21 results on '"Charles M. Chan"'
Search Results
2. Opiate prescribing patterns in the adolescent population following anterior cruciate ligament reconstruction
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Nicole A. Segovia, Austin Fan, Charles M. Chan, Alexander Karius, and Eli M. Cahan
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Male ,medicine.medical_specialty ,Adolescent ,Anterior cruciate ligament reconstruction ,Anterior cruciate ligament ,medicine.medical_treatment ,Bayesian multivariate linear regression ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Practice Patterns, Physicians' ,Medical prescription ,Aged ,Retrospective Studies ,Opiate alkaloid ,Pain, Postoperative ,Anterior Cruciate Ligament Reconstruction ,business.industry ,Opiate Alkaloids ,Retrospective cohort study ,General Medicine ,Analgesics, Opioid ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Pill ,Cohort ,Female ,business - Abstract
Objective: We sought to determine prescribing patterns for opioid analgesia following anterior cruciate ligament (ACL) reconstruction among age- and gender-stratified adolescents in a nationally representative database. Design: A retrospective study. Setting: PearlDiver Patient Records. Patients, participants: Outpatient opioid claims within 30 days of surgery were extracted. The patients were defined into age groups 10-14 (“younger’) and 15-19 (“older”). A total of 1,139 patients were included in this study (536 female and 603 males) with 108 patients in the 10-14 age category and 1,034 patients in the 15-19 category. Main outcome measure(s): The primary study outcome measures the average number of opioid pills administered, average total morphine milligram equivalents (MMEs) prescribed, and the average prescription strength (MMEs/pill). Results: No difference was found in the average number of pills (p = 0.26) or normalized total MMEs (p = 0.312) prescribed by age group. Normalized total morphine equivalents per prescription was significantly lower in females than males (p = 0.005). Multivariate linear regression analysis demonstrated that increasing patient age was predictive of fewer total pills (p = 0.017), after accounting for gender. Conclusions: There are age- and gender-based disparities in prescription patterns for adolescent ACL reconstruction. Our findings indicate that patients in the older age group on average received fewer pills than the younger age group, which consequently trended toward receiving higher total MMEs prescribed. This suggests that surgeons may be inadvertently overprescribing in the younger cohort. Additional studies that account for concurrent factors should be conducted to observe potentially similar trends.
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- 2021
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3. Radial Width of the Lateral Meniscus at the Popliteal Hiatus: Relevance to Saucerization of Discoid Lateral Menisci
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Marc Tompkins, Jamison G. Gamble, Kevin G. Shea, James G. Gamble, Theodore J. Ganley, Abdalla B Abdalla, Charles M. Chan, Thomas Rauer, Molly G Meadows, University of Zurich, Gamble, Jamison G, and Gamble, James G
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Discoid lateral meniscus ,Adolescent ,Knee Joint ,Physical Therapy, Sports Therapy and Rehabilitation ,610 Medicine & health ,Hiatus ,Meniscus (anatomy) ,Menisci, Tibial ,Arthroscopy ,2732 Orthopedics and Sports Medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,3612 Physical Therapy, Sports Therapy and Rehabilitation ,Child ,Lateral meniscus ,Centimeter ,Normal anatomy ,business.industry ,Infant ,Anatomy ,10021 Department of Trauma Surgery ,medicine.anatomical_structure ,Cross-Sectional Studies ,Child, Preschool ,Joint Diseases ,business ,Cartilage Diseases - Abstract
Background: A discoid lateral meniscus (DLM) is a congenital anomaly of the knee in which the lateral meniscus has an “O” shape and contains irregular, abnormal collagenous tissue. A DLM can cause mechanical symptoms and pain. Treatment of a symptomatic DLM is arthroscopic saucerization to reshape the meniscus to a more normal contour. Enough tissue must be removed to eliminate mechanical symptoms but not too much to create instability. The residual width of the meniscus is crucial at the popliteus hiatus because here the peripheral rim is unattached at the capsule. Reports in the literature recommend a residual width of 6 to 8 mm. Purpose/Hypothesis: The purpose of this research was to determine the width of the lateral meniscus at the popliteal hiatus in normal specimens. Our null hypothesis was that a residual width of 6 to 8 mm will be sufficient to approximate normal anatomy. Study Design: Cross-sectional study; Level of evidence, 3. Methods: We made direct measurements of the radial width of the lateral meniscus from the outer rim at the popliteal hiatus to the inner edge in 19 specimens (age, 2-120 months.) We measured one 4-year-old specimen with a bilateral complete DLM. We also measured 39 digital images of specimens (age, 1-132 months) using ImageJ. Finally, we made direct arthroscopic measurements of 8 skeletally mature specimens. Results: The average width of specimens Conclusion: We rejected our null hypothesis. Direct measurements suggest that a residual width of 6 to 8 mm is insufficient for children ≥8 years old. A width of at least a full centimeter approximates the normal for 8-year-olds and at least 15 mm for adolescents.
