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Objective To investigate the effect of concurrent chemoradiotherapy on immune function, inflammatory state, and gut microbiota in patients with pelvic tumor. Methods Peripheral blood and stool samples were collected before and after concurrent chemoradiotherapy from 60 patients with pelvic tumor who were treated in Qingdao Central Hospital from July 2021 to December 2022. Flow cytometry was used to measure the levels of peripheral blood lymphocyte subsets and cytokines, and quantitative real-time PCR was used to measure the number of Fusobacterium nucleatum, Bifidobacterium, Lactobacillus acidophilus, and Streptococcus in stool. Each index was compared in terms of change before and after concurrent chemoradiotherapy, and their correlation with treatment outcome was analyzed. Results After concurrent chemoradiotherapy, the patients with pelvic tumor had significant reductions in the percentages of peripheral blood CD3+CD8+ and CD3-CD19+ cells and the level of interleukin-10 (t=2.571-2.995,P

Purpose: To compare the efficacy of tongue appliance combined with chin-cup and facemask in the treatment of anterior crossbite, as well as the effects on the position of hyoid bone and airway, so as to provide reference for clinic., Methods: Sixty cases with anterior crossbite were selected after treatment, using tongue appliance combined with chin-cup (n=30) and facemask (n=30). Cephalometric radiographs were taken before and after treatment, skeletal, dental, hyoid, and airway space measurements were analyzed with Winceph 9.0 and AutoCAD 2016. SPSS 21.0 software package was used for statistical analysis., Results: Both appliances had a good effect on anterior crossbite. After treatment, SNA, ANS-PNS significantly increased(P<0.05), and SN-MP significantly increased(P<0.05). The upper anterior teeth showed a buccal inclination(P<0.01), the lower anterior teeth had a lingual inclination, and the overjet became normal(P<0.01). UL-E increased in both groups(P<0.05), PLA significantly increased in tongue appliance combined with chin-cup group(P<0.05). H-C3 decreased in both groups(P<0.05), while H-S, H-Ar increased(P<0.01), suggesting that the hyoid bone moved backward and downward. PNS-UPW increased in both groups(P<0.01), and U-MPW increased in facemask group(P<0.01)., Conclusions: Facemask and tongue appliance combined with chin-cup can both promote the development of the maxilla, cause a clockwise rotation of the mandible, and effectively correct the anterior crossbite. Both methods can cause a backward and downward displacement of hyoid bone. Facemask can enlarge the width of nasopharynx and palatopharynx airway, while only the width of nasopharynx can be increased by tongue appliance combined with chin-cup.

Objective: To explore the role of maternal physiology, mentality and prenatal health care on low birth weight (LBW)., Methods: A LBW-small for gestation age (SGA)-control group retrospective study was conducted based upon a population of infants born from November 2004 to June 2006. 896 cases involved in this study were entirely under voluntary participation and subject could withdraw their consent at any point. All subject recruitment and enrollment took place at Fujian Provincial Maternal and Children Hospital at the time of delivery. Using chi2 test for single factor analysis and logistic regression for multiple analyses., Results: There were 15 out of 22 single factors having statistical significances, including 2 maternal psychological, 4 physiological, 6 pathological and 3 prenatal health care factors respectively. When multi-factorial stepwise regression analyses was performed, there were 9 factors for main relative factors of LBW, including women's height, number of prenatal examination, in-normal non-stress test, umbilical cord around the neck, retardation of the umbilical blood flow, week of gestation when the first examination was performed, premature rupture of membrane, preference on the sex of the infant, abnormal family history etc. were influencing the existence of LBW. Awareness on health information appeared to be a protective factor, suggesting that LBW could be prevented during the pregnant period., Conclusion: Multiple factors seemed to be contributing to the incidence of low birth weight.