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1. Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease

Author

Österdahl, Marc F., Whiston, Ronan, Sudre, Carole H., Asnicar, Francesco, Cheetham, Nathan J., Blanco Miguez, Aitor, Bowyer, Vicky, Antonelli, Michela, Snell, Olivia, dos Santos Canas, Liane, Hu, Christina, Wolf, Jonathan, Menni, Cristina, Malim, Michael, Hart, Deborah, Spector, Tim, Berry, Sarah, Segata, Nicola, Doores, Katie, Ourselin, Sebastien, Duncan, Emma L., and Steves, Claire J.

Published
2023
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2. The effects of COVID-19 on cognitive performance in a community-based cohort: a COVID symptom study biobank prospective cohort study

Author

Cheetham, Nathan J., Penfold, Rose, Giunchiglia, Valentina, Bowyer, Vicky, Sudre, Carole H., Canas, Liane S., Deng, Jie, Murray, Benjamin, Kerfoot, Eric, Antonelli, Michela, Rjoob, Khaled, Molteni, Erika, Österdahl, Marc F., Harvey, Nicholas R., Trender, William R., Malim, Michael H., Doores, Katie J., Hellyer, Peter J., Modat, Marc, Hammers, Alexander, Ourselin, Sebastien, Duncan, Emma L., Hampshire, Adam, and Steves, Claire J.

Published
2023
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3. Profiling post-COVID-19 condition across different variants of SARS-CoV-2: a prospective longitudinal study in unvaccinated wild-type, unvaccinated alpha-variant, and vaccinated delta-variant populations

Author

Canas, Liane S, Molteni, Erika, Deng, Jie, Sudre, Carole H, Murray, Benjamin, Kerfoot, Eric, Antonelli, Michela, Rjoob, Khaled, Capdevila Pujol, Joan, Polidori, Lorenzo, May, Anna, Österdahl, Marc F, Whiston, Ronan, Cheetham, Nathan J, Bowyer, Vicky, Spector, Tim D, Hammers, Alexander, Duncan, Emma L, Ourselin, Sebastien, Steves, Claire J, and Modat, Marc

Published
2023
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5. Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study

Author

Antonelli, Michela, Penfold, Rose S, Merino, Jordi, Sudre, Carole H, Molteni, Erika, Berry, Sarah, Canas, Liane S, Graham, Mark S, Klaser, Kerstin, Modat, Marc, Murray, Benjamin, Kerfoot, Eric, Chen, Liyuan, Deng, Jie, Österdahl, Marc F, Cheetham, Nathan J, Drew, David A, Nguyen, Long H, Pujol, Joan Capdevila, Hu, Christina, Selvachandran, Somesh, Polidori, Lorenzo, May, Anna, Wolf, Jonathan, Chan, Andrew T, Hammers, Alexander, Duncan, Emma L, Spector, Tim D, Ourselin, Sebastien, and Steves, Claire J

Published
2022
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6. Courage in Decision Making: A Mixed-Methods Study of COVID-19 Vaccine Uptake in Women of Reproductive Age in the U.K.

Author

Magee, Laura A., Brown, Julia R., Bowyer, Vicky, Horgan, Gillian, Boulding, Harriet, Khalil, Asma, Cheetham, Nathan J., Harvey, Nicholas R., Mistry, Hiten D., Sudre, Carole, Silverio, Sergio A., von Dadelszen, Peter, and Duncan, Emma L.

Subjects
VACCINATION status, CHILDBEARING age, COVID-19 vaccines, DECISION making, MEDICAL personnel
Abstract