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- 2021
4. THE UTILITY OF MRI IN CLINICAL DECISION-MAKING FOR PEDIATRIC ATHLETES WITH SYMPTOMATIC SUBFIBULAR OSSICLES
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Charles M. Chan, Kevin G. Shea, Lawrence A. Rinsky, Steven L. Frick, and James G. Gamble
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medicine.medical_specialty ,biology ,Ossicles ,business.industry ,Athletes ,biology.organism_classification ,Article ,Avulsion ,medicine.anatomical_structure ,Clinical decision making ,Physical therapy ,Medicine ,Orthopedics and Sports Medicine ,Ankle ,business - Abstract
Background: Pediatric athletes commonly sustain inversion-type ankle fractures.1,2 Approximately 1% will form post-traumatic subfibular ossicles (SO), especially after tip avulsion fractures.3,4 Athletes with SOs can have pain and recurrent sprains.5,6,7 Here we show the utility of magnetic resonance imaging (MRI) in clinical decision-making for athletes with ankle symptoms and the presence of a SO. Our hypothesis is that MRI can predict which athletes have a stable SO and will respond to non-operative management, and which athletes have an unstable SO and will need surgery. Methods: We performed an IRB approved retrospective cohort study. Children were eligible from our practices if (1) they had radiographic evidence of a SO, (2) they had symptoms of pain and recurrent sprains, and (3) they had undergone MRI during their clinical evaluation. We identified 19 eligible children (20 ankles;) eight girls and eleven boys, ages 5–19 years. Nine involved the left ankle; 11 the right ankle. Most frequent sport was soccer (12/16) followed by basketball (3/14.) From the radiograph we determined ossicle size and location. MRI images were considered positive if fluid-sensitive sequences showed a high-intensity signal between the SO and the fibular epiphysis. Main outcome was treatment (non-surgical or surgical) relative to the MRI findings. Results: Size shape and location: Size and shape were variable. Width ranged from 2 – 10.4 mm and length from 4 – 13.5 mm. Concerning location all were in the distal 1/3 pf the epiphysis. Six were anterior and 14 were anterior-inferior to the fibular tip. MRI findings: Sixteen of the 20 ankles (80%) had positive MRI findings (figure 1), and 4 had negative findings (figure 2). The ATFL attached directly to the fragment in 11 of the 16 MRI positive ankles. Clinical decision making: All athletes with negative MRI findings responded to non-operatively management. Ten of the 16 ankles with positive MRIs have had surgery. Eight had excision of the ossicle and two had internal fixation based on the size of the ossicle. Surgical findings confirmed attachment of the ATFL to the fragment (figure 3.) Six athletes with positive MRIs continue to be under observation. Conclusions The results support our hypothesis that MRI has predictive value in clinical decision-making for symptomatic athletes with a SO. When fluid-sensitive MRI sequences show high signal intensity between the ossicle and the fibular epiphysis, and when the ATFL attaches to the ossicle, the athlete has a poor prognosis for non-operative management. [Figure: see text][Figure: see text] References: Su AW, Larson AN. Pediatric ankle fractures: Concepts and treatment principles. Foot Ankle Clin. 2015;20(4):705-719. Pommering TL, Kluchurosky L, Hall SL. Ankle and foot injuries in pediatric and adult athletes. Prim Care 2005;32(1):133-161. Han SH, Choi WJ, Kim S, Kim S-J, Lee JW. Ossicles associate with chronic pain around the malleoli of the ankle. 2008;90-B:1049-1054. Gamble JG, Sugi M, Tileston KR, Chan CM, Livingston KS. The natural history of type VII all-epiphyseal fractures of the lateral malleolus. Orthop J Sports Med. 2019; 7(3) (suppl 1) DOI 10.1177/2325967119S00116. Pill SG, Hatch M, Linton JM, Davidson RS. JBJS 2013;95: e115(1-6). Han SH, Choi WJ, Kim S, Kim SJ, Lee JW. Ossicles associated with chronic pain around the malleoli of the ankle. J Bone Joint Surg Br. 2008;90(8):1049-1054. Danielsson LG. Avulsion fracture of the lateral malleolus in children. Injury 12:165-167
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- 2020
5. Type VII Tibial Tubercle Fractures are Different from Osgood Schlatter Syndrome and Tibial Tubercle Physeal Fractures
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James G. Gamble, Rati Shirodkar, Jamison G. Gamble, and Charles M. Chan
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Orthopedics and Sports Medicine - Abstract
Introduction: Children and adolescents are prone to both overuse and acute injuries at the tibial tubercle. The most common overuse injury is Osgood Schlatter Syndrome (OSS,) and the most common acute severe injury is tibial tubercle avulsion fracture (TTF). Here we present evidence for a Type VII, all-epiphyseal, tibial tubercle fracture (VIITF) that is different from OSS and TTF. Methods: This IRB–approved study involved patients that were treated and registered at a tertiary care pediatric hospital from 2014 to 2020. We compared the clinical information, the radiographs, the treatments, and the outcomes of 15 patients with VIITF to 19 patients with OSS and to 14 patients with TTF. Results: All VIITF patients had a sudden onset of pain associated with a specific sports-related injury, and all had lateral radiographs showing a chip-like ossific fragment displaced from the secondary center but with no involvement of the physis. All of the OSS patients had an insidious onset of symptoms with no specific injury, and none had radiographs showing a chip-like fragment. All the TTF patients had a sudden onset of pain after an acute injury. Eleven of the 15 VIITF patients (73%) have formed retro-patellar tendon ossicles, and 7 of those patients (46%) have undergone surgery. All but one of the OSS patients have resolved, and all with non-operative management. All the TTF patients have resolved, and all except those with Ogden type IA fractures, had undergone urgent surgery. Conclusions: We accepted our hypothesis. VIITF is different from OSS and TTF and can be differentiated on the basis of clinical and radiographic data. Clinical Relevance: Most patients with OSS resolve with non-operative management, and TTF patients usually require urgent surgery. Children with VIITF do not need urgent surgery but do need to be followed because some can form painful retro-patellar tendon ossicles, have focal anterior knee pain, and may need surgery to resolve their symptoms. Level of Evidence: Level III: Case Control Study.
