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2. The establishment of diseased human whole organ model by normothermic machine perfusion technique: Principle of concept.

Author

Tang, Yunhua, Li, Jiahao, Zhang, Tao, Chen, Honghui, Qin, Meiting, Chen, Huadi, Huang, Jinbo, Miao, Ziqiang, Cai, Ruilin, Yang, Yongqi, Kang, Jun, Sun, Hanqi, Zhong, Ronghua, Li, Jingya, Wang, Tielong, Chen, Maogen, Ju, Weiqiang, Wang, Dongping, Guo, Zhiyong, and Dan, Jia

Subjects
ORGANS (Anatomy), PARTIAL pressure, BLOOD testing, LIVER transplantation, CARBON dioxide, PERFUSION
Abstract

Background: The global incidence of liver diseases is rising, yet there remains a dearth of precise research models to mimic these diseases. The use of normothermic machine perfusion (NMP) to study diseased livers recovered from liver transplantation (LT) recipients presents a promising avenue. Accordingly, we have developed a machine perfusion system tailored specifically for the human whole diseased livers and present our experience from the NMP of diseased livers. Methods: Six diseased livers recovered from LT recipients with different diagnoses were collected. The diseased livers were connected to the machine perfusion system that circulated tailored perfusate, providing oxygen and nutrients. The pressure and flow of the system were recorded, and blood gas analysis and laboratory tests of perfusate and bile were examined to analyze the function of the diseased livers. Liver tissues before and after NMP were collected for histological analysis. Results: Experiments showed that the system maintained the diseased livers in a physiological state, ensuring stable hemodynamics and a suitable partial pressure of oxygen and carbon dioxide. The results of blood gas analysis and laboratory tests demonstrated a restoration and sustenance of metabolism with minimal damage. Notably, a majority of the diseased livers exhibited bile production continuously, signifying their vivid functional integrity. The pathological characteristics remained stable before and after NMP. Conclusion: We successfully established the machine perfusion system tailored specifically for diseased human whole livers. Through the application of this system, we have developed a novel in vitro model that faithfully recapitulates the main features of human liver disease. This model holds immense promise as an advanced disease modeling platform, offering profound insights into liver diseases and potential implications for research and therapeutic development. [ABSTRACT FROM AUTHOR]

Published
2024
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4. The Establishment of Diseased Human Whole Organ Model by Normothermic Machine Perfusion Technique

Author

Tang, Yunhua, primary, Li, Jiahao, additional, Zhang, Tao, additional, Chen, Honghui, additional, Qin, Meiting, additional, Chen, Huadi, additional, Huang, Jinbo, additional, Miao, Ziqiang, additional, Cai, Ruilin, additional, Yang, Yongqi, additional, Kang, Jun, additional, Sun, Hanqi, additional, Zhong, Ronghua, additional, Li, Jingya, additional, Wang, Tielong, additional, Chen, Maogen, additional, Ju, Weiqiang, additional, Wang, Dongping, additional, Guo, Zhiyong, additional, Dan, Jia, additional, Li, Yefu, additional, He, Xiaoshun, additional, and Zhao, Qiang, additional

Published
2023
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5. Ischemia-Free Liver Transplantation as a Novel Approach to Optimize Transplant Outcome in the Acute-on-Chronic Liver Failure Scenario

Author

Tang, Yunhua, primary, Li, Jiahao, additional, Qin, Meiting, additional, Kang, Jun, additional, Chen, Huadi, additional, Huang, Jinbo, additional, Chen, Honghui, additional, Sun, Hanqi, additional, Zhong, Ronghua, additional, Li, Jingya, additional, Huang, Fei, additional, Liu, Zhiying, additional, Wang, Tielong, additional, Chen, Maogen, additional, Ju, Weiqiang, additional, Wang, Dongping, additional, Guo, Zhiyong, additional, Zhao, Qiang, additional, and He, Xiaoshun, additional

Published
2023
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10. DTYMK Expression Predicts Prognosis and Chemotherapeutic Response and Correlates with Immune Infiltration in Hepatocellular Carcinoma

Author

Guo, Yiwen, primary, Luo, Weixin, additional, Huang, Shanzhou, additional, Zhao, Wenting, additional, Chen, Huadi, additional, Ma, Yihao, additional, Ye, Maodong, additional, Nie, Yu, additional, Zhang, Yixi, additional, Huang, Changjun, additional, Zhou, Qi, additional, He, Xiaoshun, additional, and Chen, Maogen, additional

Published
2021
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12. Additional file 2 of Transcriptional analysis of the expression, prognostic value and immune infiltration activities of the COMMD protein family in hepatocellular carcinoma

Author

Wang, Xiaobo, He, Shujiao, Zheng, Xin, Huang, Shanzhou, Chen, Honghui, Chen, Huadi, Luo, Weixin, Guo, Zhiyong, He, Xiaoshun, and Zhao, Qiang

Abstract

Additional file 2: Table S1. The clinical characteristics of 344 HCC patients in TCGA. Table S2. The clinical characteristics of 124 patients with grade III HCC in TCGA. Table S3. Correlation analysis between COMMD2/3/10 and relate genes and markers of immune cells in TIMER.

Published
2021
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15. lncRNA NEAT1 regulates the proliferation and migration of hepatocellular carcinoma cells by acting as a miR‑320a molecular sponge and targeting L antigen family member 3

Author

Zhang, Yixi, primary, Huang, Changjun, additional, Zhu, Zebin, additional, Hou, Yufei, additional, Huang, Shanzhou�, additional, Sun, Chengjun, additional, Tang, Yunhua, additional, Zhang, Zhiheng, additional, Wang, Linhe�, additional, Chen, Huadi, additional, Ju, Weiqiang, additional, Qiao, Xin, additional, and Chen, Maogen, additional

Published
2020
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16. Systematic analysis on multiple Gene Expression Omnibus data sets reveals fierce immune response in hepatitis B virus‐related acute liver failure

Author

Chen, Huadi, primary, Zhao, Wenting, additional, Zhang, Yixi, additional, Guo, Yiwen, additional, Luo, Weixin, additional, Wang, Xiaobo, additional, Nie, Yu, additional, Ye, Maodong, additional, Huang, Changjun, additional, Wang, Dongping, additional, Chen, Maogen, additional, He, Xiaoshun, additional, and Zhao, Qiang, additional

Published
2020
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