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1. Stopping or maintaining oral anticoagulation in patients undergoing photoselective vaporization of the prostate (SOAP) surgery for benign prostate obstruction: study protocol for a multicentre randomized controlled trial

Author: Hélène Charbonneau, Marie Pasquié, Benoit Peyronnet, Aurélien Descazeaud, Nicolas Barry-Delongchamps, Emmanuel Della Negra, Romain Mathieu, Gilles Karsenty, Jean-Alexandre Long, Charles Ballereau, Abdel-Rahmène Azzouzi, Benjamin Pradère, Franck Bruyère, Georges Fournier, Souhil Lebdai, Jehanne Calves, Luc Corbel, Sébastien Vincendeau, Gaelle Fiard, Caroline Thuillier, Jean-Luc Descotes, Pierre Colin, Thibaut Culty, Audrey Hesbois, Valerie Fuzier, Nicolas Savy, Atul Pathak, Pierre Albaladejo, Charles Marc Samama, Felipe Guerrero, and Vincent Misraï
Subjects: Benign prostatic obstruction, GreenLight, Laser, Oral anticoagulation, Complications, Medicine (General), R5-920
Abstract: Abstract Background Lower urinary tract symptoms related to benign prostatic obstruction (BPO) are frequent in men aged > 50 years. Based on the use of innovative medical devices, a number of transurethral ablative techniques have recently been developed for the surgical treatment of BPO. In recent years, GreenLight photoselective vaporization of the prostate (PVP) has been considered as a non-inferior alternative to transurethral resection of the prostate. The GreenLight PVP is usually considered as an interesting surgical option for patients treated via oral anticoagulants (OACs) with regard to its haemostatic properties. The aim of this study was to assess the impact of maintaining OAC treatment in patients undergoing PVP. Methods This study is a multicentre, open-label, randomized controlled trial (RCT) designed to show the non-inferiority of PVP surgery in patients with BPO treated with OACs. This study is designed to enrol 386 OAC-treated patients (treated with vitamin K antagonists and direct oral anticoagulants) who are undergoing PVP for BPO. Patients will be randomized (1:1) to either maintain or stop OAC treatment during the perioperative course. The intervention group will maintain OAC treatment until the day before surgery and resume OAC treatment the day after surgery, whereas the control group will stop OAC treatment (with or without low-molecular-weight heparin bridging therapy) according to the anaesthesia guidelines. The primary outcome of interest to be assessed is the 30-day complications rate according to the Clavien-Dindo classification. The secondary endpoint will examine the 30-day rate of haemorrhagic and thrombotic events. This study will provide 80% power to show non-inferiority, defined as not worse than a 10% (non-inferiority margin) inferior change in the proportion of patients with good outcomes (Clavien-Dindo score
Published: 2018
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2. Delphi-consensus weights for ischemic and bleeding events to be included in a composite outcome for RCTs in thrombosis prevention.

Author: Agnes Dechartres, Pierre Albaladejo, Jean Mantz, Charles Marc Samama, Jean-Philippe Collet, Philippe Gabriel Steg, Philippe Ravaud, and Florence Tubach
Subjects: Medicine, Science
Abstract: To weight ischemic and bleeding events according to their severity to be used in a composite outcome in RCTs in the field of thrombosis prevention.Using a Delphi consensus method, a panel of anaesthesiology and cardiology experts rated the severity of thrombotic and bleeding clinical events. The ratings were expressed on a 10-point scale. The median and quartiles of the ratings of each item were returned to the experts. Then, the panel members evaluated the events a second time with knowledge of the group responses from the first round. Cronbach's a was used as a measure of homogeneity for the ratings. The final rating for each event corresponded to the median rating obtained at the last Delphi round.Of 70 experts invited, 32 (46%) accepted to participate. Consensus was reached at the second round as indicated by Cronbach's a value (0.99 (95% CI 0.98-1.00)) so the Delphi was stopped. Severity ranged from under-popliteal venous thrombosis (median = 3, Q1 = 2; Q3 = 3) to ischemic stroke or intracerebral hemorrhage with severe disability at 7 days and massive pulmonary embolism (median = 9, Q1 = 9; Q3 = 9). Ratings did not differ according to the medical specialty of experts.These ratings could be used to weight ischemic and bleeding events of various severity comprising a composite outcome in the field of thrombosis prevention.
Published: 2011
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3. The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition

Author: Rolf Rossaint, Arash Afshari, Bertil Bouillon, Vladimir Cerny, Diana Cimpoesu, Nicola Curry, Jacques Duranteau, Daniela Filipescu, Oliver Grottke, Lars Grønlykke, Anatole Harrois, Beverley J. Hunt, Alexander Kaserer, Radko Komadina, Mikkel Herold Madsen, Marc Maegele, Lidia Mora, Louis Riddez, Carolina S. Romero, Charles-Marc Samama, Jean-Louis Vincent, Sebastian Wiberg, and Donat R. Spahn
Subjects: Emergency medicine, Trauma, Traumatic coagulopathy, Major bleeding, Haemostasis, Practice guideline, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract: Key messages Immediate detection and management of traumatic coagulopathy improves outcomes of severely injured patients. This guideline follows management of the severe trauma patient in chronological order, with a focus on prevention of possible exsanguination. These structured recommendations support measures that prioritise the optimisation of resources for the benefit of bleeding control based on scientific evidence. Empirical management should not be implemented unless no method of monitoring bleeding and coagulation is available. Optimal organisation of the resuscitation team for the bleeding trauma patient includes implementation of these guidelines.
Published: 2023
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4. Platelet activation and coronavirus disease 2019 mortality: Insights from coagulopathy, antiplatelet therapy and inflammation

Author: Aurélien Philippe, Richard Chocron, Guillaume Bonnet, Nader Yatim, Willy Sutter, Jérôme Hadjadj, Orianne Weizman, Coralie L. Guerin, Tristan Mirault, Charles Fauvel, Caroline Hauw-Berlemont, Charles-Marc Samama, Benjamin Terrier, Benjamin Planquette, Victor Waldmann, Michaela Fontenay, Olivier Sanchez, Jean-Luc Diehl, Pascale Gaussem, Ariel Cohen, Nicolas Gendron, and David M. Smadja
Subjects: General Medicine, Cardiology and Cardiovascular Medicine
Published: 2023
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5. Perioperative management of patients on direct oral anticoagulants

Author: Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles-Marc Samama, Jean-Michel Dogné, Maximilien Gourdin, Bernard Chatelain, François Mullier, and Sarah Lessire
Subjects: Anticoagulants, Perioperative period, Invasive procedures, Spinal anesthesia, Emergency care, Blood coagulation test, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract: Abstract Direct oral anticoagulants (DOACs) have been licensed worldwide for several years for various indications. Each year, 10–15% of patients on oral anticoagulants will undergo an invasive procedure and expert groups have issued several guidelines on perioperative management in such situations. The perioperative guidelines have undergone numerous updates as clinical experience of emergency management has increased and perioperative studies including measurement of residual anticoagulant levels have been published. The high inter-patient variability of DOAC plasma levels has challenged the traditional recommendation that perioperative DOAC interruption should be based only on the elimination half-life of DOACs, especially before invasive procedures carrying a high risk of bleeding. Furthermore, recent publications have highlighted the potential danger of heparin bridging use when DOACs are stopped before an invasive procedure. As antidotes are progressively becoming available to manage severe bleeding or urgent procedures in patients on DOACs, accurate laboratory tests have become the standard to guide their administration and their actions need to be well understood by clinicians. This review aims to provide a systematic approach to managing patients on DOACs, based on recent updates of various perioperative guidance, and highlighting the advantages and limits of recommendations based on pharmacokinetic properties and laboratory tests.
Published: 2017
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6. Management of urgent invasive procedures in patients treated with direct oral anticoagulants: An observational registry analysis

Author: Alexandre Godon, Manon Gabin, Jerrold H. Levy, Olivier Huet, Xavier Chapalain, Jean-Stéphane David, Charles Tacquard, Laurent Sattler, Vincent Minville, Vincent Mémier, Antonia Blanié, Thomas Godet, Marc Leone, Emmanuel De Maistre, Yves Gruel, Stéphanie Roullet, Céline Vermorel, Charles Marc Samama, Jean-Luc Bosson, and Pierre Albaladejo
Subjects: Cohort Studies, Rivaroxaban, Pyridones, Administration, Oral, Anticoagulants, Humans, Hemorrhage, Registries, Hematology, Aged, Dabigatran
Abstract: Patients treated with direct oral anticoagulants (DOACs) may require urgent procedures. Managing these patients is challenging due to different bleeding risks and may include laboratory testing, procedural delays, or haemostatic/reversal agent administration.We evaluated management strategies and outcomes of urgent, non-haemostatic invasive procedures in patients treated with DOACs.In a descriptive cohort study, we prospectively evaluated 478 patients in the GIHP-NACO registry, from June 2013 to November 2015. Hospitalised patients receiving dabigatran (n = 160), rivaroxaban (n = 274), or apixaban (n = 44) requiring urgent, procedural interventions were evaluated, of which 384/478 (80 %) were surgical procedures. Orthopaedic surgery included 216/384 patients (56 %), while gastrointestinal surgery included 75/384 (20 %) patients. On admission, the median age was 79 (70-85), and creatinine clearance was60 mL·minIn the GIHP-NACO registry, before specific antidotes were available, DOAC treated patients undergoing urgent invasive procedures were delayed in nearly half of the cases, and showed a low rate of excessive bleeding, suggesting that most urgent procedures can be performed safely without DOAC reversal.www.gov. Identifier: NCT02185027.
Published: 2022
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7. Contributors

Author: Benjamin S. Abella, Adam Y. Adenwala, Alexander F. Arriaga, Carlos Artime, Michael Ashburn, John G.T. Augoustides, Judith Barnett, Sheila Barnett, Yaakov Beilin, Russell Bell, Sanjay M. Bhanaker, Andrew Bowdle, Jeffrey L. Carson, Maurizio Cereda, Stephanie Cheng, Lauren N. Chibucos, Jason E. Cohen, Neal H. Cohen, Steven L. Cohn, Enya Cooney, Bronwyn Cooper, Jovany Crus Navarro, Deborah Culley, Stefan De Hert, Stacie Deiner, Derek Dillane, George Djaiani, Karen B. Domino, Amit H. Doshi, Caoimhe C Duffy, Nabil Elkassabany, Lucinda L. Everett, David Faraoni, Jared Feinman, John E. Fiadjoe, Michael G. Fitzsimons, Lee A. Fleisher, Jake Fridman, Tong J. Gan, Arjunan Ganesh, Santiago Garcia, Adrian W. Gelb, Andrew Gold, Mark Grant, Dennis Grech, Harshad G. Gurnaney, Jacob T. Gutsche, Ashraf S. Habib, Izumi Harukuni, Nazish Khalid Hashmi, Laurence M. Hausman, Diane Head, David L. Hepner, Caryl Hollman, Aditya Joshi, Rosemarie Kearsley, Jesse Kiefer, Andrew W. Kofke, Katherine Kozarek, Sindhu Krishnan, Bradley H. Lee, Jinlei Li, Rosie Q. Li, Jiabin Liu, Nuttha Lumlertgul, Andrew B Lumb, Elizabeth Mahanna-Gabrielli, Gulnar Mangat, Oana Maties, Edward O. McFalls, Michael L. McGarvey, Tanya Mehta, Ilene K. Michaels, Vivek K. Moitra, Eman Nada, John Nguyen, Elizabeth O’Brien, Onyi Onuoha, Adriana Oprea, Marlies Ostermann, Paul H Panesar, Manish S. Patel, Prakash A. Patel, Carol J. Peden, Richard J. Pollard, Christopher P. Potestio, Erin W. Pukenas, Karla Pungsornruk, Sonya Randazzo, Alexander Reskallah, Stephen T. Robinson, Nidhi Rohatgi, Kathryn Rosenblatt, Marc B. Royo, Charles Marc Samama, R. Alexander Schlichter, Peter M. Schulman, Michael J. Scott, Scott Segal, Fred E. Shapiro, Eric C. Stecker, Rachel Steinhorn, Petrus Paulus Steyn, Derek Sundermann, Kim de Vasconcellos, William J. Vernick, Dorothy W.Y. Wang, Ian James Welsby, and David Wlody
Published: 2023
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8. Preventing venous thrombo-embolism after nonmajor orthopedic surgery

Author: Philippe Girard, Nadia Rosencher, Silvy Laporte, and Charles Marc Samama
Subjects: Venous Thrombosis, medicine.medical_specialty, business.industry, Patient risk, Embolism, Anticoagulants, Venous Thromboembolism, 030204 cardiovascular system & hematology, Surgery, 03 medical and health sciences, 0302 clinical medicine, Venous thrombo embolism, Orthopedic surgery, medicine, Humans, Orthopedic Procedures, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Venous thromboembolism
Abstract: The venous thromboembolism risk is low to moderate in nonmajor orthopedic surgery. The literature is unconclusive. New emerging data are now available. The global patient risk has to be taken into account to determine the need for any prophylaxis.
Published: 2021
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9. ISTH guidelines for antithrombotic treatment in COVID-19