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- 2022
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6. Can the Disoid Meniscus Remodel After Saucerization?
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Charles M. Chan, Monte V. A. Squiers, and James G. Gamble
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Orthopedics and Sports Medicine - Abstract
Background/Purpose: The discoid meniscus is a congenital variant that is reported to be present in 3-5% of the United States population. Treatment involves partial meniscectomy and saucerization to obtain a more anatomic-appearing meniscus. The immediate post-operative cross-sectional morphology is often squared due to the inherent thickness of the discoid meniscus at the resection margin. The purpose of this study is to determine if the discoid meniscus can remodel and regain the triangular cross sectional configuration of a normal meniscus after surgical intervention. Methods: A retrospective chart review was performed to identify all patients undergoing partial meniscectomy for symptomatic discoid meniscus within the past 3 years at our institution. Patients were included if they had a subsequent knee magnetic resonance imaging (MRI) study. Each MRI study was evaluated by two orthopaedic surgeons independently. The extent of remodeling was graded on the cross-sectional morphology of the saucerized discoid meniscus on coronal and sagittal T1-weighted images of the corresponding knee mri based on the following scheme: 1) complete for a triangular cross-section, 2) partial for a trapezoidal cross-section , and 3) none for a square cross-section. Descriptive means and statistical analysis for intraclass correlation coefficient (ICC) were performed using Microsoft Excel. Results: A total of 11 patients and 14 knees were included in this study. Average age at time of surgery was 10.85. Average time to the follow-up MRI of the same knee was 540.50 +/- 341.84 days. 2 knees required additional surgical intervention following their index surgery. Complete remodeling was identified in 78.5% (11/14) knees. 1 knee had no remodeling and 2 knees had partial remodeling. Our ICC was 0.87 (95% CI: [0.66,0.96]). Conclusion: Our results indicate that the discoid meniscus has the potential to remodel into a “normal” triangular cross-sectional morphology after partial meniscectomy and saucerization. In our series, 21.4% (3/14) knees did not experience complete remodeling. This may have been due to over resection of the discoid meniscus at the index surgery owing to the extent of an existing tears. The remodeling all occurred within a two-year time frame though the exact time is unknown. This study indicates no additional intervention is required at the central resection margin to thin out the thick edge that often results from the meniscal biter.
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- 2022
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7. Relationship Between Dynamic Limb Symmetry And Subjective Limb Confidence Post ACL Reconstruction In Youth Athletes
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Charles M. Chan, Emily Kraus, Jeffery J. Morgan, Salinda K. Chan, Kevin G. Shea, and Samuel M. Lyons
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medicine.medical_specialty ,Physical medicine and rehabilitation ,biology ,Athletes ,medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Symmetry (geometry) ,biology.organism_classification ,Psychology - Published
- 2020
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8. Lateral Meniscus Width at the popliteus recess and the relevance to saucerization of discoid lateral menisci
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Molly C. Meadows, Abdalla B Abdalla, Kevin G. Shea, James G. Gamble, Charles M. Chan, Jamison G. Gamble, Thomas Rauer, Theodore J. Ganley, and University of Zurich
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Lateral meniscus ,Centimeter ,Discoid lateral meniscus ,business.industry ,Key Words ,Lateral tibial plateau ,610 Medicine & health ,Anatomy ,Meniscus (anatomy) ,musculoskeletal system ,Article ,Meniscus width ,Redundant tissue ,10021 Department of Trauma Surgery ,medicine.anatomical_structure ,Saucerization ,medicine ,Orthopedics and Sports Medicine ,business - Abstract
Background: Discoid lateral meniscus (DLM) is a congenital anomaly of the knee where the normally “O” shaped lateral meniscus has redundant tissue filling the “O” and covering the lateral tibial plateau. The redundant tissue can cause mechanical symptoms and pain. Treatment of symptomatic DLM is arthroscopic saucerization to reshape the meniscus to a more normal contour. Enough tissue must be removed to eliminate mechanical symptoms but not too much as to create instability. The residual width of the meniscus is crucial at the popliteus hiatus because here the peripheral rim is unattached to the capsule. The literature recommends a residual width of 6-8 mm.1,2 Purpose/Hypothesis: The primary purpose of this research is to determine the width of the meniscus at the popliteal hiatus in normal specimens. Our null hypothesis is that a residual width of 6-8 millimeters will be sufficient for saucerization of DLM. Methods: We made direct measurements of lateral meniscus radial width from the outer rim at the popliteus hiatus to the inner edge (Figure 