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28 results on '"Chau, Nguyen Hoang"'

1. The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial

Author

Thriemer, Kamala, Commons, Robert James, Rajasekhar, Megha, Degaga, Tamiru Shibiru, Chand, Krisin, Chau, Nguyen Hoang, Assefa, Ashenafi, Naddim, Mohammad Nader, Pasaribu, Ayodhia Pitaloka, Rahim, Awab Ghulam, Sutanto, Inge, Hien, Tran Tinh, Hailu, Asrat, Hasanzai, Mohammad Anwar, Ekawati, Lenny L., Woyessa, Adugna, Teferi, Tedla, Waithira, Naomi, Taylor, Walter R. J., Ley, Benedikt, Dondorp, Arjen, Baird, J. Kevin, White, Nicholas J., Day, Nicholas P., Price, Ric N., Simpson, Julie A., and von Seidlein, Lorenz

Published
2023
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2. Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Erhart, Annette, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Koh, Gavin CKW, Mekuria, Asrat Hailu, Mueller, Ivo, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Price, David J, Sattabongkot, Jetsumon, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Commons, Robert J, Rajasekhar, Megha, Edler, Peta, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Barber, Bridget E, Chu, Cindy S, Cui, Liwang, Daher, André, Gonzalez-Ceron, Lilia, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Lidia, Kartini, Llanos-Cuentas, Alejandro, Longley, Rhea J, Pereira, Dhelio B, Pasaribu, Ayodhia P, Pukrittayakamee, Sasithon, Rijal, Komal R, Sutanto, Inge, Taylor, Walter R J, Thanh, Pham V, Thriemer, Kamala, Vieira, José Luiz F, Watson, James A, Zuluaga-Idarraga, Lina M, White, Nicholas J, Guerin, Philippe J, Simpson, Julie A, and Price, Ric N

Published
2024
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3. Primaquine dose and the risk of haemolysis in patients with uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis

Author

Adhikari, Bipin, Alam, Mohammad Shafiul, Anstey, Nicholas M, Assefa, Ashenafi, Boyd, Sarah C, Chau, Nguyen Hoang, Day, Nicholas PJ, Degaga, Tamiru Shibiru, Dondorp, Arjen M, Ferreira, Marcelo Urbano, Ghimire, Prakash, Green, Justin A, Khan, Wasif Ali, Koh, Gavin CKW, Mekuria, Asrat Hailu, Naadim, Mohammad Nader, Nelwan, Erni J, Nosten, Francois, Pasaribu, Ayodhia Pitaloka, Price, David J, Stepniewska, Kasia, von Seidlein, Lorenz, William, Timothy, Woodrow, Charles J, Woyessa, Adugna, Rajasekhar, Megha, Simpson, Julie A, Ley, Benedikt, Edler, Peta, Chu, Cindy S, Abreha, Tesfay, Awab, Ghulam R, Baird, J Kevin, Bancone, Germana, Barber, Bridget E, Grigg, Matthew J, Hwang, Jimee, Karunajeewa, Harin, Lacerda, Marcus V G, Ladeia-Andrade, Simone, Llanos-Cuentas, Alejandro, Pukrittayakamee, Sasithon, Rijal, Komal R, Saravu, Kavitha, Sutanto, Inge, Taylor, Walter R J, Thriemer, Kamala, Watson, James A, Guerin, Philippe J, White, Nicholas J, Price, Ric N, and Commons, Robert J

Published
2024
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4. Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination.

Author

Jacob, Christopher G, Thuy-Nhien, Nguyen, Mayxay, Mayfong, Maude, Richard J, Quang, Huynh Hong, Hongvanthong, Bouasy, Vanisaveth, Viengxay, Ngo Duc, Thang, Rekol, Huy, van der Pluijm, Rob, von Seidlein, Lorenz, Fairhurst, Rick, Nosten, François, Hossain, Md Amir, Park, Naomi, Goodwin, Scott, Ringwald, Pascal, Chindavongsa, Keobouphaphone, Newton, Paul, Ashley, Elizabeth, Phalivong, Sonexay, Maude, Rapeephan, Leang, Rithea, Huch, Cheah, Dong, Le Thanh, Nguyen, Kim-Tuyen, Nhat, Tran Minh, Hien, Tran Tinh, Nguyen, Hoa, Zdrojewski, Nicole, Canavati, Sara, Sayeed, Abdullah Abu, Uddin, Didar, Buckee, Caroline, Fanello, Caterina I, Onyamboko, Marie, Peto, Thomas, Tripura, Rupam, Amaratunga, Chanaki, Myint Thu, Aung, Delmas, Gilles, Landier, Jordi, Parker, Daniel M, Chau, Nguyen Hoang, Lek, Dysoley, Suon, Seila, Callery, James, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Phyo, Aung Pyae, Smithuis, Frank, Lin, Khin, Thant, Myo, Hlaing, Tin Maung, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa K, Tripura, Amar, Baidya, Subrata, Valecha, Neena, Anvikar, Anupkumar R, Ul Islam, Akhter, Faiz, Abul, Kunasol, Chanon, Drury, Eleanor, Kekre, Mihir, Ali, Mozam, Love, Katie, Rajatileka, Shavanthi, Jeffreys, Anna E, Rowlands, Kate, Hubbart, Christina S, Dhorda, Mehul, Vongpromek, Ranitha, Kotanan, Namfon, Wongnak, Phrutsamon, Almagro Garcia, Jacob, Pearson, Richard D, Ariani, Cristina V, Chookajorn, Thanat, Malangone, Cinzia, Nguyen, T, Stalker, Jim, Jeffery, Ben, Keatley, Jonathan, Johnson, Kimberly J, Muddyman, Dawn, Chan, Xin Hui S, Sillitoe, John, Amato, Roberto, Simpson, Victoria, Gonçalves, Sonia, Rockett, Kirk, Day, Nicholas P, Dondorp, Arjen M, Kwiatkowski, Dominic P, and Miotto, Olivo

