation (VF), 8 min untreated VF and cardiopulmonary resuscitation. Renal function indicators, were detected using commercial kits. Renal pathologic changes were assessed by haematoxylin–eosin (HE) staining. Oxidative stress and inflammatory responses were measured using the corresponding indicators. Apoptosis was evaluated using terminal uridine nick-end labeling (TUNEL) staining, and expression of proteins associated with apoptosis and the Nrf-2/HO-1 pathway was measured by western blotting.ResultsN-AC inhibited post-resuscitation AKI. We observed that N-AC reduced the levels of biomarkers of renal function derangement; improved renal pathological changes; and suppressed apoptosis, oxidative stress, and inflammatory response. Additionally, the production of ROS in the kidneys markedly decreased by N-AC. More importantly, compared with the control group, N-AC further upregulated the expression of nuclear Nrf2 and endogenous HO-1 in N-AC group. However, N-AC-determined protective effects on post-resuscitation AKI were markedly reversed after pretreatment of the HO-1 inhibitor zinc protoporphyrin (ZnPP).ConclusionsN-AC alleviated renal dysfunction and prolonged survival in animal models of CA. N-AC partially exerts beneficial renal protection via activation of the Nrf-2/HO-1 pathway. Altogether, all these findings indicated that N-AC as a common clinical agent, may have the potentially clinical utility to improve patients the outcomes in cardiac arrest.

Abstract This study experimentally investigated nonlinear flow characteristics of rough‐walled fractures during shear process under different boundary conditions, using the servo‐controlled shear‐flow apparatus. A series of shear‐flow tests were conducted on two types of rough fractures with different shear displacements under various boundary conditions. The effects of shear process, fracture surface roughness, boundary normal stiffness, and initial normal stress on nonlinear flow behaviors are analyzed. The results show that Forchheimer equation provides a good description of the nonlinear relationship between flow rate and pressure gradient in rough‐walled fractures. The linear and nonlinear coefficients decrease by 1‐2 and 2‐3 orders of magnitude during shear, respectively. Both the mechanical aperture and the hydraulic aperture increase with increasing shear displacement. The mechanical aperture is always larger than the hydraulic aperture, and their difference gradually increases with the increment of shear displacement. The contact area ratio exhibits a fast decrease as shear displacement ranges between 1 and 3 mm and then decreases gradually with the decreasing rate generally diminishes. With the increase in shear displacement, the critical Reynolds number shows an increasing trend. The critical Reynolds number is in range 3.22‐35.41 for fracture G1 and 1.23‐12.35 for fracture G3. As the boundary normal stiffness and initial normal stress increase, the critical Reynolds number decreases.

Nanoscale permanent magnetic materials, which possess excellent magnetic and mechanical properties, thermal stability, and corrosion resistance, have become a research hotspot for permanent magnets. In reality, however, the obtained maximum energy product, (BH)max, is not satisfactory in comparison with the theory limit, especially for exchange-coupled nanocomposite magnets. The construction of an ideal microstructure still remains a challenge in the synthesis and preparation of nanoscale permanent magnets. This work reported the impact of rapid thermal process (RTP) with electron-beam heating on the microstructures of Nd12.5-xFe80.8+xB6.2Nb0.2Ga0.3 (x = 0, 2.5) nanocomposites. It was found that the crystallization time was greatly reduced, from 15 min under the conventional annealing conditions to 0.1 s under the RTP. For Nd2Fe14B single-phase materials, the crystallization temperature of the RTP ribbons decreased by about 248 °C compared with that of the ribbons produced by the conventional annealing method. A synergetic crystallization of the Nd2Fe14B and α-Fe phases was observed under the RTP, which restrained not only the shape, size distribution, and compositions of the hard and the soft phases, but also the interface between them. This modification effect became more obvious as the fraction of Fe increased. Due to the improvement in the uniformity of the Nd2Fe14B and α-Fe phases, and their grain size distribution, better magnetic properties were achieved using RTP in comparison with the conventional annealing method. Keywords: Nanocomposites, Electron-beam heating, Landau model and Langevin dynamics simulation, Synergetic crystallization

