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6. Radioimmunotherapy of Lymphomas

Author

Bailly, Clément, Bodet-Milin, Caroline, Guerard, François, Chouin, Nicolas, Gaschet, Joelle, Cherel, Michel, Davodeau, François, Faivre-Chauvet, Alain, Kraeber-Bodéré, Françoise, Bourgeois, Mickaël, and Giovanella, Luca, editor

Published
2019
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8. Highlight selection of radiochemistry and radiopharmacy developments by editorial board

Author

Alves, Francisco, Antunes, Inês F., Cazzola, Emiliano, Cleeren, Frederik, Cornelissen, Bart, Denkova, Antonia, Engle, Jonathan, Faivre-Chauvet, Alain, Gillings, Nic, Hendrikx, Jeroen J. M. A., Jalilian, Amir R., van der Meulen, Nicholas P., Mikolajczak, Renata, Neels, Oliver C., Pillai, Maroor R. A., Reilly, Raymond, Rubow, Sietske, Seimbille, Yann, Spreckelmeyer, Sarah, Szymanski, Wiktor, and Taddei, Carlotta

Published
2021
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11. Depositing >1.5 Mt of Tin Within <1 m.y. of Initial Granitic Intrusion in the San Rafael Tin (-Copper) Deposit, Southeastern Peru

Author

Harlaux, Matthieu, primary, Kontak, Daniel J., additional, Clark, Alan H., additional, Kouzmanov, Kalin, additional, Holm-Denoma, Christopher S., additional, Gialli, Stefano, additional, Laurent, Oscar, additional, Spikings, Richard, additional, Chauvet, Alain, additional, Dini, Andrea, additional, Kalinaj, Miroslav, additional, and Fontboté, Lluís, additional

Published
2023
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15. Structural Control of Mineral Deposits : Theory and Reality

Author

Chauvet, Alain

Abstract

"Structural Control” remains a crucial point that frequently lacks in any scientific and/or economic analysis of ore deposits, whatever their type and class. The case of lode deposits is exemplary, although also other deposits, like breccia pipe, stockwerk, massive sulphides, skarn, etc., can, surprisingly, be concerned. Several concepts like the gold-bearing shear zone have not proven valid during the last few decades in terms of our understanding of gold deposit and have been totally abandoned. Additionally, the relationships between magmatism, regional tectonic context, and mineralization remain uncertain and have been debated in several recent publications. This demonstrates that this issue is still relevant, and its solution may help in the distinction between intrusion-related and orogenic deposits. In this Special Issue, we particularly invite any case study of mineral deposits, in which it has been demonstrated that structural geology may have a significant role in the establishment of the deposit model of formation and/or on exploration and exploitation programs. Examples in which the structural model diverges from those described in the classical literature are particularly welcomed, including studies in which relationships with magmatism can be suspected and/or demonstrated. Indeed, all cases that illustrate concepts that differ from the classic ones and from theoretical models may represent significant contributions to this volume.

Published
2019

18. Preclinical Evaluation of a 64Cu-Based Theranostic Approach in a Murine Model of Multiple Myeloma

Author

Métivier, Cassandra, primary, Le Saëc, Patricia, additional, Gaschet, Joëlle, additional, Chauvet, Catherine, additional, Marionneau-Lambot, Séverine, additional, Hofgaard, Peter O., additional, Bogen, Bjarne, additional, Pineau, Julie, additional, Le Bris, Nathalie, additional, Tripier, Raphaël, additional, Alliot, Cyrille, additional, Haddad, Férid, additional, Chérel, Michel, additional, Chouin, Nicolas, additional, Faivre-Chauvet, Alain, additional, and Rbah-Vidal, Latifa, additional

Published
2023
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20. [68Ga]Ga‐PentixaFor: Development of a fully automated in hospital production on the Trasis miniAllinOne synthesizer.

