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3. List of Contributors

Author

Abrams, Steven A., primary, Adams, John S., additional, Adams, Judith E., additional, Adorini, Luciano, additional, Anderson, Paul H., additional, Atkins, Gerald J., additional, Aubin, Jane E., additional, Bailleul-Forestier, Isabelle, additional, Barsony, Julia, additional, Barthel, Thomas K., additional, Bell, Norman H., additional, Berdal, Ariane, additional, Bergh, Joel J., additional, Berry, Jacqueline L., additional, Bikle, Daniel D., additional, Bilezikian, John P., additional, Binderup, Ernst, additional, Binderup, Lise, additional, Bishop, Nicholas J., additional, Bogaerts, Ilse, additional, Boland, Ricardo L., additional, Boskey, Adele L., additional, Bouillon, Roger, additional, Boyan, Barbara D., additional, Brachet, Philippe, additional, Brown, Alex J., additional, Brown, Edward M., additional, Carlberg, Carsten, additional, Carmeliet, Geert, additional, Carpenter, Thomas O., additional, Chapuy, Marie-Claire, additional, Chan, Fredriech K.W., additional, Chen, Tai C., additional, Christakos, Sylvia, additional, Clagett-Dame, Margaret, additional, Clemens, Thomas L., additional, Choi, Je-Yong, additional, Coe, Fredric L., additional, Colston, Kay, additional, Compston, Juliet E., additional, Cooke, Nancy E., additional, Crescioli, Clara, additional, Cross, Heide S., additional, Danilenko, Michael, additional, Davideau, Jean-Luc, additional, Davies, Michael, additional, DeLuca, Hector F., additional, Demay, Marie B., additional, Dhawan, Puneet, additional, Dominguez, Carlos Encinas, additional, Dowd, Diane R., additional, Drezner, Marc K., additional, Dunlop, Thomas W., additional, Dusso, Adriana S., additional, Eastell, Richard, additional, Econs, Michael J., additional, Eisman, John, additional, Epstein, Sol, additional, Eriksen, Erik Fink, additional, Esteban, Luis M., additional, Faibish, Dan, additional, Fang, Yue, additional, Farach-Carson, Mary C., additional, Favus, Murray J., additional, Feldman, David, additional, Findlay, David, additional, Frank, Christian, additional, Freedman, Leonard P., additional, Fujiki, Ryuji, additional, Fukagawa, Masafumi, additional, Gagel, Robert F., additional, Garcion, Emmanuel, additional, Gardiner, Edith M., additional, Gascon-Barré, Marielle, additional, Giovannucci, Edward, additional, Glerup, Henning, additional, Glorieux, Francis H., additional, Godtfredsen, Wagn O., additional, Goltzman, David, additional, Gutierrez, Soraya, additional, Gysemans, Conny, additional, Halloran, Bernard P., additional, Haussler, Carol A., additional, Haussler, Mark R., additional, Heaney, Robert P., additional, Heersche, Johan, additional, Henry, Helen L., additional, Hershberger, Pamela A., additional, Hewison, Martin, additional, Heyman, Richard A., additional, Higashio, Kanji, additional, Holick, Michael F., additional, Hollis, Bruce W., additional, Horst, Ronald L., additional, Hsieh, Jui-Cheng, additional, Insogna, Karl L., additional, Jacobs, Elizabeth T., additional, Javed, Amjad, additional, Jones, Glenville, additional, Johnson, Candace S., additional, Jurutka, Peter W., additional, Kahraman, Mehmet, additional, Zaidi, S. Kaleem, additional, Kalkwarf, Heidi