Author: Sam Schulman, Michelle Sholzberg, Alex C. Spyropoulos, Ryan Zarychanski, Helaine E. Resnick, Charlotte A. Bradbury, Jean Marie Connors, Anna Falanga, Toshiaki Iba, Scott Kaatz, Jerrold H. Levy, Saskia Middeldorp, Tracy Minichiello, Eduardo Ramacciotti, Charles Marc Samama, Jecko Thachil, Lisa Broxmeyer, null International Society on Thrombosis and Haemostasis, Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, and ARD - Amsterdam Reproduction and Development
Subjects: anticoagulants, Heparin, Critical Illness, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Aftercare, Anticoagulants, COVID-19, Hematology, Heparin, Low-Molecular-Weight, Patient Discharge, Fibrinolytic Agents, Rivaroxaban, Humans, critical illness, platelet aggregation inhibitors, Platelet Aggregation Inhibitors
Abstract: Contains fulltext : 282327.pdf (Publisher’s version ) (Closed access) Antithrombotic agents reduce risk of thromboembolism in severely ill patients. Patients with coronavirus disease 2019 (COVID-19) may realize additional benefits from heparins. Optimal dosing and timing of these treatments and benefits of other antithrombotic agents remain unclear. In October 2021, ISTH assembled an international panel of content experts, patient representatives, and a methodologist to develop recommendations on anticoagulants and antiplatelet agents for patients with COVID-19 in different clinical settings. We used the American College of Cardiology Foundation/American Heart Association methodology to assess level of evidence (LOE) and class of recommendation (COR). Only recommendations with LOE A or B were included. Panelists agreed on 12 recommendations: three for non-hospitalized, five for non-critically ill hospitalized, three for critically ill hospitalized, and one for post-discharge patients. Two recommendations were based on high-quality evidence, the remainder on moderate-quality evidence. Among non-critically ill patients hospitalized for COVID-19, the panel gave a strong recommendation (a) for use of prophylactic dose of low molecular weight heparin or unfractionated heparin (LMWH/UFH) (COR 1); (b) for select patients in this group, use of therapeutic dose LMWH/UFH in preference to prophylactic dose (COR 1); but (c) against the addition of an antiplatelet agent (COR 3). Weak recommendations favored (a) sulodexide in non-hospitalized patients, (b) adding an antiplatelet agent to prophylactic LMWH/UFH in select critically ill, and (c) prophylactic rivaroxaban for select patients after discharge (all COR 2b). Recommendations in this guideline are based on high-/moderate-quality evidence available through March 2022. Focused updates will incorporate future evidence supporting changes to these recommendations.
Published: 2022
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10. Lupus Anticoagulant Single Positivity During the Acute Phase of COVID‐19 Is Not Associated With Venous Thromboembolism or In‐Hospital Mortality

Author: Jeremy Boussier, Christophe Peronino, Olivier Sanchez, Benjamin Planquette, Lina Khider, Charles-Marc Samama, Frédéric Pène, Daphné Krzisch, Elise Sourdeau, Claire Goulvestre, David M. Smadja, Cherifa Cheurfa, Françoise Levasseur, Luc Darnige, Franck Pages, Tristan Mirault, Laetitia Mauge, Camille Chenevier-Gobeaux, Nicolas Gendron, Michaela Fontenay, Benjamin Debuc, Guillaume Goudot, Aurélien Philippe, Richard Chocron, Jérôme Hadjadj, Benjamin Terrier, Nadège Ochat, Jean-Luc Diehl, Tali-Anne Szwebel, Julie Brichet, Marie-Agnès Dragon-Durey, Nader Yatim, Jérôme Duchemin, Georges Jourdi, and Pascale Gaussem
Subjects: 0301 basic medicine, Lupus anticoagulant, Univariate analysis, medicine.medical_specialty, business.industry, Immunology, Hazard ratio, medicine.disease, Thrombosis, Gastroenterology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, 030220 oncology & carcinogenesis, Internal medicine, Cohort, Coagulopathy, Immunology and Allergy, Medicine, Clinical significance, business, Survival analysis
Abstract: INTRODUCTION: Antiphospholipid antibodies (APA) clinical relevance in COVID-19 is controversial. We aimed to investigate the prevalence and prognostic value of conventional and non-conventional APA in COVID-19 patients. METHODS: This study was a multi-centric, prospective observational French cohort of patients hospitalized for COVID-19 suspicion. RESULTS: 249 patients were hospitalized for suspected COVID-19, including 154 with confirmed COVID-19 and 95 not confirmed. We found a significant increase in lupus anticoagulant (LA) positivity among COVID-19 positive patients (60.9% versus 23.7% in non-COVID19 patients, p
Published: 2021
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11. Induced forms of α2-macroglobulin neutralize heparin and direct oral anticoagulant effects

Author: Sophie Gandrille, Xavier Declèves, Johan Abdoul, Georges Jourdi, Claire Pailleret, Isabelle Gouin-Thibault, Elisa Frezza, Charles Marc Samama, Virginie Siguret, Samuela Pasquali, Pascale Gaussem, N. Neveux, Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fonds de dotation CSL Behring pour la recherche, CSL Behring, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Service d’Hématologie Biologique [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Hôpital Lariboisière-Fernand-Widal [APHP], Université Paris Descartes - Paris 5 (UPD5), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Laboratoire de biologie de la nutrition (LBN), Université Paris Cité (UPCité), and Hôpital Cochin [AP-HP]
Subjects: medicine.drug_class, [SDV]Life Sciences [q-bio], 02 engineering and technology, Pharmacology, Fondaparinux, Biochemistry, Dabigatran, 03 medical and health sciences, Rivaroxaban, Structural Biology, medicine, Apixaban, Molecular Biology, 030304 developmental biology, Whole blood, 0303 health sciences, Heparin, Chemistry, Anticoagulant, General Medicine, 021001 nanoscience & nanotechnology, Antidote, Apixaban, Dabigatran, Fondaparinux, Heparin, Rivaroxaban, 3. Good health, Thromboelastometry, Antidote, 0210 nano-technology, medicine.drug
Abstract: International audience; Alpha2-macroglobulin (α2M) is a physiological macromolecule that facilitates the clearance of many proteinases, cytokines and growth factors in human. Here, we explored the effect of induced forms of α2M on anticoagulant drugs. Gla-domainless factor Xa (GDFXa) and methylamine (MA)-induced α2M were prepared and characterized by electrophoresis, immunonephelometry, chromogenic, clot waveform and rotational thromboelastometry assays. Samples from healthy volunteers and anticoagulated patients were included. In vivo neutralization of anticoagulants was evaluated in C57Bl/6JRj mouse bleeding-model. Anticoagulant binding sites on induced α2M were depicted by computer-aided energy minimization modeling. GDFXa-induced α2M neutralized dabigatran and heparins in plasma and whole blood. In mice, a single IV dose of GDFXa-induced α2M following anticoagulant administration significantly reduced blood loss and bleeding time. Being far easier to prepare, we investigated the efficacy of MA-induced α2M. It neutralized rivaroxaban, apixaban, dabigatran and heparins in spiked samples in a concentration-dependent manner and in samples from treated patients. Molecular docking analysis evidenced the ability of MA-induced α2M to bind non-covalently these compounds via some deeply buried binding sites. Induced forms of α2M have the potential to neutralize direct oral anticoagulants and heparins, and might be developed as a universal antidote in case of major bleeding or urgent surgery. © 2021 Elsevier B.V.
Published: 2021
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12. Placental growth factor level in plasma predicts COVID‐19 severity and in‐hospital mortality

Author: Michaela Fontenay, Cherifa Cheurfa, Bastien Rance, Olivier Bory, Jérôme Duchemin, Caroline Hauw-Berlemont, Elise Sourdeau, Richard Chocron, Maxime Gruest, Tristan Mirault, Agathe Beauvais, Nicolas Peron, Pascale Gaussem, Aurélien Philippe, Coralie L. Guerin, Guillaume Goudot, Jean Luc Diehl, Olivier Sanchez, Bertrand Hermann, Nicolas Gendron, Lina Khider, Françoise Levavasseur, Tali Anne Szwebel, Frédéric Pène, Charles Marc Samama, David M. Smadja, Benjamin Planquette, and Benjamin Terrier
Subjects: Adult, Vascular Endothelial Growth Factor A, Placental growth factor, medicine.medical_specialty, placental growth factor, VASCULAR BIOLOGY, 030204 cardiovascular system & hematology, Gastroenterology, angiogenesis, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Internal medicine, medicine, Humans, Hospital Mortality, Survival analysis, Placenta Growth Factor, SARS-CoV-2, Proportional hazards model, business.industry, Brief Report, COVID-19, Hematology, Odds ratio, mortality, Confidence interval, Vascular endothelial growth factor A, FGF‐2, PlGF, Biomarker (medicine), Female, business, Body mass index, Biomarkers
Abstract: Background Coronavirus disease 2019 (COVID‐19) is a respiratory disease associated with vascular inflammation and endothelial injury. Objectives To correlate circulating angiogenic markers vascular endothelial growth factor A (VEGF‐A), placental growth factor (PlGF), and fibroblast growth factor 2 (FGF‐2) to in‐hospital mortality in COVID‐19 adult patients. Methods Consecutive ambulatory and hospitalized patients with COVID‐19 infection were enrolled. VEGF‐A, PlGF, and FGF‐2 were measured in each patient ≤48 h following admission. Results The study enrolled 237 patients with suspected COVID‐19: 208 patients had a positive diagnostic for COVID‐19, of whom 23 were mild outpatients and 185 patients hospitalized after admission. Levels of VEGF‐A, PlGF, and FGF‐2 significantly increase with the severity of the disease (P
Published: 2021
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13. In reply to 'Representation of Women as Editors in Anesthesiology Journals' by McMullen et al

Author: Esther Pogatzki-Zahn, Anne-Claire Lukaszewicz, Michelle Sook-Leng Chew, and Charles Marc Samama
Subjects: Physicians, Women, Anesthesiology and Pain Medicine, Cross-Sectional Studies, Anesthesiology, Humans, Female, Periodicals as Topic
Published: 2022

14. A new European Society of Anaesthesiology and Intensive Care open access journal

Author: Marc Van de Velde, Esther Pogatzki-Zahn, Anne-Claire Lukaszewicz, Dan Longrois, Tom G. Hansen, Patrice Forget, Michelle S. Chew, Nicolas Bruder, and Charles Marc Samama
Subjects: Access to Information, Anesthesiology and Pain Medicine, Consensus, Science & Technology, Critical Care, Anesthesiology, Humans, Life Sciences & Biomedicine
Abstract: ispartof: EUROPEAN JOURNAL OF ANAESTHESIOLOGY vol:39 issue:5 pages:413-414 ispartof: location:England status: published
Published: 2022
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15. Scientific and Standardization Committee communication: Clinical guidance on the diagnosis, prevention, and treatment of venous thromboembolism in hospitalized patients with COVID‐19

Author: Charles Marc Samama, Toshiaki Iba, Dimitrios Giannis, Alex C. Spyropoulos, Marcel Levi, Beverley J. Hunt, James D. Douketis, Jean M. Connors, Jerrold H. Levy, Jecko Thachil, and Walter Ageno
Subjects: Diagnostic Techniques, Cardiovascular, antithrombotic therapy, Aftercare, Disease, 030204 cardiovascular system & hematology, Cardiovascular, medicine.disease_cause, COVID-19 Testing, 0302 clinical medicine, Mass Screening, Thrombophilia, Viral, Disease management (health), Coronavirus, Incidence (epidemiology), Disease Management, Venous Thromboembolism, Hematology, Point-of-Care Testing, Coronavirus Infections, Cytokine Release Syndrome, hospitalization, SARS-CoV-2, anticoagulant, coronavirus disease 2019, Anticoagulants, Biomarkers, Clinical Laboratory Techniques, Critical Care, Drug Administration Schedule, Fibrin Fibrinogen Degradation Products, Hemorrhage, Humans, Inpatients, Pandemics, Pneumonia, Viral, Pulmonary Edema, Sensitivity and Specificity, Betacoronavirus, medicine.medical_specialty, Point-of-care testing, 03 medical and health sciences, medicine, cardiovascular diseases, Intensive care medicine, Mass screening, business.industry, COVID-19, Pneumonia, medicine.disease, Diagnostic Techniques, Middle East respiratory syndrome, business
Abstract: The novel coronavirus disease of 2019 (COVID‐19) pandemic, as declared by the World Health Organization, is caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV2). Cardiovascular disease and, in particular, venous thromboembolism (VTE) has emerged as an important consideration in the management of hospitalized patients with COVID‐19. The diagnosis of VTE using standardized objective testing is problematic in these patients, given the risk of infecting non‐COVID‐19 hospitalized patients and hospital personnel, coupled with the usual challenges of performing diagnostic testing in critically‐ill patients. Early reports suggest a high incidence of VTE in hospitalized COVID‐19 patients, particularly those with severe illness, that is similar to the high VTE rates observed in patients with other viral pneumonias, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS‐CoV).
Published: 2020
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16. Intraoperative transfusion practices and perioperative outcome in the European elderly: A secondary analysis of the observational ETPOS study

