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517 results on '"Chen, Guo‐Liang"'

7. Synthesis and evaluation of L-quebrachitol derivatives against platelet aggregation.

Author

Cai, Peng-Cheng, Liang, Xin-Jie, Feng, Qi-Xun, Bao, Xue-Fei, and Chen, Guo-Liang

Subjects
THROMBOLYTIC therapy, BLOOD platelet aggregation, ANTICOAGULANTS, RESEARCH funding, NUCLEAR magnetic resonance spectroscopy, ASPIRIN, THIN layer chromatography, BIOLOGICAL products, PHYTOCHEMICALS, PLATELET-rich plasma, BARK, RATS, PLANT extracts, DOSE-effect relationship in pharmacology, GAS chromatography, ANIMAL experimentation, MOLECULAR structure, MASS spectrometry, ANALYTICAL chemistry techniques, PHARMACODYNAMICS
Abstract

Thrombosis plays an important role in the occurrence and development of cardiovascular and cerebrovascular diseases that contribute to high mortality and morbidity in patients. L-(-)-Quebrachitol (QCT), a natural product, was first isolated from quebracho bark. It can inhibit PAF receptor and decrease gastric damage induced by indomethacin, as a drug against platelet aggregation. Here, five QCT derivatives were synthesized and investigated for their inhibitory effects on platelet aggregation. Among them, compound 3a showed anticoagulant effects comparable to aspirin, while compound 4b showed dose-independent inhibitory activities in rats that were stronger than aspirin. [ABSTRACT FROM AUTHOR]

Published
2024
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30. AOP++: A Generic Aspect-Oriented Programming Framework in C++

Author

Yao, Zhen, Zheng, Qi-long, Chen, Guo-liang, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Glück, Robert, editor, and Lowry, Michael, editor

Published
2005
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31. Algorithms for Loosely Constrained Multiple Sequence Alignment

Author

Song, Bin, Zhou, Feng-feng, Chen, Guo-liang, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Zhang, Jun, editor, He, Ji-Huan, editor, and Fu, Yuxi, editor

Published
2005
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34. GOOMPI: A Generic Object Oriented Message Passing Interface : Design and Implementation

Author

Yao, Zhen, Zheng, Qi-long, Chen, Guo-liang, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Dough, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Jin, Hai, editor, Gao, Guang R., editor, Xu, Zhiwei, editor, and Chen, Hao, editor

Published
2004
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