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266 results on '"Chen, Hui‐Jiuan"'

16. Au 24 Cd Nanoenzyme Coating for Enhancing Electrochemical Sensing Performance of Metal Wire Microelectrodes.

Author

Chen, Jia-Yi, Huang, Shuang, Liu, Shuang-Jie, Liu, Zheng-Jie, Xu, Xing-Yuan, He, Meng-Yi, Yao, Chuan-Jie, Zhang, Tao, Yang, Han-Qi, Huang, Xin-Shuo, Liu, Jing, Zhang, Xiao-Dong, Xie, Xi, and Chen, Hui-Jiuan

Subjects
ELECTRODE performance, CYCLIC voltammetry, MICROELECTRODES, VITAMIN C, URIC acid
Abstract

Dopamine (DA), ascorbic acid (AA), and uric acid (UA) are crucial neurochemicals, and their abnormal levels are involved in various neurological disorders. While electrodes for their detection have been developed, achieving the sensitivity required for in vivo applications remains a challenge. In this study, we proposed a synthetic Au24Cd nanoenzyme (ACNE) that significantly enhanced the electrochemical performance of metal electrodes. ACNE-modified electrodes demonstrated a remarkable 10-fold reduction in impedance compared to silver microelectrodes. Furthermore, we validated their excellent electrocatalytic activity and sensitivity using five electrochemical detection methods, including cyclic voltammetry, differential pulse voltammetry, square-wave pulse voltammetry, normal pulse voltammetry, and linear scanning voltammetry. Importantly, the stability of gold microelectrodes (Au MEs) modified with ACNEs was significantly improved, exhibiting a 30-fold enhancement compared to Au MEs. This improved performance suggests that ACNE functionalization holds great promise for developing micro-biosensors with enhanced sensitivity and stability for detecting small molecules. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Nanoparticle mediated heating for non-invasive thermal therapies

Author

Chen, Hui-Jiuan

Subjects
620, Engineering, Materials Science, Nanomaterials
Abstract

Nanomaterials have unique physics and chemistry properties compared with their bulk counterparts and have been widely studied in different fields ranging from energy to biomedicines. This thesis investigates controlled synthesis of gold nanomaterials, the heating and interactions of gold nanomaterials with external electromagnetic and ultrasonic fields, and their potential applications in non-invasive heat-related biomedicines. Gold nanomaterials have been synthesised by the citrate reduction method with the aid of ultrasonification. Through ultrasonification, the size of obtained spherical GNPs can be controlled between 10nm and 15nm, and the prepared nanoplates can be controlled between 50 nm to 150 nm. Purification process has been performed through membrane dialysis, in order to obtain pure nanoparticles for investigating the heating behavior of nanoparticle dispersions under EM/ultrasound field and elucidating the impurity effect. Moreover, the purified gold nanoparticles have been characterized by various means, such as FTIR, atomic absorption spectrometer, zetasizer, SEM, TEM and UV-Vis absorption for the purpose of fully understand the properties of gold nanoparticle in terms of purity, concentration, size, morphology and optical properties. The bulk heating effects of low-concentration GNPs have been investigated by using ultrasonic field, electromagnetic (EM) field, and laser irradiation. The results have shown that significant bulk temperature increase can be achieved for the lowconcentration gold nanoparticle dispersions under ultrasonic field, the EM field at 200 kHz and 400 kHz, and laser irradiation. Comparatively, the purified GNPs did not show significant heating effect under the EM fields of 13.56 MHz and 2.45 GHz. 6 Different mechanisms are thereby discussed to explain the heating effects. While some can be explained by established theories, such as the ultrasonic and laser heating, it is still unclear about the heating effect under low frequency EM field. A few possible reasons could be attributed to the changes of the dielectric properties and the electrophoresis effect. In addition, GNP incorporated microcapsules have been fabricated through the layer-bylayer technology, and laser treatments of the microcapsules embedded with different shapes of gold particles have been studied. The results have shown that matching between the laser wavelength and the absorption band of gold nanoparticles, which can be shifted by controlling the morphology of nanoparticles, is a prerequisite to achieve the maximum heating effect to deform the microcapsules and hence to present the microcapsules for biomedical uses. In vitro (B50 cell) and in vivo (fruit fly) studies of the biocompatibilities of our synthesised GNPs have been exanimated. The results demonstrated that the GNPs have high biocompatibility for B50 cells and fruit flies. GNPs assisted laser treatment of B50 cells has shown faster thermal damage to the cells in contrast to the cells without addition of GNPs. Keywords: nanomaterial, gold nanoparticle, capsules, hyperthermia, ablation, electromagnetic, ultraosound, surface Plasmon resonance, biocompatibility.