J., additional, Kato, Shigeaki, additional, Kissmeyer, Anne-Marie, additional, Kitagawa, Hirochika, additional, Koberle, Lilia M.C., additional, Koeffler, H. Phillip, additional, Koren, Ruth, additional, Kream, Barbara E., additional, Kremer, Richard, additional, Krishnan, Aruna V., additional, Kubodera, Noboru, additional, Kumar, Rajiv, additional, Kurokawa, Kiyoshi, additional, Laing, Christopher J., additional, Lemire, Jacques, additional, Lézot, Frédéric, additional, Li, Yan Chun, additional, Lian, Jane B., additional, Lichtler, Alexander C., additional, Lips, Paul, additional, Liu, Yan, additional, MacDonald, Paul, additional, Maehr, Hubert, additional, Maggi, Mario, additional, Malloy, Peter J., additional, Mangelsdorf, David J., additional, Mathieu, Chantal, additional, May, Brian, additional, Mee, Andrew P., additional, Meunier, Pierre J., additional, Michigami, Toshimi, additional, Montecino, Martin, additional, Moras, Dino, additional, Morosetti, Roberta, additional, Morris, Howard A., additional, Motola, Daniel L., additional, Muindi, Josephia, additional, Nakajima, Shigeo, additional, Naveh-Many, Tally, additional, Naveilhan, Philippe, additional, Neveu, Isabelle, additional, Norman, Anthony W., additional, Nykjaer, Anders, additional, O'Kelly, James, additional, Omdahl, John L., additional, Ordentlich, Peter, additional, Ozono, Keiichi, additional, Parfitt, A. Michael, additional, Peehl, Donna M., additional, Peleg, Sara, additional, Peng, Xiaorong, additional, Pettifor, John M., additional, Pike, J. Wesley, additional, Platz, Elizabeth A., additional, Plum, Lori A., additional, Pockwinse, Shirwin, additional, Pols, Huibert A.P., additional, Portale, Anthony A., additional, Posner, Gary H., additional, Rahmaniyan, Mehrdad, additional, Ravid, Amiram, additional, Reddy, G. Satyanarayana, additional, Reichrath, Jörg, additional, Reinhardt, Timothy A., additional, Reszka, Alfred A., additional, Riggs, B. Lawrence, additional, Rochel, Natacha, additional, Rubin, Mishaela R., additional, Russo, Andrew F., additional, Sambrook, Philip, additional, Schneider, Adina E., additional, Schwartz, Gary G., additional, Schwartz, Zvi, additional, Shen, Jiali, additional, Shevde, Nirupama K., additional, Sicinski, Rafal R., additional, Silver, Justin, additional, Slatopolsky, Eduardo A., additional, Specker, Bonny L., additional, St-Arnaud, René, additional, Stein, Gary S., additional, Stein, Janet L., additional, Stern, Paula H., additional, Studzinski, George P., additional, Suda, Tatsuo, additional, Sutton, Amelia L.M., additional, Tebben, Peter, additional, Tenenhouse, Harriet S., additional, Thatcher, Michelle L., additional, Thys-Jacobs, Susan, additional, Towler, Dwight A., additional, Trump, Donald L., additional, Uitterlinden, André G., additional, Uskoković, Milan R., additional, Väisänen, Sami, additional, Van Baelen, Hugo, additional, Van Cromphaut, Sophie, additional, van Leeuwen, Johannes P.T.M., additional, van Meurs, Joyce B.J., additional, van Wijnen, Andre J., additional, Verboven, Christel, additional, Vieth, Reinhold, additional, Wasserman, Robert H., additional, Welsh, JoEllen, additional, Whitfield, G. Kerr, additional, Whyte, Michael P., additional, Willnow, Thomas, additional, Wion, Didier, additional, Yasuda, Hisataka, additional, Young, Daniel, additional, and Zhang, Chi, additional

