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7. Physiological responses of Bassia dasyphylla to drought during seed germination from different provenances.

Author

Chen, Juanli, Luo, Yongqing, Zhao, Xueyong, Li, Yan, Gao, Biao, Wang, Ruolan, Lou, Yuanxin, Mu, Junpeng, Gao, Yong, and Xianhua, Zhang

Subjects
GERMINATION, DROUGHTS, DROUGHT tolerance, REACTIVE oxygen species, SOIL seed banks
Abstract

Bassia dasyphylla is a prevalent herbaceous plant that exhibits enhanced resilience to dryness and elevated temperatures. It is frequently found in dispersed or grouped formation on sandy soil within steppe, semi-desert, and desert regions. Herein, we conducted experiments to examine the growth and physiological traits of B. dasyphylla seeds originated from various regions in response to water scarcity. The study seeks to investigate the ability of these seeds to germinate under drought conditions and offer valuable insights for the development and breeding of high-quality germplasm resources in Inner Mongolia. The results demonstrated that B. dasyphylla originating from desert steppe (DS) exhibited a greater capacity to endure drought conditions in comparison to its counterparts from sandy land (SL). At a water potential of -0.30 MPa, the Seed germination rate from DS was 33.3%, while from SL it was 22.7%. With the increase in drought duration and intensity, germination rate, plumule length, both single-seed weight (SSW) and seed water content (SWC) of B. dasyphylla declined. The protective enzyme activity exhibited an initial increase, followed by a subsequent decline as the duration of the drought increased. Notably, we found that the protective enzyme activity from DS was higher than that from SL. During the initial and intermediate stages of dryness, the soluble sugar and protein of the plant from DS effectively inhibited the peroxidation of membrane lipids, whereas the osmoregulatory properties from SL did not have a significant impact. The findings suggest that the ability of B. dasyphylla to withstand drought conditions in DS can be attributed to its elevated amounts of protective enzymes and osmoregulatory factors, which serve to safeguard the cell membrane during periods of drought. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Epigenetic modification in Parkinson’s disease

Author

Song, Hao, primary, Chen, Juanli, additional, Huang, Jin, additional, Sun, Peng, additional, Liu, Yanming, additional, Xu, Li, additional, Wei, Chuanfei, additional, Mu, Xin, additional, Lu, Xianjie, additional, Wang, Wei, additional, Zhang, Nan, additional, Shang, Miwei, additional, Mo, Mei, additional, Zhang, Wei, additional, Zhao, Hui, additional, and Han, Fabin, additional

Published
2023
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21. Aloperine protects human retinal pigment epithelial cells against hydrogen peroxide–induced oxidative stress and apoptosis through activation of Nrf2/HO-1 pathway.

Author

Zhang, Junhui, Zhou, Haitao, Chen, Juanli, Lv, Xiaoyan, and Liu, Hongsong

Abstract

Age-related macular degeneration (AMD) is a complex multifactorial disease associated with the dysfunction of retinal pigment epithelium (RPE). Aloperine is a quinolizidine alkaloid that has been proven to possess broad pharmacological activities. However, the effects of aloperine on AMD remain unclear. In the present study, we used hydrogen peroxide (H2O2) to induce oxidative injury in human RPE cells (ARPE-19 cells). ARPE-19 cells were pretreated with different concentrations of aloperine for 2 h, followed by H2O2 exposure. Cell cytotoxicity was determined using lactate dehydrogenase (LDH) release assay. Cell viability was measured using Cell Counting Kit-8 (CCK-8) assay. The reactive oxygen species (ROS) generation, malondialdehyde (MDA) level, superoxide dismutase (SOD) activity and glutathione peroxidase (GSH-PX) activity were detected to reflect oxidative status. Western blot was performed to detect the expressions of bcl-2, bax, nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1). The activity of caspase-3 was also assessed to indicate cell apoptosis. In addition, ARPE-19 cells were transfected with siNrf2 to knock down Nrf2. Our results showed that pretreatment with aloperine elevated the reduced cell viability of H2O2-induced ARPE-19 cells in a dose-dependent manner. Aloperine greatly decreased the production of ROS and MDA, and increased the activities of SOD and GSH-PX in H2O2-stimulated ARPE-19 cells. H2O2-caused a decrease in bcl-2 expression and increases in bax expression and caspase-3 activity were mitigated by aloperine. Moreover, aloperine treatment enhanced the expression levels of Nrf2 in nuclear fraction and the HO-1 expression in lysates. Knockdown of Nrf2 reversed the protective effects of aloperine on H2O2-induced ARPE-19 cells. In conclusion, these findings demonstrated that aloperine protected ARPE-19 cells from H2O2-induced oxidative stress and apoptosis in part via activating the Nrf2/HO-1 signaling pathway. The findings suggested a therapeutic potential of aloperine for the treatment of ADM. [ABSTRACT FROM AUTHOR]

Published
2022
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