Author: Grusser L., Keszei A., Coburn M., Rossaint R., Ziemann S., Kowark A, Daniela Filipescu, Sibylle Kozek-Langenecker, Juan V Llau Pitarch, Susan Mallett, Peter Martus, Idit Matot, Jens Meier, Axel Unterrainer, Dieter Adelmann, Daniel von Langen, Petra Innerhofer, Nicole Innerhofer-Pompernigg, Stefan De Hert, Luc De Baerdemaeker, Jurgen van Limmen, Piet Wyffels, Björn Heyse, Margot Vanderlaenen, Maud Beran, David Kahn, Audrey Prospiech, Luc Jamaer, Freya Mulders, Stefan Jacobs, Wannes Baeten, Sofie Platteau, Isabelle Maquoi, Severine Lauwick, Marc Senard, Vincent Ninane, Jean-Pierre Lecoq, Pierre Boveroux, Grégory Hans, Marcel Vercauteren, Brigitte Leva, Benoit Plichon, Vojislav Vujanovič, Ismet Suljevic, Hened Kelle, Denis Gustin, Matea Bogdanovic Dvorscak, Tamara Lupis, Jadranka Pavičić Šarić, Nataša Paklar, Dagmar Oberhofer, Ira Skok, Borana Kirigin, Ikic Visnja, Marina Kresic, Slavica Kvolik, Renatas Krobot, Vladimir Cerny, Jana Striteska, Marcela Bilska, Petr Štourač, Hana Harazim, Olga Smékalová, Martina Kosinová, Jozef Klučka, Rita Pacasová, Kim Ekelund, Indrek Rätsep, Juri Oganjan, Nadezda Smirnova, Peeter Kivik, Juri Karjagin, Alar Rokk, Alar Sõrmus, Bertrand Rozec, Jean-Christophe Rigal, Jean-Pierre Gouraud, Anne-Marie Chupin, Xavier Ambrosi, Laurent Brisard, Sylvie Decagny, Charles Marc Samama, Lionel Lidzborski, Matthieu Boisson, Anne-Laure Arcade, Gilbert Lorre, Peter Rosenberger, Hannah Merz, Ulrich Goebel, Bettina Schnitter, Hartmut Buerkle, Roland Tomasi, Vera von Dossow-Hanfstingl, Florian Brettner, Andreas Bayer, André Gottschalk, Nicolas Jakobs, Mark Coburn, Ana Kowark, Rolf Rossaint, Rita Laufenberg, Marion Ferner, Michael Schuster, Lydia Strys, Susanne Mauff, Kornel Skitek, Ewa Zielinska-Skitek, Gregor Schittek, Andreas Hoeft, Andreas Fleischer, Maria Wittmann, Florian Kessler, Anne Rohner, Peter Kranke, Christian Wunder, Johanna Jokinen, Kristin Budow, Christopher Prasser, Eva Werner, Alina Balandin, Norbert Ahrens, Kai Zacharowski, Patrick Meybohm, Kassiani Theodoraki, George Giokas, Tasoulis Marios-Konstantinos, Ageliki Pandazi, Aikaterini Kyttari, Eygenia Koursoumi, Georgios Anthopoulos, Antonis Andreou, Athanasios Rantis, Dimitrios Valsamidis, Pelagia Klimi, Konstantinos Katsanoulas, Demetrios Korfiotis, Christos Soumelidis, Fotios Papaspyros, Olga Kiskira, Tilemachos Paraskeuopoulos, Donal Buggy, Mortimer Kelleher, Liz Coghlan, Vladimir Verenkin, Anat Cattan, Francesco Bona, Felicino Debernardi, Andrea Cortegiani, Santi Maurizio Raineri, Giuseppe Accurso, Elena Gramigni, Leonardo Cenni, Laura Campiglia, Irene Lorenzi, Maria Grazia Militello, Tamara Biscioni, Andrius Macas, Daiva Apanaviciute, Darius Trepenaitis, Arunas Gelmanas, Diana Bilshiene, Jurate Sipylaite, Gabija Tomkute, Egle Kontrimaviciut, Renatas Tikuisis, Francis Borg, Ion Chesov, Serghei Cobiletchi, Victoria Moghildea, Bas Verdouw, J F van Poorten, Nick van Dasselaar, Marcus Daniel Lance, Britta de Waal, Lucienne Kropman, Peter van Noord, Benedikt Preckel, Lena Koers, Markus W Hollmann, Holger Baumann, Ankie W M M Koopman-van Gemert, Tore Reikvam, Tore Hervig, Kasper Gymoese Berthelsen, Ingvild Hausberg Sørvoll, Mirosław Czuczwar, Michał Borys, Paweł Piwowarczyk, Suzana Parente, Diogo Martins, Gloria Tareco, Ligia Reis, Joana Amaral, Daniel Ferreira, José Manuel Gonçalves Aguiar, Zélia Moreira, Filipa Lagarto, Filipa Pereira, Maria Lina Miranda, Sofia Serra, Alexandre Carrilho, José Pinto, Sandra Dias, Rita Poeria, Filipe Linda, Silvia Pica, Helder Martinho, Francisco Matias, Claudia Alves, Valentina Almeida, Margarida Marques, Emilia Martires, Piedade Gomes, Elizabete Pereira, Joana Jesus, Claudia Carreira, Carlos Seco, Carlos Bento, Helena Vieira, Luciane Pereira, Fernando Pinto, Luisa Silva, Marta Azenha, Maged Zarif, Ana Bernardino, Ana Raimundo, Ana Lopes, Melissa Fernandes, Beatriz Campos, Ana Macedo, Filipe Pinheiro, Sonia Duarte, Alexandra Saraiva, Catia Real, Marilena Alina Paunescu, Alexandru Bogdan Prodan, Mihai Stefan, Cristian Boros, Marius Tifrea, Anca Dragan, Horhota Lucian, Alida Moise, Carmen Arion-Balescu, Natalia Mincu, Viorel Gherghina, Iulia Cindea, Dan Costea, Ravzan Popescu, Dana Tomescu, Ecaterina Scarlatescu, Esenia Calancea, Ruxandra Copotoiu, Sanda Maria Copotoiu, Victoria Barsan, Dan Corneci, Rely Manolescu, Toma Diana, Denisa Nitu, Georgian Popica, Gabriela Droc, Nicoleta Jipa Lavina, Roxana Ciobanasu, Anna Maria Munteanu, Denisa Anastase, Iona Grintescu, Liliana Mirea, Alexandra Manoleli, Ciobanu Elena, Mary Nicoleta Lupu, Madalina Nina Sandu, Bicolae Bacalbasa, Florenta Calarasu, Alexey Grytsan, Andrey Gasenkampf, Alexander Kulikov, Alexander Shmigelsky, Vojislava Nescovic, Rade Vukovic, Uros Petrovic, Milic Veljovic, Dragana Unic-Stojanovic, Gordana Jovanovic, Ivana Kvrgic, Dragana Rakic, Roman Záhorec, Daniel Cintula, Tomas Veselovsky, Katarina Galkova, Jordana Stevikova, Andrea Číková, Zora Flassikova, Anna Dobisova, Jasmina Markovic Bozic, Minca Voje, Andriy Grynyuk, Alenka Spindler Yesel, Sabina Stivan, Peter Poredos, Darja Kasnik, Jasna Uranjek, Raquel Ferrandis, Sofia Machado, Liliana Henao, Tania Moreno, Ana Izquierdo, Carlos Delgado, Angela Camps, Susana Manrique, Alejandro Arbelaez, Pilar Tormos, Helena Serrano, Irene Garcia, Elvira Bisbe Vives, Luís Moltó, Tania Villar, Enrique Moret, Raquel Tolós, Esther Martínez, Misericordia Basora, Beatriz Tena, Roger Pujol, Jorge Vera Bella, Thomas Mallor, Pablo Mondero, Luis Lopez, Francisco Hidalgo, Maria Bermudez Lopez, Ana Velasco, Begona Bascuas, Victoria Moral, Diana Gómez Martinez, Alfredo Merten, J A Fernández, Nadia Diana Kinast, A Font, Maggi Genaro, Emilia Guasch, Fernando Gilsanz, Raul Martinez, Renato Schiraldi, Ever Martinez, Marta Barquero López, Alexo Lopez Alvarez, Yvan Enrique Sanchez Sanchez, Adriana Roman Fernandez, Olalla Varela Garcia, Marian Angeles Orallo Moran, Veronica Gonzalez Monzon, Óscar Sánchez López, David Sanchez Perez, Pablo Molano Diaz, Concepcion Cassinello, Maria Pilar Jubera, Maria Soler Pedrola, Julio Belmonte Cuenca, Sören Söndergaard, Till Rudolph, Kristin Åkeröy, Monir Jawad, Yousif Saeed, Sergej Safonov, Mona Andersson, Jan Wernerman, Suzanne Odeberg-Wernerman, Tommi Blom, Nesil Deger Coskunfirat, Zekiye Bigat, Suat Sanlı, O Koray Coskunfirat, Atilla Ramazanoğlu, Neval Boztug Uz, Ali Emre Camci, Omur Aksoy, Esra Saka, Oguzhan Arun, Sevda Ozkardesler, Dilek Omur, Mert Akan, Zuleyha Kazak Bengisun, Hakan Yılmaz, Perihan Ekmekci, Onur Selvi, Neslihan Alkis, Çiğdem Yıldırım, Başak Ceyda Meço, Zekeriyye Alanoğlu, Sergiy Vorotyntsev, Yevgen Yakymenko, Galina Troyan, Mohammed Alousi, Sarah James, Paula Meale, Ahmed Chishti, Matt Garner, Rita Singh, Nicola Hirschauer, Charley Higham, Andrea Bell, Alistair Cain, Chris Perry, Katy Davies, Claire Leech, Verity Calder, Shaman Jhanji, Varma Sandeep, Karen Simeson, Philip Watt, Nigel Dunk, Rosemary Ferrie, Margaret Wright, Lynn Everett, Andrew Ferguson, Laura Espie, Gail Browne, Matthew Dickinson, Ashok Nair, Deborah Clements, Peter Carvalho, Thomas Collyer, Jens Bolten, Lajos Zsisku, Attila Petri, Mohammed Ramadan, Tracey Ellimah, Martus, Peter, Laufenberg, Rita, Ferner, Marion, Schuster, Michael, Strys, Lydia, Mauff, Susanne, Skitek, Kornel, Zielinska-Skitek, Ewa, Schittek, Gregor, Hoeft, Andreas, Fleischer, Andreas, Matot, Idit, Wittmann, Maria, Kessler, Florian, Rohner, Anne, Kranke, Peter, Wunder, Christian, Jokinen, Johanna, Budow, Kristin, Prasser, Christopher, Werner, Eva, Balandin, Alina, Meier, Jens, Ahrens, Norbert, Zacharowski, Kai, Meybohm, Patrick, Theodoraki, Kassiani, Giokas, George, Marios-Konstantinos, Tasoulis, Pandazi, Ageliki, Kyttari, Aikaterini, Koursoumi, Eygenia, Anthopoulos, Georgios, Unterrainer, Axel, Andreou, Antonis, Rantis, Athanasios, Valsamidis, Dimitrios, Klimi, Pelagia, Katsanoulas, Konstantinos, Korfiotis, Demetrios, Soumelidis, Christos, Papaspyros, Fotios, Kiskira, Olga, Paraskeuopoulos, Tilemachos, Adelmann, Dieter, Buggy, Donal, Kelleher, Mortimer, Coghlan, Liz, Verenkin, Vladimir, Cattan, Anat, Bona, Francesco, Debernardi, Felicino, Cortegiani, Andrea, Raineri, Santi Maurizio, Accurso, Giuseppe, von Langen, Daniel, Gramigni, Elena, Cenni, Leonardo, Campiglia, Laura, Lorenzi, Irene, Militello, Maria Grazia, Biscioni, Tamara, Macas, Andrius, Apanaviciute, Daiva, Trepenaitis, Darius, Gelmanas, Arunas, Innerhofer, Petra, Bilshiene, Diana, Sipylaite, Jurate, Tomkute, Gabija, Kontrimaviciut, Egle, Tikuisis, Renatas, Borg, Francis, Chesov, Ion, Cobiletchi, Serghei, Moghildea, Victoria, Verdouw, Bas, Innerhofer-Pompernigg, Nicole, van Poorten, J. F., van Dasselaar, Nick, Lance, Marcus Daniel, de Waal, Britta, Kropman, Lucienne, van Noord, Peter, Preckel, Benedikt, Koers, Lena, Hollmann, Markus W., Baumann, Holger, De Hert, Stefan, Koopman-van Gemert, Ankie W. M. M., Reikvam, Tore, Hervig, Tore, Berthelsen, Kasper Gymoese, Sørvoll, Ingvild Hausberg, Czuczwar, Mirosław, Borys, Michał, Piwowarczyk, Paweł, Parente, Suzana, Martins, Diogo, De Baerdemaeker, Luc, Tareco, Gloria, Reis, Ligia, Amaral, Joana, Ferreira, Daniel, Gonçalves Aguiar, José Manuel, Moreira, Zélia, Lagarto, Filipa, Pereira, Filipa, Miranda, Maria Lina, Serra, Sofia, van Limmen, Jurgen, Carrilho, Alexandre, Pinto, José, Dias, Sandra, Poeria, Rita, Linda, Filipe, Pica, Silvia, Martinho, Helder, Matias, Francisco, Alves, Claudia, Almeida, Valentina, Wyffels, Piet, Marques, Margarida, Martires, Emilia, Gomes, Piedade, Pereira, Elizabete, Jesus, Joana, Carreira, Claudia, Seco, Carlos, Bento, Carlos, Vieira, Helena, Pereira, Luciane, Heyse, Björn, Pinto, Fernando, Silva, Luisa, Azenha, Marta, Zarif, Maged, Bernardino, Ana, Raimundo, Ana, Lopes, Ana, Fernandes, Melissa, Campos, Beatriz, Macedo, Ana, Vanderlaenen, Margot, Pinheiro, Filipe, Duarte, Sonia, Saraiva, Alexandra, Real, Catia, Paunescu, Marilena Alina, Bogdan Prodan, Alexandru, Stefan, Mihai, Boros, Cristian, Tifrea, Marius, Dragan, Anca, Beran, Maud, Lucian, Horhota, Moise, Alida, Arion-Balescu, Carmen, Mincu, Natalia, Gherghina, Viorel, Cindea, Iulia, Costea, Dan, Popescu, Ravzan, Tomescu, Dana, Scarlatescu, Ecaterina, Kahn, David, Calancea, Esenia, Copotoiu, Ruxandra, Copotoiu, Sanda Maria, Barsan, Victoria, Corneci, Dan, Manolescu, Rely, Diana, Toma, Nitu, Denisa, Popica, Georgian, Droc, Gabriela, Prospiech, Audrey, Jipa Lavina, Nicoleta, Ciobanasu, Roxana, Munteanu, Anna Maria, Anastase, Denisa, Grintescu, Iona, Mirea, Liliana, Manoleli, Alexandra, Elena, Ciobanu, Lupu, Mary Nicoleta, Sandu, Madalina Nina, Jamaer, Luc, Bacalbasa, Bicolae, Calarasu, Florenta, Grytsan, Alexey, Gasenkampf, Andrey, Kulikov, Alexander, Shmigelsky, Alexander, Nescovic, Vojislava, Vukovic, Rade, Petrovic, Uros, Veljovic, Milic, Mulders, Freya, Unic-Stojanovic, Dragana, Jovanovic, Gordana, Kvrgic, Ivana, Rakic, Dragana, Záhorec, Roman, Cintula, Daniel, Veselovsky, Tomas, Galkova, Katarina, Stevikova, Jordana, Číková, Andrea, Jacobs, Stefan, Flassikova, Zora, Dobisova, Anna, Markovic Bozic, Jasmina, Voje, Minca, Grynyuk, Andriy, Spindler Yesel, Alenka, Stivan, Sabina, Poredos, Peter, Kasnik, Darja, Uranjek, Jasna, Baeten, Wannes, Ferrandis, Raquel, Machado, Sofia, Henao, Liliana, Moreno, Tania, Izquierdo, Ana, Delgado, Carlos, Camps, Angela, Manrique, Susana, Arbelaez, Alejandro, Tormos, Pilar, Platteau, Sofie, Serrano, Helena, Garcia, Irene, Bisbe Vives, Elvira, Moltó, Luís, Villar, Tania, Moret, Enrique, Tolós, Raquel, Martínez, Esther, Basora, Misericordia, Tena, Beatriz, Maquoi, Isabelle, Pujol, Roger, Vera Bella, Jorge, Mallor, Thomas, Mondero, Pablo, Lopez, Luis, Hidalgo, Francisco, Bermudez Lopez, Maria, Velasco, Ana, Bascuas, Begona, Moral, Victoria, Lauwick, Severine, Gómez Martinez, Diana, Merten, Alfredo, Fernández, J. A., Kinast, Nadia Diana, Font, A., Genaro, Maggi, Guasch, Emilia, Gilsanz, Fernando, Martinez, Raul, Schiraldi, Renato, Senard, Marc, Martinez, Ever, Barquero López, Marta, Lopez Alvarez, Alexo, Sanchez Sanchez, Yvan Enrique, Roman Fernandez, Adriana, Varela Garcia, Olalla, Orallo Moran, Marian Angeles, Gonzalez Monzon, Veronica, Sánchez López, Óscar, Sanchez Perez, David, Ninane, Vincent, Molano Diaz, Pablo, Cassinello, Concepcion, Pilar Jubera, Maria, Soler Pedrola, Maria, Belmonte Cuenca, Julio, Söndergaard, Sören, Rudolph, Till, Åkeröy, Kristin, Jawad, Monir, Saeed, Yousif, Lecoq, Jean-Pierre, Safonov, Sergej, Andersson, Mona, Wernerman, Jan, Odeberg-Wernerman, Suzanne, Blom, Tommi, Deger Coskunfirat, Nesil, Bigat, Zekiye, Sanlı, Suat, Coskunfirat, O. Koray, Ramazanoğlu, Atilla, Boveroux, Pierre, Boztug Uz, Neval, Camci, Ali Emre, Aksoy, Omur, Saka, Esra, Arun, Oguzhan, Ozkardesler, Sevda, Omur, Dilek, Akan, Mert, Bengisun, Zuleyha Kazak, Yılmaz, Hakan, Hans, Grégory, Ekmekci, Perihan, Selvi, Onur, Alkis, Neslihan, Yıldırım, Çiğdem, Ceyda Meço, Başak, Alanoğlu, Zekeriyye, Vorotyntsev, Sergiy, Yakymenko, Yevgen, Troyan, Galina, Alousi, Mohammed, Vercauteren, Marcel, James, Sarah, Meale, Paula, Chishti, Ahmed, Garner, Matt, Singh, Rita, Hirschauer, Nicola, Higham, Charley, Bell, Andrea, Cain, Alistair, Perry, Chris, Leva, Brigitte, Davies, Katy, Leech, Claire, Calder, Verity, Jhanji, Shaman, Sandeep, Varma, Simeson, Karen, Watt, Philip, Dunk, Nigel, Ferrie, Rosemary, Wright, Margaret, Plichon, Benoit, Everett, Lynn, Ferguson, Andrew, Espie, Laura, Browne, Gail, Dickinson, Matthew, Nair, Ashok, Clements, Deborah, Carvalho, Peter, Collyer, Thomas, Bolten, Jens, Vujanovič, Vojislav, Zsisku, Lajos, Petri, Attila, Ramadan, Mohammed, Ellimah, Tracey, Suljevic, Ismet, Kelle, Hened, Gustin, Denis, Bogdanovic Dvorscak, Matea, Lupis, Tamara, Pavičić Šarić, Jadranka, Paklar, Nataša, Oberhofer, Dagmar, Skok, Ira, Kirigin, Borana, Visnja, Ikic, Kresic, Marina, Kvolik, Slavica, Krobot, Renatas, Cerny, Vladimir, Striteska, Jana, Bilska, Marcela, Filipescu, Daniela, Štourač, Petr, Harazim, Hana, Smékalová, Olga, Kosinová, Martina, Klučka, Jozef, Pacasová, Rita, Ekelund, Kim, Rätsep, Indrek, Oganjan, Juri, Smirnova, Nadezda, Kozek-Langenecker, Sibylle, Kivik, Peeter, Karjagin, Juri, Rokk, Alar, Sõrmus, Alar, Rozec, Bertrand, Rigal, Jean-Christophe, Gouraud, Jean-Pierre, Chupin, Anne-Marie, Ambrosi, Xavier, Brisard, Laurent, Llau Pitarch, Juan V., Decagny, Sylvie, Samama, Charles Marc, Lidzborski, Lionel, Boisson, Matthieu, Arcade, Anne-Laure, Lorre, Gilbert, Rosenberger, Peter, Merz, Hannah, Goebel, Ulrich, Schnitter, Bettina, Mallett, Susan, Buerkle, Hartmut, Tomasi, Roland, von Dossow-Hanfstingl, Vera, Brettner, Florian, Bayer, Andreas, Gottschalk, André, Jakobs, Nicolas, Coburn, Mark, Kowark, Ana, Rossaint, Rolf, Grusser L., Keszei A., Coburn M., Rossaint R., Ziemann S., Kowark A, Daniela Filipescu, Sibylle Kozek-Langenecker, Juan V Llau Pitarch, Susan Mallett, Peter Martus, Idit Matot, Jens Meier, Axel Unterrainer, Dieter Adelmann, Daniel von Langen, Petra Innerhofer, Nicole Innerhofer-Pompernigg, Stefan De Hert, Luc De Baerdemaeker, Jurgen van Limmen, Piet Wyffels, Björn Heyse, Margot Vanderlaenen, Maud Beran, David Kahn, Audrey Prospiech, Luc Jamaer, Freya Mulders, Stefan Jacobs, Wannes Baeten, Sofie Platteau, Isabelle Maquoi, Severine Lauwick, Marc Senard, Vincent Ninane, Jean-Pierre Lecoq, Pierre Boveroux, Grégory Hans, Marcel Vercauteren, Brigitte Leva, Benoit Plichon, Vojislav Vujanovič, Ismet Suljevic, Hened Kelle, Denis Gustin, Matea Bogdanovic Dvorscak, Tamara Lupis, Jadranka Pavičić Šarić, Nataša Paklar, Dagmar Oberhofer, Ira Skok, Borana Kirigin, Ikic Visnja, Marina Kresic, Slavica Kvolik, Renatas Krobot, Vladimir Cerny, Jana Striteska, Marcela Bilska, Petr Štourač, Hana Harazim, Olga Smékalová, Martina Kosinová, Jozef Klučka, Rita Pacasová, Kim Ekelund, Indrek Rätsep, Juri Oganjan, Nadezda Smirnova, Peeter Kivik, Juri Karjagin, Alar Rokk, Alar Sõrmus, Bertrand Rozec, Jean-Christophe Rigal, Jean-Pierre Gouraud, Anne-Marie Chupin, Xavier Ambrosi, Laurent Brisard, Sylvie Decagny, Charles Marc Samama, Lionel Lidzborski, Matthieu Boisson, Anne-Laure Arcade, Gilbert Lorre, Peter Rosenberger, Hannah Merz, Ulrich Goebel, Bettina Schnitter, Hartmut Buerkle, Roland Tomasi, Vera von Dossow-Hanfstingl, Florian Brettner, Andreas Bayer, André Gottschalk, Nicolas Jakobs, Mark Coburn, Ana Kowark, Rolf Rossaint, Rita Laufenberg, Marion Ferner, Michael Schuster, Lydia Strys, Susanne Mauff, Kornel Skitek, Ewa Zielinska-Skitek, Gregor Schittek, Andreas Hoeft, Andreas Fleischer, Maria Wittmann, Florian Kessler, Anne Rohner, Peter Kranke, Christian Wunder, Johanna Jokinen, Kristin Budow, Christopher Prasser, Eva Werner, Alina Balandin, Norbert Ahrens, Kai Zacharowski, Patrick Meybohm, Kassiani Theodoraki, George Giokas, Tasoulis Marios-Konstantinos, Ageliki Pandazi, Aikaterini Kyttari, Eygenia Koursoumi, Georgios Anthopoulos, Antonis Andreou, Athanasios Rantis, Dimitrios Valsamidis, Pelagia Klimi, Konstantinos Katsanoulas, Demetrios Korfiotis, Christos Soumelidis, Fotios Papaspyros, Olga Kiskira, Tilemachos Paraskeuopoulos, Donal Buggy, Mortimer Kelleher, Liz Coghlan, Vladimir Verenkin, Anat Cattan, Francesco Bona, Felicino Debernardi, Andrea Cortegiani, Santi Maurizio Raineri, Giuseppe Accurso, Elena Gramigni, Leonardo Cenni, Laura Campiglia, Irene Lorenzi, Maria Grazia Militello, Tamara Biscioni, Andrius Macas, Daiva Apanaviciute, Darius Trepenaitis, Arunas Gelmanas, Diana Bilshiene, Jurate Sipylaite, Gabija Tomkute, Egle Kontrimaviciut, Renatas Tikuisis, Francis Borg, Ion Chesov, Serghei Cobiletchi, Victoria Moghildea, Bas Verdouw, J F van Poorten, Nick van Dasselaar, Marcus Daniel Lance, Britta de Waal, Lucienne Kropman, Peter van Noord, Benedikt Preckel, Lena Koers, Markus W Hollmann, Holger Baumann, Ankie W M M Koopman-van Gemert, Tore Reikvam, Tore Hervig, Kasper Gymoese Berthelsen, Ingvild Hausberg Sørvoll, Mirosław Czuczwar, Michał Borys, Paweł Piwowarczyk, Suzana Parente, Diogo Martins, Gloria Tareco, Ligia Reis, Joana Amaral, Daniel Ferreira, José Manuel Gonçalves Aguiar, Zélia Moreira, Filipa Lagarto, Filipa Pereira, Maria Lina Miranda, Sofia Serra, Alexandre Carrilho, José Pinto, Sandra Dias, Rita Poeria, Filipe Linda, Silvia Pica, Helder Martinho, Francisco Matias, Claudia Alves, Valentina Almeida, Margarida Marques, Emilia Martires, Piedade Gomes, Elizabete Pereira, Joana Jesus, Claudia Carreira, Carlos Seco, Carlos Bento, Helena Vieira, Luciane Pereira, Fernando Pinto, Luisa Silva, Marta Azenha, Maged Zarif, Ana Bernardino, Ana Raimundo, Ana Lopes, Melissa Fernandes, Beatriz Campos, Ana Macedo, Filipe Pinheiro, Sonia Duarte, Alexandra Saraiva, Catia Real, Marilena Alina Paunescu, Alexandru Bogdan Prodan, Mihai Stefan, Cristian Boros, Marius Tifrea, Anca Dragan, Horhota Lucian, Alida Moise, Carmen Arion-Balescu, Natalia Mincu, Viorel Gherghina, Iulia Cindea, Dan Costea, Ravzan Popescu, Dana Tomescu, Ecaterina Scarlatescu, Esenia Calancea, Ruxandra Copotoiu, Sanda Maria Copotoiu, Victoria Barsan, Dan Corneci, Rely Manolescu, Toma Diana, Denisa Nitu, Georgian Popica, Gabriela Droc, Nicoleta Jipa Lavina, Roxana Ciobanasu, Anna Maria Munteanu, Denisa Anastase, Iona Grintescu, Liliana Mirea, Alexandra Manoleli, Ciobanu Elena, Mary Nicoleta Lupu, Madalina Nina Sandu, Bicolae Bacalbasa, Florenta Calarasu, Alexey Grytsan, Andrey Gasenkampf, Alexander Kulikov, Alexander Shmigelsky, Vojislava Nescovic, Rade Vukovic, Uros Petrovic, Milic Veljovic, Dragana Unic-Stojanovic, Gordana Jovanovic, Ivana Kvrgic, Dragana Rakic, Roman Záhorec, Daniel Cintula, Tomas Veselovsky, Katarina Galkova, Jordana Stevikova, Andrea Číková, Zora Flassikova, Anna Dobisova, Jasmina Markovic Bozic, Minca Voje, Andriy Grynyuk, Alenka Spindler Yesel, Sabina Stivan, Peter Poredos, Darja Kasnik, Jasna Uranjek, Raquel Ferrandis, Sofia Machado, Liliana Henao, Tania Moreno, Ana Izquierdo, Carlos Delgado, Angela Camps, Susana Manrique, Alejandro Arbelaez, Pilar Tormos, Helena Serrano, Irene Garcia, Elvira Bisbe Vives, Luís Moltó, Tania Villar, Enrique Moret, Raquel Tolós, Esther Martínez, Misericordia Basora, Beatriz Tena, Roger Pujol, Jorge Vera Bella, Thomas Mallor, Pablo Mondero, Luis Lopez, Francisco Hidalgo, Maria Bermudez Lopez, Ana Velasco, Begona Bascuas, Victoria Moral, Diana Gómez Martinez, Alfredo Merten, J A Fernández, Nadia Diana Kinast, A Font, Maggi Genaro, Emilia Guasch, Fernando Gilsanz, Raul Martinez, Renato Schiraldi, Ever Martinez, Marta Barquero López, Alexo Lopez Alvarez, Yvan Enrique Sanchez Sanchez, Adriana Roman Fernandez, Olalla Varela Garcia, Marian Angeles Orallo Moran, Veronica Gonzalez Monzon, Óscar Sánchez López, David Sanchez Perez, Pablo Molano Diaz, Concepcion Cassinello, Maria Pilar Jubera, Maria Soler Pedrola, Julio Belmonte Cuenca, Sören Söndergaard, Till Rudolph, Kristin Åkeröy, Monir Jawad, Yousif Saeed, Sergej Safonov, Mona Andersson, Jan Wernerman, Suzanne Odeberg-Wernerman, Tommi Blom, Nesil Deger Coskunfirat, Zekiye Bigat, Suat Sanlı, O Koray Coskunfirat, Atilla Ramazanoğlu, Neval Boztug Uz, Ali Emre Camci, Omur Aksoy, Esra Saka, Oguzhan Arun, Sevda Ozkardesler, Dilek Omur, Mert Akan, Zuleyha Kazak Bengisun, Hakan Yılmaz, Perihan Ekmekci, Onur Selvi, Neslihan Alkis, Çiğdem Yıldırım, Başak Ceyda Meço, Zekeriyye Alanoğlu, Sergiy Vorotyntsev, Yevgen Yakymenko, Galina Troyan, Mohammed Alousi, Sarah James, Paula Meale, Ahmed Chishti, Matt Garner, Rita Singh, Nicola Hirschauer, Charley Higham, Andrea Bell, Alistair Cain, Chris Perry, Katy Davies, Claire Leech, Verity Calder, Shaman Jhanji, Varma Sandeep, Karen Simeson, Philip Watt, Nigel Dunk, Rosemary Ferrie, Margaret Wright, Lynn Everett, Andrew Ferguson, Laura Espie, Gail Browne, Matthew Dickinson, Ashok Nair, Deborah Clements, Peter Carvalho, Thomas Collyer, Jens Bolten, Lajos Zsisku, Attila Petri, Mohammed Ramadan, Tracey Ellimah, Anesthesiology, ACS - Diabetes & metabolism, APH - Quality of Care, ACS - Heart failure & arrhythmias, APH - Global Health, and ACS - Microcirculation
Subjects: Clinical Oncology, Male, Science, Clinical Decision-Making, Cancer Treatment, Surgical and Invasive Medical Procedures, Geographical Locations, Diagnostic Medicine, Outcome Assessment, Health Care, Medicine and Health Sciences, Humans, Blood Transfusion, Prospective Studies, Aged, Aged, 80 and over, Intraoperative Care, Multidisciplinary, Transfusion Medicine, Anemia, Hematology, Clinical Laboratory Sciences, Health Care, Europe, Surgical Oncology, Oncology, Age Groups, Elective Surgical Procedures, People and Places, Medicine, Population Groupings, Female, Geriatric Care, Clinical Medicine, Erythrocyte Transfusion, Research Article
Abstract: PLOS ONE 17(1), e0262110 (2022). doi:10.1371/journal.pone.0262110, Published by PLOS, San Francisco, California, US
Published: 2022
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17. Extended anticoagulant treatment with full- or reduced-dose apixaban in patients with cancer-associated venous thromboembolism