COVID-19 vaccination rates are lower in women of reproductive age (WRA), including pregnant/postpartum women, despite their poorer COVID-19-related outcomes. We evaluated the vaccination experiences of 3568 U.K. WRA, including 1983 women (55.6%) experiencing a pandemic pregnancy, recruited through the ZOE COVID Symptom Study app. Two staggered online questionnaires (Oct–Dec 2021: 3453 responders; Aug–Sept 2022: 2129 responders) assessed reproductive status, COVID-19 status, vaccination, and attitudes for/against vaccination. Descriptive analyses included vaccination type(s), timing relative to age-based eligibility and reproductive status, vaccination delay (first vaccination >28 days from eligibility), and rationale, with content analysis of free-text comments. Most responders (3392/3453, 98.2%) were vaccinated by Dec 2021, motivated by altruism, vaccination supportiveness in general, low risk, and COVID-19 concerns. Few declined vaccination (by Sept/2022: 20/2129, 1.0%), citing risks (pregnancy-specific and longer-term), pre-existing immunity, and personal/philosophical reasons. Few women delayed vaccination, although pregnant/postpartum women (vs. other WRA) received vaccination later (median 3 vs. 0 days after eligibility, p < 0.0001). Despite high uptake, concerns included adverse effects, misinformation (including from healthcare providers), ever-changing government advice, and complex decision making. In summary, most women in this large WRA cohort were promptly vaccinated, including pregnant/post-partum women. Altruism and community benefit superseded personal benefit as reasons for vaccination. Nevertheless, responders experienced angst and received vaccine-related misinformation and discouragement. These findings should inform vaccination strategies in WRA. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Symptom experience before vs. after confirmed SARS-CoV-2 infection: a population and case control study using prospectively recorded symptom data.

Author

Sudre, Carole Helene, primary, Antonelli, Michela, additional, Cheetham, Nathan J, additional, Molteni, Erika, additional, Canas, Liane S, additional, Bowyer, Vicky, additional, Murray, Benjamin, additional, Rjoob, Khaled, additional, Modat, Marc, additional, Capdevia Pujol, Joan, additional, Hu, Christina, additional, Wolf, Jonathan, additional, Spector, Timothy D, additional, Hammers, Alexander, additional, Steves, Claire J, additional, Ourselin, Sebastien, additional, and Duncan, Emma L, additional

Published
2023
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9. The effects of COVID-19 on cognitive performance in a community-based cohort: A COVID Symptom Study Biobank observational study

Author

Cheetham, Nathan J, primary, Penfold, Rose, additional, Giunchiglia, Valentina, additional, Bowyer, Vicky, additional, Sudre, Carole H, additional, Canas, Liane S, additional, Deng, Jie, additional, Murray, Benjamin, additional, Kerfoot, Eric, additional, Antonelli, Michela, additional, Rjoob, Khaled, additional, Molteni, Erika, additional, Osterdahl, Marc F, additional, Harvey, Nicholas R, additional, Trender, William R, additional, Malim, Michael H, additional, Doores, Katie J, additional, Hellyer, Peter J, additional, Modat, Marc, additional, Hammers, Alexander, additional, Ourselin, Sebastien, additional, Duncan, Emma L, additional, Hampshire, Adam, additional, and Steves, Claire J, additional

Published
2023
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10. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Cheetham, Nathan J, primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J, additional, Knuppel, Anika, additional, Williams, Dylan M, additional, Hamilton, Olivia KL, additional, Lee, Paul H, additional, Bridger Staatz, Charis, additional, Di Gessa, Giorgio, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, Thompson, Ellen J, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H, additional, Mitchell, Ruth E, additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex SF, additional, Doores, Katie, additional, chaturvedi, Nishi, additional, Duncan, Emma L, additional, Timpson, Nicholas J, additional, and Steves, Claire J, additional

Published
2023
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11. Author response: Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Cheetham, Nathan J, primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J, additional, Knuppel, Anika, additional, Williams, Dylan M, additional, Hamilton, Olivia KL, additional, Lee, Paul H, additional, Bridger Staatz, Charis, additional, Di Gessa, Giorgio, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B, additional, Thompson, Ellen J, additional, Bowyer, Ruth CE, additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H, additional, Mitchell, Ruth E, additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex SF, additional, Doores, Katie, additional, Chaturvedi, Nishi, additional, Duncan, Emma L, additional, Timpson, Nicholas J, additional, and Steves, Claire J, additional

Published
2022
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12. Metabolomic and gut microbiome profiles across the spectrum of community-based COVID and non-COVID disease: A COVID-19 Biobank study

Author

Österdahl, Marc F., primary, Whiston, Ronan, additional, Sudre, Carole H., additional, Asnicar, Francesco, additional, Cheetham, Nathan J., additional, Miguez, Aitor Blanco, additional, Bowyer, Vicky, additional, Antonelli, Michela, additional, Snell, Olivia, additional, dos Santos Canas, Liane, additional, Hu, Christina, additional, Wolf, Jonathan, additional, Menni, Cristina, additional, Malim, Michael, additional, Hart, Deborah, additional, Spector, Tim, additional, Berry, Sarah, additional, Segata, Nicola, additional, Doores, Katie, additional, Ourselin, Sebastien, additional, Duncan, Emma L, additional, and Steves, Claire J, additional