Author

Costes, Julien, Casasagrande, Kilian, Dubegny, Constance, Castillo, Juan, Kaufman, Jens, Masset, Julien, Vriamont, Charles, Warnier, Corentin, Faivre‐Chauvet, Alain, and Delage, Judith Anna

Subjects
QUALITY control, ENVIRONMENTAL monitoring, RADIOACTIVE tracers, HOSPITALS, CARDIOVASCULAR diseases
Abstract

[68Ga]Ga‐PentixaFor is a frequently used radiotracer to image the CXCR4/CXCL12 axis in various malignancies, infections, and cardiovascular diseases. To answer increasing clinical needs, an automatized synthesis process ensuring efficient and reproducible production and improving operator's radioprotection is needed. [68Ga]Ga‐PentixaFor synthesis has been described on other synthesizers but not on the miniAiO. In this work, we defined automated synthesis process and an analytical method for the quality control of [68Ga]Ga‐PentixaFor. Validation batches were performed under aseptic conditions in a class A hotcell. All the quality controls required by the European Pharmacopea (Eur. Ph) were performed. The analytical methods were validated according to the International Conference Harmonization (ICH) recommendations. Validation batches were performed with a radiochemical yield of 94.8 ± 2.6%. All the quality controls were in conformity with the Eur. Ph, and the validation of the analytical method complied with the ICH. The environmental monitoring performed during the synthesis process showed that the aseptic conditions were ensured. [68Ga]Ga‐PentixaFor was successfully synthesized with the miniAiO by a fully automated process. This robust production mode and the quality control have been validated in this study allowing to increase the access of patients to this new promising radiopharmaceutical. [ABSTRACT FROM AUTHOR]

Published
2023
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21. New Advances in Radioimmunotherapy for the Treatment of Cancers

Author

Kraeber-Bodéré, Françoise, Bodet-Milin, Caroline, Rousseau, Caroline, Carlier, Thomas, Ferrer, Ludovic, Chouin, Nicolas, Haddad, Férid, Davodeau, François, Chatal, Jean-François, Faivre-Chauvet, Alain, Gestin, Jean-François, Chérel, Michel, Barbet, Jacques, and Rezaei, Nima, editor

Published
2015
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23. Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution

Author

Pineau, Julie, primary, Lima, Luís M. P., additional, Le Roy, Marie M., additional, Marionneau-Lambot, Séverine, additional, Cordier, Marie, additional, Le Saëc, Patricia, additional, Zeevaart, Jan Rijn, additional, Driver, Cathryn H. S., additional, Faivre-Chauvet, Alain, additional, Le Bris, Nathalie, additional, and Tripier, Raphaël, additional

Published
2023
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26. Preclinical Evaluation of a 64 Cu-Based Theranostic Approach in a Murine Model of Multiple Myeloma.

Author

Métivier, Cassandra, Le Saëc, Patricia, Gaschet, Joëlle, Chauvet, Catherine, Marionneau-Lambot, Séverine, Hofgaard, Peter O., Bogen, Bjarne, Pineau, Julie, Le Bris, Nathalie, Tripier, Raphaël, Alliot, Cyrille, Haddad, Férid, Chérel, Michel, Chouin, Nicolas, Faivre-Chauvet, Alain, and Rbah-Vidal, Latifa

Subjects
MULTIPLE myeloma, POSITRON emission tomography, TUMOR markers, MEDICAL dosimetry, NUCLEAR medicine, PROTEIN microarrays, RADIOISOTOPES
Abstract