Subjects
asia, drug resistance, epidemiology, genetic surveillance, global health, infectious disease, malaria, microbiology, Biochemistry and Cell Biology
Abstract

BackgroundNational Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.MethodsSamples from symptomatic patients are processed by SpotMalaria, a high-throughput system that produces a comprehensive set of genotypes comprising several drug resistance markers, species markers and a genomic barcode. GenRe-Mekong delivers Genetic Report Cards, a compendium of genotypes and phenotype predictions used to map prevalence of resistance to multiple drugs.ResultsGenRe-Mekong has worked with NMCPs and research projects in eight countries, processing 9623 samples from clinical cases. Monitoring resistance markers has been valuable for tracking the rapid spread of parasites resistant to the dihydroartemisinin-piperaquine combination therapy. In Vietnam and Laos, GenRe-Mekong data have provided novel knowledge about the spread of these resistant strains into previously unaffected provinces, informing decision-making by NMCPs.ConclusionsGenRe-Mekong provides detailed knowledge about drug resistance at a local level, and facilitates data sharing at a regional level, enabling cross-border resistance monitoring and providing the public health community with valuable insights. The project provides a rich open data resource to benefit the entire malaria community.FundingThe GenRe-Mekong project is funded by the Bill and Melinda Gates Foundation (OPP11188166, OPP1204268). Genotyping and sequencing were funded by the Wellcome Trust (098051, 206194, 203141, 090770, 204911, 106698/B/14/Z) and Medical Research Council (G0600718). A proportion of samples were collected with the support of the UK Department for International Development (201900, M006212), and Intramural Research Program of the National Institute of Allergy and Infectious Diseases.

Published
2021

5. Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity in Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis

Author

Fadilah, Ihsan, primary, Commons, Robert J, additional, Chau, Nguyen Hoang, additional, Chu, Cindy S, additional, Day, Nicholas PJ, additional, Koh, Gavin CKW, additional, Green, Justin A, additional, Lacerda, Marcus VG, additional, Llanos-Cuentas, Alejandro, additional, Nelwan, Erni J, additional, Nosten, Francois, additional, Pasaribu, Ayodhia Pitaloka, additional, Sutanto, Inge, additional, Taylor, Walter RJ, additional, Thriemer, Kamala, additional, Price, Ric N, additional, White, Nicholas J, additional, Baird, J Kevin, additional, and Watson, James A, additional

Published
2024
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6. Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial

Author

Peto, Thomas J, Tripura, Rupam, Callery, James J, Lek, Dysoley, Nghia, Ho Dang Trung, Nguon, Chea, Thuong, Nguyen Thi Huyen, van der Pluijm, Rob W, Dung, Nguyen Thi Phuong, Sokha, Meas, Van Luong, Vo, Long, Le Thanh, Sovann, Yok, Duanguppama, Jureeporn, Waithira, Naomi, Hoglund, Richard M, Chotsiri, Palang, Chau, Nguyen Hoang, Ruecker, Andrea, Amaratunga, Chanaki, Dhorda, Mehul, Miotto, Olivo, Maude, Richard J, Rekol, Huy, Chotivanich, Kesinee, Tarning, Joel, von Seidlein, Lorenz, Imwong, Mallika, Mukaka, Mavuto, Day, Nicholas P J, Hien, Tran Tinh, White, Nicholas J, and Dondorp, Arjen M

Published
2022
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7. Case Series of Primaquine-Induced Haemolytic Events in Controlled Trials with G6PD Screening

Author

Kosasih, Ayleen, primary, James, Robert, additional, Chau, Nguyen Hoang, additional, Karman, Michelle M., additional, Panggalo, Lydia Visita, additional, Wini, Lyndes, additional, Thanh, Ngo Viet, additional, Obadia, Thomas, additional, Satyagraha, Ari Winasti, additional, Asih, Puji Budi Setia, additional, Syafruddin, Din, additional, Taylor, Walter R. J., additional, Mueller, Ivo, additional, Sutanto, Inge, additional, Karunajeewa, Harin, additional, Pasaribu, Ayodhia Pitaloka, additional, and Baird, J. Kevin, additional

Published
2023
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8. Weekly primaquine for radical cure of patients with Plasmodium vivax malaria and glucose-6-phosphate dehydrogenase deficiency

Author

Taylor, Walter R. J., primary, Meagher, Niamh, additional, Ley, Benedikt, additional, Thriemer, Kamala, additional, Bancone, Germana, additional, Satyagraha, Ari, additional, Assefa, Ashenafi, additional, Chand, Krisin, additional, Chau, Nguyen Hoang, additional, Dhorda, Mehul, additional, Degaga, Tamiru S., additional, Ekawati, Lenny L., additional, Hailu, Asrat, additional, Hasanzai, Mohammad Anwar, additional, Naddim, Mohammad Nader, additional, Pasaribu, Ayodhia Pitaloka, additional, Rahim, Awab Ghulam, additional, Sutanto, Inge, additional, Thanh, Ngo Viet, additional, Tuyet-Trinh, Nguyen Thi, additional, Waithira, Naomi, additional, Woyessa, Adugna, additional, Dondorp, Arjen, additional, von Seidlein, Lorenz, additional, Simpson, Julie A., additional, White, Nicholas J., additional, Baird, J. Kevin, additional, Day, Nicholas P., additional, and Price, Ric N., additional

Published
2023
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9. Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

Author

van der Pluijm, Rob W, Imwong, Mallika, Chau, Nguyen Hoang, Hoa, Nhu Thi, Thuy-Nhien, Nguyen Thanh, Thanh, Ngo Viet, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Chutasmit, Kitipumi, Saelow, Chalermpon, Runjarern, Ratchadaporn, Kaewmok, Weerayuth, Tripura, Rupam, Peto, Thomas J, Yok, Sovann, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Lek, Dysoley, Huy, Rekol, Dhorda, Mehul, Chotivanich, Kesinee, Ashley, Elizabeth A, Mukaka, Mavuto, Waithira, Naomi, Cheah, Phaik Yeong, Maude, Richard J, Amato, Roberto, Pearson, Richard D, Gonçalves, Sónia, Jacob, Christopher G, Hamilton, William L, Fairhurst, Rick M, Tarning, Joel, Winterberg, Markus, Kwiatkowski, Dominic P, Pukrittayakamee, Sasithon, Hien, Tran Tinh, Day, Nicholas PJ, Miotto, Olivo, White, Nicholas J, and Dondorp, Arjen M