Published
2022
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13. Profiling post-COVID syndrome across different variants of SARS-CoV-2

Author

Canas, Liane S., primary, Molteni, Erika, additional, Deng, Jie, additional, Sudre, Carole H., additional, Murray, Benjamin, additional, Kerfoot, Eric, additional, Antonelli, Michela, additional, Chen, Liyuan, additional, Rjoob, Khaled, additional, Pujol, Joan Capdevila, additional, Polidori, Lorenzo, additional, May, Anna, additional, Österdahl, Marc F., additional, Whiston, Ronan, additional, Cheetham, Nathan J., additional, Bowyer, Vicky, additional, Spector, Tim D., additional, Hammers, Alexander, additional, Duncan, Emma L., additional, Ourselin, Sebastien, additional, Steves, Claire J., additional, and Modat, Marc, additional

Published
2022
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14. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors

Author

Cheetham, Nathan J., primary, Kibble, Milla, additional, Wong, Andrew, additional, Silverwood, Richard J., additional, Knuppel, Anika, additional, Williams, Dylan M., additional, Hamilton, Olivia K. L., additional, Lee, Paul H., additional, Staatz, Charis Bridger, additional, Gessa, Giorgio Di, additional, Zhu, Jingmin, additional, Katikireddi, Srinivasa Vittal, additional, Ploubidis, George B., additional, Thompson, Ellen J., additional, Bowyer, Ruth C. E., additional, Zhang, Xinyuan, additional, Abbasian, Golboo, additional, Garcia, Maria Paz, additional, Hart, Deborah, additional, Seow, Jeffrey, additional, Graham, Carl, additional, Kouphou, Neophytos, additional, Acors, Sam, additional, Malim, Michael H., additional, Mitchell, Ruth E., additional, Northstone, Kate, additional, Major-Smith, Daniel, additional, Matthews, Sarah, additional, Breeze, Thomas, additional, Crawford, Michael, additional, Molloy, Lynn, additional, Kwong, Alex S. F., additional, Doores, Katie J., additional, Chaturvedi, Nishi, additional, Duncan, Emma L., additional, Timpson, Nicholas J., additional, and Steves, Claire J., additional

Published
2022
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15. Slow Energy Transfer in Self‐Doped β‐Conformation Film of Steric Polydiarylfluorenes toward Stable Dual Deep‐Blue Amplified Spontaneous Emission

Author

Xu, Man, primary, Sun, Lili, additional, Wang, Shengjie, additional, Lin, Jinyi, additional, Yu, Mengna, additional, Wang, Xuhua, additional, Stavrinou, Paul N., additional, Xie, Linghai, additional, Cheetham, Nathan J., additional, Ding, Xuehua, additional, Bradley, Donal D. C., additional, and Huang, Wei, additional

Published
2021
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16. Post-vaccination SARS-CoV-2 infection: risk factors and illness profile in a prospective, observational community-based case-control study

Author

Antonelli, Michela, primary, Penfold, Rose S, additional, Merino, Jordi, additional, Sudre, Carole H, additional, Molteni, Erika, additional, Berry, Sarah, additional, Canas, Liane S, additional, Graham, Mark S, additional, Klaser, Kerstin, additional, Modat, Marc, additional, Murray, Benjamin, additional, Kerfoot, Eric, additional, Chen, Liyuan, additional, Deng, Jie, additional, Österdahl, Marc F, additional, Cheetham, Nathan J, additional, Drew, David, additional, Nguyen, Long, additional, Pujol, Joan Capdevila, additional, Hu, Christina, additional, Selvachandran, Somesh, additional, Polidori, Lorenzo, additional, May, Anna, additional, Wolf, Jonathan, additional, Chan, Andrew T, additional, Hammers, Alexander, additional, Duncan, Emma L, additional, Spector, Tim D, additional, Ourselin, Sebastien, additional, and Steves, Claire J, additional

Published
2021
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17. Highly Deformed o ‐Carborane Functionalised Non‐linear Polycyclic Aromatics with Exceptionally Long C−C Bonds

