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Cervical orthoses, vital for neck immobilization in medical care and sports, often struggle to provide adequate support due to individual neck shape and size variations. This study addresses this issue by developing a specific computer-aided orthosis design software tailored for creating customized 3D-printed cervical orthoses. The self-developed software embedded anatomical and rehabilitation knowledge into the orthosis design process, ensuring consistency and reducing manual modification. Finite element analysis of cervical orthoses determined that a minimum thickness of 5 mm PLA (polylactic acid) material is necessary to meet safety requirements. This study highlights the automation potential of customized computer-aided orthosis design and underscores the potential to revolutionize orthopedic care. We also applied easy-to-access 3D printing technology to fabricate well-fitting and immobilized cervical orthoses. These customized cervical orthoses offer a promising future with the advantages of being cost-effective, lightweight, immobility, comfortable, easy to wear, and minimal accessories to meet clinical needs, enhancing patient comfort and compliance and providing reassurance about the economic benefits of the technology. [ABSTRACT FROM AUTHOR]

In this paper, critical buckling analysis and nonlinear load-deflection curve for sandwich beam with functionally graded material are presented based on refined zigzag theory (RZT). By using the variational principle, the equilibrium equations in buckling analysis are given based on the RZT formulations as well as the nonlinear strain-displacement relations. The solutions are also derived for eigenvalue problems in critical buckling load calculations and for load-deflection relations with initial geometric imperfection. The solutions are presented analytically, and the mathematical properties during the derivation process have been proven in order to keep the mathematical rigor. The present analytical RZT critical buckling loads are validated by the RZT FEM, which is the finite element solutions of the sandwich beam meshed by the beam elements based on RZT. These solutions are also compared by commercial software ANSYS, resulting that this approach can obtain an accurate critical buckling load. Various parameters such as aspect ratio, thickness ratio and modulus ratio are considered to investigate their effects on the critical buckling loads. The present results are compared to the beams with higher-order shear deformation theory (HSDT). From the comparisons of the RZT and the HSDT results, it is seen that both theories approach to CBT for slender beam. The results show that the HSDT overestimates the stiffness in the load-deflection curve. It is shown that the RZT exhibits the zigzag displacements at high accuracy, resulting in accurate calculation in critical buckling loads, mode shapes and nonlinear load-deflection curves than HSDT. The superiority of the RZT solutions is presented especially for the case of FGM sandwich beam with soft middle layer. [ABSTRACT FROM AUTHOR]

In this paper, the bending singularity at the apex of a V-notched composite laminate plate is investigated. The anisotropy of the laminate is modeled by the Stroh formalism. Based on the eigenfunction expansion method, the bending singularity orders can be determined by solving an eigenvalue problem numerically. The singularity orders depend on the plate angle, material orientation, material anisotropy and the laminate stacking sequence. The comparison cases show that the material orientation should avoid in order to reduce the bending singularity. The layers near the free surfaces have more significant effects on the singularity order. The findings presented in this paper are helpful in the design of the composite laminate with V-notch.

Optimization of the initial phasing has been a decisive factor in the success of the subsequent electron-density modification, model building and structure determination of biological macromolecules using the single-wavelength anomalous dispersion (SAD) method. Two possible phase solutions (ϕ1 and ϕ2) generated from two symmetric phase triangles in the Harker construction for the SAD method cause the well known phase ambiguity. A novel direct phase-selection method utilizing the θDS list as a criterion to select optimized phases ϕam from ϕ1 or ϕ2 of a subset of reflections with a high percentage of correct phases to replace the corresponding initial SAD phases ϕSAD has been developed. Based on this work, reflections with an angle θDS in the range 35-145° are selected for an optimized improvement, where θDS is the angle between the initial phase ϕSAD and a preliminary density-modification (DM) phase ϕDMNHL. The results show that utilizing the additional direct phase-selection step prior to simple solvent flattening without phase combination using existing DM programs, such as RESOLVE or DM from CCP4, significantly improves the final phases in terms of increased correlation coefficients of electron-density maps and diminished mean phase errors. With the improved phases and density maps from the direct phase-selection method, the completeness of residues of protein molecules built with main chains and side chains is enhanced for efficient structure determination. [ABSTRACT FROM AUTHOR]