Author: Eric Vicaut, Frederikus A. Klok, Charles Marc Samama, Cecilia Becattini, Isabelle Mahé, Alexander T. Cohen, Giancarlo Agnelli, Menno V. Huisman, Sebastian Szmit, D. Mayeur, Peter Verhamme, Marc Philip Righini, Marc Carrier, Tzu-Fei Wang, Manuel Monreal, Kostas N. Syrigos, Adam Torbicki, Juan J. López-Núñez, Cihan Ay, Céline Chapelle, Anthony Maraveyas, Olivier Mir, Aristotelis Bamias, Philippe Girard, Guy Meyer, and Silvy Laporte
Subjects: medicine.medical_specialty, Pyridones, venous thromboembolism, apixaban, Hemorrhage, Internal medicine, Neoplasms, Medicine, Humans, cancer, business.industry, Incidence (epidemiology), Hazard ratio, Cancer, Anticoagulants, Hematology, medicine.disease, Thrombosis, Confidence interval, Pulmonary embolism, Regimen, randomized, Pyrazoles, Apixaban, business, medicine.drug
Abstract: Cancer-associated thrombosis (CT) is associated with a high risk of recurrent venous thromboembolic (VTE) events that require extended anticoagulation in patients with active cancer, putting them at risk of bleeding. The aim of the API-CAT study (NCT03692065) is to assess whether a reduced-dose regimen of apixaban (2.5 mg twice daily [bid]) is noninferior to a full-dose regimen of apixaban (5 mg bid) for the prevention of recurrent VTE in patients with active cancer who have completed ≥6 months of anticoagulant therapy for a documented index event of proximal deep-vein thrombosis and/or pulmonary embolism. API-CAT is an international, randomized, parallel-group, double-blind, noninferiority trial with blinded adjudication of outcome events. Consecutive patients are randomized to receive apixaban 2.5 or 5 mg bid for 12 months. The primary efficacy outcome is a composite of recurrent symptomatic or incidental VTE during the treatment period. The principal safety endpoint is clinically relevant bleeding, defined as a composite of major bleeding or nonmajor clinically relevant bleeding. Assuming a 12-month incidence of the primary outcome of 4% with apixaban and an upper limit of the two-sided 95% confidence interval of the hazard ratio
Published: 2021

