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915 results on '"Chen, Jia-Rong"'

9. Recent advances in C(sp3)–N bond formation via metallaphoto-redox catalysis.

Author

Zhang, Juan, Huan, Xiao-Die, Wang, Xin, Li, Guo-Qing, Xiao, Wen-Jing, and Chen, Jia-Rong

Subjects
CATALYSIS, COPPER, TRANSITION metals, NATURAL products, RADICALS (Chemistry), PALLADIUM
Abstract

The C(sp3)–N bond is ubiquitous in natural products, pharmaceuticals, biologically active molecules and functional materials. Consequently, the development of practical and efficient methods for C(sp3)–N bond formation has attracted more and more attention. Compared to the conventional ionic pathway-based thermal methods, photochemical processes that proceed through radical mechanisms by merging photoredox and transition-metal catalyses have emerged as powerful and alternative tools for C(sp3)–N bond formation. In this review, recent advances in the burgeoning field of C(sp3)–N bond formation via metallaphotoredox catalysis have been highlighted. The contents of this review are categorized according to the transition metals used (copper, nickel, cobalt, palladium, and iron) together with photocatalysis. Emphasis is placed on methodology achievements and mechanistic insight, aiming to inspire chemists to invent more efficient radical-involved C(sp3)–N bond-forming reactions. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Visible‐Light‐Driven Four‐Component Radical Relay Aminocarbonylation of Unactivated Alkenes†.

Author

Lu, Bin, Bao, Feng‐Shuo, He, Zi‐Wei, Xiao, Wen‐Jing, and Chen, Jia‐Rong

Subjects
RADICALS (Chemistry), CARBOXYLIC acid derivatives, AMIDES, CARBOXYLIC acids, CARBONYL compounds, TRANSITION metals, CARBONYLATION
Abstract

Comprehensive Summary: Catalytic four‐component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl compounds. Given the significance of fluorine‐containing groups, this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal catalysis. Herein, we report a visible‐light‐driven radical relay 1,2‐perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst. A wide range of alkenes and amines were well tolerated, providing the valuable β‐perfluoroalkylated amides with generally good yields and high chemoselectivity. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.

Author

Tang, Zi-Hua, Chen, Jia-Rong, Zheng, Jing, Shi, Hao-Song, Ding, Jie, Qian, Xiao-Dan, Zhang, Cui, Chen, Jian-Ling, Wang, Cui-Cui, Li, Liang, Chen, Jun-Zhen, Yin, Shan-Kai, Huang, Tao-Sheng, Chen, Ping, Guan, Min-Xin, and Wang, Jin-Fu

Subjects
Cell Line, Humans, Hearing Loss, Sensorineural, Genetic Predisposition to Disease, Myosins, Transfection, Pedigree, DNA Mutational Analysis, Recovery of Function, Cell Differentiation, Cell Shape, Gene Expression Regulation, Heredity, Membrane Potentials, Heterozygote, Phenotype, Mutation, Female, Male, Targeted Gene Repair, Hair Cells, Auditory, Induced Pluripotent Stem Cells, CRISPR-Cas Systems, Myosin VIIa, Deafness, Genetic correction, Human induced pluripotent stem cells, Inner ear hair cells, MYO7A, Rescue, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Stem Cell Research, Rehabilitation, Regenerative Medicine, Clinical Research, Neurosciences, Genetics, 2.1 Biological and endogenous factors, 5.2 Cellular and gene therapies, Aetiology, Development of treatments and therapeutic interventions, Congenital, Ear, Biochemistry and Cell Biology, Medical Biotechnology, Clinical Sciences
Abstract

UnlabelledThe genetic correction of induced pluripotent stem cells (iPSCs) induced from somatic cells of patients with sensorineural hearing loss (caused by hereditary factors) is a promising method for its treatment. The correction of gene mutations in iPSCs could restore the normal function of cells and provide a rich source of cells for transplantation. In the present study, iPSCs were generated from a deaf patient with compound heterozygous MYO7A mutations (c.1184G>A and c.4118C>T; P-iPSCs), the asymptomatic father of the patient (MYO7A c.1184G>A mutation; CF-iPSCs), and a normal donor (MYO7A(WT/WT); C-iPSCs). One of MYO7A mutation sites (c.4118C>T) in the P-iPSCs was corrected using CRISPR/Cas9. The corrected iPSCs (CP-iPSCs) retained cell pluripotency and normal karyotypes. Hair cell-like cells induced from CP-iPSCs showed restored organization of stereocilia-like protrusions; moreover, the electrophysiological function of these cells was similar to that of cells induced from C-iPSCs and CF-iPSCs. These results might facilitate the development of iPSC-based gene therapy for genetic disorders.SignificanceInduced pluripotent stem cells (iPSCs) were generated from a deaf patient with compound heterozygous MYO7A mutations (c.1184G>A and c.4118C>T). One of the MYO7A mutation sites (c.4118C>T) in the iPSCs was corrected using CRISPR/Cas9. The genetic correction of MYO7A mutation resulted in morphologic and functional recovery of hair cell-like cells derived from iPSCs. These findings confirm the hypothesis that MYO7A plays an important role in the assembly of stereocilia into stereociliary bundles. Thus, the present study might provide further insight into the pathogenesis of sensorineural hearing loss and facilitate the development of therapeutic strategies against monogenic disease through the genetic repair of patient-specific iPSCs.

Published
2016

47. Metabolomics study of Angelica sinensis (Oliv.) Diels on the abnormal uterine bleeding rats by ultra‐performance liquid chromatography–quadrupole–time‐of‐flight mass spectrometry analysis

Author

Chen, Ting‐Ting, primary, Zou, Liang, additional, Wang, Di, additional, Li, Wei, additional, Yang, Yong, additional, Liu, Xiao‐Min, additional, Cao, Xin, additional, Chen, Jia‐Rong, additional, Zhang, Yan, additional, and Fu, Jia, additional

Published
2021
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