Published
2005
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7. Phototype, statut en vitamine D et densité minérale osseuse chez des femmes à risque d'ostéoporose

Author

Guinot, Christiane, Ezzedine, Khaled K, Mauger, Emmanuelle, Ambroisine, Laurence, Latreille, Julie, Bertrais, Sandrine, Preziosi, Paul, Galan, Pilar, Chapuy, Marie Claire, Arnaud, Solange, Meunier, Pierre J., Tschachler, Erwin, Hercberg, Serge, Malvy, Denis Jean Marie, Guinot, Christiane, Ezzedine, Khaled K, Mauger, Emmanuelle, Ambroisine, Laurence, Latreille, Julie, Bertrais, Sandrine, Preziosi, Paul, Galan, Pilar, Chapuy, Marie Claire, Arnaud, Solange, Meunier, Pierre J., Tschachler, Erwin, Hercberg, Serge, and Malvy, Denis Jean Marie

Abstract

Purpose: The aim of this study was to test the influence of phototype and vitamin D status feature on the bone mineral density (BMD) of the femoral neck in a group of middle-aged women considered at risk of osteoporosis (low levels of vitamin D [25(OH)D3 < 78 nmol/L] and hyperparathyroidism [parathormone level > 36 pg/mL]). Methods: This two-step study was conducted on 122 French women enrolled in the SUVIMAX (supplémentation en vitamines et minéraux antioxydants: antioxidant vitamin and mineral supplementation) cohort. The impact of various variables on BMD, including age, body mass index (BMI), vitamin D status, alcohol intake, sun exposure intensity and phototype was investigated using regression models. Results: No statistical link was found between BMD and the variables documenting vitamin D status and parathormone levels, nor phototype. Nevertheless, fair phototypes tended to be associated with lower BMD values. However, BMD decreased with age and increased with BMI and physical activity level. Conclusions: Whatever their phototype, adult women concerned about precarious vitamin D status should undergo a vitamin D supplementation in combination with an adequate calcium intake all year long and a proper sun protection. Moreover, a physical activity maintenance should provide an additional benefit for prevention of osteoporosis. © 2006 Elsevier SAS. All rights reserved., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2006

15. Calcium and vitamin D supplements: effects on calcium metabolism in elderly people.

Author

Chapuy, Marie-Claire, Chapuy, Paul, and Meunier, Pierre J.

Subjects
CALCIUM, VITAMIN D, CALCIUM metabolism, OLDER people, METABOLOMICS
Abstract

Calcium and vitamin D status were studied in 193 healthy elderly French people. Calcium intake was < 500 mg/d in 62% of the patients and the vitamin D intake was < 5 µg/d in all patients. They also exhibited reduced levels of serum calcium (SCa) and 25-hydroxyvitarnin D (25-OHD) and high levels of parathyroid hormone (PTH) and alkaline phosphatase(SAP). The response to calcium (1000 mg/d)and ergocalciferol (20 μg/d) given for 6 mo was evaluated in 65 patients with 69 subjects taken as controls. The treatment induced a significant increase in SCa and in 25-OHD levels, and a subsequent decrease in PTH levels without modification of the mean calcitriol levels. The biochemical changes were more marked in long-stay hospital patients than in outpatients. All these changes were significantly different from those observed in the control group. Increasing the calcium and vitamin D intake reduces the biochemical signs of secondary hyperparathyroidism in elderly people. [ABSTRACT FROM AUTHOR]

Published
1987
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18. Age-related Changes in Parathyroid Hormone and 25 Hydroxycholecalciferol Levels1.

Author

Chapuy, Marie-claire, Durr, Franchise, and Chapuy, Paul

Abstract

Serum parathyroid hormone and 25hydroxyvitamin D were measured in 124 normal subjects aged from 20 to 90 years. There was a significant progressive increase in serum parathyroid levels with age associated with a progressive decrease in total serum calcium. After the sixth decade there was a significant reduction of 25hydroxyvitamin D serum levels. In each age group, there were no significant differences between men and women in all parameters measured. In normal elderly subjects there is an age-related decline of calcium absorption associated with reduced calcium intake and sun exposure leading to secondary hyperparathyroidism. These results emphasize the importance of calcium and vitamin d supplementation in elderly european population, not only in long-stay patients but in ambulatory normal people after 60 years. [ABSTRACT FROM PUBLISHER]

Published
1983
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20. Deferoxamine-induced bone changes in haemodialysis patients: A histomorphometric study

Author

Charhon, Sam A., Chavassieux, Pascale, Boivin, Georges, Parisien, May, Chapuy, Marie-Claire, Traeger, Jules, and Meunier, Pierre J.