18. Management of perioperative thromboprophylaxis for surgery following COVID-19: an expert-panel survey

Author: A. Gómez-Luque, Juan V. Llau, Charles-Marc Samama, Arash Afshari, James D. Douketis, and R. Ferrandis
Subjects: Panel survey, 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Perioperative Care, Time, Correspondence, Humans, Medicine, perioperative thromboembolism, anticoagulation, Thrombotic risk, SARS-CoV-2, business.industry, Anticoagulants, COVID-19, Venous Thromboembolism, Perioperative, Anesthesiology and Pain Medicine, Perioperative care, Emergency medicine, thromboprophylaxis, business, Venous thromboembolism, thrombotic risk
Published: 2021

19. Modified ROTEM for the detection of rivaroxaban and apixaban anticoagulant activity in whole blood

Author: Isabelle Gouin-Thibault, Virginie Siguret, Bernard Le Bonniec, Pascale Gaussem, Georges Jourdi, Charles Marc Samama, Sophie Gandrille, Alain Stepanian, Emmanuel Curis, Claire Pailleret, and Jean-Louis Golmard
Subjects: Adult, Male, Time Factors, Adolescent, Critical Care, Pyridones, Administration, Oral, Pharmacology, Fibrinogen, Sensitivity and Specificity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Rivaroxaban, 030202 anesthesiology, medicine, Humans, Platelet, Blood Coagulation, Aged, Whole blood, Aged, 80 and over, business.industry, 030208 emergency & critical care medicine, Middle Aged, Thrombelastography, Thromboelastometry, Anesthesiology and Pain Medicine, Clotting time, Coagulation, Feasibility Studies, Pyrazoles, Female, Apixaban, business, Factor Xa Inhibitors, medicine.drug
Abstract: Background Rapid detection of the anticoagulant effect of oral factor Xa (FXa) inhibitors may be essential in several emergency clinical situations. Specific assays quantifying the drugs are performed in plasma and require a turnaround time that is too long to be useful in emergency situations. Rotational thromboelastometry (ROTEM) is a whole blood coagulation assay of blood viscoelasticity and could be of interest for FXa inhibitor detection in emergency. However, conventional ROTEM reagents only detect high amounts of inhibitors. Objective The aim of this study was first to assess the effect of whole blood components on the viscoelastic measurement of the effects of FXa inhibitors, and second to evaluate whether a modified ROTEM, triggered with a low amount of tissue factor and a saturating amount of phospholipid vesicles, can reliably detect low levels of FXa inhibitor activity in whole blood. Design Diagnostic test study. Settings A university research laboratory. From November 2014 to April 2016. Patients Sixty-six patients: 30 treated with rivaroxaban, 17 with apixaban and 19 without treatment. Intervention ROTEM was triggered with 2.5 pmol l of tissue factor and 10 μmol l of phospholipid vesicles. Main outcome measures Modified ROTEM parameters were measured in different experimental conditions: platelet-poor plasma (PPP), platelet-rich plasma, PPP supplemented with fibrinogen and reconstituted whole blood with various haematocrit levels adjusted between 30 and 60%. Modified ROTEM was further validated using whole blood from patients who were either treated or not treated with FXa inhibitors. Results Modified ROTEM allowed detection of as little as 25 ng ml FXa inhibitors in PPP, with at least a 1.4-fold increase of the clotting time (P ≤ 0.02). Neither changes of fibrinogen concentration nor variations of platelet count or haematocrit precluded FXa inhibitor detection. A lengthened modified ROTEM clotting time of more than 197 s allowed detection of FXa inhibitor concentrations above 30 ng ml in whole blood with 90% sensitivity and 85% specificity. Conclusion Modified ROTEM may be applicable in emergency situations for the detection of FXa inhibitors in whole blood.
Published: 2019
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20. Gestion des agents antiplaquettaires en cas de procédure invasive non programmée ou d’hémorragie. Propositions du Groupe d’intérêt en hémostase périopératoire (GIHP) et du Groupe français d’études sur l’hémostase et la thrombose (GFHT) en collaboration avec la Société française d’anesthésie et de réanimation (SFAR)

Author: Normand Blais, François Mullier, Dan Longrois, Nathalie Nathan, Serge Motte, S. Laporte, Juan V. Llau, Yves Gruel, Stéphanie Roullet, J. Guay, J.-L. Bosson, Philippe Nguyen, P. van Der Linden, Dominique Lasne, Annick Steib, P.E. Morange, Anne Godier, Pierre Albaladejo, Sophie Susen, Brigitte Ickx, Jerrold H. Levy, G. Pernod, Emmanuel Marret, Samia Madi-Jebara, Guy Meyer, Yves Ozier, David Faraoni, Fanny Bonhomme, E. van Belle, Jean-François Schved, Mikael Mazighi, André Vincentelli, Patrick Mismetti, J.L. Mas, P.M. Roy, Emmanuel de Maistre, Jean-Philippe Collet, Sylvie Schlumberger, Y. Huet, Pierre Fontana, Charles Marc Samama, Delphine Garrigue, J.Y. Borg, Nadia Rosencher, S. Belisle, Jean-François Hardy, Thomas Lecompte, P. Sié, D. Garrigue Huet, P. Zufferey, A. Borel-Derlon, A. Cohen, S. Lessire, G. Le Gal, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'anesthésiologie, and UCL - (MGD) Laboratoire de biologie clinique
Subjects: 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, Agent antiplaquettaireChirurgieHémorragieThromboseAnesthésie locorégionale, 030202 anesthesiology, 030204 cardiovascular system & hematology
Abstract: Le Groupe d’intérêt en hémostase périopératoire (GIHP) et le Groupe français d’études sur l’hémostase et la thrombose (GFHT), en collaboration avec la Société française d’anesthésie et de réanimation (SFAR) ont fait des propositions de gestion des agents antiplaquettaires (AAP) pour une procédure invasive programmée. Ces propositions ont été discutées et validées par vote ; toutes sauf une ont fait l’objet d’un accord fort. La gestion des AAP dépend de leur indication et de la procédure considérée. Le risque hémorragique lié à la procédure invasive peut être divisé en bas, intermédiaire ou élevé, selon la possibilité ou non de réaliser la procédure sous traitement (sous respectivement bithérapie antiplaquettaire, aspirine en monothérapie ou aucun AAP). Si une interruption des AAP est indiquée avant la procédure, une dernière prise d’aspirine, clopidogrel, ticagrélor et prasugrel 3, 5, 5 et 7 jours avant la procédure est proposée. Le risque thrombotique associé à l’interruption des AAP doit être évalué en fonction de l’indication des AAP. Il est plus élevé chez les patients traités par bithérapie pour un stent coronaire que chez ceux traités par monothérapie pour une prévention cardiovasculaire, un antécédent d’accident vasculaire cérébral ischémique ou une artériopathie oblitérante des membres inférieurs. Ces propositions concernent aussi le rôle potentiel des tests fonctionnels plaquettaires, la gestion des AAP pour l’anesthésie locorégionale, centrale et périphérique, et pour la chirurgie cardiaque coronaire.
Published: 2019
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21. A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing

Author: Thomas G. Deloughery, Beverley J. Hunt, Geoffrey D. Barnes, Jean M. Connors, Cihan Ay, Stefano Barco, Lana Castellucci, Gabriela Cesarman‐Maus, Erich Vinicius De Paula, Mert Dumantepe, Maria Cecilia Guillermo Esposito, Federica Fedele, Lai Heng Lee, Claire McLintock, Eriko Morishita, Charles Marc Samama, Helen Okoye, and Todd Robertson
Subjects: Hematology
Abstract: Testing for polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene is still a standard part of thrombophilia testing in many laboratories. However, it is clear that these polymorphisms are not risk factors for arterial or venous thrombosis and therefore should not be part of thrombophilia testing. Eliminating MTHFR from thrombophilia testing will reduce patient concerns and health care costs.
Published: 2022
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22. Our project for the Journal(s)