Although the concept of theranostics is neither new nor exclusive to nuclear medicine, it is a particularly promising approach for the future of nuclear oncology. This approach is based on the use of molecules targeting specific biomarkers in the tumour or its microenvironment, associated with optimal radionuclides which, depending on their emission properties, allow the combination of diagnosis by molecular imaging and targeted radionuclide therapy (TRT). Copper-64 has suitable decay properties (both β+ and β- decays) for PET imaging and potentially for TRT, making it both an imaging and therapy agent. We developed and evaluated a theranostic approach using a copper-64 radiolabelled anti-CD138 antibody, [64Cu]Cu-TE1PA-9E7.4 in a MOPC315.BM mouse model of multiple myeloma. PET imaging using [64Cu]Cu-TE1PA-9E7.4 allows for high-resolution PET images. Dosimetric estimation from ex vivo biodistribution data revealed acceptable delivered doses to healthy organs and tissues, and a very encouraging tumour absorbed dose for TRT applications. Therapeutic efficacy resulting in delayed tumour growth and increased survival without inducing major or irreversible toxicity has been observed with 2 doses of 35 MBq administered at a 2-week interval. Repeated injections of [64Cu]Cu-TE1PA-9E7.4 are safe and can be effective for TRT application in this syngeneic preclinical model of MM. [ABSTRACT FROM AUTHOR]

Published
2023
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27. 90Y-labelled anti-CD22 epratuzumab tetraxetan in adults with refractory or relapsed CD22-positive B-cell acute lymphoblastic leukaemia: a phase 1 dose-escalation study

Author

Chevallier, Patrice, Eugene, Thomas, Robillard, Nelly, Isnard, Françoise, Nicolini, Franck, Escoffre-Barbe, Martine, Huguet, Françoise, Hunault, Mathilde, Marcais, Antoine, Gaschet, Joelle, Cherel, Michel, Guillaume, Thierry, Delaunay, Jacques, Peterlin, Pierre, Eveillard, Marion, Thomas, Xavier, Ifrah, Norbert, Lapusan, Simona, Bodet-Milin, Caroline, Barbet, Jacques, Faivre-Chauvet, Alain, Ferrer, Ludovic, Bene, Marie C, Le Houerou, Claire, Goldenberg, David M, Wegener, William A, and Kraeber-Bodéré, Françoise

Published
2015
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28. Radiopharmaceutical good practices: Regulation between hospital and industry

Author

Faivre-Chauvet, Alain, Bourdeau, Cécile, and Bourgeois, Mickaël

Abstract

Radiopharmaceutical practices are divided into large-scale industrial manufacturing and small-scale “in-house” hospital radiopharmacy unit. The recent evolution of nuclear medicine involves deep consequences in this ever-present regulatory state, and hospital radiopharmacy units cannot be considered as contract manufacturing organizations (CMO). This review provides an updated status report of the official (and non-official) guidelines supporting the regulations required to meet hospital and industry common radiopharmaceutical manufacturing standards to facilitate the current and future innovative radiopharmaceutical development.

Published
2022

30. Antitumor Immunity Induced after α Irradiation

Author

Gorin, Jean-Baptiste, Ménager, Jérémie, Gouard, Sébastien, Maurel, Catherine, Guilloux, Yannick, Faivre-Chauvet, Alain, Morgenstern, Alfred, Bruchertseifer, Frank, Chérel, Michel, Davodeau, François, and Gaschet, Joëlle

Published
2014
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32. From bench to bedside: 64Cu/177Lu 1C1m-Fc anti TEM-1: mice-to-human dosimetry extrapolations for future theranostic applications.

Author

Gnesin, Silvano, Chouin, Nicolas, Cherel, Michel, Dunn, Steven Mark, Schaefer, Niklaus, Faivre-Chauvet, Alain, Prior, John O., and Delage, Judith Anna

Subjects
MEDICAL dosimetry, ABSORBED dose, NUCLEAR medicine, EXTRAPOLATION, COPPER, COMPANION diagnostics, POSITRON emission tomography
Abstract

