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Reinforced concrete (RC) frames with masonry infills represent a prevalent construction typology across the globe, including moderate to high seismic regions. Such structures are often characterized by high seismic vulnerability, and consequently, there is an urgent need for retrofit solutions to effectively improve their seismic performance. Buckling‐restrained braces (BRBs) represent one such solution. They are a type of dissipative device that can be included within the frames of an existing structure to increase its strength, stiffness, and energy dissipation capacity. Although a substantial amount of research has already been performed to understand the effectiveness of BRBs as a retrofit strategy, these studies have often neglected the contribution of masonry infills and the interactions between the infills and the BRBs. While masonry infills are usually overlooked in the analysis and design stage (owing to their brittle nature), past studies indicated that their strength and stiffness may significantly alter the structure's seismic performance, leading to undesirable and unexpected results. This study presents a detailed investigation of the impact of masonry infills on the seismic response and fragility of BRB‐retrofitted RC frames. A three‐story, three‐bay, low‐ductile RC frame has been selected for case study purposes. High‐fidelity finite element models are developed in OpenSees for combinations of infilled and non‐infilled structures—with and without BRBs. Nonlinear static and dynamic analyses are performed to evaluate the seismic response of the different configurations at local and global levels. Successively, cloud analyses are conducted by considering a set of 150 ground motion records to account for the record‐to‐record variability and develop seismic fragility curves. The present study sheds some light on the mutual interaction between the infill panels and BRBs retrofit intervention and highlights the critical aspects that must be considered in the design. [ABSTRACT FROM AUTHOR]