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Your search keyword '"Che, Yue-Ping"' showing total 5 results
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5 results on '"Che, Yue-Ping"'

4. Efficacy and Toxicity of Addition of Bevacizumab to Chemotherapy in Patients with Metastatic Colorectal Cancer

Author

Ruan, Wen-Cong, Che, Yue-Ping, Ding, Li, and Li, Hai-Feng

Abstract

Background: Pre-treated patients with first-line treatment can be offered a second treatment with the aim of improving their poor clinical prognosis. The therapy of metastatic colorectal cancer (CRC) patients who did not respond to first-line therapy has limited treatment options. Recently, many studies have paid much attention to the efficacy of bevacizumab as an adjuvant treatment for metastatic colorectal cancer. Objectives: We aimed to evaluate the efficacy and toxicity of bevacizumab plus chemotherapy compared with bevacizumab-naive based chemotherapy as second-line treatment in people with metastatic CRC. Methods: Electronic databases were searched for eligible studies updated to March 2018. Randomized-controlled trials comparing addition of bevacizumab to chemotherapy without bevacizumab in MCRC patients were included, of which, the main interesting results were the efficacy and safety profiles of the addition of bevacizumab in patients with MCRC as second-line therapy. Result: Five trials were eligible in the meta-analysis. Patients who received the combined bevacizumab and chemotherapy treatment in MCRC as second-line therapy showed a longer overall survival (OS) (OR=0.80,95%CI=0.72-0.89, P<0.0001) and progression-free survival (PFS) (OR=0.69,95%CI=0.61-0.77, P<0.00001). In addition, there was no significant difference in objective response rate (ORR) (RR=1.36,95%CI=0.82-2.24, P=0.23) or severe adverse event (SAE) (RR=1.02,95%CI=0.88-1.19, P=0.78) between bevacizumab-based chemotherapy and bevacizumabnaive based chemotherapy. Conclusion: Our results suggest that the addition of bevacizumab to the chemotherapy therapy could be an efficient and safe treatment option for patients with metastatic colorectal cancer as second-line therapy and without increasing the risk of an adverse event.

Published
2018

5. [Efficacy of acupuncture for spastic cerebral palsy in infancy stage].

Author

Zhang X, Che YP, Li HF, Yin HW, Chen T, Dong Q, and Du Y

Subjects
Acupuncture Points, Child, Humans, Infant, Muscle Spasticity, Needles, Acupuncture Therapy, Cerebral Palsy therapy
Abstract

Objective: To explore the therapeutic effect of acupuncture for spastic cerebral palsy in infancy stage., Methods: A total of 62 children with spastic cerebral palsy were randomized into an observation group and a control group, 31 cases in each one. Both groups were given comprehensive rehabilitation therapy (sport therapy, electronic biofeedback therapy, speech cognitive training, massage therapy). On the basis of comprehensive rehabilitation therapy, the acupuncture group was treated with acupuncture at Baihui (GV 20), Sishencong (EX-HN1), motor area, Jiaji (EX-B 2), Weizhong (BL 40), Xuanzhong (GB 39), Zusanli (ST 36) and Hegu (LI 4), etc, the needles were retained for 15-20 min each time, once a day, 5 days a week, 45 days as a course with 10 days interval, a total of 3 courses were required. The Gesell development scale adaptive DQ scores, gross motor function measure (GMFM88) and muscular tension of adductor and gastrocnemius muscle were compared before and after treatment in the two groups., Results: The Gesell development scale adaptive DQ score after treatment in the observation group was increased ( P <0.05), there was no significant difference before and after treatment in the control group ( P >0.05), the change of the observation group was larger than the control group ( P <0.05). After treatment, the GMFM88 scores in the two groups were significantly increased ( P <0.05), the change of the observation group was larger than the control group ( P <0.05). After treatment, the muscular tension of the adductor in the two groups were decreased ( P <0.05), the change of the observation group was larger than the control group ( P <0.05). After treatment, the muscle tension of the gastrocnemius muscle in the two groups were decreased ( P <0.05), there was no significant difference between the two groups in the variation range ( P >0.05)., Conclusion: Acupuncture combined with comprehensive rehabilitation therapy can improve cognitive function, spasticity and motor function of children with spastic cerebral palsy.

Published
2019
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