Abstract

1. The histological effects of deferoxamine therapy were assessed on transiliac bone biopsies taken after double tetracycline labelling from 16 uraemic patients undergoing chronic haemodialysis, all having aluminium deposits in bone. Eight patients had osteomalacia, five had an ‘aplastic’ bone lesion and three a high bone turnover with a marked increase in osteoid volume. 2. Deferoxamine was administered intravenously once a week at doses ranging from 1 to 6 g for a mean duration of 7.6 ± 3.3 (sd) months. 3. Deferoxamine therapy was associated with significant reductions in stainable aluminium deposits, osteoid volume, osteoid surfaces and thickness index of osteoid seams. The osteoblastic osteoid surfaces as well as the bone formation rates also increased significantly. 4. A rise in resorption parameters and in serum parathyroid hormone levels was observed in patients with osteomalacia. The percentage reductions in stainable aluminium and in osteoid volume were correlated with the degree of hyperparathyroidism. 5. These data show that deferoxamine therapy reduces stainable bone aluminium and improves bone mineralization in low turnover osteomalacia and that the presence of hyperparathyroidism is associated with an increased response to deferoxamine therapy.

Published
1987
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21. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis

Author

Dr. Garnero, Patrick, Sornay‐Rendu, Elizabeth, Chapuy, Marie‐Claire, and Delmas, Pierre D.

Abstract

Changes of bone turnover with aging are responsible for bone loss and play a major role in osteoporosis. Although an increase of bone turnover has been documented at the time of menopause, the subsequent abnormalities of bone resorption and formation and their potential role in determining bone mass in the elderly have not been investigated. To address this issue, we have measured a battery of new sensitive and specific markers of bone turnover in a population‐based study of 653 healthy women analyzed cross‐sectionally, including 432 women postmenopausal from 1 to 40 years, and the data were correlated with bone mineral density (BMD) measured by dual‐energy X‐ray absorptiometry (DXA) at different skeletal sites. Bone formation was assessed by serum osteocalcin (OC), serum bone‐specific alkaline phosphatase (B‐ALP), serum C‐propeptide of type I collagen (PICP), and bone resorption by the urinary excretion of two pyridinoline cross‐linked peptides (NTX and CTX). Bone turnover increased in perimenopausal women with both irregular menses and elevated serum follicle stimulating hormone (FSH). Menopause induced a 37–52% and 79–97% increase in the bone formation and bone resorption marker levels, respectively (p< 0.0001 except for PICP). In postmenopausal women, bone formation markers did not decrease with age. When resorption markers were corrected by whole body bone mineral content (BMC), the fraction of bone resorbed per day was not correlated with age in postmenopausal women and remained elevated for up to 40 years after menopause. In premenopausal women, the bone turnover rate accounted for only 0–10% of the variation in whole body BMC, total hip, distal radius, and lumbar spine BMD. With increasing time after menopause, the importance of the bone turnover rate as a determinant of bone mass increased at all sites and accounted for up to 52% of the BMD variance in elderly women. Thus, in women 20 years or more postmenopause, bone turnover was higher in those in the lowest quartile than in those in the highest quartile of BMD. In elderly women, 20 years since menopause and over, but not in younger ones, serum PTH was negatively correlated with serum 25‐hydroxyvitamin D (r= −0.22,p< 0.05) and explained only 5–8% of the bone turnover variance (p< 0.01‐0.001). These data indicate that the overall rates of both bone formation and bone resorption remain high in elderly women. The rate of bone turnover appears to play an increasing role as a determinant of bone mass with increasing time since menopause with a high bone turnover rate being associated with a low bone mass. Thus assessing bone marker levels may be useful in the evaluation of osteoporosis risk. In elderly women, secondary hyperparathyroidism caused in part by reduced serum 25‐hydroxyvitamin D appears to be a marginal determinant of an increased bone turnover rate.