Published
2019
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10. Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study

Author

Hamilton, William L, Amato, Roberto, van der Pluijm, Rob W, Jacob, Christopher G, Quang, Huynh Hong, Thuy-Nhien, Nguyen Thanh, Hien, Tran Tinh, Hongvanthong, Bouasy, Chindavongsa, Keobouphaphone, Mayxay, Mayfong, Huy, Rekol, Leang, Rithea, Huch, Cheah, Dysoley, Lek, Amaratunga, Chanaki, Suon, Seila, Fairhurst, Rick M, Tripura, Rupam, Peto, Thomas J, Sovann, Yok, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Chau, Nguyen Hoang, Imwong, Mallika, Dhorda, Mehul, Vongpromek, Ranitha, Chan, Xin Hui S, Maude, Richard J, Pearson, Richard D, Nguyen, T, Rockett, Kirk, Drury, Eleanor, Gonçalves, Sónia, White, Nicholas J, Day, Nicholas P, Kwiatkowski, Dominic P, Dondorp, Arjen M, and Miotto, Olivo

Published
2019
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11. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

Author

Adam, Ishag, Alam, Mohammad Shafiul, Alemu, Sisay, Amaratunga, Chanaki, Amato, Roberto, Andrianaranjaka, Voahangy, Anstey, Nicholas M, Aseffa, Abraham, Ashley, Elizabeth, Assefa, Ashenafi, Auburn, Sarah, Barber, Bridget E, Barry, Alyssa, Batista Pereira, Dhelio, Cao, Jun, Chau, Nguyen Hoang, Chotivanich, Kesinee, Chu, Cindy, Dondorp, Arjen M, Drury, Eleanor, Echeverry, Diego F, Erko, Berhanu, Espino, Fe, Fairhurst, Rick, Faiz, Abdul, Fernanda Villegas, María, Gao, Qi, Golassa, Lemu, Goncalves, Sonia, Grigg, Matthew J, Hamedi, Yaghoob, Hien, Tran Tinh, Htut, Ye, Johnson, Kimberly J, Karunaweera, Nadira, Khan, Wasif, Krudsood, Srivicha, Kwiatkowski, Dominic P, Lacerda, Marcus, Ley, Benedikt, Lim, Pharath, Liu, Yaobao, Llanos-Cuentas, Alejandro, Lon, Chanthap, Lopera-Mesa, Tatiana, Marfurt, Jutta, Michon, Pascal, Miotto, Olivo, Mohammed, Rezika, Mueller, Ivo, Namaik-Larp, Chayadol, Newton, Paul N, Nguyen, Thuy-Nhien, Nosten, Francois, Noviyanti, Rintis, Pava, Zuleima, Pearson, Richard D, Petros, Beyene, Phyo, Aung P, Price, Ric N, Pukrittayakamee, Sasithon, Rahim, Awab Ghulam, Randrianarivelojosia, Milijaona, Rayner, Julian C, Rumaseb, Angela, Siegel, Sasha V, Simpson, Victoria J, Thriemer, Kamala, Tobon-Castano, Alberto, Trimarsanto, Hidayat, Urbano Ferreira, Marcelo, Vélez, Ivan D, Wangchuk, Sonam, Wellems, Thomas E, White, Nicholas J, William, Timothy, Yasnot, Maria F, Yilma, Daniel, Alam, Mohammad Shafiul [0000-0001-8330-5499], Ashley, Elizabeth [0000-0002-7620-4822], Barber, Bridget E [0000-0003-1066-7960], Batista Pereira, Dhelio [0000-0002-7761-5498], Chu, Cindy [0000-0001-9465-8214], Dondorp, Arjen M [0000-0001-5190-2395], Echeverry, Diego F [0000-0003-0301-4478], Espino, Fe [0000-0003-1690-1711], Faiz, Abdul [0000-0002-3460-7535], Golassa, Lemu [0000-0002-1216-8711], Grigg, Matthew J [0000-0001-9914-8352], Karunaweera, Nadira [0000-0003-3985-1817], Kwiatkowski, Dominic P [0000-0002-5023-0176], Ley, Benedikt [0000-0002-5734-0845], Miotto, Olivo [0000-0001-8060-6771], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Pearson, Richard D [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Urbano Ferreira, Marcelo [0000-0002-5293-9090], Wellems, Thomas E [0000-0003-3899-8454], Yasnot, Maria F [0000-0001-8081-4212], Yilma, Daniel [0000-0001-6058-2696], and Apollo - University of Cambridge Repository

Subjects
parasitic diseases, Genomics, Genomic Epidemiology, Plasmodium vivax, Malaria, Data Resource
Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination.

