Search

Your search keyword '"Chen, Hsin-Chien"' showing total 347 results
Start Over Author "Chen, Hsin-Chien"
347 results on '"Chen, Hsin-Chien"'

3. Notoginsenoside R1 Attenuates Cisplatin-Induced Ototoxicity by Inducing Heme Oxygenase-1 Expression and Suppressing Oxidative Stress.

Author

Lin, Yi-Chun, Ho, Yi-Jung, Lin, Yuan-Yung, Liao, Ai-Ho, Kuo, Chao-Yin, Chen, Hang-Kang, Chen, Hsin-Chien, Wang, Chih-Hung, and Shih, Cheng-Ping

Subjects
HAIR cells, GENE expression, REACTIVE oxygen species, CISPLATIN, CHILD patients
Abstract

Cisplatin-induced ototoxicity occurs in approximately half of patients treated with cisplatin, and pediatric patients are more likely to be affected than adults. The oxidative stress elicited by cisplatin is a key contributor to the pathogenesis of ototoxicity. Notoginsenoside R1 (NGR1), the main bioactive compound of Panax notoginseng saponins, has antioxidant and antiapoptotic effects. This study investigated the ability of NGR1 to protect against cisplatin-induced damage in auditory HEI-OC1 cells and neonatal murine cochlear explants. The viability of HEI-OC1 cells treated with NGR1 and cisplatin was greater than that of cells treated with cisplatin alone. The results of Western blots and immunostaining for cleaved caspase-3 revealed that the level of cleaved caspase-3 in the cells treated with cisplatin was repressed by NGR1. NGR1 attenuated cisplatin-induced cytotoxicity in HEI-OC1 cells. Intracellular reactive oxygen species (ROS) were detected with a DCFDA assay and immunostaining for 4-HNE. The result revealed that its expression was induced by cisplatin and was significantly reduced by NGR1. Moreover, NGR1 can promote heme oxygenase-1 (HO-1) expression at both the mRNA and protein levels. ZNPPIX, an HO-1 inhibitor, was administered to cisplatin-treated cells to investigate the role of HO-1 in the protective effect of NGR1. The suppression of HO-1 activity by ZNPPIX markedly abolished the protective effect of NGR1 on cisplatin-treated cells. Therefore, NGR1 protects cells from cisplatin-induced damage by activating HO-1 and its antioxidative activity. In cochlear explants, NGR1 protects cochlear hair cells and attenuates cisplatin-induced ototoxicity by inhibiting ROS generation. In the group treated with cisplatin alone, prominent loss of outer hair cells and severe damage to the structure of the stereociliary bundles of inner and outer hair cells were observed. Compared with the group treated with cisplatin alone, less loss of outer hair cells (p = 0.009) and better preservation of the stereociliary bundles of hair cells were observed in the group treated with cisplatin and NGR1. In conclusion, these findings indicate that NGR1 can protect against cisplatin-induced ototoxicity by inducing HO-1 expression and suppressing oxidative stress. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Bilateral sudden sensorineural hearing loss in patient with Behçet disease.

Author

Chuang, Kai-Fen, Liu, Feng-Cheng, and Chen, Hsin-Chien

Subjects
STEROIDS, SENSORINEURAL hearing loss, BEHCET'S disease, AUDIOMETRY, PREDNISOLONE, ORAL drug administration, ACUPUNCTURE, AUTOIMMUNE diseases, HYPERBARIC oxygenation
Abstract

Bacckground: Approximately 80% to 85% of sudden sensorineural hearing loss (SSNHL) is idiopathic, but immune-mediated mechanisms are thought to be involved. Behçet disease is an autoinflammatory vasculitis that may involve vessels of the inner ear. It can cause sensorineural hearing loss (SNHL) and an increased risk of SSNHL. Study Sample: We report a 21-year-old man who was diagnosed with Behçet disease in childhood and presented to our clinic with a 10-day history of abrupt hearing deterioration in both ears. Pure-tone audiometry showed severe to profound bilateral SNHL. Results: Oral prednisolone was prescribed for 3 weeks. Concurrent intratympanic steroid injections (ITSIs) were administered in each ear every 2 days for 5 days. A total of 15 daily sessions of hyperbaric oxygen therapy (HBOT) were completed. Acupuncture was performed every 2 days for 1 month. After these combined therapies, the patient's hearing threshold by 20 dB and his speech recognition threshold were improved. Conclusions: Some patients with SSNHL recover no hearing improvement after routine treatment, and alternative treatments including ITSI, HBOT, and acupuncture can be considered as optional. We used an aggressive multimodal approach to treat severe bilateral SSNHL in patient with Behçet disease. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