To analyze the shear characteristics and mesoscopic failure mechanism of irregular serrated rock discontinuities, a great deal of interview samples of irregular serrated structures were made by 3D printing technology, and laboratory shear tests were carried out on them under different normal stresses. At the same time, PFC numerical simulation software is used to establish relevant models to study the evolution of microcracks and the distribution characteristics of the force chain on the rock discontinuity during the shear process. The results show that the shear mechanical properties of irregular serrated rock discontinuities are affected by normal stress, undulating angle, and undulating height. The shear strength increases with the increase of normal stress and undulating height, and decreases with the increase of undulating angle. The numerical simulation results show that the irregular structural surface cracks under different undulation angles, which first start at the near force end serration root on both sides and further evolve to the adjacent serrations, while the irregular structural surface cracks under different undulation heights, which first start at the serration root with the lowest height and expand to the adjacent serrations. At the same time, the number of cracks increases with the increase of normal stress and the force chain is mainly distributed near the sawtooth surface. The force chain is more concentrated near the near force end sawtooth and at the tip and root of the rest of the sawtooth. At the same time, the direction of the force chain is approximately perpendicular to the force surface of the sawtooth. The research results are helpful in further understanding the shear mechanical properties and differences of irregular serrated rock discontinuities.

Understanding the asperity damage behaviors of joints during shearing is critical for evaluating the stability of deep underground engineering structures. In this paper, we prepared plaster joints and used them for direct shear tests under different normal stiffness (0–7 MPa/mm) and various shear rate (0.5–20 mm/min) conditions. The effects of normal stiffness and shear rate on mechanical behavior and AE characteristics were studied. With the increase of normal stiffness, the damaged area of the surface of the joint and the weight of the damaged, rough body basically show a linear increase. With the increase of the shear rate, the peak shear stress and the final shear stress of the joint are non-linearly decreased (the decrease rate at the shear rate of 0.5–5 mm/min is much larger than that at the shear rate of 5–20 mm/min), more local cracks appear on the surface of the joint, and the dilatancy of the joint slightly decreases. More than 60% of the acoustic emission signals in the shearing process of the joint are concentrated in the post-peak phase. With the increase of normal stiffness, the cumulative number of acoustic emission impacts and cumulative energy both increase. With the increase in shear rate, the accumulated acoustic emission impact number decreases, and the accumulated AE energy tends to increase when the shear rate is 0.5–5 mm/min and decreases when the shear rate increases to 5–20 mm/min.

Cardiac arrest (CA) remains a major public health issue. Inflammatory responses with overproduction of interleukin-1β regulated by NLRP3 inflammasome activation play a crucial role in cerebral ischemia/reperfusion injury. We investigated the effects of the selective NLRP3-inflammasome inhibitor MCC950 on post-resuscitation cerebral function and neurologic outcome in a rat model of cardiac arrest. Thirty-six male rats were randomized into the MCC950 group, the control group, or the sham group (N = 12 of each group). Each group was divided into a 6 h non-survival subgroup (N = 6) and a 24 h survival subgroup (N = 6). Ventricular fibrillation (VF) was electrically induced and untreated for 6 min, followed by 8 min of precordial compressions and mechanical ventilation. Resuscitation was attempted with a 4J defibrillation. Either MCC950 (10 mg/kg) or vehicle was injected intraperitoneally immediately after the return of spontaneous circulation (ROSC). Rats in the sham group underwent the same surgical procedures without VF and CPR. Brain edema, cerebral microcirculation, plasma interleukin Iβ (IL-1β), and neuron-specific enolase (NSE) concentration were measured at 6 h post-ROSC of non-survival subgroups, while 24 h survival rate, neurological deficits were measured at 24 h post-ROSC of survival subgroups. Post-resuscitation brain edema was significantly reduced in animals treated with MCC950 (p

Developing hybrid rice cultivars requires time consuming random crossing. Here, the authors develop a new next generation sequencing-based quantitative trait locus mapping method to dissect heterotic gene OsMADS1 and demonstrate the feasibility of pyramiding two genes to achieve large heterotic effect.

