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Your search keyword '"Chaubey, Sushma"' showing total 11 results
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11 results on '"Chaubey, Sushma"'

5. Additional file 1 of Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6

Author

Chaubey, Sushma, Thueson, Sam, Devasena Ponnalagu, Alam, Mohammad Afaque, Gheorghe, Ciprian P., Zubair Aghai, Singh, Harpreet, and Bhandari, Vineet

Subjects
mental disorders, behavioral disciplines and activities
Abstract

Supplementary experimental procedures. Table S1. Comparison of different parameters in the exosome dose. Table S2. Clinical data for BPD and No BPD (n = 10). Figure S1. Preterm hUCs MSCs, but not fibroblasts, improve the BPD pulmonary phenotype. i.p. injections of MSCs from preterm (32 weeks) hUCs, in our mouse BPD model, at PN2 and PN4 showed improvement in lung architecture (at PN14), as evidenced by decreased chord length compared to the BPD mice. Human primary dermal fibroblast (HDF) cells, injected as control cells in the BPD mice, demonstrated no difference as compared to BPD mice. All values are expressed as mean ± standard deviation (SD); four experiments, N = 3 mice per group; one-way ANOVA with Tukey’s post hoc correction; *p

Published
2021
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11. The apicoplast ofPlasmodium falciparumis translationally active.

Author

Chaubey, Sushma, Kumar, Ambrish, Singh, Divya, and Habib, Saman

Subjects
*APICOMPLEXA, *TARGETED drug delivery, *MICROBIAL proteins, *PLASTIDS, *ORGANELLES, *PROTOZOA, *PARASITIC diseases
Abstract

Apicoplast, the plastid-like organelle of apicomplexan parasites, has generated interest as a putative drug target. Although transcripts for genes encoded by the 35 kb circular plastid DNA have been detected, the actual presence of their protein products has only been postulated. We provide evidence for translation of thetufAgene encoded by thePlasmodium falciparumapicoplast genome. Translation elongation factor Tu (EF-Tu), the product oftufA, was localized within the organelle.TufAwas found to express maximally in the trophozoite stage of the intraerythrocytic cycle. Additionally, the drug thiostrepton that has a binding site in apicoplast LSU rRNA, reducedP. falciparumapicoplast EF-Tu levels thus strengthening the view that translation in the apicoplast is the site of action of this drug. [ABSTRACT FROM AUTHOR]

Published
2005
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