The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under development necessitating both biokinetic and dosimetry extrapolations for effective human translation. The validation of different animal-to-human dosimetry extrapolation methods still is an open issue. This study reports the mice-to-human dosimetry extrapolation of 64Cu/177Lu 1C1m-Fc anti-TEM-1 for theranostic application in soft-tissue sarcomas. We adopt four methods; direct mice-to-human extrapolation (M1); dosimetry extrapolation considering a relative mass scaling factor (M2), application of a metabolic scaling factor (M3) and combination of M2 and M3 (M4). Predicted in-human dosimetry for the [64Cu]Cu-1C1m-Fc resulted in an effective dose of 0.05 mSv/MBq. Absorbed dose (AD) extrapolation for the [177Lu]Lu-1C1m-Fc indicated that the AD of 2 Gy and 4 Gy to the red-marrow and total-body can be reached with 5–10 GBq and 25–30 GBq of therapeutic activity administration respectively depending on applied dosimetry method. Dosimetry extrapolation methods provided significantly different absorbed doses in organs. Dosimetry properties for the [64Cu]Cu-1C1m-Fc are suitable for a diagnostic in-human use. The therapeutic application of [177Lu]Lu-1C1m-Fc presents challenges and would benefit from further assessments in animals' models such as dogs before moving into the clinic. [ABSTRACT FROM AUTHOR]

Published
2023
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34. Development and in vitro evaluation of a copper-64 radiolabeled antibody for targeting the CXCR4 receptor in human multiple myeloma

Author

Métivier, Cassandra, primary, Le Saec, Patricia, additional, Bouhsine, Hela, additional, Marionneau-Lambot, Séverine, additional, Garçion, Emmanuel, additional, Tripier, Raphaël, additional, Haddad, Ferid, additional, Chérel, Michel, additional, Faivre-Chauvet, Alain, additional, and Rbah-Vidal, Latifa, additional

Published
2022
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35. Highly inert Cu(II) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution.

Author

Pineau, Julie, Lima, Luís M. P., Le Roy, Marie M., Marionneau-Lambot, Séverine, Cordier, Marie, Le Saëc, Patricia, Zeevaart, Jan Rijn, Driver, Cathryn H. S., Faivre-Chauvet, Alain, Le Bris, Nathalie, and Tripier, Raphaël

Subjects
COPPER, CARBOXYL group, CHEMICAL properties, NUCLEAR medicine, IMMUNOGLOBULINS, LIGANDS (Chemistry), CHELATING agents
Abstract

Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine. [ABSTRACT FROM AUTHOR]

Published
2023
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39. 200 Ma de deformation et de fusion partielle dans la croute Archéenne: la marge Nord du Craton du Kaapvaal, Afrique du Sud

Author

Moyen, Jean-François, Chauvet, Alain, Vézinet, Adrien, Paquette, Jean-Louis, Cochelin, Bryan, Bruand, Emilie, Diener, Johann, Stevens, Gary, Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Laboratoire Magmas et Volcans (LMV), Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Institut de Recherche pour le Développement et la société-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Institut national des sciences de l'Univers (INSU - CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la Terre d'Orléans - UMR7327 (ISTO), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Métallogénie - UMR7327, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), SGF, CNRS, Laboratoire de Géologie de Lyon ou l’étude de la Terre, des planètes et de l’environnement, and Sciencesconf.org, CCSD

Subjects
[SDU] Sciences of the Universe [physics], fusion partielle, [SDU]Sciences of the Universe [physics], Archéen, Kaapvaal, Déformation, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

40. Copper-64-Labeled 1C1m-Fc, a New Tool for TEM-1 PET Imaging and Prediction of Lutetium-177-Labeled 1C1m-Fc Therapy Efficacy and Safety

Author

Delage, Judith Anna, primary, Gnesin, Silvano, additional, Prior, John O., additional, Barbet, Jacques, additional, Le Saëc, Patricia, additional, Marionneau-Lambot, Séverine, additional, Gouard, Sébastien, additional, Chérel, Michel, additional, Bourgeois, Mickael, additional, Schaefer, Niklaus, additional, Viertl, David, additional, Fierle, Julie Katrin, additional, Dunn, Steven Mark, additional, and Faivre-Chauvet, Alain, additional

Published
2021
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41. New Advances in Radioimmunotherapy for the Treatment of Cancers

