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269 results on '"Chauhan, Shyam S."'

10. Involvement of DPP3 in modulating oncological features and oxidative stress response in esophageal squamous cell carcinoma

Author

Arora, Mohit, primary, Kumari, Sarita, additional, Kadian, Lokesh, additional, Anupa, Geethadevi, additional, Singh, Jay, additional, Kumar, Anurag, additional, Verma, Deepika, additional, Pramanik, Raja, additional, Kumar, Sunil, additional, Yadav, Rajni, additional, Chopra, Anita, additional, and Chauhan, Shyam S., additional

Published
2023
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31. Alterations in Autophagy and Mammalian Target of Rapamycin (mTOR) Pathways Mediate Sarcopenia in Patients with Cirrhosis

Author

Anand, Abhinav, primary, Nambirajan, Aruna, additional, Kumar, Vikas, additional, Agarwal, Samagra, additional, Sharma, Sanchit, additional, Mohta, Srikant, additional, Gopi, Srikanth, additional, Kaushal, Kanav, additional, Gunjan, Deepak, additional, Singh, Namrata, additional, Madhusudhan, Kumble S., additional, Chauhan, Shyam S., additional, Sharma, Mehar C., additional, Bansal, Virinder K., additional, and Saraya, Anoop, additional

Published
2021
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37. Prognostic Relevance of Expression of EMP1, CASP1, and NLRP3 Genes in Pediatric B-Lineage Acute Lymphoblastic Leukemia

Author

Singh, Jay, primary, Kumari, Sarita, additional, Arora, Mohit, additional, Verma, Deepak, additional, Palanichamy, Jayanth Kumar, additional, Kumar, Rajive, additional, Sharma, Gunjan, additional, Bakhshi, Sameer, additional, Pushpam, Deepam, additional, Ali, M. Shadab, additional, Ranjan, Amar, additional, Tanwar, Pranay, additional, Chauhan, Shyam S., additional, Singh, Archna, additional, and Chopra, Anita, additional

Published
2021
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38. Prognostic and therapeutic relevance of cathepsin B in pediatric acute myeloid leukemia

Author

Pandey, Garima, Bakhshi, Sameer, Kumar, Manoj, Thakur, Bhaskar, Jain, Prerna, Kaur, Punit, and Chauhan, Shyam S

Subjects
Original Article
Abstract

AML, the second most common childhood leukemia is also one of the deadliest cancers. High mortality rate in AML is due to high incidence of relapse after complete remission with chemotherapy and inadequate prognostic assessment of patients. Moreover, there is dearth of therapeutic targets for treatment of this malignancy. Previous pilot study (n = 24) by our group revealed strong association between cathepsin B (CTSB) overexpression in peripheral blood mononuclear cells (PBMCs) and poor survival outcome in pediatric AML patients. To further explore the clinical utility and role of this protease in pediatric AML, we measured its enzymatic activity and mRNA expression in PBMCs as well as bone marrow mononuclear cells (BMMCs) of patients (n = 101) and PBMCs of healthy controls. Our results revealed elevated CTSB activity (P < 0.01) and overexpression of its mRNA (P < 0.01) in AML patients. Interestingly CTSB in BMMCs of patients emerged as an independent prognostic marker when compared with other known risk factors. Moreover, chemical inhibition of CTSB activity compromised survival, and induced apoptosis in an AML cell line THP-1. We further demonstrate the inhibition of CTSB activity by chemotherapeutic agent doxorubicin in these cells. Docking and simulation studies suggested the binding of doxorubicin to CTSB with higher affinity than its known specific inhibitor CA-074 Me, thereby indicating that cell death induced by this drug may at least partly be mediated by CTSB inhibition. CTSB, therefore, may serve as a prognostic marker and an attractive chemotherapeutic target in pediatric AML.

Published
2019

43. Effects of submucosally administered platelet-rich plasma on the rate of tooth movement:: A single-center, split-mouth, randomized controlled trial with clinical and biochemical analysis.

Author

Angel, Saraa L., Samrit, Vilas D., Kharbanda, Om Prakash, Duggal, Ritu, Kumar, Vikas, Chauhan, Shyam S., and Coshic, Poonam

Subjects
PLATELET-rich plasma, CLINICAL trials, CORRECTIVE orthodontics, ENZYME-linked immunosorbent assay, TEETH, MANN Whitney U Test
Abstract

To evaluate the effects of submucosally administered platelet-rich plasma (PRP) on the rate of maxillary canine retraction. Levels of soluble receptor activator of nuclear factor-κb ligand (sRANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) were also measured over 2 months. This split-mouth trial involved 20 sites in 10 subjects randomly assigned to PRP (experimental) side and control side. After alignment, the freshly prepared PRP was injected submucosally distal to the experimental side maxillary canine, and retraction was performed using NiTi closed-coil springs (150 g) on 0.019 × 0.025-inch stainless steel wire. The rate of canine movement was assessed using digital model superimposition at 0, 30, and 60 days. The OPG and sRANKL were assayed using enzyme-linked immunosorbent assay from GCF collected at 0, 1, 7, 21, 30, and 60 days. Twenty sites were analyzed using paired t test. The rate of tooth movement increased significantly by 35% on the PRP side compared with the control side in the first month (P =.0001) and by 14% at the end of the second month (P =.015). Using the Mann–Whitney U test, OPG levels were found to be significantly decreased on the 7th (P =.003) and 30th day on the PRP side (P =.01), while sRANKL became detectable by the third week postinjection on the PRP side (P =.069). Submucosal injection of platelet-rich plasma significantly increased tooth movement during the 60-day observation period. Local injection of PRP significantly altered the levels of OPG and sRANKL in GCF. [ABSTRACT FROM AUTHOR]

Published
2022
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