The petrophysical properties can be proper indicators to identify oil and gas reservoirs, since the pore fluids have significant effects on the wave response. We have performed ultrasonic measurements on two sets of tight siltstones and dolomites at partial saturation. P- and S-wave velocities are obtained by the pulse transmission technique, while attenuation is calculated using the centroid-frequency shift and spectral-ratio methods. The fluid sensitivities of different properties (i.e., P- and S-wave velocities, impedances and attenuation, Poisson's ratio, density, and their combinations) are quantitatively analyzed by considering the data distribution, based on the crossplot technique. The result shows that the properties (P- to S-wave velocity and attenuation ratios, Poisson's ratio, and first to second Lamé constant ratio) with high fluid-sensitivity indicators successfully distinguish gas from oil and water, unlike oil from water. Moreover, siltstones and dolomites can be identified on the basis of data distribution areas. Ultrasonic rock-physics templates of the P- to S-wave velocity ratio vs. the product of first Lamé constant with density obtained with a poroelastic model, considering the structural heterogeneity and patchy saturation, are used to predict the saturation and porosity, which are in good agreement with the experimental data at different porosity ranges.

Y2Fe14-xCoxB (X=8.5,9,9.5,10,10.5) melt-spun ribbons were prepared by modifying alloy composition and optimizing melt-spinning technique. It is found that Y2Fe14-xCoxB ribbons with a saturation magnetization of ∼120 emu/g and a coercivity less than 1 Oe can be prepared at x = 9.5 and a wheel rate of 55 m/s. TEM investigations exhibit that the ribbons are composed of Y2(Fe,Co)14B nanocrystals with a mean grain size of ∼5 nm and an amorphous matrix. The ribbons were subsequently pulverized by high energy ball milling technology, and the flakey particles with a length of ∼30 um and a thickness of ∼250 nm were obtained. Finally, the high-frequency electromagnetic properties of the composite magnetic ring formed by mixing flakey particles and paraffin wax in the mass ratio of 2:1 were measured, and the reflection loss (RL) value of the composite is less than -20 dB near 1-2 GHz, which indicates that the material is beneficial to the absorption of electromagnetic wave in 1-2 GHz band.

With the development in communication technology, severe electromagnetic wave radiation pollution has been created, resulting in electromagnetic interference and health hazards. Thus, materials with excellent microwave absorbing properties have become an urgent need. Magnetic particles with core-shell structures are widely used as microwave absorbers due to their high magnetic loss, little eddy current effect, and tunable dielectric properties. Herein, carbonized Metal-Organic Framework (MOF), and Graphene Oxide (GO) are used to coat the Y2Fe16Si (YFeSi) magnetic powders to form YFeSi@MOF and YFeSi@GO core-shell structures. Their microwave absorption properties are studied. The reflection loss (RL) of YFeSi@MOF can reach -19.2dB@15.1GHz under 1.4 mm thickness with an effective bandwidth of 4.7 GHz, and the reflection loss of YFeSi@GO can reach -18.3dB@16.2GHz under 1.6 mm thickness with an effective bandwidth of 3.9 GHz.

Abstract: For transverse isotropic fast formations, the evaluation method of the least horizontal principal stress by using logging data is an important unresolved issue. An innovative method is proposed to solve this problem by derivation of five independent stiffness coefficients (C11, C33, C44, C66 and C13) in this kind of formation. Based on the functional relations between acoustic anisotropy coefficients and clay volume, and that between different stiffness coefficients, which are all approved by the assorted experiment data, an effective method is built to calculate the stiffness coefficients and the least horizontal stress of anisotropic fast formations. Successful applications in the Ordos Basin illustrate that the method is complementary to that based on the horizontal shear wave velocity which is only fit for slow formations, and is applicable to evaluating rock mechanical parameters of tight oil and gas reservoirs and selecting intervals for fracturing and testing oil. Key words: rock mechanical parameters, well logging evaluation, anisotropy, fast formation, stiffness coefficients, least horizontal principal stress

The site preference of N atom for R2Fe14BNx (R= Pr, Nd) and the interstitial nitrogen effect on the magnetic properties have been studied by the first-principles method. It was found that the nitrogen is more likely to occupy the 4e site for Pr2Fe14BNx compound, while 4f site for Nd2Fe14BNx. When N atoms entering some specific crystal sites (such as 2a and 4f), the total magnetic moments of these compounds are not reduced, but slightly increased. Although the doping of N may reduce the total magnetic moments of some R2Fe14B compounds in the cases of optimal occupancy, the volumetric effect caused by N doping can still change the electron density distributions of Fe near the Fermi level, improving the magnetic ordering temperature of such compounds.