Author

Marsh, Adam V., primary, Little, Mark, additional, Cheetham, Nathan J., additional, Dyson, Matthew J., additional, Bidwell, Matthew, additional, White, Andrew J. P., additional, Warriner, Colin N., additional, Swain, Anthony C., additional, McCulloch, Iain, additional, Stavrinou, Paul N., additional, and Heeney, Martin, additional

Published
2020
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18. Modelling the health and economic impacts of different testing and tracing strategies for COVID-19 in the UK

Author

Colbourn, Tim, primary, Waites, William, additional, Manheim, David, additional, Foster, Derek, additional, Sturniolo, Simone, additional, Sculpher, Mark, additional, Kerr, Cliff C, additional, Colbourn, Greg, additional, Bowie, Cam, additional, Godfrey, Keith M, additional, Peto, Julian, additional, Burgess, Rochelle A, additional, McCoy, David, additional, Alwan, Nisreen A, additional, Yao, Guiqing, additional, Ouyang, Kang, additional, Roderick, Paul J, additional, Pizzo, Elena, additional, Hill, Tony, additional, McGrath, Nuala, additional, Orcutt, Miriam, additional, Evans, Owain, additional, Cheetham, Nathan J, additional, Bonell, Chris, additional, Gomes, Manuel, additional, Panovska-Griffiths, Jasmina, additional, and Raine, Rosalind, additional

Published
2020
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19. Slow Energy Transfer in Self‐Doped β‐Conformation Film of Steric Polydiarylfluorenes toward Stable Dual Deep‐Blue Amplified Spontaneous Emission.

Author

Xu, Man, Sun, Lili, Wang, Shengjie, Lin, Jinyi, Yu, Mengna, Wang, Xuhua, Stavrinou, Paul N., Xie, Linghai, Cheetham, Nathan J., Ding, Xuehua, Bradley, Donal D. C., and Huang, Wei

Subjects
ENERGY transfer, CONJUGATED polymers, POLYFLUORENES, TIME-resolved spectroscopy, PHOTOEXCITATION
Abstract

Exciton behavior is crucial for improving the optoelectronic property of a light‐emitting conjugated polymer. Herein, the photoexcitation dynamics of exciton migration and energy transfer in a self‐doped β‐conformation film of the polydiarylfluorenes (poly[4‐(octyloxy)‐9,9‐diphenylfluoren‐2,7‐diyl]‐co‐[5‐(octyloxy)‐9,9‐ diphenylfluoren‐2,7‐diyl], PODPF) are demonstrated. Compared to the first generation of the β‐conformation polyfluorene, poly(9,9‐dioctylfluorene) (PFO), energy transfer occurs in PODPF β‐conformation films in a time period of ≈150 ps, much longer than those of the PFO ones (<5 ps), associated with the effective intrachain energy transfer (few hundred picoseconds), rather than interchain Förster energy transfer (a few picoseconds). Similar to PFO, the PODPF β‐conformation also displays well‐resolved vibronic emission peaks at 20 K, attributed to the planar and rigid conformation. Interestingly, a residual 0‐0 band emission of nonplanar conformation chain segments (435 nm, 2.85 eV) at 20 K also further confirms the exciton migration from the amorphous state to the β‐conformation domain in PODPF films. Therefore, the stable dual amplified spontaneous emission (ASE) behavior of the PODPF self‐doped films at 461 nm (2.69 eV) and 483 nm (2.57 eV), originates from the individual amorphous and β‐conformation domains. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Correlating the Structural and Photophysical Properties of Ortho , Meta , and Para ‐Carboranyl–Anthracene Dyads

Author

Marsh, Adam V., primary, Dyson, Matthew J., additional, Cheetham, Nathan J., additional, Bidwell, Matthew, additional, Little, Mark, additional, White, Andrew J. P., additional, Warriner, Colin N., additional, Swain, Anthony C., additional, McCulloch, Iain, additional, Stavrinou, Paul N., additional, Meskers, Stefan C. J., additional, and Heeney, Martin, additional

Published
2020
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21. Modelling the Health and Economic Impacts of Population-Wide Testing, Contact Tracing and Isolation (PTTI) Strategies for COVID-19 in the UK