1) in 19 specimens (ages 2 months to 120 months.) We measured one four-year-old specimen with bilateral complete DLM. We also measured 39 digital images of specimens (ages 1 month to 132 months) using ImageJ. Finally, we made direct measurements of 8 skeletally mature specimens. Results: Figure 2 shows the relationship of meniscus width as a function age. The average width of specimens Conclusions: We rejected our null hypothesis. Direct measurements suggest that a residual width of 6-8mm is insufficient for children 8-years and older. A width of at least a full centimeter more closely approximates our findings, and for adolescents consider a residual rim of 15 mm. For children less than six-years-old a residual width of 6-8mm is sufficient. References: Kocher MS, Logan CA, Kramer DE. Discoid lateral meniscus in children: diagnosis, management, and outcomes. J Am Acad Orthop Surg 2017;25:736-743. Hayashi LK, Yamaga H, Ida K, Miura T. Arthroscopic meniscectomy for discoid lateral meniscus in children. J Bone Joint Surg. 1988;70-A: 1495-1500. [Figure: see text][Figure: see text]
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- 2020
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9. Computer Navigation for Pediatric Femoral ACL Tunnel Placement
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Charles A, Popkin, Charles M, Chan, Jared A, Nowell, Stephen G, Crowley, Margaret, Wright, and Christopher S, Ahmad
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Models, Anatomic ,Adolescent ,Anterior Cruciate Ligament Reconstruction ,Surgery, Computer-Assisted ,Fluoroscopy ,Humans ,Minimally Invasive Surgical Procedures ,Femur ,Child ,Sports Medicine ,Pediatrics ,Sensitivity and Specificity - Abstract
BACKGROUND: To compare accuracy, time and radiation exposure of pediatric femoral tunnel placement using computer navigation with a traditional freehand technique. METHODS: A single all-epiphyseal femoral tunnel was placed in the distal femur of 20 Sawbones™ adolescent knee models. Ten tunnels were drilled using standard fluoroscopic guidance (FG). An additional 10 tunnels were drilled using 3D fluoroscopic computer navigation (CN). Both techniques aimed to match an exact point described by the quadrant system of Bernard. Time to perform the procedure was recorded as were number of single shot fluoroscopic images and approximate effective radiation doses. RESULTS: The deviation from ideal femoral tunnel position was on average 6.4 ± 4.2 mm for FG tunnels and 2.7 ± 3.1 mm for CN tunnels (p
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- 2019
10. Computer Modeling Analysis of the Talar Dome as a Graft for the Humeral Head
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Michael D. Maloney, Ilya Voloshin, Charles M. Chan, Matthew R. LeVasseur, and Amy L. Lerner
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Adult ,Male ,Models, Anatomic ,medicine.medical_specialty ,Adolescent ,Talus ,Young Adult ,03 medical and health sciences ,Graft size ,0302 clinical medicine ,Humeral Heads ,medicine ,Humans ,Computer Simulation ,Orthopedics and Sports Medicine ,Potential source ,Defect size ,Orthodontics ,030222 orthopedics ,Bone Transplantation ,business.industry ,030229 sport sciences ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Bankart lesion ,Bone transplantation ,Bankart Lesions ,Humeral Head ,Tissue and Organ Harvesting ,business ,Software - Abstract
Purpose To study the degree of surface congruency between the talar dome and humeral head, to determine the size of graft harvestable from the talar dome, and to determine if there are surrogate markers that correspond to a higher degree of surface congruency. Methods Computer models of 7 nonmatched humeral heads and 7 talar domes were generated by digital segmentation of magnetic resonance (MR) images. Modeled defect regions of each humeral head were then aligned with medial and lateral surfaces of each talar dome using software to maximally limit surface mismatch. Modeled defect sizes ranging from 24 × 10 mm to 30 × 10 mm were tested. Congruence match of Results The average surface match between randomly selected talar domes to humeral head surfaces was 87.2% when 1 mm was selected as the maximal acceptable congruence difference. Congruence match was not affected by graft size or laterality of talar dome as source of graft. Matching radius of curvature of talar dome to humeral head and height of donor to recipient correlated with improved congruence match. Under best match conditions, a maximal congruence match of 95.2% was achieved. Conclusions The present study indicates that the talar dome can be a potential source of osteochondral allograft for Hill-Sachs lesions with a maximal defect size of 30 × 10 mm for a single graft. Larger graft sizes resulted in decreased success of actual graft harvest as a result of dimensional constraints of the talar dome. Additional studies are required to determine the biomechanical compatibility of this graft. Clinical Relevance The talar dome has a high degree of surface congruency in comparison with the humeral head though the maximal graft size harvestable limits its clinical applicability.
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- 2016
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11. SAUCERIZATION OF DISCOID LATERAL MENISCI. HOW MUCH RESIDUAL WIDTH IS RIGHT?
