1. Comparison between robot-assisted radical hysterectomy and abdominal radical hysterectomy for cervical cancer: A multicentre retrospective study.
- Author
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Chen, Biliang, Ji, Mei, Li, Pengfei, Liu, Ping, Zou, Wei, Zhao, Zhao, Qu, Bo, Li, Zhiqiang, Bin, Xiaonong, Lang, Jinghe, Wang, Hailin, and Chen, Chunlin
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HYSTERECTOMY , *CERVICAL cancer , *TRACHELECTOMY , *PROPORTIONAL hazards models , *PROPENSITY score matching , *LOG-rank test - Abstract
To compare 3-year overall survival (OS) and disease-free survival (DFS) rates of robot-assisted radical hysterectomy (RRH) and abdominal radical hysterectomy (ARH) for cervical cancer. We retrospectively compared the oncological outcomes of 10,314 cervical cancer patients who received RRH (n = 1048) or ARH (n = 9266) and whose stages were IA1 with lymphovascular space invasion (LVSI)-IIA2. Kaplan-Meier survival analysis and log-rank tests were used to compare the 3-year OS and DFS rates between the RRH and ARH groups. Cox proportional hazards model and propensity score matching was used to estimate the surgical approach-specific survival. RRH and ARH showed similar 3-year OS and DFS rates (93.5% vs. 94.1%, p = 0.486; 90.0% vs. 90.4%, p = 0.302). RRH was not associated with a lower 3-year OS rate by the multivariable analysis (HR 1.23, 95% CI 0.89–1.70, p = 0.206), but it was associated with a lower 3-year DFS rate (HR 1.20, 95% CI 1.09–1.52, p = 0.035). After propensity score matching, patients who underwent RRH had decreased 3-year OS and DFS rates compared to those who underwent ARH (94.4% vs. 97.8%, p = 0.002; 91.1% vs. 95.4%, p = 0.001), and RRH was associated with lower 3-year OS and DFS rates. Among patients with stage IB1 and tumor size <2 cm, RRH was not associated with decreased 3-year OS and DFS rates (HR1.688, 95% CI 0.423–6.734, p = 0.458; HR1.267, 95%CI 0.518–3.098, p = 0.604). Overall, RRH was associated with worse 3-year oncological outcomes than ARH in patients with FIGO stage IA1 with LVSI- IIA2 cervical cancer. However, RRH showed similar 3-year oncological outcomes with ARH among those with stage IB1 and tumor size <2 cm. • We investigated the 3-year oncological outcomes of RRH and ARH for cervical cancer. • RRH was associated with worse 3-year oncological outcomes than ARH among those with stage IA1 with LVSI- IIA2. • RRH showed similar 3-year oncological outcomes with ARH in the subgroup of stage IB1 and a tumour size <2 cm. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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