Author

Colbourn, Tim, primary, Waites, William, additional, Panovska-Griffiths, Jasmina, additional, Manheim, David, additional, Sturniolo, Simone, additional, Colbourn, Greg, additional, Bowie, Cam, additional, Godfrey, Keith M., additional, Peto, Julian, additional, Burgess, Rochelle A., additional, Foster, Derek, additional, McCoy, David, additional, Alwan, Nisreen A., additional, Yao, Guiqing, additional, Ouyang, Kang, additional, Roderick, Paul J., additional, Pizzo, Elena, additional, Hill, Tony, additional, McGrath, Nuala, additional, Orcutt, Miriam, additional, Evans, Owain, additional, Cheetham, Nathan J., additional, Sculpher, Mark, additional, Bonell, Chris, additional, Gomes, Manuel, additional, and Raine, Rosalind, additional

Published
2020
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22. The importance of microstructure in determining polaron generation yield in poly(9,9-dioctylfluorene)

Author

Cheetham, Nathan J., Ortiz, Manuel, Perevedentsev, Aleksandr, Dion-Bertrand, Laura-Isabelle, Greetham, Gregory M., Sazanovich, Igor V., Towrie, Michael, Parker, Anthony W., Nelson, Jenny, Silva, Carlos, Bradley, Donal D. C., Hayes, Sophia C., Stavrinou, Paul N., Hayes, Sophia C. [0000-0002-2809-6193], and Stavrinou, Paul N. [0000-0001-6075-2587]

Subjects
chemistry.chemical_classification, Yield (engineering), Materials science, chemistry, Chemical physics, Exciton dissociation, General Chemical Engineering, Materials Chemistry, General Chemistry, Polymer, Conjugated system, Microstructure, Polaron
Abstract

Understanding the structure–property relationships that govern exciton dissociation into polarons in conjugated polymers is key in developing materials for optoelectronic applications such as light-emitting diodes and solar cells. Here, the polymer poly(9,9-dioctylfluorene) (PFO), which can form a minority population of chain segments in a distinct, lower-energy “β-phase” conformation, is studied to examine the influence of conformation and microstructure on polaron generation in neat thin films. Through use of ultrafast transient absorption spectroscopy to probe PFO thin films with glassy-phase and β-phase microstructures and selectively exciting each phase independently, the dynamics of exciton dissociation are resolved. Ultrafast polaron generation is consistently found to be significantly higher and long-lived in thin films containing β-phase chain segments, with an average polaron yield that increases by over a factor of three to 4.9% vs 1.4% in glassy-phase films. The higher polaron yield, attributed to an increased exciton dissociation yield at the interface between conformational phases, is most likely due to a combination of the significant energetic differences between glassy-phase and β-phase segments and disparities in electronic delocalization and charge carrier mobilities between phases. 31 17 6787 6797

Published
2019

23. Assembly-Induced Bright-Light Emission from Solution-Processed Platinum(II) Inorganic Polymers

Author

Perevedentsev, Aleksandr, primary, Bargardi, Fabio L., additional, Sánchez-Ferrer, Antoni, additional, Cheetham, Nathan J., additional, Sousaraei, Ahmad, additional, Busato, Stephan, additional, Gierschner, Johannes, additional, Milián-Medina, Begoña, additional, Mezzenga, Raffaele, additional, Wannemacher, Reinhold, additional, Cabanillas-Gonzalez, Juan, additional, Campoy-Quiles, Mariano, additional, and Caseri, Walter R., additional

Published
2019
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24. The Importance of Microstructure in Determining Polaron Generation Yield in Poly(9,9-dioctylfluorene)

Author

Cheetham, Nathan J., primary, Ortiz, Manuel, additional, Perevedentsev, Aleksandr, additional, Dion-Bertrand, Laura-Isabelle, additional, Greetham, Gregory M., additional, Sazanovich, Igor V., additional, Towrie, Michael, additional, Parker, Anthony W., additional, Nelson, Jenny, additional, Silva, Carlos, additional, Bradley, Donal D. C., additional, Hayes, Sophia C., additional, and Stavrinou, Paul N., additional

Published
2019
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25. Thioalkyl- and sulfone-substituted poly(p-phenylene vinylene)s

Author

Rimmele, Martina, primary, Ableidinger, Klaus, additional, Marsh, Adam V., additional, Cheetham, Nathan J., additional, Taublaender, M. Josef, additional, Buchner, Alina, additional, Prinz, Jonathan, additional, Fröhlich, Johannes, additional, Unterlass, Miriam M., additional, Heeney, Martin, additional, and Glöcklhofer, Florian, additional

Published
2019
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26. Thioalkyl- and Sulfone-Substituted Poly(p-Phenylene Vinylene)s

Author

Rimmele, Martina, primary, Ableidinger, Klaus, primary, Marsh, Adam V., primary, Cheetham, Nathan J., primary, Taublaender, M. Josef, primary, Buchner, Alina, primary, Prinz, Jonathan, primary, Fröhlich, Johannes, primary, Unterlass, Miriam M., primary, Heeney, Martin, primary, and Glöcklhofer, Florian, primary

Published
2018
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27. Highly Deformed o‐Carborane Functionalised Non‐linear Polycyclic Aromatics with Exceptionally Long C−C Bonds.