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Thomas Rauer, Jamison Gamble, Kevin G. Shea, Molly Meadows, James Gamble, Abdalla Abdalla, Charles M. Chan, Theodore J. Ganley, and University of Zurich
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Lateral meniscus ,Discoid lateral meniscus ,Centimeter ,business.industry ,Lateral tibial plateau ,610 Medicine & health ,Anatomy ,Meniscus (anatomy) ,Residual ,Article ,Redundant tissue ,10021 Department of Trauma Surgery ,medicine.anatomical_structure ,Medicine ,Orthopedics and Sports Medicine ,business - Abstract
Objectives: Discoid lateral meniscus (DLM) is a congenital anomaly of the knee where the normally “O” shaped lateral meniscus has redundant tissue filling the “O” and covering the lateral tibial plateau. The redundant tissue can degenerate and cause mechanical symptoms and pain. Treatment of symptomatic DLM is arthroscopic saucerization to reshape the meniscus to a more normal contour. Enough tissue must be removed to eliminate mechanical symptoms but not too much as to create instability. The residual width of the meniscus is crucial at the popliteus hiatus because here the peripheral rim is unattached to the capsule. The literature recommends a residual width of 6-8 mm. The primary purpose of this research was to determine the width of the meniscus at the popliteal hiatus in normal specimens. Our null hypothesis was that a residual width of 6-8 millimeters will be sufficient for saucerization of DLM. Methods: We made direct measurements of lateral meniscus radial width from the outer rim at the popliteus hiatus to the inner edge (Figure 1) in 19 specimens (ages 2 months to 11 years.) We measured one four-year-old specimen with bilateral complete DLM (Figure 2.) We also measured 39 digital images of specimens (ages 1-month to 12-years) using ImageJ. Finally, we made direct measurements of 8 skeletally mature specimens. Results: Figure 3 shows the relationship of meniscus width as a function age. The average width of specimens Conclusions: We rejected our null hypothesis. Direct measurements suggest that a residual width of 6-8mm is insufficient for children 8-years and older. A width of at least a full centimeter more closely approximates our findings, and for adolescents consider a residual rim of 15 mm. For children less than six-years-old a residual width of 6-8mm is sufficient.
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- 2020
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12. Cartilage Surgery in the Juvenile
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Nathan L. Grimm, Charles M. Chan, Alison P. Toth, and Kevin G. Shea
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medicine.medical_specialty ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Cartilage ,Population ,Magnetic resonance imaging ,Surgery ,Lesion ,medicine.anatomical_structure ,Subchondral bone ,Cartilage injury ,Medicine ,Juvenile ,Favorable outcome ,medicine.symptom ,business ,education - Abstract
Cartilage injuries pose a challenging problem for the surgeon. This is especially true in the skeletally immature patient. Given the skeletal size of a juvenile patient, a seemingly small cartilage injury may represent a proportionally large area, respectively. An algorithmic approach to management of cartilage injuries in this population is helpful when determining treatment strategies to address cartilage injuries. Characterization of the lesion dimensions, cartilage health, and status of subchondral bone is quantified through the use of magnetic resonance imaging sequences. As several options exist for treating cartilage injuries, the comfort and training of the surgeon, along with a shared decision-making with the patient and family must be employed to optimize the most favorable outcome for the patient.
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- 2019
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13. Patellar Instability in the Skeletally Immature
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Ahmad F Bayomy, Lauren H. Redler, Charles M. Chan, Evan Trupia, and Charles A. Popkin
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030222 orthopedics ,medicine.medical_specialty ,Surgical approach ,Sports medicine ,business.industry ,Patellofemoral instability ,Advances in Patellofemoral Surgery (L Redler, Section Editor) ,Treatment options ,030229 sport sciences ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Guided growth ,Orthopedic surgery ,Medicine ,Orthopedics and Sports Medicine ,business ,Pediatric population - Abstract
This review will focus on the evaluation and management of patellar instability in the developing patient. A large number of surgical techniques have been described to prevent recurrent patellofemoral instability in the pediatric population, including both proximal and distal realignment procedures. The wide variety of treatment options highlights the lack of agreement as to the best surgical approach. However, when a comprehensive exam and workup are paired with a surgical plan to address each of the identified abnormalities, outcomes are predictably good. Patellar instability is a common knee disorder in the skeletally immature patient that presents a unique set of challenges. Rates of re-dislocation in pediatric and adolescent patients are higher than in their adult counterparts. Careful consideration of the physeal and apophyseal anatomy is essential in these patients. While the majority of primary patellar instability events can be treated conservatively, multiple events often require surgical intervention.