Published
2022

12. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples

Author

MalariaGEN, Adam, Ishag, Alam, Mohammad Shafiul, Alemu, Sisay, Amaratunga, Chanaki, Amato, Roberto, Andrianaranjaka, Voahangy, Anstey, Nicholas M, Aseffa, Abraham, Ashley, Elizabeth, Assefa, Ashenafi, Auburn, Sarah, Barber, Bridget E, Barry, Alyssa, Batista Pereira, Dhelio, Cao, Jun, Chau, Nguyen Hoang, Chotivanich, Kesinee, Chu, Cindy, Dondorp, Arjen M, Drury, Eleanor, Echeverry, Diego F, Erko, Berhanu, Espino, Fe, Fairhurst, Rick, Faiz, Abdul, Fernanda Villegas, María, Gao, Qi, Golassa, Lemu, Goncalves, Sonia, Grigg, Matthew J, Hamedi, Yaghoob, Hien, Tran Tinh, Htut, Ye, Johnson, Kimberly J, Karunaweera, Nadira, Khan, Wasif, Krudsood, Srivicha, Kwiatkowski, Dominic P, Lacerda, Marcus, Ley, Benedikt, Lim, Pharath, Liu, Yaobao, Llanos-Cuentas, Alejandro, Lon, Chanthap, Lopera-Mesa, Tatiana, Marfurt, Jutta, Michon, Pascal, Miotto, Olivo, Mohammed, Rezika, Mueller, Ivo, Namaik-Larp, Chayadol, Newton, Paul N, Nguyen, Thuy-Nhien, Nosten, Francois, Noviyanti, Rintis, Pava, Zuleima, Pearson, Richard D, Petros, Beyene, Phyo, Aung P, Price, Ric N, Pukrittayakamee, Sasithon, Rahim, Awab Ghulam, Randrianarivelojosia, Milijaona, Rayner, Julian C, Rumaseb, Angela, Siegel, Sasha V, Simpson, Victoria J, Thriemer, Kamala, Tobon-Castano, Alberto, Trimarsanto, Hidayat, Urbano Ferreira, Marcelo, Vélez, Ivan D, Wangchuk, Sonam, Wellems, Thomas E, White, Nicholas J, William, Timothy, Yasnot, Maria F, Yilma, Daniel, AII - Infectious diseases, Intensive Care Medicine, MalariaGEN, Alam, Mohammad Shafiul [0000-0001-8330-5499], Ashley, Elizabeth [0000-0002-7620-4822], Barber, Bridget E [0000-0003-1066-7960], Batista Pereira, Dhelio [0000-0002-7761-5498], Chu, Cindy [0000-0001-9465-8214], Dondorp, Arjen M [0000-0001-5190-2395], Echeverry, Diego F [0000-0003-0301-4478], Espino, Fe [0000-0003-1690-1711], Faiz, Abdul [0000-0002-3460-7535], Golassa, Lemu [0000-0002-1216-8711], Karunaweera, Nadira [0000-0003-3985-1817], Kwiatkowski, Dominic P [0000-0002-5023-0176], Ley, Benedikt [0000-0002-5734-0845], Miotto, Olivo [0000-0001-8060-6771], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Pearson, Richard D [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Urbano Ferreira, Marcelo [0000-0002-5293-9090], Wellems, Thomas E [0000-0003-3899-8454], Yasnot, Maria F [0000-0001-8081-4212], Yilma, Daniel [0000-0001-6058-2696], and Apollo - University of Cambridge Repository

Subjects
Data resource, parasitic diseases, Medicine (miscellaneous), Genomics, Genomic epidemiology, Plasmodium vivax, General Biochemistry, Genetics and Molecular Biology, Malaria
Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr, dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination.

Published
2022

13. Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivax malaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase 2 trial

Author

Vélez, Iván D, primary, Hien, Tran T, additional, Green, Justin A, additional, Martin, Ana, additional, Sharma, Hema, additional, Rousell, Victoria M, additional, Breton, John J, additional, Ernest, Terry B, additional, Rolfe, Katie, additional, Taylor, Maxine, additional, Mohamed, Khadeeja, additional, Jones, Siôn W, additional, Chau, Nguyen Hoang, additional, Hoa, Nhu Thi, additional, Duparc, Stephan, additional, Tan, Lionel K, additional, and Goyal, Navin, additional

Published
2022
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14. Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Author

Jacob, Christopher G, primary, Thuy-Nhien, Nguyen, additional, Mayxay, Mayfong, additional, Maude, Richard J, additional, Quang, Huynh Hong, additional, Hongvanthong, Bouasy, additional, Vanisaveth, Viengxay, additional, Ngo Duc, Thang, additional, Rekol, Huy, additional, van der Pluijm, Rob, additional, von Seidlein, Lorenz, additional, Fairhurst, Rick, additional, Nosten, François, additional, Hossain, Md Amir, additional, Park, Naomi, additional, Goodwin, Scott, additional, Ringwald, Pascal, additional, Chindavongsa, Keobouphaphone, additional, Newton, Paul, additional, Ashley, Elizabeth, additional, Phalivong, Sonexay, additional, Maude, Rapeephan, additional, Leang, Rithea, additional, Huch, Cheah, additional, Dong, Le Thanh, additional, Nguyen, Kim-Tuyen, additional, Nhat, Tran Minh, additional, Hien, Tran Tinh, additional, Nguyen, Hoa, additional, Zdrojewski, Nicole, additional, Canavati, Sara, additional, Sayeed, Abdullah Abu, additional, Uddin, Didar, additional, Buckee, Caroline, additional, Fanello, Caterina I, additional, Onyamboko, Marie, additional, Peto, Thomas, additional, Tripura, Rupam, additional, Amaratunga, Chanaki, additional, Myint Thu, Aung, additional, Delmas, Gilles, additional, Landier, Jordi, additional, Parker, Daniel M, additional, Chau, Nguyen Hoang, additional, Lek, Dysoley, additional, Suon, Seila, additional, Callery, James, additional, Jittamala, Podjanee, additional, Hanboonkunupakarn, Borimas, additional, Pukrittayakamee, Sasithon, additional, Phyo, Aung Pyae, additional, Smithuis, Frank, additional, Lin, Khin, additional, Thant, Myo, additional, Hlaing, Tin Maung, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa K, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Valecha, Neena, additional, Anvikar, Anupkumar R, additional, Ul Islam, Akhter, additional, Faiz, Abul, additional, Kunasol, Chanon, additional, Drury, Eleanor, additional, Kekre, Mihir, additional, Ali, Mozam, additional, Love, Katie, additional, Rajatileka, Shavanthi, additional, Jeffreys, Anna E, additional, Rowlands, Kate, additional, Hubbart, Christina S, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Kotanan, Namfon, additional, Wongnak, Phrutsamon, additional, Almagro Garcia, Jacob, additional, Pearson, Richard D, additional, Ariani, Cristina V, additional, Chookajorn, Thanat, additional, Malangone, Cinzia, additional, Nguyen, T, additional, Stalker, Jim, additional, Jeffery, Ben, additional, Keatley, Jonathan, additional, Johnson, Kimberly J, additional, Muddyman, Dawn, additional, Chan, Xin Hui S, additional, Sillitoe, John, additional, Amato, Roberto, additional, Simpson, Victoria, additional, Gonçalves, Sonia, additional, Rockett, Kirk, additional, Day, Nicholas P, additional, Dondorp, Arjen M, additional, Kwiatkowski, Dominic P, additional, and Miotto, Olivo, additional

