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21 results on '"Chaplin, Andrei, V"'

2. Bacteroidesvesicles promote functional alterations in gut microbiota composition

Author

Shagaleeva, Olga Yu., primary, Kashatnikova, Daria A., additional, Kardonsky, Dmitry A., additional, Efimov, Boris A., additional, Ivanov, Viktor A., additional, Evsiev, Suleiman S., additional, Zubkov, Eugene A., additional, Abramova, Olga V., additional, Zorkina, Yana A., additional, Morozova, Anna Y., additional, Vorobeva, Elizaveta A., additional, Silantiev, Artemiy S., additional, Kolesnikova, Irina V., additional, Markelova, Maria I., additional, Olekhnovich, Evgenii I., additional, Morozov, Maxim D., additional, Zoruk, Polina Y., additional, Boldyreva, Daria I., additional, Vanyushkina, Anna A., additional, Chaplin, Andrei V., additional, Grigoryeva, Tatiana V., additional, and Zakharzhevskaya, Natalya B., additional

Published
2024
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3. Investigating volatile compounds in the Bacteroides secretome

Author

Shagaleeva, Olga Yu, primary, Kashatnikova, Daria A., additional, Kardonsky, Dmitry A., additional, Konanov, Dmitry N., additional, Efimov, Boris A., additional, Bagrov, Dmitry V., additional, Evtushenko, Evgeniy G., additional, Chaplin, Andrei V., additional, Silantiev, Artemiy S., additional, Filatova, Julia V., additional, Kolesnikova, Irina V., additional, Vanyushkina, Anna A., additional, Stimpson, Joanna, additional, and Zakharzhevskaya, Natalya B., additional

Published
2023
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7. Diplocloster agilis gen. nov., sp. nov. and Diplocloster modestus sp. nov., two novel anaerobic fermentative members of Lachnospiraceae isolated from human faeces

Author

Chaplin, Andrei V., primary, Shcherbakova, Viktoria A., additional, Pikina, Alla P., additional, Sokolova, Sofia R., additional, Korzhanova, Margarita, additional, Belova, Vera A., additional, Korostin, Dmitriy O., additional, Rebrikov, Denis V., additional, Kardonsky, Dmitry A., additional, Urban, Anatoly S., additional, Zakharzhevskaya, Natalia B., additional, Suzina, Natalia E., additional, Podoprigora, Irina V., additional, Das, Milana S., additional, Kholopova, Daria O., additional, and Efimov, Boris A., additional

Published
2022
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9. R uthenibacterium

Author

Shkoporov, Andrey N., primary, Chaplin, Andrei V., additional, Kafarskaia, Lyudmila I., additional, and Efimov, Boris A., additional

Published
2019
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19. Species Composition of BacteroidalesOrder Bacteria in the Feces of Healthy People of Various Ages

Author

KULAGINA, Elena V., EFIMOV, Boris A., MAXIMOV, Phillipp Y., KAFARSKAIA, Lyudmila I., CHAPLIN, Andrei V., and SHKOPOROV, Andrei N.

Abstract

A study of species distribution of numerically predominant Bacteroidalesorder isolates in feces of healthy people aged 1–33 years was accomplished using a combination of amplified ribosomal DNA restriction analysis (ARDRA) and 16S ribosomal DNA (rDNA) sequencing. It was found that the majority of isolates in all age groups belonged to species B. xylanisolvens, B. vulgatus, and B. uniformis. Members of genera Alistipes, Parabacteroides, Odoribacter, Barnesiella, and Prevotellawere also detected frequently.

Published
2012
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20. Bacteroides vesicles promote functional alterations in the gut microbiota composition.