18. Solitary neurofibroma in the external auditory canal.

Author

Lee, Pei-Rong and Chen, Hsin-Chien

Subjects
*EXTERNAL ear, *NECK, *NEUROFIBROMA, *DIFFERENTIAL diagnosis, *PALLIATIVE treatment, *COMPUTED tomography, *HEAD, *MAGNETIC resonance imaging, *EAR canal, *HEARING disorders, *MICROSCOPY, *OTOSCOPY, *PATIENT aftercare
Abstract

Significance Statement: Neurofibromas, derived from perineural cells, are usually benign in the nervous system. Although neurofibromas are common in the head and neck, they rarely affect the external auditory canal (EAC), and few cases have been reported. We describe a case of a solitary EAC neurofibroma with otoscopy, radiological imaging, a surgical approach, and an uneventful outcome. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. Analysis of caloric test responses in sudden hearing loss

Author

Shih, Cheng-Ping, Chou, Yu-Ching, Chen, Hsin-Chien, Lee, Jih-Chin, Chu, Yueng-Hsiang, and Wang, Chih-Hung

Subjects
Calories -- Health aspects, Vestibulo-ocular reflex -- Research, Hearing loss -- Risk factors -- Care and treatment, Health
Abstract

Abstract Sudden sensorineural hearing loss is characterized by a rapid-onset hearing loss that develops within 3 days. Vertigo may also be present. We conducted a retrospective study to investigate whether [...]

Published
2017

34. Ultrasound Microbubble–Facilitated Inner Ear Delivery of Gold Nanoparticles Involves Transient Disruption of the Tight Junction Barrier in the Round Window Membrane

Author

Lin, Yi-Chun, primary, Shih, Cheng-Ping, additional, Chen, Hsin-Chien, additional, Chou, Ying-Liang, additional, Sytwu, Huey-Kang, additional, Fang, Mei-Cho, additional, Lin, Yuan-Yung, additional, Kuo, Chao-Yin, additional, Su, Hsiao-Han, additional, Hung, Chia-Lien, additional, Chen, Hang-Kang, additional, and Wang, Chih-Hung, additional

Published
2021
Full Text
View/download PDF

38. Quantitative spectroscopic comparison of the optical properties of mouse cochlea microstructures using optical coherence tomography at 1.06 µm and 1.3 µm wavelengths

Author

Tsai, Ting-Yen, primary, Chen, Ting-Hao, additional, Chen, Hsin-Chien, additional, Chueh, Chuan-Bor, additional, Huang, Yin-Peng, additional, Hung, Yi-Ping, additional, Tsai, Meng-Tsan, additional, Baumann, Bernhard, additional, Wang, Chih-Hung, additional, and Lee, Hsiang-Chieh, additional

Published
2021
Full Text
View/download PDF

39. The Immediate and Long-Term Impact of Military Aircraft Noise on Hearing: A Cross-Sectional Comparison of Fighter Pilots and Ground Staff

Author

Kuo, Chao-Yin, primary, Hung, Chia-Lien, additional, Chen, Hsin-Chien, additional, Shih, Cheng-Ping, additional, Lu, Rou-Huei, additional, Chen, Chen-Wai, additional, Hung, Li-Wen, additional, Lin, Yi-Chun, additional, Chen, Hang-Kang, additional, Chu, Da-Ming, additional, Lin, Yuan-Yung, additional, Chen, Yueh-Chun, additional, and Wang, Chih-Hung, additional

Published
2021
Full Text
View/download PDF

44. Risk of Acquired Cholesteatoma and External Auditory Canal Stenosis in Traumatic Brain Injury: A Nationwide Population-Based Cohort Study

Author

Lin, Hung-Che, primary, Shih, Cheng-Ping, additional, Chen, Hsin-Chien, additional, Cheng, Chun-An, additional, Huang, Yuahn-Sieh, additional, Lin, Chen-Shien, additional, Chung, Chi-Hsian, additional, Huang, Bor-Rong, additional, Lee, Jih-Chin, additional, Shangkuan, Wei-Chuan, additional, Chien, Wu-Chien, additional, and Chu, Chi-Ming, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results