Published
2021
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15. Author response: Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

Author

Jacob, Christopher G, primary, Thuy-Nhien, Nguyen, additional, Mayxay, Mayfong, additional, Maude, Richard J, additional, Quang, Huynh Hong, additional, Hongvanthong, Bouasy, additional, Vanisaveth, Viengxay, additional, Ngo Duc, Thang, additional, Rekol, Huy, additional, van der Pluijm, Rob, additional, von Seidlein, Lorenz, additional, Fairhurst, Rick, additional, Nosten, François, additional, Hossain, Md Amir, additional, Park, Naomi, additional, Goodwin, Scott, additional, Ringwald, Pascal, additional, Chindavongsa, Keobouphaphone, additional, Newton, Paul, additional, Ashley, Elizabeth, additional, Phalivong, Sonexay, additional, Maude, Rapeephan, additional, Leang, Rithea, additional, Huch, Cheah, additional, Dong, Le Thanh, additional, Nguyen, Kim-Tuyen, additional, Nhat, Tran Minh, additional, Hien, Tran Tinh, additional, Nguyen, Hoa, additional, Zdrojewski, Nicole, additional, Canavati, Sara, additional, Sayeed, Abdullah Abu, additional, Uddin, Didar, additional, Buckee, Caroline, additional, Fanello, Caterina I, additional, Onyamboko, Marie, additional, Peto, Thomas, additional, Tripura, Rupam, additional, Amaratunga, Chanaki, additional, Myint Thu, Aung, additional, Delmas, Gilles, additional, Landier, Jordi, additional, Parker, Daniel M, additional, Chau, Nguyen Hoang, additional, Lek, Dysoley, additional, Suon, Seila, additional, Callery, James, additional, Jittamala, Podjanee, additional, Hanboonkunupakarn, Borimas, additional, Pukrittayakamee, Sasithon, additional, Phyo, Aung Pyae, additional, Smithuis, Frank, additional, Lin, Khin, additional, Thant, Myo, additional, Hlaing, Tin Maung, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa K, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Valecha, Neena, additional, Anvikar, Anupkumar R, additional, Ul Islam, Akhter, additional, Faiz, Abul, additional, Kunasol, Chanon, additional, Drury, Eleanor, additional, Kekre, Mihir, additional, Ali, Mozam, additional, Love, Katie, additional, Rajatileka, Shavanthi, additional, Jeffreys, Anna E, additional, Rowlands, Kate, additional, Hubbart, Christina S, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Kotanan, Namfon, additional, Wongnak, Phrutsamon, additional, Almagro Garcia, Jacob, additional, Pearson, Richard D, additional, Ariani, Cristina V, additional, Chookajorn, Thanat, additional, Malangone, Cinzia, additional, Nguyen, T, additional, Stalker, Jim, additional, Jeffery, Ben, additional, Keatley, Jonathan, additional, Johnson, Kimberly J, additional, Muddyman, Dawn, additional, Chan, Xin Hui S, additional, Sillitoe, John, additional, Amato, Roberto, additional, Simpson, Victoria, additional, Gonçalves, Sonia, additional, Rockett, Kirk, additional, Day, Nicholas P, additional, Dondorp, Arjen M, additional, Kwiatkowski, Dominic P, additional, and Miotto, Olivo, additional

Published
2021
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16. The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.

Author

Zhu, Lei, primary, Pluijm, Rob W. van der, additional, Kucharski, Michal, additional, Nayak, Sourav, additional, Tripathi, Jaishree, additional, Nosten, François, additional, Faiz, Abul, additional, Amaratunga, Chanak, additional, Lek, Dysoley, additional, Ashley, Elizabeth A, additional, Smithuis, Frank, additional, Phyo, Aung Pyae, additional, Lin, Khin, additional, Imwong, Mallika, additional, Mayxay, Mayfong, additional, Dhorda, Mehul, additional, Chau, Nguyen Hoang, additional, Thuy, Nhien Nguyen Thanh Thuy, additional, Newton, Paul N, additional, Jittamala, Podjanee, additional, Tripura, Rupam, additional, Pukrittayakamee, Sasithon, additional, Peto, Thomas J, additional, Miotto, Olivo, additional, von Seidlein, Lorenz, additional, Hien, Tran Tinh, additional, Ginsburg, Hagai, additional, Day, Nicholas PJ, additional, White, Nicholas J., additional, Dondorp, Arjen M, additional, and Bozdech, Zbynek, additional

Published
2021
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17. Genetic surveillance in the Greater Mekong Subregion and South Asia to support malaria control and elimination