- Published
- 2018
14. Minocycline-Induced Bone Discoloration: A Case Report
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Brian D. Giordano, Charles M. Chan, and David G. Hicks
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Pathology ,medicine.medical_specialty ,medicine.drug_class ,business.industry ,Osteoid ,Tetracycline ,Antibiotics ,Soft tissue ,chemistry.chemical_element ,Minocycline ,Calcium ,Hyperpigmentation ,Staining ,chemistry ,medicine ,Orthopedics and Sports Medicine ,Surgery ,medicine.symptom ,business ,medicine.drug - Abstract
Minocycline is a semisynthetic second-generation tetracycline derivative that is widely used as a broad-spectrum antibiotic and anti-inflammatory agent1. Long-term treatment with tetracycline and its related derivatives causes discoloration and hyperpigmentation of the skin, bone, teeth, sclerae, thyroid, and oral mucosa2-11. Minocycline shares the same basic ringed structure found in other tetracyclines, with the exception of a dimethylamino group substitution at C7 and a functional group absence at C6. These differences in chemical structure result in more lipophilic properties than in other members of the tetracycline family12. Whereas tetracycline is known to cause discoloration in bone by oxidation-induced color change after binding irreversibly to hydroxyapatite, which is later deposited at the mineralization front on unmineralized mature osteoid, minocycline poorly chelates calcium and is thought to cause bone discoloration by a less well-understood mechanism13. Findings, including minocycline’s ability to discolor fully formed mature teeth as well as the presence of iron with trace amounts of calcium in minocycline-induced dark pigment, give credence to this idea14-16. Because of its lipophilic nature, minocycline is believed to achieve extensive tissue penetration, and in vitro protein-binding studies have also shown minocycline to bind collagen6,17. Once deposited, it is believed that minocycline is either degraded or lysosomally oxidized from its naturally yellow crystalline appearance to a black deposit3,18. Gross examination often reveals a bluish-gray or black discoloration of the bone and surrounding soft tissue, although these findings can be mutually exclusive1. The incidence of minocycline-induced discoloration of bone is unknown since it is more commonly found as an incidental finding during routine surgical procedures. However, staining of adult dentition has been reported to occur in 3% to 6% of patients on long-term minocycline …
- Published
- 2017
15. The Effect of Rod Diameter on Correction of Adolescent Idiopathic Scoliosis at Two Years Follow-Up
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Charles M. Chan, Michael G. Vitale, David P. Roye, Hiroko Matsumoto, Daniel E. Prince, Joshua E. Hyman, and Jaime A. Gomez
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Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Databases, Factual ,Radiography ,Idiopathic scoliosis ,Scoliosis ,Risk Assessment ,Severity of Illness Index ,Cohort Studies ,Young Adult ,Postoperative Complications ,medicine ,Deformity ,Humans ,Orthopedic Procedures ,Orthopedics and Sports Medicine ,Child ,Retrospective Studies ,Orthodontics ,Analysis of Variance ,Univariate analysis ,Chi-Square Distribution ,Equipment Safety ,business.industry ,Equipment Design ,Recovery of Function ,General Medicine ,medicine.disease ,Internal Fixators ,Sagittal plane ,Surgery ,Spinal Fusion ,Treatment Outcome ,medicine.anatomical_structure ,Coronal plane ,Multivariate Analysis ,Pediatrics, Perinatology and Child Health ,Regression Analysis ,Female ,Implant ,medicine.symptom ,business ,Follow-Up Studies - Abstract
Study Design: The review of multicenter national pediatric scoliosis database. Objective: The purpose of this study was to compare the radiographic outcomes of patients who underwent scoliosis surgery utilizing different rod diameter constructs by the posterior approach. Background: Little attention has specifically been focused on the effect of rod diameter on correction of spinal deformity after posterior spinal instrumentation and fusion in children with adolescent idiopathic scoliosis (AIS). Methods: The review of national database comprised of 1125 patients, of which 352 patients had a minimum follow-up of 2 years. Of these, 163 patients received 5.5 mm and 189 patients received 6.35 mm diameter rods for posterior spinal instrumentation. Results: The 6.35 mm rods were used more often for patients who were male, taller, heavier, with larger coronal curves, and more flexible curves. Larger diameter rods were also more likely to be stainless steel, implanted with an increased number of implants per level, and an increased number of pedicle screws used on the concavity of the curve. Univariate analysis of coronal curve showed a significant difference between 5.5 and 6.35 mm rods in correction (67.0% vs. 57.3%) at 2 years. Multivariate analysis revealed that the most significant factors affecting coronal curve correction at 2 years were rod diameter, the patient’s preoperative coronal major curve and flexibility, and the implant density. In the sagittal plane, preoperative sagittal curve and rod diameter are the predictors of sagittal correction at 2 years. Conclusions: The study did not support our hypothesis that larger rods would be associated with a greater correction of frontal and sagittal plane in patients with AIS. In addition to rod diameter, implant density and the inherent flexibility and deformity of the patient were found to be influential factors contributing for the correction and maintenance of coronal and sagittal curves in AIS.