Author: Esther Pogatzki-Zahn, Michelle S Chew, Patrice Forget, Anne-Claire Lukaszewicz, Nicolas Bruder, Marc Van de Velde, Charles Marc Samama, Dan Longrois, and Tom Hansen
Subjects: Anesthesiology and Pain Medicine, business.industry, Library science, Medicine, business
Published: 2020
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23. Diagnosis and management of heparin-induced thrombocytopenia

Author: Yves Ozier, F. Mullier, P. Albaladejo, Grégoire Le Gal, Jean-François Schved, Sophie Susen, Jean-Philippe Collet, Emmanuel Marret, Yves Gruel, Jean-François Hardy, Claire Pouplard, N. Blais, D. Lasne, Sylvie Schlumberger, Thomas Lecompte, A. Vincentelli, J.Y. Borg, Brigitte Ickx, A. Godier, Guy Meyer, E de Maistre, Dan Longrois, Samia Madi-Jebara, Sophie Testa, Nathalie Nathan, Mikael Mazighi, André Vincentelli, Joanne Guay, S. Laporte, P.M. Roy, Emmanuel de Maistre, D. Garrigue Huet, P. Zufferey, Y. Huet, Nadia Rosencher, P. Van der Linden, Dominique Lasne, S. Roullet, Y. Gruel, François Mullier, P. Sié, Philippe Nguyen, David Faraoni, Normand Blais, Jerrold H. Levy, Annick Steib, P.E. Morange, S. Lessire, G. Le Gal, Juan V. Llau, Anne Godier, Sylvain Bélisle, Pierre Albaladejo, Serge Motte, Stéphanie Roullet, J.-L. Bosson, Patrick Mismetti, Fanny Bonhomme, Charles-Marc Samama, E. van Belle, J.L. Mas, Pierre Fontana, G. Pernod, S. Susen, A. Borel-Derlon, A. Cohen, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Laboratoire de biologie clinique, Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_specialty, Clinique, business.industry, MEDLINE, General Medicine, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, medicine.disease, Gastroenterology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030220 oncology & carcinogenesis, Heparin-induced thrombocytopenia, Internal medicine, medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Heparin-induced thrombocytopenia (HIT) is a rare, iatrogenic disease characterised by its potential severity, mainly related to thrombosis, and by difficulties regarding its diagnosis and management of affected patients. In 2002, a conference of experts mobilised by the French Society of Anaesthesia and Intensive Care Medicine (Société française d’anesthésie et de réanimation [SFAR]) drafted recommendations for the management of HIT [...]
Published: 2020
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24. A new ESAIC open access journal

Author: Marc Van de Velde, Esther Pogatzki-Zahn, Anne-Claire Lukaszewicz, Dan Longrois, Tom G. Hansen, Patrice Forget, Michelle S. Chew, Nicolas Bruder, and Charles-Marc Samama
Published: 2022
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25. Thromboprophylaxis for ambulatory surgery: Results from a prospective national cohort

Author: Charles Marc Samama, Frédéric Aubrun, Jean-Luc Bosson, Pierre Albaladejo, and Dan Benhamou
Subjects: medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Conventional surgery, Intermittent pneumatic compression, Low molecular weight heparin, Guidelines as Topic, Compression stockings, Critical Care and Intensive Care Medicine, Risk Assessment, National cohort, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Clinical Protocols, 030202 anesthesiology, medicine, Humans, Medical history, Prospective Studies, cardiovascular diseases, 030212 general & internal medicine, Medical History Taking, Intermittent Pneumatic Compression Devices, business.industry, Anticoagulants, Venous Thromboembolism, General Medicine, equipment and supplies, Surgery, Anesthesiology and Pain Medicine, Ambulatory Surgical Procedures, Health Care Surveys, Ambulatory, France, business, Venous thromboembolism, Stockings, Compression, Recovery Room
Abstract: Background Venous thromboembolism (VTE) prophylaxis is not always part of the usual care of ambulatory surgery patients, and few guidelines are available. Objectives To collect data on the application of VTE prophylaxis in ambulatory patients. Design The OPERA study is a large national survey performed in 221 healthcare facilities. Patients Among patients, 2174 who underwent one of ten selected procedures over two pre-defined days of investigation. Main outcome measures Assessment and management of the postoperative VTE risk. Results The postoperative VTE risk was assessed as nil (4.1% of the physicians), low (74%) or moderate (20%). This risk was assessed as lower (71%) in ambulatory surgery as compared to conventional surgery. In most centres (94%), a personal patient history of VTE was recorded preoperatively, and in 72% a prophylaxis protocol was systematically applied but only 40% of the responding centres had a written protocol for VTE prophylaxis. The postoperative period (discharge at home) was covered by a VTE protocol for 75% of the centres, with VTE prophylaxis starting postoperatively in 21% of the patients. In these patients, different treatments were applied: below-knee compression stockings (25%); thigh-length compression stockings (21%); intermittent pneumatic compression in the recovery room (1.2%); unfractionated heparin (2.0%); low molecular weight heparins (65%); vitamin K antagonists (0.5%); other treatments, including direct oral anticoagulants (0.5%). Conclusion These data underline the need for a better assessment of the VTE risk in ambulatory patients and new studies either with conventional or new agents to be able to build guidelines in this new setting.
Published: 2018
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26. The place of fibrinogen concentrates in the management of perioperative bleeding: A position paper from the Francophone Working Group on Perioperative Haemostasis (GIHP)

Author: Sophie Susen, Annick Steib, Y. Ozier, Charles Marc Samama, A. Godier, and Brigitte Ickx
Subjects: medicine.medical_specialty, Blood Loss, Surgical, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Fibrinogen, Hemostatics, Perioperative Care, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, medicine, Humans, Intensive care medicine, Thrombotic risk, Hemostasis, business.industry, Authorization, Thrombosis, General Medicine, Perioperative, medicine.disease, Polytrauma, Anesthesiology and Pain Medicine, Plasma concentration, Position paper, Narrative review, business, medicine.drug
Abstract: The consumption of fibrinogen concentrates has been increasing steadily for several years in surgery, trauma and obstetrics. However, data from the literature are conflicting. The French Working Group on Perioperative Haemostasis (GIHP) proposes a position paper based on a narrative review of the literature, and addresses the following questions: What is the exact role of fibrinogen in haemostasis? Which rational support for the use of perioperative fibrinogen? Which thrombotic risk? What are the most recent professional recommendations on the use of fibrinogen concentrates? Then, evidence-based recommendations are proposed: 1) it is suggested not to administer prophylactic FC to prevent haemorrhage; 2) it is suggested not to use FC alone. Haemostatic treatment must be comprehensive, include other haemostatic treatments and must be limited in cases of severe active haemorrhage; 3) the GIHP suggests urgent measurement of fibrinogen plasma concentration in a biology laboratory or functional fibrinogen by viscoelastic methods. The choice between the two methods must be guided by the time to receive the results from a certified organisation with, in particular, authorisation to perform delocalised biologic examinations; 4) it is suggested not to administer FC when the fibrinogen concentration is superior to 1.5g/L or when there is a functional fibrinogen deficit (with the possible exception in obstetrics where the threshold could be 2.0g/L); 5) if FC are administered, an initial dose of 25-50mg/kg is proposed.
Published: 2018
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27. Emphysematous Gastritis Is a Severe Infectious Disease

Author: Gilles Troché, Julien Mezghani, Charles-Marc Samama, Jean Pierre Bedos, Fabrice Bruneel, and Melanie Fromentin
Subjects: Microbiology (medical), medicine.medical_specialty, Conservative management, business.industry, Critically ill, Emphysematous gastritis, Immunocompromised patient, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Infectious disease (medical specialty), 030220 oncology & carcinogenesis, Medicine, 030211 gastroenterology & hepatology, Gastritis, medicine.symptom, business, Intensive care medicine
Abstract: PurposeEmphysematous gastritis (EG) is a rare form of infectious gastritis reported in many immunocompromised patient with extreme severity and many potential comorbidities. However, despite lots of critically ill case reports, there is a trend towards conservative management. Furthermore, it has ne
Published: 2018
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28. Evaluation of recombinant factor VIIa, tranexamic acid and desmopressin to reduce prasugrel-related bleeding

Author: Anne Godier, Charles Marc Samama, Thomas Lecompte, Pierre Fontana, and Fanny Bonhomme
Subjects: Male, Prasugrel, Thienopyridine, Drug Evaluation, Preclinical, Hemorrhage, Factor VIIa, 030204 cardiovascular system & hematology, Loading dose, Hemostatics, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Bleeding time, medicine, Animals, Deamino Arginine Vasopressin, 030212 general & internal medicine, Desmopressin, ddc:616, ddc:617, medicine.diagnostic_test, biology, business.industry, Clopidogrel, Antifibrinolytic Agents, Recombinant Proteins, Anesthesiology and Pain Medicine, Tranexamic Acid, Recombinant factor VIIa, Anesthesia, Models, Animal, biology.protein, Administration, Intravenous, Rabbits, business, Prasugrel Hydrochloride, Platelet Aggregation Inhibitors, Tranexamic acid, medicine.drug
Abstract: BACKGROUND Prasugrel is a thienopyridine that inhibits platelet aggregation more rapidly and effectively than clopidogrel, with an increased bleeding risk. OBJECTIVE The current study aimed to evaluate the efficacy of three nonspecific haemostatic drugs - recombinant activated factor VII (rFVIIa), tranexamic acid and desmopressin (DDAVP) - to limit blood loss after administration of prasugrel in a rabbit model of bleeding while also evaluating any prothrombotic effects. DESIGN Randomised, placebo-controlled study. SETTING Faculty of Medicine, University of Geneva, Switzerland, in 2013. ANIMALS Anaesthetised and artificially ventilated rabbits (n=56). INTERVENTIONS Animals were randomly allocated to one of five groups: control (placebo-placebo), prasugrel-placebo, rFVIIa (prasugrel-rFVIIa 150 μg kg), tranexamic acid (prasugrel-tranexamic acid 20 mg kg) or DDAVP (prasugrel-DDAVP 1 μg kg). Two hours after an oral prasugrel loading dose (4 mg kg), a stenosis and an injury were inflicted on the carotid artery to induce cyclic flow reductions (CFRs) due to thrombosis. Haemostatic drugs were administered during the ensuing observation period. MAIN OUTCOME MEASURES Standardised hepatosplenic sections were performed to evaluate the primary endpoint of blood loss, monitored for 15 min. Ear-immersion bleeding time and incidence of CFRs were secondary endpoints. RESULTS Prasugrel decreased ADP-induced platelet aggregation (light transmission method) from 66 ± 4% (mean ± SD) to 41 ± 7% (P
Published: 2018
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29. European guidelines on perioperative venous thromboembolism prophylaxis

Author: Arash Afshari, Charles Marc Samama, and Esa Vte Guidelines Task Force
Subjects: medicine.medical_specialty, business.industry, General surgery, MEDLINE, Perioperative, Surgical procedures, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030202 anesthesiology, medicine, 030212 general & internal medicine, business, Venous thromboembolism, Introductory Journal Article
Published: 2018
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30. Use of factor concentrates for the management of perioperative bleeding: guidance from the SSC of the ISTH

Author: Charles Marc Samama, Jerrold H. Levy, David Faraoni, Anne Godier, and Andreas Greinacher
Subjects: Consensus, Blood Loss, Surgical, Factor VIIa, Postoperative Hemorrhage, 030204 cardiovascular system & hematology, Hemostatics, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, 030202 anesthesiology, medicine, Humans, Platelet, Acidosis, Evidence-Based Medicine, Factor XIII, business.industry, Fibrinogen, Hematology, Perioperative, Hypothermia, Blood Coagulation Factors, Recombinant Proteins, Treatment Outcome, Multiple factors, Coagulation, Anesthesia, Inflammatory pathways, medicine.symptom, Complication, business
Abstract: Perioperative bleeding is a common complication following major surgery. Despite surgical measures to minimize bleeding, patients develop acquired hemostatic defects due to multiple factors that include hemorrhagic loss, consumption, dilution of coagulation factors and platelets, hypothermia, acidosis, and activation of fibrinolytic and inflammatory pathways. Therapeutic approaches for restoring haemostasis include allogeneic blood product administration. This article is protected by copyright. All rights reserved.
Published: 2018
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31. Stopping or maintaining oral anticoagulation in patients undergoing photoselective vaporization of the prostate (SOAP) surgery for benign prostate obstruction: A multicentre randomized controlled trial

Author: Pierre Albaladejo, Gilles Karsenty, E. Della Negra, Charles Marc Samama, B. Peyronnet, C. Ballereau, B. Pradere, Sébastien Vincendeau, F. Guerrero, J. Calves, L. Corbel, Jean-Alexandre Long, N. Barry Delongchamps, Romain Mathieu, S. Lebdai, F. Bruyère, Hélène Charbonneau, A. Descazeaud, Pierre Colin, Atul Pathak, Georges Fournier, and Vincent Misrai
Subjects: medicine.medical_specialty, business.industry, Urology, Surgery, law.invention, medicine.anatomical_structure, Randomized controlled trial, Prostate, law, Medicine, Photoselective vaporization, In patient, business, Benign prostate, Oral anticoagulation
Published: 2019
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32. A retrospective comparison between delayed and early hip fracture surgery in patients taking clopidogrel: same total bleeding but different timing of blood transfusion