Author

Jacob, Christopher G, primary, Thuy-Nhien, Nguyen, additional, Mayxay, Mayfong, additional, Maude, Richard J, additional, Quang, Huynh Hong, additional, Hongvanthong, Bouasy, additional, Vanisaveth, Viengxay, additional, Duc, Thang Ngo, additional, Rekol, Huy, additional, van der Pluijm, Rob W, additional, Von Seidlein, Lorenz, additional, Fairhurst, Rick M, additional, Nosten, Francois H, additional, Hossain, Md Amir, additional, Park, Naomi, additional, Goodwin, Scott, additional, Ringwald, Pascal, additional, Chindavongsa, Keobouphaphone, additional, Newton, Paul N, additional, Ashley, Elizabeth A, additional, Phalivong, Sonexay, additional, Maude, Rapeephan R, additional, Leang, Rithea, additional, Huch, Cheah, additional, Dong, Le Thanh, additional, Nguyen, Kim-Tuyen, additional, Nhat, Tran Minh, additional, Hien, Tran Tinh, additional, Nguyen, Hoa, additional, Zdrojewski, Nicole, additional, Canavati, Sara E, additional, Sayeed, Abdullah Abu, additional, Uddin, Didar, additional, Buckee, Caroline, additional, Fanello, Caterina I, additional, Onyamboko, Marie, additional, Peto, Thomas, additional, Tripura, Rupam, additional, Amaratunga, Chanaki, additional, Thu, Aung Myint, additional, Delmas, Gilles, additional, Landier, Jordi, additional, Parker, Daniel M, additional, Chau, Nguyen Hoang, additional, Lek, Dysoley, additional, Suon, Seila, additional, Callery, James J, additional, Jittamala, Podjanee, additional, Hanboonkunupakarn, Borimas, additional, Pukrittayakamee, Sasithon, additional, Phyo, Aung Pyae, additional, Smithuis, Frank, additional, Lin, Khin, additional, Thant, Myo, additional, Hlaing, Tin Maung, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa K, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Valecha, Neena, additional, Anvikar, Anupkumar R, additional, Islam, Akhter ul, additional, Faiz, Abul, additional, Kunasol, Chanon, additional, Drury, Eleanor, additional, Kekre, Mihir, additional, Ali, Mozam, additional, Love, Katie, additional, Rajatileka, Shavanthi, additional, Jeffreys, Anna E, additional, Rowlands, Kate, additional, Hubbart, Christina S, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Kotanan, Namfon, additional, Wongnak, Phrutsamon, additional, Garcia, Jacob Almagro, additional, Pearson, Richard D, additional, Ariani, Cristina V, additional, Chookajorn, Thanat, additional, Malangone, Cinzia, additional, Nguyen, T, additional, Stalker, Jim, additional, Jeffery, Ben, additional, Keatley, Jonathan, additional, Johnson, Kimberly J, additional, Muddyman, Dawn, additional, Chan, Xin Hui S, additional, Sillitoe, John, additional, Amato, Roberto, additional, Simpson, Victoria, additional, Gonçalves, Sonia, additional, Rockett, Kirk, additional, Day, Nicholas P, additional, Dondorp, Arjen M, additional, Kwiatkowski, Dominic P, additional, and Miotto, Olivo, additional

Published
2020
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18. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

Author

van der Pluijm, Rob W, primary, Tripura, Rupam, additional, Hoglund, Richard M, additional, Pyae Phyo, Aung, additional, Lek, Dysoley, additional, ul Islam, Akhter, additional, Anvikar, Anupkumar R, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa Kumari, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Onyamboko, Marie, additional, Chau, Nguyen Hoang, additional, Sovann, Yok, additional, Suon, Seila, additional, Sreng, Sokunthea, additional, Mao, Sivanna, additional, Oun, Savuth, additional, Yen, Sovannary, additional, Amaratunga, Chanaki, additional, Chutasmit, Kitipumi, additional, Saelow, Chalermpon, additional, Runcharern, Ratchadaporn, additional, Kaewmok, Weerayuth, additional, Hoa, Nhu Thi, additional, Thanh, Ngo Viet, additional, Hanboonkunupakarn, Borimas, additional, Callery, James J, additional, Mohanty, Akshaya Kumar, additional, Heaton, James, additional, Thant, Myo, additional, Gantait, Kripasindhu, additional, Ghosh, Tarapada, additional, Amato, Roberto, additional, Pearson, Richard D, additional, Jacob, Christopher G, additional, Gonçalves, Sónia, additional, Mukaka, Mavuto, additional, Waithira, Naomi, additional, Woodrow, Charles J, additional, Grobusch, Martin P, additional, van Vugt, Michele, additional, Fairhurst, Rick M, additional, Cheah, Phaik Yeong, additional, Peto, Thomas J, additional, von Seidlein, Lorenz, additional, Dhorda, Mehul, additional, Maude, Richard J, additional, Winterberg, Markus, additional, Thuy-Nhien, Nguyen Thanh, additional, Kwiatkowski, Dominic P, additional, Imwong, Mallika, additional, Jittamala, Podjanee, additional, Lin, Khin, additional, Hlaing, Tin Maung, additional, Chotivanich, Kesinee, additional, Huy, Rekol, additional, Fanello, Caterina, additional, Ashley, Elizabeth, additional, Mayxay, Mayfong, additional, Newton, Paul N, additional, Hien, Tran Tinh, additional, Valecha, Neena, additional, Smithuis, Frank, additional, Pukrittayakamee, Sasithon, additional, Faiz, Abul, additional, Miotto, Olivo, additional, Tarning, Joel, additional, Day, Nicholas P J, additional, White, Nicholas J, additional, Dondorp, Arjen M, additional, van der Pluijm, Rob W, additional, Phyo, Aung Pyae, additional, Thuy-Nhien, Nguyen T, additional, Valeche, Neena, additional, and Day, Nicholas PJ, additional

Published
2020
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20. A molecular barcode and online tool to identify and map imported infection with Plasmodium vivax