Author

Kraeber-Bodéré, Françoise, primary, Bodet-Milin, Caroline, additional, Rousseau, Caroline, additional, Carlier, Thomas, additional, Ferrer, Ludovic, additional, Chouin, Nicolas, additional, Haddad, Férid, additional, Davodeau, François, additional, Chatal, Jean-François, additional, Faivre-Chauvet, Alain, additional, Gestin, Jean-François, additional, Chérel, Michel, additional, and Barbet, Jacques, additional

Published
2014
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42. Investigation on the reactivity of nucleophilic radiohalogens with arylboronic acids in water: access to an efficient single-step method for the radioiodination and astatination of antibodies

Author

Berdal, Marion, Gouard, Sébastien, Eychenne, Romain, Marionneau-Lambot, Séverine, Croyal, Mikaël, Faivre-Chauvet, Alain, Chérel, Michel, Gaschet, Joëlle, Gestin, Jean-François, Guérard, François, Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), GIP ARRONAX [Nantes] (Saint-Herblain), Université de Nantes (UN), Mass Spectrometry Core Facility [Nantes] (CRNH-O ), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de Médecine Nucléaire [Nantes], Hôpital Laennec, CRLCC René Gauducheau, INCa-DGOS-Inserm_12558, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011), ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Nutrition Humaine Ouest (CRNH Ouest), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Bernardo, Elizabeth, Nucléaire pour la Santé - - ARRONAXPLUS2011 - ANR-11-EQPX-0004 - EQPX - VALID, Radiopharmaceutiques Innovants en Oncologie et Neurologie - - IRON2011 - ANR-11-LABX-0018 - LABX - VALID, and NExT (I-SITE) - - NExT (I-SITE)2016 - ANR-16-IDEX-0007 - IDEX - VALID

Subjects
Biodistribution, medicine.drug_class, [SDV]Life Sciences [q-bio], Single step, [SDV.CAN]Life Sciences [q-bio]/Cancer, 010402 general chemistry, Monoclonal antibody, 01 natural sciences, Nucleophile, [SDV.CAN] Life Sciences [q-bio]/Cancer, Labelling, medicine, Reactivity (chemistry), biology, 010405 organic chemistry, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, Combinatorial chemistry, 6. Clean water, 0104 chemical sciences, 3. Good health, [SDV] Life Sciences [q-bio], biology.protein, Antibody, Divergent synthesis
Abstract

Easy access to radioiodinated and 211At-labelled bio(macro)molecules is essential to develop new strategies in nuclear imaging and targeted radionuclide therapy of cancers. Yet, the labelling of complex molecules with heavy radiohalogens is often poorly effective due to the multiple steps and intermediate purifications needed. Herein, we investigate the potential of arylboron chemistry as an alternative approach for the late stage labelling of antibodies. The reactivity of a model precursor, 4-chlorobenzeneboronic acid (1) with nucleophilic iodine-125 and astatine-211 was at first investigated in aqueous conditions. In the presence of a copper(ii) catalyst and 1,10-phenanthroline, quantitative radiochemical yields (RCYs) were achieved within 30 minutes at room temperature. The optimum conditions were then applied to a CD138 targeting monoclonal antibody (mAb) that has previously been validated for imaging and therapy in a preclinical model of multiple myeloma. RCYs remained high (>80% for 125I-labelling and >95% for 211At-labelling), and the whole procedure led to increased specific activities within less time in comparison with previously reported methods. Biodistribution study in mice indicated that targeting properties of the radiolabelled mAb were well preserved, leading to a high tumour uptake in a CD138 expressing tumour model. The possibility of divergent synthesis from a common modified carrier protein demonstrated herein opens facilitated perspectives in radiotheranostic applications with the radioiodine/211At pairs. Overall, the possibility to develop radiolabelling kits offered by this procedure should facilitate its translation to clinical applications., The high reactivity of astatine and iodine in water with arylboronic acids provides access to an efficient single-step antibody radiolabelling.