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- 2014
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16. Detection of Femoral Neck Fractures in Pediatric Patients With Femoral Shaft Fractures
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Lindsey S Caldwell, Charles M. Chan, James O. Sanders, and John T. Gorczyca
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Adult ,Male ,Risk ,medicine.medical_specialty ,Delayed Diagnosis ,Adolescent ,Pathologic fracture ,Radiography ,030230 surgery ,Femoral Neck Fractures ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Orthopedics and Sports Medicine ,Femur ,Child ,Femoral neck ,Aged ,Retrospective Studies ,Aged, 80 and over ,030222 orthopedics ,business.industry ,Incidence (epidemiology) ,Incidence ,Trauma center ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Female ,Radiology ,business ,Tomography, X-Ray Computed ,Femoral Fractures - Abstract
BACKGROUND Ipsilateral femoral neck fractures occur in 1% to 9% of adult trauma patients with femoral shaft fractures making dedicated imaging important. This is not as clear in children. Our purpose is to establish the incidence of ipsilateral femoral neck fractures in children with femoral shaft fractures and to provide recommendations regarding diagnostic imaging protocols. METHODS A retrospective analysis of medical records was performed for pediatric patients (below 18 y) with femoral shaft fractures seen at our trauma center over a 10-year period. Mechanism of injury, associated injuries, procedures, and follow-up data were collected, and all radiographs reviewed. Exclusion criteria included peri-implant fractures or evidence of pathologic fracture. A similar retrospective analysis was performed in a cohort of adult patients. RESULTS Of 267 pediatric patients with femoral shaft fractures, 2 patients (0.7%) had ipsilateral femoral neck fractures. One femoral neck fracture was detected on initial plain radiographs and the other on a pelvic computed tomography (CT) scan. Both of these fractures resulted from high-energy trauma, which accounted for 92 (42%) of pediatric femoral shaft fractures. The cohort of 100 adults aged 18 to 89 years with femoral shaft fractures revealed 6 adult patients (6%) with ipsilateral femoral neck fractures, all from high-energy trauma. High-energy trauma accounted for 85% of the adult femoral shaft fractures, and was more common than in the pediatric population (P
- Published
- 2016
17. Musashi1 antigen expression in human fetal germinal matrix development
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Halit Pinar, Clive N. Svendsen, Hideyuki Okano, Conrad E. Johanson, Carl W. Cotman, Rosemarie Tavares, Brian E. Moore, Charles M. Chan, Virginia Hovanesian, and Edward G. Stopa
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Gestational Age ,Nerve Tissue Proteins ,Germinal matrix ,Biology ,Cerebral Ventricles ,Fetal Development ,Nestin ,Intermediate Filament Proteins ,Developmental Neuroscience ,Neurosphere ,Glial Fibrillary Acidic Protein ,Humans ,Progenitor cell ,Interleukin 3 ,Brain Chemistry ,CD40 ,Brain ,RNA-Binding Proteins ,Immunohistochemistry ,Neural stem cell ,Cell biology ,Endothelial stem cell ,Ki-67 Antigen ,Neurology ,Immunology ,biology.protein ,Stem cell - Abstract
Musashi1 is a highly conserved protein found in neural progenitor cells. We examined the expression dynamics of Musashi1 in conjunction with other representative neural progenitor antigenic determinants (Ki-67 and nestin) during 8 different stages of the developing human fetal germinal matrix. Our results indicate that Musashi1 is a useful marker for immature cells in periventricular areas inhabited by stem cells, progenitor cells, and differentiating cells.
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- 2006
- Full Text
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18. Effect of Preoperative Indications Conference on Procedural Planning for Treatment of Scoliosis
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Hasani W. Swindell, Benjamin D. Roye, David P. Roye, Howard Y. Park, Joshua E. Hyman, Charles M. Chan, Hiroko Matsumoto, and Michael G. Vitale
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Reoperation ,medicine.medical_specialty ,medicine.medical_treatment ,Idiopathic scoliosis ,Scoliosis ,Osteotomy ,Surgical planning ,Patient Care Planning ,Article ,Cerebral palsy ,03 medical and health sciences ,0302 clinical medicine ,Preoperative Care ,Medicine ,Humans ,Orthopedics and Sports Medicine ,Kyphosis ,skin and connective tissue diseases ,030222 orthopedics ,business.industry ,Evidence-based medicine ,Neuromuscular Diseases ,medicine.disease ,Surgery ,Spinal Fusion ,Orthopedic surgery ,sense organs ,Growing rod ,business ,030217 neurology & neurosurgery - Abstract
Study Design This study determines the rate of change in the scoliosis surgery plan in cases presented in preoperative indications conference. Objectives To determine the effect of preoperative indications conference on the plan of surgery and to identify characteristics that increased the likelihood of change. Summary of Background Data Preoperative indications conferences are used as a teaching and planning tool. Levels of fusion, construct options, and necessity for osteotomies are often debated in the planning of scoliosis surgery. Methods Scoliosis surgeries were presented at preoperative indications conference with four attending pediatric orthopedic surgeons present. The operative surgeon committed to a surgical plan before conference. A consensus-based plan was made without knowledge of the operative surgeon's preconference plan. Changes of plan were classified as major, minor, or no change. Results Of the 107 surgical plans, 50 were index surgeries, 13 were revisions, and 44 were scheduled growing rod lengthenings. There were two major changes, including a change to a growing construct from planned fusion, and a change in fusion levels in an adolescent idiopathic scoliosis (AIS) patient. There were 13 minor changes, which included changes in fusion levels (1 to 3; mean = 1.23) and the addition of an osteotomy. The rate of change was 28% for index surgeries and 7.69% for revisions. Of the 14 changes in the 50 index surgeries, there were 8 AIS, 3 cerebral palsy, 1 congenital scoliosis, 1 Ehlers-Danlos, and 1 patient with an undetermined neuromuscular condition. There was 1 change in 13 revision surgeries. There were no changes for growing rod lengthenings and no cancellations as a result of indications conference. Conclusions Although revision scoliosis surgery is complex, index AIS/JIS surgery was most subject to the influence of indications conference. This likely reflects controversy around choosing levels of fusion. Level of Evidence IV.