Author

Shagaleeva OY, Kashatnikova DA, Kardonsky DA, Efimov BA, Ivanov VA, Smirnova SV, Evsiev SS, Zubkov EA, Abramova OV, Zorkina YA, Morozova AY, Vorobeva EA, Silantiev AS, Kolesnikova IV, Markelova MI, Olekhnovich EI, Morozov MD, Zoruk PY, Boldyreva DI, Kazakova VD, Vanyushkina AA, Chaplin AV, Grigoryeva TV, and Zakharzhevskaya NB

Subjects
Animals, Mice, Disease Models, Animal, Feces microbiology, Mice, Inbred C57BL, Male, Female, Inflammatory Bowel Diseases microbiology, Humans, Extracellular Vesicles metabolism, Gastrointestinal Microbiome drug effects, Colitis microbiology, Colitis chemically induced, Bacteroides fragilis genetics, Dextran Sulfate, RNA, Ribosomal, 16S genetics
Abstract

Inflammatory bowel diseases are characterized by chronic intestinal inflammation and alterations in the gut microbiota composition. Bacteroides fragilis , which secretes outer membrane vesicles (OMVs) with polysaccharide A (PSA), can moderate the inflammatory response and possibly alter the microbiota composition. In this study, we created a murine model of chronic sodium dextran sulfate (DSS)-induced intestinal colitis and treated it with B. fragilis OMVs. We monitored the efficiency of OMV therapy by determining the disease activity index (DAI) and performing histological examination (HE) of the intestine before and after vesicle exposure. We also analyzed the microbiota composition using 16S rRNA gene sequencing. Finally, we evaluated the volatile compound composition in the animals' stools by HS-GC/MS to assess the functional activity of the microbiota. We observed more effective intestinal repair after OMV treatment according to the DAI and HE. A metabolomic study also revealed changes in the functional activity of the microbiota, with a predominance of phenol and pentanoic acid in the control group compared to the group treated with DSS and the group treated with OMVs (DSS OMVs). We also observed a positive correlation of these metabolites with Saccharibacteria and Acetivibrio in the control group, whereas in the DSS group, there was a negative correlation of phenol and pentanoic acid with Lactococcus and Romboutsia . According to the metabolome and sequencing data, the microbiota composition of the DSS-treated OMV group was intermediate between that of the control and DSS groups. OMVs not only have an anti-inflammatory effect but also contribute to the recovery of the microbiota composition.IMPORTANCE Bacteroides fragilis vesicles contain superficially localized polysaccharide A (PSA), which has unique immune-modulating properties. Isolated PSA can prevent chemically induced colitis in a murine model. Outer membrane vesicles (OMVs) also contain digestive enzymes and volatile metabolites that can complement the anti-inflammatory properties of PSA. OMVs showed high therapeutic activity against sodium dextran sulfate-induced colitis, as confirmed by histological assays. 16S rRNA sequencing of fecal samples from different inflammatory stages, supplemented with comprehensive metabolome analysis of volatile compounds conducted by HS-GC/MS, revealed structural and functional alterations in the microbiota composition under the influence of OMVs. Correlation analysis of the OMV-treated and untreated experimental animal groups revealed associations of phenol and pentanoic acid with Lactococcus , Romboutsia , Saccharibacteria , and Acetivibrio ., Competing Interests: The authors declare no conflict of interest.

Published
2024
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21. Species composition of Bacteroidales order bacteria in the feces of healthy people of various ages.

Author

Kulagina EV, Efimov BA, Maximov PY, Kafarskaia LI, Chaplin AV, and Shkoporov AN

Subjects
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Male, Phylogeny, Young Adult, Aging, Bacteroidetes classification, Bacteroidetes isolation & purification, Feces microbiology, Health
Abstract

A study of species distribution of numerically predominant Bacteroidales order isolates in feces of healthy people aged 1-33 years was accomplished using a combination of amplified ribosomal DNA restriction analysis (ARDRA) and 16S ribosomal DNA (rDNA) sequencing. It was found that the majority of isolates in all age groups belonged to species B. xylanisolvens, B. vulgatus, and B. uniformis. Members of genera Alistipes, Parabacteroides, Odoribacter, Barnesiella, and Prevotella were also detected frequently.

Published
2012
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