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Introduction Unruptured intracranial aneurysms (UIA) are common in the adult population, but only a relatively small proportion will rupture. It is therefore essential to have accurate estimates of rupture risk to target treatment towards those who stand to benefit and avoid exposing patients to the risks of unnecessary treatment. The best available UIA natural history data are the PHASES study. However, this has never been validated and given the known heterogeneity in the populations, methods and biases of the constituent studies, there is a need to do so. There are also many potential predictors not considered in PHASES that require evaluation, and the estimated rupture risk is largely based on short-term follow-up (mostly 1 year). The aims of this study are to: (1) test the accuracy of PHASES in a UK population, (2) evaluate additional predictors of rupture and (3) assess long-term UIA rupture rates.Methods and analysis The Risk of Aneurysm Rupture study is a longitudinal multicentre study that will identify patients with known UIA seen in neurosurgery units. Patients will have baseline demographics and aneurysm characteristics collected by their neurosurgery unit and then a single aggregated national cohort will be linked to databases of hospital admissions and deaths to identify all patients who may have subsequently suffered a subarachnoid haemorrhage. All matched admissions and deaths will be checked against medical records to confirm the diagnosis of aneurysmal subarachnoid haemorrhage. The target sample size is 20 000 patients. The primary outcome will be aneurysm rupture resulting in hospital admission or death. Cox regression models will be built to test each of the study’s aims.Ethics and dissemination Ethical approval has been given by South Central Hampshire A Research Ethics Committee (21SC0064) and Confidentiality Advisory Group support (21CAG0033) provided under Section 251 of the NHS Act 2006. The results will be disseminated in peer-reviewed journals.Trial registration number ISRCTN17658526.

IUD occurred in 1.8% (95% CI 0.4-4.4) of DCDA pregnancies with and in 0.6% (95% CI 0.4-0.9) of those non-complicated by sFGR, while the corresponding figures for NND were 2.1% (95% CI 1.2-3.1) and 2.8% (95% 1.0-5.5). Relative risk (RR) and 95% confidence interval (CI) was calculated to assess the association between SGA and stillbirth using the two standards. OP.0024 Prenatal exome sequencing and Central Nervous System anomalies: Systematic review and meta-an... Gillian Blayney 1; Preethi Jacob 2; Caitlin Baptiste 3; Heinz Gabriel 4; Teresa Sparks 5... 1 Fetal Medicine Department, Royal Jubilee Maternity Service, Belfast Health and Social Care... B Objective: b Structural anomalies detected on ultrasound in fetuses with normal conventional karyotyping or chromosomal microarray (CMA) often pose a diagnostic and management challenge. The IG21 standard designated 3096 EFWs as SGA (1.4%) including 12 stillbirths (RR 3.4 CI 1.9-6.0), while according to the customised GROW standard, 9145 (4.2%) EFWs were SGA, with 25 stillbirths (RR 2.4; CI 1.6-3.6). [Extracted from the article]

Primary outcome was pregnancy loss (miscarriage, neonatal death, termination, stillbirth), secondary outcomes included pregnancy prolongation, preterm birth, and maternal and neonatal outcomes. 24 Reducing inequalities in preterm birth and stillbirth through personalised risk-assessment an... Jenny Carter 1; Jane Sandall 1; Tommy's National Centre for Maternity Improvement 2 1 King's College London, London, UK; 2 Royal College of Obstetricians and Gynaecologists, Lon... B Abstract b B Background: b The Tommy's App (a web-based, CE-marked medical device) assesses risk of placental dysfunction and preterm birth much more accurately than current methods, and instantly recommends personalised evidenced-based care pathways. The model included mothers age, height, parity, smoking status, ethnicity, and any history of hypertension, pre-eclampsia, previous stillbirth or SGA baby, and gestational age at delivery. Longitudinal maternal cardiac adaptation in hypertensive disorders of pregnancy Hua Zen Ling; Gavin Guy; Kypros H. Nicolaides; Nikos A. Kametas Fetal Medicine Research Institute, King's College London, London, UK B Abstract b Preeclampsia (PE), compared to gestational hypertension (GH) has traditionally been considered the most severe hypertensive disorders in pregnancy, with worse outcomes and future cardiovascular morbidities. The model included mothers age, height, weight, mode of conception, parity, smoking status, ethnicity, and any history of diabetes, hypertension, pre-eclampsia, previous stillbirth or SGA baby, and gestational age at delivery. [Extracted from the article]