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Background: Acute aortic syndrome (AAS) is a life-threatening condition. Inflammation plays a key role in the pathogenesis, development and progression of AAS, and is associated with significant mortality and morbidity. Understanding the inflammatory responses and inflammation resolutions is essential for an appropriate management of AAS. Method: Thirty Chinese cardiovascular centers have collaborated to create a multicenter observational registry (named Chinese Additive Anti-inflammatory Action for Aortopathy & Arteriopathy [5A] registry), with consecutive enrollment of adult patients who underwent surgery for AAS that was started on Jan 1, 2016 and will be ended on December 31, 2040. Specially, the impact of inflammation and anti-inflammatory strategies on the early and late adverse events are investigated. Primary outcomes are severe systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), Sequential Organ Failure Assessment (SOFA) scores at 7 days following this current surgery. Secondary outcomes are SISR, 30-day mortality, operative mortality, hospital mortality, new-onset stroke, acute kidney injury, surgical site infection, reoperation for bleeding, blood transfusion and length of stay in the intensive care unit. Discussion: The analysis of this multicenter registry will allow our better knowledge of the prognostic importance of preoperative inflammation and different anti-inflammatory strategies in adverse events after surgery for AAS. This registry is expected to provide insights into novel different inflammatory resolutions in management of AAS beyond conventional surgical repair. Trial registration: ClinicalTrials.gov Identifier: NCT04398992 (Initial Release: 05/19/2020). [ABSTRACT FROM AUTHOR]

Introduction: Knowledge is limited regarding the significance of pulmonary arterial pressure (PAP) in predominantly congenital mitral valve regurgitation (MR)-based intracardiac abnormalities. Methods: From a prospective cohort, we included 200 patients with congenital MR regardless of other associated intracardiac abnormalities (mean age 60.4 months, 67% female, systolic PAP (sPAP) 54.2 mm Hg) surgically repaired in 2012–2019 and followed up to 2020 (median 30.0 months). Significant pulmonary hypertension (PH) was defined as sPAP >50 mm Hg at rest or mean PAP >25 mm Hg on right heart catheterization. By perioperative sPAP changes, patients were stratified as group I (pre-normotension to post-normotension), group II (pre-hypertension to post-normotension), or group III (pre-hypertension to post-hypertension). Primary outcomes were the recurrence of MR (defined as the regurgitation grade of moderate or greater) and the progression of MR (defined as any increase in the magnitude of regurgitation grade after surgery). Cox proportional hazard and Kaplan-Meier curve were performed. Results: There was no association between preoperative PH and the recurrent MR (adjusted hazard ratios [aHR]: 1.146 [95% CI: 0.453–2.899]) and progressive MR (aHR: 1.753 [95% CI: 0.807–3.804]), respectively. There were no significant differences among group I, group II, and group III in the recurrent MR but in the progressive MR. A dose dependency was identified for preoperative sPAP with recurrent MR (aHR: 1.050 [95% CI: 1.029–1.071]) and progressive MR risks (aHR: 1.037 [95% CI: 1.019–1.055]), respectively. Conclusions: Preoperative higher sPAP is associated with worse outcomes, warranting heightened attention to the identification of perioperative sPAP. [ABSTRACT FROM AUTHOR]

Recent development of particle manipulation has led to high demand for dynamic optical tweezer structures. However, confining and rotating a single microparticle in the far-field region with a uniform potential distribution remains a complicated task. A plasmonic vortex lens (PVL) has been proven to easily rotate the dielectric particle owing to its effect on orbital angular momentum (OAM). Here we propose and demonstrate PVL multiple arms with a circular groove (CG). The device consists of a multiple arm spiral slit that generates a plasmonic vortex (PV) and a circular groove to bring the PV from the surface to the far-field region. Numerical simulations are performed to calculate the intensity distribution of the primary ring, the optical force and potential. The primary ring size can be adjusted using different polarization directions. PVL 2-arms with a CG has primary ring sizes of 1082 nm under right-handed circular polarization (RCP) and 517 nm under left-handed circular polarization (LCP). Based on these primary ring sizes, a 1 μm polystyrene (PS) bead can be rotated under RCP with a minimum required power of 7.45 mW and trapped under LCP with a minimum required power of 11.84 mW. For PVL 4-arms with a CG under RCP illumination, we optimize the uniform potential distribution by carefully selecting the radius of the groove. Using a groove radius of 1050 nm, we obtain the potential difference between the smallest and largest depth along the x - and y -directions of only 70 k B T / W with a minimum required power of 14.86 mW. The method and design discussed here offer an efficient way to manipulate microparticles for micro-rotors, cell dynamic analysis, etc., Competing Interests: The authors declare no conflicts of interest., (This journal is © The Royal Society of Chemistry.)