Published
2021

43. Fluid mixing as primary trigger for cassiterite deposition: Evidence from in situ δ18O-δ11B analysis of tourmaline from the world-class San Rafael tin (-copper) deposit, Peru

Author

Harlaux, Matthieu, primary, Kouzmanov, Kalin, additional, Gialli, Stefano, additional, Marger, Katharina, additional, Bouvier, Anne-Sophie, additional, Baumgartner, Lukas P., additional, Rielli, Andrea, additional, Dini, Andrea, additional, Chauvet, Alain, additional, Kalinaj, Miroslav, additional, and Fontboté, Lluís, additional

Published
2021
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44. Radionuclide Metabolic Therapy

Author

Mantel, Eleanor S., additional, Williams, Jessica, additional, Szczepura, Katy, additional, Sjögreen Gleisner, Katarina, additional, Strigari, Lidia, additional, Flux, Glenn, additional, Larg, Maria Iulia, additional, Testanera, Giorgio, additional, Chiti, Arturo, additional, Piciu, Doina, additional, Menghis, Ruth Berhane, additional, Lowry, Brian A., additional, Mayes, Christopher, additional, Vinjamuri, Sobhan, additional, Silva, Nadine, additional, do Rosário Vieira, Maria, additional, Rauscher, Aurore, additional, Bodet-Milin, Caroline, additional, Faivre-Chauvet, Alain, additional, Pallardy, Amandine, additional, Kraeber-Bodéré, Françoise, additional, Gorgan, Ana, additional, Lupu, Nicoleta, additional, and Cutler, Cathy S., additional

Published
2013
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50. Textural and mineralogical constraints on the mode of formation of the bou Azzer Co-Ni arsenide mineralization (Anti-Atlas, Morocco): Tectonic implications

Author

Tourneur, Enora, Chauvet, Alain, Kouzmanov, Kalin, Johann Tuduri, Sizaret, Stanislas, Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), Section des Sciences de la Terre, University of Geneva [Switzerland], Université de Genève (UNIGE), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM), Institut des Sciences de la Terre d'Orléans - UMR7327 (ISTO), Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université d'Orléans (UO)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Métallogénie - UMR7327, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Observatoire des Sciences de l'Univers en région Centre (OSUC), and Chauvet, Alain

Subjects
[SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics, [SDU.STU.AG] Sciences of the Universe [physics]/Earth Sciences/Applied geology, [SDU.STU.TE] Sciences of the Universe [physics]/Earth Sciences/Tectonics, [SDU.STU.AG]Sciences of the Universe [physics]/Earth Sciences/Applied geology, [SDU.STU.MI] Sciences of the Universe [physics]/Earth Sciences/Mineralogy, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
Abstract

International audience; The hydrothermal native element-arsenide mineralization (five-element) type comprises native Ag and/or native Bi as well as Ni-, Co-, and Fe-arsenides and-sulfarsenides. Due to the current surge in Co-demand, this mineralization type has regained recent economic interest. Thus, it is of interest to further understand the paragenetic and possible spatial relation of Co-bearing minerals and the formation mechanism/process of this mineralization type. This is achieved through an extensive literature review in combination with newly calculated stability relations. The mineralization is host rock independent, but spatially linked to sources of reducing agents (as this is the cause of precipitation). This reduction process results in a thermodynamically controlled characteristic Ni- Co- Fe-diarsenides sequence, as well as a transition from native elements to mono-to di-arsenides. The temporal Ni  Co  Fe trend has also been described to occur on a special scale, and since it is ubiquitous, it may be used as a tool in constraining Co rich sections of a deposit. The formation of this mineralization is, however, not only thermodynamically, but also kinetically controlled, as is evident by the abundant dendritic textures. Kinetics favor a sulfate-sulfide disequilibrium which enables an aqueous sulfide poor system that allows for arsenide formation.

Published
2019

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