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- 2014
19. Radial Head, Radial Neck, and Olecranon Fractures
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Joshua M. Abzug, Joshua E. Hyman, Charles M. Chan, and Brandon S. Schwartz
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medicine.anatomical_structure ,business.industry ,Radial neck ,Olecranon ,Medicine ,Radial head ,Anatomy ,business - Published
- 2014
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20. Effects of varying locations for biceps tendon tenotomy and superior labral integrity on shoulder stability in a cadaveric concavity-compression model
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Ilya Voloshin, Charles M. Chan, Edward Shields, Michael D. Maloney, and Caleb Behrend
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Joint Instability ,Male ,Shoulder ,Glenoid labrum ,medicine.medical_treatment ,Tenotomy ,Joint stability ,Biceps ,Tendons ,medicine ,Cadaver ,Pressure ,Humans ,Orthopedics and Sports Medicine ,Humerus ,Aged ,Subluxation ,Labrum ,business.industry ,Shoulder Joint ,Shoulder Dislocation ,Anatomy ,medicine.disease ,Biomechanical Phenomena ,medicine.anatomical_structure ,Humeral Head ,Shoulder joint ,Female ,business - Abstract
The purpose of this study was to examine the location of biceps tenotomy and the integrity of the superior labrum as they relate to superior glenohumeral joint stability in a cadaveric concavity-compression model.Eight cadaveric glenoid labrums were mounted individually onto a load cell with the corresponding humerus fixed to the loading arm in the hanging-arm position. All surrounding soft tissue was removed except the labrum and proximal stump of the long head of the biceps (LHB) tendon, simulating a biceps tenotomy. A compressive load of 22 N was applied across the glenohumeral joint. The humerus was then translated superiorly until it subluxated over the glenoid labrum. The force resisting superior translation was characterized for each of 50 cycles. Each specimen was tested under the following conditions: (1) with a 4 cm biceps stump after tenotomy, (2) with a 0 cm biceps stump, (3) after full detachment of the superior labrum, and (4) after repair of the labrum.Biceps tenotomy performed at the biceps-labral junction resulted in an average decrease in force required to superiorly subluxate the humeral head by 8.6% (P = .01) when compared with leaving 4 cm of biceps stump. Resection of the entire superior labrum resulted in a future decrease to 15.2% (P.001) from baseline. Repair of the labrum resulted in restoration of stability with a mean of 101.1% (P = .82) and was not statistically different from baseline. The kinematics of the glenohumeral joint was affected by labral repair, with an earlier upslope on the force-to-displacement curve and alteration in the total energy required to cause subluxation of the humeral head noted.In this study, location of the biceps tenotomy and integrity of the superior labrum affected glenohumeral stability during axial loading in the hanging-arm position. Repair of the labrum restored stability for superior subluxation but also changed the kinematics of the subluxation event.Preservation of superior labrum after biceps tenotomy provides increased resistive force to superior translation in a unidirectional biomechanical model.
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- 2013
21. Unilateral Meniscomeniscal Ligament
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John P. Goldblatt and Charles M. Chan
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Medial Collateral Ligament, Knee ,Meniscus (anatomy) ,Menisci, Tibial ,Arthroscopy ,medicine ,Humans ,Orthopedics and Sports Medicine ,Lateral meniscus ,Medial collateral ligament ,medicine.diagnostic_test ,business.industry ,Anatomy ,musculoskeletal system ,Magnetic Resonance Imaging ,Tibial Meniscus Injuries ,Surgery ,medicine.anatomical_structure ,Posterior cruciate ligament ,Ligaments, Articular ,Ligament ,Female ,business ,human activities ,Medial meniscus - Abstract
Four normal variants of meniscomeniscal ligaments have been previously reported in the anatomy, arthroscopy, and radiology literature. The anterior and posterior transverse meniscal ligaments are the 2 most commonly observed, with a reported frequency of 58% and 1% to 4%, respectively. The last 2 variants include the medial and lateral oblique meniscomeniscal ligaments and account for a combined frequency of 1% to 4%. This article describes 2 patients with unilateral meniscomeniscal ligaments observed on magnetic resonance imaging. One patient had a unilateral lateral meniscomeniscal ligament extending from the anterior horn of the lateral meniscus to the posterior horn of the lateral meniscus and underwent conservative management. The second patient had a unilateral medial meniscomeniscal ligament with a concomitant medial meniscus tear and underwent arthroscopic intervention. The ligament was stable intraoperatively and, therefore, was not resected. Both patients had resolution of their symptoms. These 2 variants are additions to the previously described 4 normal intermeniscal ligament variants. The functions of the 2 new variants described in this article are poorly understood but are thought to involve meniscal stability. Accurate descriptions of normal variants can lead to the proper management of anomalous rare structures and prevent false imaging interpretations because these structures can closely mimic a double posterior cruciate ligament sign. Furthermore, an understanding of the various normal variants of intermeniscal ligaments can prevent unnecessary surgery that could result in further iatrogenic meniscus injury.
- Published
- 2012
- Full Text
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