Author

Marsh, Adam V., Little, Mark, Cheetham, Nathan J., Dyson, Matthew J., Bidwell, Matthew, White, Andrew J. P., Warriner, Colin N., Swain, Anthony C., McCulloch, Iain, Stavrinou, Paul N., and Heeney, Martin

Subjects
ACENES, POLYCYCLIC aromatic hydrocarbons, CHEMICAL bond lengths, BENZANTHRACENES, CRYSTAL structure, EXCIMERS
Abstract

The effect of substituting o‐carborane into the most sterically hindered positions of phenanthrene and benzo(k)tetraphene is reported. Synthesised via a Bull–Hutchings–Quayle benzannulation, the crystal structures of these non‐linear acenes exhibited the highest aromatic deformation parameters observed for any reported carborane compound to date, and among the largest carboranyl C−C bond length of all organo‐substituted o‐carboranes. Photoluminescence studies of these compounds demonstrated efficient intramolecular charge‐transfer, leading to aggregation induced emission properties. Additionally, an unusual low‐energy excimer was observed for the phenanthryl compound. These are two new members of the family of carborane‐functionalised non‐linear acenes, notable for their peculiar structures and multi‐luminescent properties. [ABSTRACT FROM AUTHOR]

Published
2021
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32. Assembly-Induced Bright-Light Emission from Solution-Processed Platinum(II) Inorganic Polymers

Author

Perevedentsev, Aleksandr, Bargardi, Fabio L., Sánchez-Ferrer, Antoni, Cheetham, Nathan J., Sousaraei, Ahmad, Busato, Stephan, Gierschner, Johannes, Milián-Medina, Begoña, Mezzenga, Raffaele, Wannemacher, Reinhold, Cabanillas-Gonzalez, Juan, Campoy-Quiles, Mariano, and Caseri, Walter R.

Subjects
7. Clean energy, 3. Good health, 12. Responsible consumption
Abstract

Synthesis, processing, and characterization are reported for a series of tetracyanoplatinate Magnus’ salt (TCN-MS) derivatives—soluble derivatives of the generally intractable Magnus’ green salt—that feature the general structure [Pt(NH2R)4][Pt(CN)4] where R is a branched alkyl group or a ω-phenylalkyl group. In solutions, these coordination compounds generally dissolve on the level of individual ion pairs as shown by X-ray diffraction analysis. To enable the formation of quasi-one-dimensional linear stacks of Pt(II) atoms in thin films, the matrix-assisted assembly is employed, whereby the compounds are codissolved with poly(ethylene oxide) (PEO), followed by film casting, thermally activated assembly, and eventual removal of PEO. Remarkably, assembled TCN-MS inorganic polymers exhibit bright blue-green photoluminescence. A detailed investigation of the assembly process and simultaneously modified solid-state optical properties is performed using a range of microscopy, optical and vibrational spectroscopy, and thermal analysis techniques. Given their unusual combination of optical properties, namely, transparency in the visible region, high photoluminescence quantum efficiencies (up to 13% in first-demonstration samples), and large Stokes shifts (up to 1 eV), TCN-MS derivatives are proposed as a promising class of light-emitting materials for emerging applications in molecular optoelectronics, the potential and challenges of which are discussed., ACS Omega, 4 (6), ISSN:2470-1343

33. Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

Author

Nathan J Cheetham, Milla Kibble, Andrew Wong, Richard J Silverwood, Anika Knuppel, Dylan M Williams, Olivia KL Hamilton, Paul H Lee, Charis Bridger Staatz, Giorgio Di Gessa, Jingmin Zhu, Srinivasa Vittal Katikireddi, George B Ploubidis, Ellen J Thompson, Ruth CE Bowyer, Xinyuan Zhang, Golboo Abbasian, Maria Paz Garcia, Deborah Hart, Jeffrey Seow, Carl Graham, Neophytos Kouphou, Sam Acors, Michael H Malim, Ruth E Mitchell, Kate Northstone, Daniel Major-Smith, Sarah Matthews, Thomas Breeze, Michael Crawford, Lynn Molloy, Alex SF Kwong, Katie Doores, Nishi Chaturvedi, Emma L Duncan, Nicholas J Timpson, Claire J Steves, Cheetham, Nathan J [0000-0002-2259-1556], Kibble, Milla [0000-0003-1130-4010], Hamilton, Olivia KL [0000-0002-5874-0058], Lee, Paul H [0000-0002-5729-6450], Bridger Staatz, Charis [0000-0002-2872-6968], Di Gessa, Giorgio [0000-0001-6154-1845], Zhu, Jingmin [0000-0001-8325-7589], Acors, Sam [0000-0001-6428-7707], Malim, Michael H [0000-0002-7699-2064], Major-Smith, Daniel [0000-0001-6467-2023], Duncan, Emma L [0000-0002-8143-4403], Steves, Claire J [0000-0002-4910-0489], and Apollo - University of Cambridge Repository

Subjects
medicine, COVID-19 Vaccines, General Immunology and Microbiology, SARS-CoV-2, General Neuroscience, Vaccination, COVID-19, global health, General Medicine, ALSPAC, Antibodies, Viral, General Biochemistry, Genetics and Molecular Biology, Coronavirus, TwinsUK, Epidemiology and Global Health, Cross-Sectional Studies, Risk Factors, London, antibodies, Humans, epidemiology, human, Longitudinal Studies, Antibody, Research Article
Abstract

Peer reviewed: True, Background: SARS-CoV-2 antibody levels can be used to assess humoral immune responses following SARS-CoV-2 infection or vaccination, and may predict risk of future infection. Higher levels of SARS-CoV-2 anti-Spike antibodies are known to be associated with increased protection against future SARS-CoV-2 infection. However, variation in antibody levels and risk factors for lower antibody levels following each round of SARS-CoV-2 vaccination have not been explored across a wide range of socio-demographic, SARS-CoV-2 infection and vaccination, and health factors within population-based cohorts. Methods: Samples were collected from 9,361 individuals from TwinsUK and ALSPAC UK population-based longitudinal studies and tested for SARS-CoV-2 antibodies. Cross-sectional sampling was undertaken jointly in April-May 2021 (TwinsUK, N = 4,256; ALSPAC, N = 4,622), and in TwinsUK only in November 2021-January 2022 (N = 3,575). Variation in antibody levels after first, second, and third SARS-CoV-2 vaccination with health, socio-demographic, SARS-CoV-2 infection and SARS-CoV-2 vaccination variables were analysed. Using multivariable logistic regression models, we tested associations between antibody levels following vaccination and: (1) SARS-CoV-2 infection following vaccination(s); (2) health, socio-demographic, SARS-CoV-2 infection and SARS-CoV-2 vaccination variables. Results: Within TwinsUK, single-vaccinated individuals with the lowest 20% of anti-Spike antibody levels at initial testing had 3-fold greater odds of SARS-CoV-2 infection over the next six to nine months (OR = 2.9, 95% CI: 1.4, 6.0), compared to the top 20%. In TwinsUK and ALSPAC, individuals identified as at increased risk of COVID-19 complication through the UK 'Shielded Patient List' had consistently greater odds (2- to 4-fold) of having antibody levels in the lowest 10%. Third vaccination increased absolute antibody levels for almost all individuals, and reduced relative disparities compared with earlier vaccinations. Conclusions: These findings quantify the association between antibody level and risk of subsequent infection, and support a policy of triple vaccination for the generation of protective antibodies. Funding: Antibody testing was funded by UK Health Security Agency. The National Core Studies program is funded by COVID-19 Longitudinal Health and Wellbeing - National Core Study (LHW-NCS) HMT/UKRI/MRC (MC_PC_20030 & MC_PC_20059). Related funding was also provided by the NIHR 606 (CONVALESCENCE grant COV-LT-0009). TwinsUK is funded by the Wellcome Trust, Medical Research Council, Versus Arthritis, European Union Horizon 2020, Chronic Disease Research Foundation (CDRF), Zoe Ltd and the National Institute for Health Research (NIHR) Clinical Research Network (CRN) and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust in partnership with King's College London. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC.

