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In electroencephalography (EEG) and event related potentials (ERP), localizing the electrical sources at the origin of scalp potentials (inverse problem) imposes, in a first step, the computation of scalp potential distribution from the simulation of sources (forward problem). This article proposes an alternative method for mimicing both the electrical and geometrical properties of the head, including brain, skull, and scalp tissue with resistors. Two resistor mesh models have been designed to reproduce the three-sphere reference model (analytical model). The first one (spherical resistor mesh) closely mimics the geometrical and electrical properties of the analytical model. The second one (cubic resistor mesh) is designed to conveniently handle anatomical data from magnetic resonance imaging. Both models have been validated, in reference to the analytical solution calculated on the three-sphere model, by computing the magnification factor and the relative difference measure. Results suggest that the mesh models can be used as robust and user-friendly simulation or exploration tools in EEG/ERP. [ABSTRACT FROM AUTHOR]

Presents abstracts of several studies on medical instruments and imaging. Exploration on the use of image texture analysis for the automated identification of tissue abnormalities in low-power scans of prostate histology; Details of a proposed projection operator that can be changed easily according to the system specified; Development of an algorithm customized to badly defined objects detected in hippocampus atrophy.

In-vivo dosimetry is still a challenge in stereotactic radiosurgery since most of treatments are delivered using rotational technique with small fields. A realistic and practical solution for these treatments delivered in conformal radiotherapy is proposed to control the absorbed dose at isocentre, using multiple surface MOSFET measurements over an arc. On the one hand, a forward method was developed to optimize the location of the detectors at the patient surface, taking into account arc length, prescribed isocentre dose, collimator and field size. On the other hand, an inverse method was used to compute the dose at isocentre for conformal arc therapy in stereotactic radiosurgery, using MOSFET measurements. Finally, the reconstructed dose at isocentre was compared to real measurement, obtained for several detectors positioned at a phantom surface. Results show that the inverse method gives good results with five MOSFET equi-spaced positioned within the arc beam course: deviation between prescribed and computed average total dose at isocentre was below 2% both for 30×30 mm2 and 18×18 mm2 field size

Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathy that is characterized by severe subacute proximal weakness, myofiber necrosis, and significantly elevated serum creatine kinase. Anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme-A reductase autoantibodies have been found in about two-thirds of patients with IMNM. This myopathy is usually idiopathic and there is a scarce literature concerning its association with connective tissue diseases. Herein, we report an unusual case of a young woman who presented with both rheumatoid arthritis and severe anti-SRP IMNM. Thankfully to a therapeutic protocol combining rituximab and cyclophosphamide, an important improvement was achieved, and notably no serious side effect was observed., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Background: Although nocturnal leg cramps are common, little research is available about their impact on quality of life. This mixed-methods study explored the impact of nocturnal leg cramps on health-related quality of life (HRQoL)., Methods: The study included primary care patients (>50 years) who reported suffering from nocturnal leg cramps (2016-2017). In the quantitative phase, patients completed a questionnaire about their HRQoL (SF-36) and the frequency of their cramps, and we computed the SF-36 scores. Then, we conducted a qualitative study using semi-structured interviews with patients with various levels of HRQol to explore their perception of the impact of cramps on their lives., Results: A total of 114 patients (49%) agreed to participate in the quantitative study (mean age: 71, women: 62%) and 15 patients were included in the qualitative study (mean age: 69, women: 67%). The number of cramps in the previous week was low (mean: 1.6 (SD 1.5)). The SF-36 mean physical and mental summary scores were 43 and 50, respectively, and the domain scores were similar to a comparative general population. Whilst some patients reported little interference with their daily lives, others reported a major decrease in their HRQoL. SF-36 scores were not sufficient to describe the cramp-related impairment, as patients from all levels of SF-36 scores reported major impacts of NLC in the interviews., Conclusions: Some patients describe a specific impact of cramps on their lives, regardless of their HRQoL. These patients should be the target of future intervention trials., (© The Author(s) 2021. Published by Oxford University Press. All rights reserved.For permissions, please e-mail: journals.permissions@oup.com.)

Background: There is no specificity of emergency or long-term management of benign electrical injuries (EI). The main objective of our work was to describe the occurrence of long-term complications of EI considered as benign., Methods: Single-center retrospective study of a cohort of adult patients who consulted for EI without initials signs of severity in an emergency department between 2012 and 2019. All included patients were secondarily contacted by telephone at least one year after their EI to complete a questionnaire., Results: 76 adult patients visited the emergency department and 48 of them could be contacted by phone. 82% of the recalled patients had at least one complication following their EI. The main long-term complications were neurological (65%), psychological (58%) and cardiological (31%). Patients recalled eight years after EI had higher rates of neuropsychological complications than those recalled one year after EI. Only the time spent in the emergency department was statistically longer in patients who developed long-term complications compared to those who did not., Discussion: The occurrence of long-term neuropsychological complications predominates. The knowledge and management of these long-term consequences must be particularly well known by emergency physicians because they are often the first medical contact of the patient. Our results also seem to show a crescendo in time of the occurrence of long-term complications., Conclusion: all health professionals involved in the care of victims of a EI must be made widely aware of the occurrence of these long-term complications, particularly neuropsychological ones, in order to improve the long-term patient care., Competing Interests: Declaration of Competing Interest The authors have nothing to declare., (Copyright © 2021 Elsevier Inc. All rights reserved.)