Published
1996
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22. Journal of Bone and Mineral Research

Author

Boivin, Georges, Chavassieux, Pascale, Chapuy, Marie‐Claire, Meunier, Pierre J., and Baud, Charles A.

Abstract

Histomorphometric analysis of undecalcified sections was performed in transiliac biopsy cores taken from 29 patients (16 men, 13 women, aged 51 ± 17 years) suffering from skeletal fluorosis due to chronic exposure to fluoride. The origin of the exposure, known in 20 patients, was either hydric (endemic or sporadic), or industrial, or in a few cases iatrogenic. Measured on calcined bone using a specific ion electrode, bone fluoride content was significantly high in each specimen (mean ± SD: 0.79 ± 0.36% of bone ash) as compared to control values (< 0.10%). The radiologically evident osteosclerosis observed in each patient was confirmed by the significant increase of cancellous bone volume (40.1 ± 11.2 vs. 19.0 ± 2.8% in controls, p< 0.0001). There were significant increases in cortical width (1292 ± 395 vs. 934 ± 173 μm, p< 0.0001) and porosity (14.4 ± 6.4 vs. 6.5 ± 1.7%, p< 0.002), but without reduction of cortical bone mass. Osteoid parameters were significantly increased in fluorotic patients. The increase in cancellous osteoid perimeter was almost threefold greater than that noted in cancellous eroded perimeter. The fluorotic group had a greater number of osteoblasts than controls, with a very high proportion of flat osteoblasts. In 15 patients doubly labeled with tetracycline, the mineral apposition rate was significantly decreased, while mineralization lag time significantly increased. Bone formation rate and adjusted apposition rate were significantly decreased in skeletal fluorosis. Cancellous wall width was normal in fluorosis but the formation period and active formation period were significantly increased. Skeletal fluorosis is thus characterized by an unbalanced coupling in favor of bone formation, and also by a great number of osteoblasts with a high proportion of flat osteoblasts. These osteoblasts have a very increased formation period mainly due to a prolonged inactive formation period. Our results support the view that fluoride may have a dual effect on osteoblasts: an increased birthrate at the tissue level, and a toxic effect at the individual cell level. The addition of these two effects represents, however, a marked increase of bone formation at the organ level.

Published
1990
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26. Calcium–vitamin D3 supplementation is cost-effective in hip fractures prevention

Author

Lilliu, Hervé, Pamphile, Raymond, Chapuy, Marie-Claire, Schulten, Jeltje, Arlot, Monique, Meunier, Pierre J., and Lilliu, Hervé

Subjects
*COST effectiveness, *VITAMIN D
Abstract

Objective: To assess the cost implications for a preventive treatment strategy for institutionalised elderly women with a combined 1200 mg/day calcium and 800 IU/day vitamin D3 supplementation in seven European countries. Design: Retrospective cost effectiveness analysis based on a prospective placebo-controlled randomised clinical trial. Data sources: Recently published cost studies in seven European countries. Clinical results from Decalyos, a 3-year placebo-controlled study in elderly institutionalised women. Trials: Decalyos study, with 36 months follow-up of 3270 mobile elderly women living in 180 nursing homes, allocated to two groups. One group received 1200 mg/day elemental calcium in the form of tricalcium phosphate together with 800 IU/day (20 μg) of cholecalciferol (vitamin D3), the other placebo. Results: In the 36 months analysis of the Decalyos study, 138 hip fractures occurred in the group of 1176 women, receiving supplementation and 184 hip fractures in the placebo group of 1127 women. The mean duration of treatment was 625.4 days. Adjusted to 1000 women, 46 hip fractures were avoided by the calcium and vitamin D3 supplementation. For all countries, the total costs in the placebo group were higher than in the group receiving supplementation, resulting in a net benefit of €79 000–711 000 per 1000 women. Conclusion: This analysis suggests that the supplementation strategy is cost saving. The results may underestimate the net benefits, as this treatment has also shown to be effective in decreasing the incidence of other non-vertebral fractures in elderly institutionalised women. [Copyright &y& Elsevier]

Published
2003
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