1. Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
- Author
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Mine Sibel Gurun, Zulfiye Gul, Deniz Bagdas, Julie A. Meade, Betul Cam, Nilufer Cinkilic, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı., Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı., Cam, Betül, Cinkılıç, Nilüfer, Gürün, Mine Sibel, AAH-5296-2021, CGO-3719-2022, and DVX-8040-2022
- Subjects
Antioxidant ,Inflammatory pain ,Cnidium officinale extract ,medicine.medical_treatment ,Chronic pain ,Review ,Pharmacology ,Antinociception ,0302 clinical medicine ,Pharmacology (medical) ,Inflammatory ,Hypericum perforatum extract ,General Medicine ,Chlorogenic ,Psychiatry and Mental health ,Nociception ,Neurology ,Medicinal herbs ,Ion channel ,Drug mechanism ,Analgesic agent ,Human ,endocrine system ,Antiinflammatory activity ,Incuded liver-injury ,Gated potassium channels ,Disease models ,Carlina Oxide ,Lonicera ,03 medical and health sciences ,Chlorogenic acid ,Antiinflammatory agent ,Sepsis ,Humans ,Porana sinensis extract ,Oxygen species ros ,Pharmacology & pharmacy ,Animal ,Disease model ,Arthritis ,medicine.disease ,Antiallodynic ,030104 developmental biology ,Gaba receptor agonists ,chemistry ,Degenerative disease ,Neurology (clinical) ,Complication ,030217 neurology & neurosurgery ,0301 basic medicine ,Unclassified drug ,Neuropathic pain ,medicine.disease_cause ,In-vitro ,In vivo study ,chemistry.chemical_compound ,Anti-inflammatory agents ,Analgesics ,Plant extract ,Antihyperalgesic ,Cheilanthes farinose extract ,Erycibe obtusifolia extract ,Encephalitis ,medicine.symptom ,Bidens pilosa extract ,NF-Kappa B ,Consensus ,Nitric-oxide synthase ,Pain ,Inflammation ,Chlorogenic acid derivative ,Neurosciences & neurology ,Neuropharmacology ,Acid ,medicine ,Animals ,Rheumatoid arthritis ,Caffeic acid ,Mansoa alliacea extract ,business.industry ,Neurosciences ,Plant extracts ,Ferulic acid ,Nonhuman ,Urtica circularis extract ,Rosae multiflorae extract ,Disease Models, Animal ,Metabolism ,Drug metabolite ,Ethnopharmacology ,Neuropathic ,business ,Hypericum-perforatum ,Oxidative stress - Abstract
Background: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.
- Published
- 2020
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