Author: Claire Pailleret, Zakaria Ait Hamou, Christophe Baillard, François Chilot, Nadia Rosencher, Violaine Eyraud, and Charles-Marc Samama
Subjects: Male, medicine.medical_specialty, Ticlopidine, Time Factors, Blood transfusion, medicine.medical_treatment, Hemorrhage, Hip fracture surgery, Time-to-Treatment, Fracture Fixation, Internal, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Blood loss, Transfusion requirement, Humans, Medicine, Blood Transfusion, Orthopedics and Sports Medicine, In patient, Hospital Mortality, 030212 general & internal medicine, Perioperative Period, Aged, Retrospective Studies, Aged, 80 and over, 030222 orthopedics, Hip fracture, Hip Fractures, business.industry, Length of Stay, medicine.disease, Clopidogrel, Surgery, Withholding Treatment, Anesthesia, Orthopedic surgery, Female, Hip Joint, Hemiarthroplasty, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract: Managing hip fracture surgery in patients taking clopidogrel is challenging. The optimal timing for surgery remains unclear. Early surgery in such patients potentially increases peri-operative bleeding, whereas delayed surgery has been shown to be associated with worse postoperative outcomes. The aim of this study was to investigate whether a delay to surgery affects total blood loss, bleeding kinetics, blood transfusion requirements, or post-operative outcomes. A retrospective monocentric study including all hip fracture patients treated with clopidogrel between 2011 and 2016 (39 patients) was carried out. Patients who underwent delayed surgery after withholding clopidogrel for five days or more, from 2011 to 2013, were compared to patients who benefited from earlier surgical procedures (within 48 hours of admission) from 2014 to 2016. Total blood loss, amount of blood transfusion and rate of postoperative complications did not differ between the two groups. However, the timing of bleeding was significantly different; blood loss occurred during the pre-operative phase in the delayed surgery group (p
Published: 2017
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33. Use of factor concentrates for the management of perioperative bleeding: reply

Author: David Faraoni, Charles-Marc Samama, Anne Godier, Andreas Greinacher, and Jerrold H. Levy
Subjects: medicine.medical_specialty, business.industry, MEDLINE, Hemorrhage, 030208 emergency & critical care medicine, Hematology, Perioperative, 030204 cardiovascular system & hematology, Blood coagulation factors, Blood Coagulation Factors, 03 medical and health sciences, 0302 clinical medicine, Text mining, medicine, Humans, Intensive care medicine, business
Published: 2018
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34. Scientific and Standardization Committee Communication: Guidance document on the periprocedural management of patients on chronic oral anticoagulant therapy: Recommendations for standardized reporting of procedural/surgical bleed risk and patient-specific thromboembolic risk

Author: Charles Marc Samama, Deborah M. Siegal, Alfonso Tafur, Joseph A. Caprini, Alex C. Spyropoulos, James D. Douketis, Karim Brohi, and Peter Verhamme
Subjects: medicine.medical_specialty, Time Factors, Standardization, Clinical Decision-Making, MEDLINE, Administration, Oral, Hemorrhage, Risk Assessment, Drug Administration Schedule, Perioperative Care, Risk Factors, Thromboembolism, medicine, Humans, Intensive care medicine, business.industry, Anticoagulants, Hematology, Perioperative, Patient specific, Bleed, medicine.disease, Thrombosis, Thromboembolic risk, Treatment Outcome, Surgical Procedures, Operative, Oral anticoagulant, business
Published: 2019

35. Andexanet alfa for the reversal of factor Xa inhibitors

Author: Julien Favresse, Michael Hardy, Charles-Marc Samama, A L Sennesael, M A van Dievoet, Ovidiu Ionut Vornicu, Sarah Lessire, Anne-Sophie Dincq, François Mullier, Jonathan Douxfils, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - (MGD) Service d'anesthésiologie, UCL - (MGD) Laboratoire de biologie clinique, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de biologie hématologique, and UCL - SSS/LDRI - Louvain Drug Research Institute
Subjects: 0301 basic medicine, medicine.drug_mechanism_of_action, factor Xa, medicine.medical_treatment, Clinical Biochemistry, Factor Xa Inhibitor, Hemorrhage, Pharmacology, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Drug Discovery, Factor Xa Inhibitors/immunology, medicine, Humans, In patient, Recombinant Proteins/biosynthesis, Antidote, Clinical Trials as Topic, business.industry, ANNEXA, virus diseases, Factor Xa/genetics, Andexanet alfa, DOACs, Recombinant Proteins, 030104 developmental biology, major bleeding, 030220 oncology & carcinogenesis, Factor Xa, Recombinant DNA, reversal agents, business, Major bleeding, antidote, Hemorrhage/drug therapy, medicine.drug, Factor Xa Inhibitors, Half-Life
Abstract: INTRODUCTION: Andexanet alfa is a recombinant modified factor Xa protein that has been developed to reverse factor Xa inhibitors. Since May 2018, the FDA has approved its utilization in patients treated with apixaban and rivaroxaban in case of life-threatening or uncontrolled bleeding. On 28 of February 2019, the Committee for Medicinal Products for Human Use adopted a positive opinion, recommending the granting of a conditional marketing authorization for andexanet alfa in Europe. Area covered: The authors provide an overview of andexanet alfa development and its pharmacokinetic and pharmacodynamic properties. The results of the clinical phase III trial ANNEXA as well as current limitations related to andexanet alfa are also discussed. Expert opinion: Although phase I and II studies have proven that andexanet alfa can be effective in reversing the effect of factor Xa inhibitors, its efficacy in major bleeding patients has only been shown for apixaban and rivaroxaban, without any comparator group. Well-designed studies comparing the efficacy and safety of andexanet alfa to other reversal strategies are required to confirm preliminary data. The benefit of andexanet alfa in specific settings needs to be investigated and its use in clinical practice needs to be facilitated by the implementation of international guidelines.
Published: 2019

36. Fast-Track Procedures in Major Orthopaedic Surgery: Is Venous Thromboembolism Prophylaxis Still Mandatory?

Author: Charles Marc Samama
Subjects: medicine.medical_specialty, business.industry, General surgery, Arthroplasty, Replacement, Hip, Cardiology, Anticoagulants, Hematology, Venous Thromboembolism, Continuity of Patient Care, Length of Stay, Combined Modality Therapy, United States, Postoperative Complications, Research Design, Orthopedic surgery, Practice Guidelines as Topic, medicine, Humans, Orthopedic Procedures, Fast track, business, Arthroplasty, Replacement, Knee, Venous thromboembolism, Societies, Medical
Published: 2019

37. Additional file 2: of The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition

Author: Spahn, Donat, Bouillon, Bertil, Cerny, Vladimir, Duranteau, Jacques, Filipescu, Daniela, Hunt, Beverley, Komadina, Radko, Maegele, Marc, Nardi, Giuseppe, Riddez, Louis, Charles-Marc Samama, Jean-Louis Vincent, and Rossaint, Rolf
Abstract: Levels of evidence according to [45] for evidence cited in this guideline. (PDF 794 kb)
Published: 2019
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38. Additional file 3: of The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition

Author: Spahn, Donat, Bouillon, Bertil, Cerny, Vladimir, Duranteau, Jacques, Filipescu, Daniela, Hunt, Beverley, Komadina, Radko, Maegele, Marc, Nardi, Giuseppe, Riddez, Louis, Charles-Marc Samama, Jean-Louis Vincent, and Rossaint, Rolf
Abstract: Summary of recommendations. (PDF 103 kb)
Published: 2019
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39. Additional file 1: of The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition

Author: Spahn, Donat, Bouillon, Bertil, Cerny, Vladimir, Duranteau, Jacques, Filipescu, Daniela, Hunt, Beverley, Komadina, Radko, Maegele, Marc, Nardi, Giuseppe, Riddez, Louis, Charles-Marc Samama, Jean-Louis Vincent, and Rossaint, Rolf
Abstract: Structured literature search strategies. (PDF 34 kb)
Published: 2019
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40. Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after total hip or knee replacement: A nationwide database cohort study

Author: Régis Lassalle, Simon Lorrain, Stéphanie Lamarque, S. Lignot-Maleyran, Cécile Droz-Perroteau, Patrick Blin, Jacques Benichou, Nicholas Moore, Alain Sautet, Patrick Mismetti, Charles-Marc Samama, CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Rouen, Normandie Université (NU), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier
Subjects: Risk, Male, 0301 basic medicine, medicine.medical_specialty, Databases, Factual, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Total hip replacement, Knee replacement, Effectiveness, Hemorrhage, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Hip replacement, medicine, Humans, Arthroplasty, Replacement, Knee, Aged, Pharmacology, business.industry, Absolute risk reduction, Anticoagulants, Health Care Costs, Venous Thromboembolism, Heparin, Low-Molecular-Weight, Middle Aged, 3. Good health, Total knee replacement, Treatment Outcome, 030104 developmental biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Relative risk, Propensity score matching, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Venous thromboembolism prevention, France, business, Venous thromboembolism, Cohort study
Abstract: International audience; BACKGROUND: Venous thromboembolism (VTE) after total knee or hip replacement (TKR, THR) is usually prevented with low-molecular weight heparin (LMWH), and increasingly by direct oral anticoagulants (DOAC). The aim of the present study was to compare the benefit-risk and medical costs of DOAC vs. LMWH in a real-life setting. METHODS: All patients with THR or TKR in France between Jan-1st 2013 and Sep-30th 2014, discharged to home, were identified and followed-up for 3 months in the French nationwide claims database, SNDS. DOAC users were 1:1 matched with LWMH users on gender, age and propensity score. Relative risks (RR) of hospitalized VTE, hospitalized bleeding and death were estimated using quasi-Poisson models. Medical costs were calculated according to the societal perspective, including total cost for outpatient claims and national DRG costs for hospitalisations. RESULTS: Most DOAC users (>/= 98.8%) were matched to a LMWH patient. For the 63,238 matched THR patients, the 3-month absolute risk of VTE was 0.9 per thousand with DOAC and 2.5 per thousand with LMWH (RR = 0.35 [0.23 to 0.54]), of bleeding 1.8 per thousand and 2.1 per thousand (0.88 [0.62-1.25]), death 0.7 per thousand and 1.1 per thousand (0.68 [0.40-1.15]). For the 31,440 matched TKR patients, risks were 1.6 per thousand and 2.3 per thousand (0.69 [0.42-1.16]) for VTE, 2.4 per thousand and 3.8 per thousand (0.64 [0.43 to 0.97]) for bleeding, and 0.6 per thousand and 0.8 per thousand (0.69 [0.30-1.62]) for all-cause death. Mean medical costs were 28% and 21% lower with DOAC than LMWH for THR and TKR, respectively. This nationwide study found a very low risk of VTE, hospitalized bleeding and death after THR or TKR discharge in patients with VTE prevention in real-life setting, with better benefit-risk profiles of DOAC compared to LMWH, and associated cost savings.
Published: 2019
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41. Gestion des anticoagulants oraux directs pour la chirurgie et les actes invasifs programmés : propositions réactualisées du Groupe d’intérêt en hémostase périopératoire (GIHP) – septembre 2015

Author: Normand Blais, Patrick Mismetti, Emmanuel Marret, Pierre Fontana, Fanny Bonhomme, Sophie Susen, Annick Steib, Nadia Rosencher, Charles Marc Samama, Pierre Sié, Stéphanie Roullet, Dan Longrois, David Faraoni, Jean-François Schved, Jean-Philippe Collet, Juan V. Llau, Anne Godier, and Pierre Albaladejo
Subjects: 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030202 anesthesiology, 030204 cardiovascular system & hematology
Abstract: Resume Depuis 2011, l’experience et les donnees concernant les patients traites par anticoagulants oraux directs (AOD) et beneficiant d’un acte invasif programme se sont enrichies. Dans le meme temps, un accroissement du risque hemorragique lors de la realisation de relais anticoagulants preoperatoires a ete mis en evidence, sans reduction du risque thrombotique. Ces donnees nouvelles conduisent a adapter les propositions emises par le GIHP en 2011. Pour les actes programmes a risque hemorragique faible, il est propose de ne pas prendre d’AOD la veille au soir ni le matin de l’intervention, quel que soit le schema therapeutique du patient ; et de reprendre le traitement selon le schema habituel du patient et au moins 6 heures apres la fin du geste invasif. Pour les actes invasifs a risque hemorragique eleve, il est propose une derniere prise a j–3 pour le rivaroxaban, l’apixaban et l’edoxaban ; une derniere prise de dabigatran a j–4 si la clairance de la creatinine est superieure a 50 mL/min, a j–5 si la clairance est comprise entre 30 et 50 mL/min. Dans le cas de la neurochirurgie intracrânienne et de l’anesthesie neuraxiale, des delais plus longs sont conseilles. Il n’y a plus de place pour les relais anticoagulants ni pour la mesure des concentrations d’AOD sauf situations exceptionnelles.
Published: 2016
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42. Observational study of dabigatran etexilate 150 mg in patients with moderate renal impairment undergoing elective total hip or knee replacement