Author

Trimarsanto, Hidayat, primary, Amato, Roberto, additional, Pearson, Richard D, additional, Sutanto, Edwin, additional, Noviyanti, Rintis, additional, Trianty, Leily, additional, Marfurt, Jutta, additional, Pava, Zuleima, additional, Echeverry, Diego F, additional, Lopera-Mesa, Tatiana M, additional, Montenegro, Lidia Madeline, additional, Tobón-Castaño, Alberto, additional, Grigg, Matthew J, additional, Barber, Bridget, additional, William, Timothy, additional, Anstey, Nicholas M, additional, Getachew, Sisay, additional, Petros, Beyene, additional, Aseffa, Abraham, additional, Assefa, Ashenafi, additional, Rahim, Awab Ghulam, additional, Chau, Nguyen Hoang, additional, Hien, Tran Tinh, additional, Alam, Mohammad Shafiul, additional, Khan, Wasif A, additional, Ley, Benedikt, additional, Thriemer, Kamala, additional, Wangchuck, Sonam, additional, Hamedi, Yaghoob, additional, Adam, Ishag, additional, Liu, Yaobao, additional, Gao, Qi, additional, Sriprawat, Kanlaya, additional, Ferreira, Marcelo U, additional, Barry, Alyssa, additional, Mueller, Ivo, additional, Drury, Eleanor, additional, Goncalves, Sonia, additional, Simpson, Victoria, additional, Miotto, Olivo, additional, Miles, Alistair, additional, White, Nicholas J, additional, Nosten, Francois, additional, Kwiatkowski, Dominic P, additional, Price, Ric N, additional, and Auburn, Sarah, additional

Published
2019
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21. Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial

Author

Taylor, Walter R J, primary, Thriemer, Kamala, additional, von Seidlein, Lorenz, additional, Yuentrakul, Prayoon, additional, Assawariyathipat, Thanawat, additional, Assefa, Ashenafi, additional, Auburn, Sarah, additional, Chand, Krisin, additional, Chau, Nguyen Hoang, additional, Cheah, Phaik Yeong, additional, Dong, Le Thanh, additional, Dhorda, Mehul, additional, Degaga, Tamiru Shibru, additional, Devine, Angela, additional, Ekawati, Lenny L, additional, Fahmi, Fahmi, additional, Hailu, Asrat, additional, Hasanzai, Mohammad Anwar, additional, Hien, Tran Tinh, additional, Khu, Htee, additional, Ley, Benedikt, additional, Lubell, Yoel, additional, Marfurt, Jutta, additional, Mohammad, Hussein, additional, Moore, Kerryn A, additional, Naddim, Mohammad Nader, additional, Pasaribu, Ayodhia Pitaloka, additional, Pasaribu, Syahril, additional, Promnarate, Cholrawee, additional, Rahim, Awab Ghulam, additional, Sirithiranont, Pasathron, additional, Solomon, Hiwot, additional, Sudoyo, Herawati, additional, Sutanto, Inge, additional, Thanh, Ngo Viet, additional, Tuyet-Trinh, Nguyen Thi, additional, Waithira, Naomi, additional, Woyessa, Adugna, additional, Yamin, Fazal Yamin, additional, Dondorp, Arjen, additional, Simpson, Julie A, additional, Baird, J Kevin, additional, White, Nicholas J, additional, Day, Nicholas P, additional, and Price, Ric N, additional

Published
2019
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22. Tafenoquine exposure assessment, safety, and relapse prevention efficacy in children with Plasmodium vivaxmalaria: open-label, single-arm, non-comparative, multicentre, pharmacokinetic bridging, phase 2 trial

Author

Vélez, Iván D, Hien, Tran T, Green, Justin A, Martin, Ana, Sharma, Hema, Rousell, Victoria M, Breton, John J, Ernest, Terry B, Rolfe, Katie, Taylor, Maxine, Mohamed, Khadeeja, Jones, Siôn W, Chau, Nguyen Hoang, Hoa, Nhu Thi, Duparc, Stephan, Tan, Lionel K, and Goyal, Navin

Abstract

Single-dose tafenoquine 300 mg is approved for Plasmodium vivaxmalaria relapse prevention in patients at least 16 years old. We aimed to determine appropriate oral tafenoquine paediatric dosing regimens, including a dispersible formulation, and evaluated tafenoquine efficacy and safety in children infected with P vivax.

Published
2022
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23. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparummalaria: a multicentre, open-label, randomised clinical trial

Author

van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Dondorp, Arjen M, van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Phyo, Aung Pyae, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen T, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valeche, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas PJ, White, Nicholas J, and Dondorp, Arjen M

Abstract

Artemisinin and partner-drug resistance in Plasmodium falciparumare major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance.

Published
2020
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24. Evolution and expansion of multidrug resistant malaria in Southeast Asia: a genomic epidemiology study

Author

Hamilton, William L, primary, Amato, Roberto, additional, van der Pluijm, Rob W, additional, Jacob, Christopher G, additional, Quang, Huynh Hong, additional, Thuy-Nhien, Nguyen Thanh, additional, Hien, Tran Tinh, additional, Hongvanthong, Bouasy, additional, Chindavongsa, Keobouphaphone, additional, Mayxay, Mayfong, additional, Rekol, Huy, additional, Leang, Rithea, additional, Huch, Cheah, additional, Dysoley, Lek, additional, Amaratunga, Chanaki, additional, Suon, Seila, additional, Fairhurst, Rick M, additional, Tripura, Rupam, additional, Peto, Thomas J, additional, Sovann, Yok, additional, Jittamala, Podjanee, additional, Hanboonkunupakarn, Borimas, additional, Pukrittayakamee, Sasithon, additional, Chau, Nguyen Hoang, additional, Imwong, Mallika, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Chan, Xin Hui S, additional, Maude, Richard J, additional, Pearson, Richard D, additional, Nguyen, T, additional, Rockett, Kirk, additional, Drury, Eleanor, additional, Gonçalves, Sonia, additional, White, Nicholas J, additional, Day, Nicholas P, additional, Kwiatkowski, Dominic P, additional, Dondorp, Arjen M, additional, and Miotto, Olivo, additional

Published
2019
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26. Short-course primaquine for the radical cure of Plasmodium vivaxmalaria: a multicentre, randomised, placebo-controlled non-inferiority trial