Published
2013

22. Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer

Author

Xie, Xi, Doloff, Joshua C., Yesilyurt, Volkan, Sadraei, Atieh, McGarrigle, James J., Omami, Mustafa, Veiseh, Omid, Farah, Shady, Isa, Douglas, Ghani, Sofia, Joshi, Ira, Vegas, Arturo, Li, Jie, Wang, Weiheng, Bader, Andrew, Tam, Hok Hei, Tao, Jun, Chen, Hui-jiuan, Yang, Boru, Williamson, Katrina Ann, Oberholzer, Jose, Langer, Robert, and Anderson, Daniel G.

Published
2018
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27. Capacitive–piezoresistive hybrid flexible pressure sensor based on conductive micropillar arrays with high sensitivity over a wide dynamic range

Author

Shen, Zhiran, primary, Yang, Chengduan, additional, Yao, Chuanjie, additional, Liu, Ziqi, additional, Huang, Xinshuo, additional, Liu, Zhengjie, additional, Mo, Jingshan, additional, Xu, Huihua, additional, He, Gen, additional, Tao, Jun, additional, Xie, Xi, additional, Hang, Tian, additional, Chen, Hui-Jiuan, additional, and Liu, Fanmao, additional

Published
2023
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42. Determination of Transdermal Rate of Metallic Microneedle Array through an Impedance Measurements-Based Numerical Check Screening Algorithm

Author

Mo, Jingshan, primary, Liu, Junqing, additional, Huang, Shuang, additional, Liang, Baoming, additional, Huang, Xinshuo, additional, Yang, Cheng, additional, Chen, Meiwan, additional, Liu, Jing, additional, Zhang, Tong, additional, Xie, Xi, additional, Guo, Jun, additional, Liu, Fanmao, additional, and Chen, Hui-Jiuan, additional

Published
2022
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49. Integrated Multiplex Sensing Clear Aligner for In Situ Monitoring of Dental Enamel Demineralization

Author

Liu, Ziqi, Sun, Tiancheng, Chen, Yiyin, Mo, Xiaoyi, Kao, Hsiaohan, and Chen, Hui-Jiuan

Abstract

Clear aligners have become one of the most important tools in orthodontic treatment. However, over a lengthy period of orthodontic treatment, enamel demineralization or even dental caries could be susceptible for occurrence. Therefore, early diagnosis of enamel demineralization has been widely investigated. Nevertheless, for reasons including bulky monitoring equipment and complexity of operation, few techniques reported to date possessed clinical utility. The combination of flexible electronics and electrochemical sensing technology presented a promising strategy. Herein, an integrated multiplex sensing clear aligner (IMSCA) system, including a clear aligner with a multiplex sensor array patch, was developed for in situ monitoring of Ca2+, pH, and PO43–in the oral environment to provide a foundation for early diagnosis of enamel demineralization. The IMSCA exhibited a broad linear response range, great selectivity, temporal stability, reproducibility, and biological safety. Results of enamel demineralization simulating experiments and human permanent tooth demineralization experiments validate the capability of the IMSCA to indicate the occurrence of enamel demineralization. All results ultimately point to the promising clinical utility of the IMSCA, which facilitates the quantitative characterization of enamel demineralization in complex oral environments. This study provides a novel strategy in the early diagnosis of enamel demineralization.

Published
2023
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