Published
2023

34. Symptoms before and after COVID-19: a population and case-control study using prospective data.

Author

Sudre CH, Antonelli M, Cheetham NJ, Molteni E, Canas LS, Bowyer V, Murray B, Rjoob K, Modat M, Capdevila Pujol J, Hu C, Wolf J, Spector TD, Hammers A, Steves CJ, Ourselin S, and Duncan EL

Subjects
Humans, Female, Male, Case-Control Studies, Middle Aged, Prospective Studies, Adult, Aged, Time Factors, Post-Acute COVID-19 Syndrome, Survival Analysis, Fatigue epidemiology, COVID-19 epidemiology, COVID-19 complications, SARS-CoV-2
Abstract

Background: Some individuals experience prolonged illness after acute coronavirus disease 2019 (COVID-19). We assessed whether pre-infection symptoms affected post-acute COVID illness duration., Methods: Survival analysis was performed in adults (n=23 452) with community-managed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection prospectively self-logging data through the ZOE COVID Symptom Study app, at least weekly, from 8 weeks before to 12 weeks after COVID-19 onset, conditioned on presence versus absence of baseline symptoms (4-8 weeks before COVID-19). A case-control study was performed in 1350 individuals with long illness (≥8 weeks, including 906 individuals (67.1%) with illness ≥12 weeks), matched 1:1 (for age, sex, body mass index, testing week, prior infection, vaccination, smoking, index of multiple deprivation) with 1350 individuals with short illness (<4 weeks). Baseline symptoms were compared between the two groups, and against post-COVID symptoms., Results: Individuals reporting baseline symptoms had longer COVID-related symptom duration (median 15 days versus 10 days for individuals without baseline symptoms) with baseline fatigue nearly doubling duration. Two-thirds (910 (67.4%) of 1350) of individuals with long illness were asymptomatic beforehand. However, 440 (32.6%) had baseline symptoms, versus 255 (18.9%) of 1350 individuals with short illness (p<0.0001). Baseline symptoms doubled the odds ratio for long illness (2.14, 95% CI 1.78-2.57). Prior comorbidities were more common in individuals with long versus short illness. In individuals with long illness, baseline symptomatic ( versus asymptomatic) individuals were more likely to be female, younger, and have prior comorbidities; and baseline and post-acute symptoms, and symptom burden, correlated strongly., Conclusions: Individuals experiencing symptoms before COVID-19 had longer illness duration and increased odds of long illness. However, many individuals with long illness were well before SARS-CoV-2 infection., Competing Interests: Conflict of interest: T.D. Spector and J. Wolf are co-founders and founder shareholders of ZOE Ltd. C. Hu and J. Capdevila Pujol are employees of ZOE Ltd. C.J. Steves and S. Ourselin have consulted for ZOE Ltd. All other authors (M. Antonelli, C.H. Sudre, E. Molteni, L.S. Canas, N.J. Cheetham, A. Hammers, E.L. Duncan, V. Bowyer, K. Rjoob, M. Modat and B. Murray) declare no conflict of interest., (Copyright ©The authors 2024.)

Published
2024
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35. Highly Deformed o-Carborane Functionalised Non-linear Polycyclic Aromatics with Exceptionally Long C-C Bonds.

Author

Marsh AV, Little M, Cheetham NJ, Dyson MJ, Bidwell M, White AJP, Warriner CN, Swain AC, McCulloch I, Stavrinou PN, and Heeney M

Abstract

The effect of substituting o-carborane into the most sterically hindered positions of phenanthrene and benzo(k)tetraphene is reported. Synthesised via a Bull-Hutchings-Quayle benzannulation, the crystal structures of these non-linear acenes exhibited the highest aromatic deformation parameters observed for any reported carborane compound to date, and among the largest carboranyl C-C bond length of all organo-substituted o-carboranes. Photoluminescence studies of these compounds demonstrated efficient intramolecular charge-transfer, leading to aggregation induced emission properties. Additionally, an unusual low-energy excimer was observed for the phenanthryl compound. These are two new members of the family of carborane-functionalised non-linear acenes, notable for their peculiar structures and multi-luminescent properties., (© 2020 The Authors. Published by Wiley-VCH GmbH.)

Published
2021
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