In coal-bed methane recovery, water is generally drained out along with gas. In order to address the influence of different gas-water ratios, fracture intersecting angles, and gas desorption positions on gas and water distributions along fractures and hence understand the two-phase flow behavior in fracture network, an experimental study was conducted on three artificial models with intersecting fractures. The results show that (1) with gas and water injected at different rates, the flow of water and gas is divided into three stages. In the first stage, gas flowed as small bubbles. The transport of gas was stable, which was similar to single-phase laminar flow. The difference in gas injection positions led to totally contrary flow results of water and gas. (2) In the second stage, larger gas bubbles were formed and the interactions between water and gas became serious. The gas-water distribution was dominated by different inertias between water and gas. The difference in gas injection positions did not take much effect on the gas-water distribution. (3) In the third stage, the influence of the inertia difference was still important, but some other factors also influenced the gas-water distribution. The difference in gas injection positions led to different distribution results. (4) The water injection rate has impact on the distribution of the water flow rate in each outlet. In the second stage, when water was injected at small rates, the difference between the cases in which gas was injected from different positions can be neglected. When water injection rates became larger, this difference became obvious. (5) The intersecting angle of the fractures influences the distribution of water and gas. The larger the intersecting angle is, the larger the inertial effect will be. Consequently, the intersecting angle influences the length of the second stage, which is dominated by the inertial effect.

Taking the Triassic Chang 7 Member tight reservoirs of the Yanchang Formation in the Ordos Basin as study object, transverse relaxation simulation was made using nuclear magnetic resonance (NMR) experimental data, CT images and random-walker algorithm to evaluate microscopic pore-throats of the tight reservoirs. The smoothing degree of well logging curves was utilized to evaluate sand structure of the tight reservoirs; and through multi-well analysis and the calibration of well testing data, a grading chart of tight reservoir productivity was established based on sand structure. Reservoir quality was judged and analyzed by pore level: Transverse surface relaxivity ρ2 was obtained by comparing transverse relaxation time T2 of numerical simulation and that of NMR experiment, and the distribution of pore-throat radius was obtained according to the corrected NMR logging curves. The study shows there is an obvious correlation between productivity and sand structure of Chang 7 tight reservoirs. The more homogeneous the distribution of lithology, physical property and oiliness of the massive sand, and the smoother the well logging curves, the more likely the high oil yield will occur. Based on well logging evaluation and grading chart of productivity of tight reservoirs, sweet spots in well area W of Jiyuan Oilfield in Ordos Basin were identified, the comparison of the evaluation results and well testing data shows the accuracy rate is as high as 94.7%. Key words: tight oil, well logging evaluation, microscopic pore-throat distribution, sand structure, sweet spot distribution, Ordos Basin

Ferromagnetic phase of Mn-Al exhibits great potential in the rare-earth free permanent magnetic materials due to its high magnetocrystalline anisotropy, high magnetization, high Curie temperature and low cost. In this work, the strip casting technique was applied to prepare MnAl magnetic phase. X-ray diffraction and energy dispersive X-ray analyses indicate that the as-prepared Mn54Al46 strip sample consists of pure τ-MnAl magnetic phase. It is found that the composition of Mn54Al46 is suitable to prepare τ-MnAl phase during the strip casting process. The Mn54Al46 strip sample synthesized through the strip casting exhibits a fairly high magnetization of 114 emu/g under a field of 5 T, while the coercivity of iHc = 2.8 kOe, magnetization of M5T = 63.9 emu/g at room temperature can be obtained for Mn54Al46 powder sample. This preparation method can produce a large amount of τ-phase MnAl alloy and promote mass industrialized production.