Author

Taylor, Walter R J, Thriemer, Kamala, von Seidlein, Lorenz, Yuentrakul, Prayoon, Assawariyathipat, Thanawat, Assefa, Ashenafi, Auburn, Sarah, Chand, Krisin, Chau, Nguyen Hoang, Cheah, Phaik Yeong, Dong, Le Thanh, Dhorda, Mehul, Degaga, Tamiru Shibru, Devine, Angela, Ekawati, Lenny L, Fahmi, Fahmi, Hailu, Asrat, Hasanzai, Mohammad Anwar, Hien, Tran Tinh, Khu, Htee, Ley, Benedikt, Lubell, Yoel, Marfurt, Jutta, Mohammad, Hussein, Moore, Kerryn A, Naddim, Mohammad Nader, Pasaribu, Ayodhia Pitaloka, Pasaribu, Syahril, Promnarate, Cholrawee, Rahim, Awab Ghulam, Sirithiranont, Pasathron, Solomon, Hiwot, Sudoyo, Herawati, Sutanto, Inge, Thanh, Ngo Viet, Tuyet-Trinh, Nguyen Thi, Waithira, Naomi, Woyessa, Adugna, Yamin, Fazal Yamin, Dondorp, Arjen, Simpson, Julie A, Baird, J Kevin, White, Nicholas J, Day, Nicholas P, and Price, Ric N

Abstract

Primaquine is the only widely used drug that prevents Plasmodium vivaxmalaria relapses, but adherence to the standard 14-day regimen is poor. We aimed to assess the efficacy of a shorter course (7 days) of primaquine for radical cure of vivax malaria.

Published
2019
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27. Lineage-informative microhaplotypes for spatio-temporal surveillance of Plasmodium vivax malaria parasites.

Author

Siegel SV, Amato R, Trimarsanto H, Sutanto E, Kleinecke M, Murie K, Whitton G, Taylor AR, Watson JA, Imwong M, Assefa A, Rahim AG, Chau NH, Hien TT, Green JA, Koh G, White NJ, Day N, Kwiatkowski DP, Rayner JC, Price RN, and Auburn S

Abstract

Challenges in understanding the origin of recurrent Plasmodium vivax infections constrains the surveillance of antimalarial efficacy and transmission of this neglected parasite. Recurrent infections within an individual may arise from activation of dormant liver stages (relapse), blood-stage treatment failure (recrudescence) or new inoculations (reinfection). Molecular inference of familial relatedness (identity-by-descent or IBD) based on whole genome sequence data, together with analysis of the intervals between parasitaemic episodes ("time-to-event" analysis), can help resolve the probable origin of recurrences. Whole genome sequencing of predominantly low-density P. vivax infections is challenging, so an accurate and scalable genotyping method to determine the origins of recurrent parasitaemia would be of significant benefit. We have developed a P. vivax genome-wide informatics pipeline to select specific microhaplotype panels that can capture IBD within small, amplifiable segments of the genome. Using a global set of 615 P. vivax genomes, we derived a panel of 100 microhaplotypes, each comprising 3-10 high frequency SNPs within <200 bp sequence windows. This panel exhibits high diversity in regions of the Asia-Pacific, Latin America and the horn of Africa (median H E = 0.70-0.81) and it captured 89% (273/307) of the polyclonal infections detected with genome-wide datasets. Using data simulations, we demonstrate lower error in estimating pairwise IBD using microhaplotypes, relative to traditional biallelic SNP barcodes. Our panel exhibited high accuracy in predicting the country of origin (median Matthew's correlation coefficient >0.9 in 90% countries tested) and it also captured local infection outbreak and bottlenecking events. The informatics pipeline is available open-source and yields microhaplotypes that can be readily transferred to high-throughput amplicon sequencing assays for surveillance in malaria-endemic regions.

Published
2023
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28. An open dataset of Plasmodium vivax genome variation in 1,895 worldwide samples.

Author

Adam I, Alam MS, Alemu S, Amaratunga C, Amato R, Andrianaranjaka V, Anstey NM, Aseffa A, Ashley E, Assefa A, Auburn S, Barber BE, Barry A, Batista Pereira D, Cao J, Chau NH, Chotivanich K, Chu C, Dondorp AM, Drury E, Echeverry DF, Erko B, Espino F, Fairhurst R, Faiz A, Fernanda Villegas M, Gao Q, Golassa L, Goncalves S, Grigg MJ, Hamedi Y, Hien TT, Htut Y, Johnson KJ, Karunaweera N, Khan W, Krudsood S, Kwiatkowski DP, Lacerda M, Ley B, Lim P, Liu Y, Llanos-Cuentas A, Lon C, Lopera-Mesa T, Marfurt J, Michon P, Miotto O, Mohammed R, Mueller I, Namaik-Larp C, Newton PN, Nguyen TN, Nosten F, Noviyanti R, Pava Z, Pearson RD, Petros B, Phyo AP, Price RN, Pukrittayakamee S, Rahim AG, Randrianarivelojosia M, Rayner JC, Rumaseb A, Siegel SV, Simpson VJ, Thriemer K, Tobon-Castano A, Trimarsanto H, Urbano Ferreira M, Vélez ID, Wangchuk S, Wellems TE, White NJ, William T, Yasnot MF, and Yilma D

Abstract

This report describes the MalariaGEN Pv4 dataset, a new release of curated genome variation data on 1,895 samples of Plasmodium vivax collected at 88 worldwide locations between 2001 and 2017. It includes 1,370 new samples contributed by MalariaGEN and VivaxGEN partner studies in addition to previously published samples from these and other sources. We provide genotype calls at over 4.5 million variable positions including over 3 million single nucleotide polymorphisms (SNPs), as well as short indels and tandem duplications. This enlarged dataset highlights major compartments of parasite population structure, with clear differentiation between Africa, Latin America, Oceania, Western Asia and different parts of Southeast Asia. Each sample has been classified for drug resistance to sulfadoxine, pyrimethamine and mefloquine based on known markers at the dhfr , dhps and mdr1 loci. The prevalence of all of these resistance markers was much higher in Southeast Asia and Oceania than elsewhere. This open resource of analysis-ready genome variation data from the MalariaGEN and VivaxGEN networks is driven by our collective goal to advance research into the complex biology of P. vivax and to accelerate genomic surveillance for malaria control and elimination., Competing Interests: No competing interests were disclosed., (Copyright: © 2022 MalariaGEN et al.)

Published
2022
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