Author: Jenny Gullberg, Charles-Marc Samama, Eva Kleine, Nadia Rosencher, Martin Feuring, Simon P. Frostick, Martina Brueckmann, and Andreas Clemens
Subjects: Adult, Male, medicine.drug_class, Arthroplasty, Replacement, Hip, medicine.medical_treatment, Knee replacement, Renal function, Hemorrhage, 030204 cardiovascular system & hematology, Antithrombins, Dabigatran, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Renal Insufficiency, Arthroplasty, Replacement, Knee, Adverse effect, Aged, Aged, 80 and over, business.industry, Anticoagulant, Venous Thromboembolism, Hematology, Middle Aged, Confidence interval, Clinical trial, Treatment Outcome, 030228 respiratory system, Anesthesia, Female, Observational study, business, medicine.drug
Abstract: Introduction The standard dabigatran etexilate dosage for prevention of venous thromboembolism (VTE) after elective total hip or knee replacement (THR/TKR) is 220mg once daily (qd), with 150mg qd for patients with moderate renal impairment. As clinical trial experience in patients with moderate renal impairment was limited at the time of approval, we conducted an observational study to evaluate the 150mg qd dose. Materials and methods This open-label, prospective, uncontrolled, observational study in patients with creatinine clearance (CrCl) 30–50mL/min was conducted in seven European countries. Patients received 75mg dabigatran etexilate 1–4h after surgery and 150mg qd on days 2–10 (TKR) or 2–35 (THR), per the European Summary of Product Characteristics. Coprimary outcomes were major bleeding events (MBEs) and a composite of symptomatic VTE and all-cause mortality. Results 428 renally impaired patients with median CrCl 43.4mL/min (range 30.0–49.9), and median age 80years (range 32–96) received dabigatran etexilate: median treatment duration THR 31days, TKR 28days. Ten MBEs occurred in nine patients (2.1%; 95% confidence interval [CI]: 1.0–4.0; THR 1.8%; TKR 2.4%); none were fatal or involved a critical organ. Symptomatic VTE and all-cause mortality occurred in three patients (0.7%; 95% CI: 0.1–2.0; THR 0.9%; TKR 0.5%). Overall, 54 patients discontinued treatment prematurely, including 35 due to an adverse event (nine bleeding-related) and 16 switching to another anticoagulant. Conclusions Dabigatran etexilate 150mg qd had a good safety profile and was efficacious in fragile, elderly, renally impaired patients undergoing THR or TKR. These findings from the clinical practice setting add to the existing clinical trial data.
Published: 2016
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43. Réhabilitation rapide après chirurgie de résection pulmonaire

Author: Nithiya Ung, Charles-Marc Samama, and Yên-Lan Nguyen
Subjects: Gynecology, medicine.medical_specialty, business.industry, 030204 cardiovascular system & hematology, Emergency Nursing, Fast tracking, 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, 030228 respiratory system, Emergency Medicine, medicine, business, Enhanced recovery after surgery
Abstract: Resume La chirurgie de resection pulmonaire est le traitement de reference des cancers non a petites cellules. Cette chirurgie est a risque avec un taux de complications concernant pres d’un patient sur 3. La mise en place d’un programme de rehabilitation rapide apres chirurgie (RRAC) a pour objectif de reduire cette morbidite. Peu de donnees ont ete publiees sur la mise en place de ces programmes en chirurgie pulmonaire. Les etudes sont heterogenes par leur qualite, les populations et les programmes mis en place. Elles objectivent neanmoins une reduction du taux de complications postoperatoires, de duree de sejour hospitalier, sans augmentation du taux de readmissions et des couts engendres. Les parametres des programmes RRAC applicables a la chirurgie de resection pulmonaire sont le sevrage tabagique, la prise en charge analgesique, la gestion des drains pleuraux et la rehabilitation respiratoire et motrice. Le sevrage tabagique doit etre encourage meme peu de temps avant l’intervention. L’analgesie postoperatoire repose sur une technique locoregionale associee a une analgesie systemique. Il faut minimiser le nombre et la duree de mise en place des drainages pleuraux. Pour optimiser, la kinesitherapie respiratoire doit debuter en preoperatoire et se poursuivre en postoperatoire. La mise au fauteuil et la marche doivent etre initiees dans les premieres 24 heures.
Published: 2016
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44. Prévention de la maladie thromboembolique veineuse, chirurgie ambulatoire et nouveaux anticoagulants oraux directs

Author: Charles Marc Samama
Subjects: 03 medical and health sciences, 0302 clinical medicine, Anesthesiology and Pain Medicine, Emergency Medicine, 030212 general & internal medicine, 030204 cardiovascular system & hematology, Emergency Nursing
Abstract: Resume L’incidence d’evenements thromboemboliques est tres faible lors de la chirurgie ambulatoire. Les nouveaux anticoagulants oraux directs (AOD) ont une autorisation de mise sur le marche en thromboprophylaxie uniquement pour les suites de prothese totale de hanche et de genou. Certains ont un risque hemorragique un peu augmente. L’utilisation des AOD en thromboprophylaxie chez les patients ambulatoires n’est pas recommandee. Chez les patients traites par AOD pour fibrillation atriale, l’arret du traitement doit se faire 3 jours (xabans) ou 4 jours au moins (dabigatran) avant l’intervention et le delai de reprise peut etre de 48 a 72 heures.
Published: 2016
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45. Assessment of haemostasis in patients with cirrhosis

Author: Marie Bazin, Philippe Sogni, Claire Flaujac, Isabelle Gouin-Thibault, Firas Ibrahim, Charles-Marc Samama, and Claude Lentschener
Subjects: medicine.medical_specialty, Cirrhosis, Cross-sectional study, business.industry, 030204 cardiovascular system & hematology, medicine.disease, Gastroenterology, Surgery, 03 medical and health sciences, Thromboelastometry, 0302 clinical medicine, Anesthesiology and Pain Medicine, Internal medicine, Predictive value of tests, Hemostasis, medicine, 030211 gastroenterology & hepatology, In patient, Liver dysfunction, business, Prospective cohort study
Abstract: BACKGROUNDIn patients with cirrhosis, decreased rotational thromboelastometry (ROTEM) parameters suggest hypocoagulability secondary to liver dysfunction. However, observed normal or increased thrombin generation suggests preserved haemostasis and/or a procoagulant state. The correlated levels of bo
Published: 2016
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46. Open access to research data

Author: Stefan De Hert and Charles Marc Samama
Subjects: Open science, medicine.medical_specialty, Biomedical Research, Quality management, MEDLINE, Alternative medicine, Publishing ethics, 030204 cardiovascular system & hematology, Access to Information, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, media_common.cataloged_instance, European Union, 030212 general & internal medicine, European union, Policy Making, media_common, Research data, Publishing, Information Dissemination, business.industry, Public relations, Quality Improvement, Anesthesiology and Pain Medicine, Reporting bias, business
Published: 2017
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47. Stopping or maintaining oral anticoagulation in patients undergoing photoselective vaporization of the prostate (SOAP) surgery for benign prostate obstruction: study protocol for a multicentre randomized controlled trial

Author: L. Corbel, Emmanuel Della Negra, Abdel-Rahmène Azzouzi, Marie Pasquie, Sébastien Vincendeau, Valerie Fuzier, Franck Bruyère, Benoit Peyronnet, Benjamin Pradere, Atul Pathak, Georges Fournier, Aurélien Descazeaud, Thibaut Culty, Hélène Charbonneau, Pierre Albaladejo, Gilles Karsenty, C. Thuillier, Audrey Hesbois, Gaelle Fiard, Jean-Luc Descotes, Souhil Lebdai, C. Ballereau, Nicolas Savy, Nicolas Barry-Delongchamps, J. Calves, Vincent Misrai, Romain Mathieu, Pierre Colin, Charles Marc Samama, Felipe Guerrero, Jean-Alexandre Long, Clinique Pasteur [Toulouse], Service d'urologie [Rennes] = Urology [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'urologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Privé des Côtes d'Armor (HPCA), Chirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Gestes Medico-chirurgicaux Assistés par Ordinateur (TIMC-IMAG-GMCAO), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service d'urologie [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service d'urologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Mathématiques de Toulouse UMR5219 (IMT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Service d'urologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10
Subjects: Male, medicine.medical_specialty, Time Factors, Complications, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Prostatic Hyperplasia, 030232 urology & nephrology, Oral anticoagulation, Administration, Oral, Medicine (miscellaneous), Laser, Equivalence Trials as Topic, Drug Administration Schedule, law.invention, Study Protocol, 03 medical and health sciences, 0302 clinical medicine, Lower Urinary Tract Symptoms, Randomized controlled trial, law, Prostate, Lower urinary tract symptoms, medicine, Humans, Multicenter Studies as Topic, Pharmacology (medical), Transurethral resection of the prostate, lcsh:R5-920, business.industry, Anticoagulants, GreenLight, Perioperative, Evidence-based medicine, Heparin, medicine.disease, Confidence interval, 3. Good health, Surgery, Treatment Outcome, medicine.anatomical_structure, 030220 oncology & carcinogenesis, France, Laser Therapy, Benign prostatic obstruction, lcsh:Medicine (General), business, medicine.drug
Abstract: Lower urinary tract symptoms related to benign prostatic obstruction (BPO) are frequent in men aged > 50 years. Based on the use of innovative medical devices, a number of transurethral ablative techniques have recently been developed for the surgical treatment of BPO. In recent years, GreenLight photoselective vaporization of the prostate (PVP) has been considered as a non-inferior alternative to transurethral resection of the prostate. The GreenLight PVP is usually considered as an interesting surgical option for patients treated via oral anticoagulants (OACs) with regard to its haemostatic properties. The aim of this study was to assess the impact of maintaining OAC treatment in patients undergoing PVP. This study is a multicentre, open-label, randomized controlled trial (RCT) designed to show the non-inferiority of PVP surgery in patients with BPO treated with OACs. This study is designed to enrol 386 OAC-treated patients (treated with vitamin K antagonists and direct oral anticoagulants) who are undergoing PVP for BPO. Patients will be randomized (1:1) to either maintain or stop OAC treatment during the perioperative course. The intervention group will maintain OAC treatment until the day before surgery and resume OAC treatment the day after surgery, whereas the control group will stop OAC treatment (with or without low-molecular-weight heparin bridging therapy) according to the anaesthesia guidelines. The primary outcome of interest to be assessed is the 30-day complications rate according to the Clavien-Dindo classification. The secondary endpoint will examine the 30-day rate of haemorrhagic and thrombotic events. This study will provide 80% power to show non-inferiority, defined as not worse than a 10% (non-inferiority margin) inferior change in the proportion of patients with good outcomes (Clavien-Dindo score
Published: 2018
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48. Postoperative outcomes of frequent exacerbator patients with Chronic Obstructive Pulmonary Disease after resection of Non-Small Cells Lung Cancer

Author: C. Lorut, Nicolas Roche, A. Lefebvre, Antoine Rabbat, Charles-Marc Samama, Jean-François Regnard, Marco Alifano, Suela Demiri, Daniel Dusser, and Daniel Luu van Lang
Subjects: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Pulmonary Atelectasis, Lung Neoplasms, Vital Capacity, Pulmonary disease, 030204 cardiovascular system & hematology, Resection, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Postoperative Complications, Sex Factors, Risk Factors, Internal medicine, Carcinoma, Non-Small-Cell Lung, Forced Expiratory Volume, Surveys and Questionnaires, medicine, Odds Ratio, Humans, Prospective Studies, Risk factor, Lung cancer, Bronchitis, Pneumonectomy, Respiratory Tract Infections, Aged, COPD, business.industry, Pneumonia, Middle Aged, medicine.disease, Respiration, Artificial, respiratory tract diseases, Logistic Models, Phenotype, 030228 respiratory system, Disease Progression, Female, Tracheitis, business, Respiratory Insufficiency
Abstract: Chronic obstructive pulmonary disease (COPD) is a risk factor of post-operative complications after lung cancer resection. The influence of the "frequent exacerbator (FE)" phenotype (at least three exacerbations per year) is unknown. Postoperative outcomes of frequent exacerbators (POFE) was a prospective observational study of patients with COPD undergoing lung resection for cancer. The inclusion criteria were: age40 years, FEV1/FVC70%, non-urgent surgery for lung cancer, filled out self-questionnaires. The primary outcome was assessment of postoperative pulmonary complications (purulent tracheobronchitis, atelectasis, pneumonia, acute respiratory failure, need of mechanical ventilation). Secondary outcomes encompassed the prevalence of the FE phenotype and its impact on postoperative complications. A total of 682 patients were screened from June 2014 to October 2015. 93 patients with COPD were included, 21 (23%) were FE. Postoperative tracheobronchitis, atelectasis pneumonia or respiratory failure (isolated or associated) occurred in 47%, 48%, 26%, and 38% of patients, respectively. Non-invasive and invasive mechanical ventilation were necessary in 4 (4%) and 22 (23%) patients. Purulent tracheobronchitis, pneumonia and hypercapnia (this last requiring noninvasive mechanical ventilation) were more frequent in FE (p = 0.043, 0.042, 0.015); however the number of patients wth at least one respiratory complication was not different (76% vs. 52%, p = 0.056). In all patients, multivariate logistic regression identified two independent factors of postoperative respiratory complications: male sex (OR 10.6 [95% CI 1.97-57.6], p = 0.006) and the FE phenotype (OR 6.33 [1.04-38.39], p = 0.045). Occurrence of postoperative complications in patients with COPD is high. FE phenotype is an independent risk factor.
Published: 2018

49. Hémostase et anesthésie

Author: Fanny Bonhomme, Benjamin Gafsou, and Charles Marc Samama
Published: 2018
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50. The utility of viscoelastic methods in the prevention and treatment of bleeding and hospital-associated venous thromboembolism in perioperative care: guidance from the SSC of the ISTH

Author: W. Thomas, Andreas Greinacher, Charles-Marc Samama, and Beverley J Hunt
Subjects: medicine.medical_specialty, Cardiology, Hemorrhage, 030204 cardiovascular system & hematology, Perioperative Care, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, medicine, Humans, Intensive care medicine, Perioperative Period, Blood Coagulation, Hemostasis, business.industry, Viscosity, Anticoagulants, Fibrinogen, Hematology, Venous Thromboembolism, Elasticity, Hospitalization, Perioperative care, Practice Guidelines as Topic, business, Venous thromboembolism
Published: 2018

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