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Background: Treatment failure following androgen deprivation therapy (ADT) presents a significant challenge in the management of advanced prostate cancer. Thus, understanding the genetic factors influencing this process could facilitate the development of personalized treatments and innovative therapeutic strategies. The phosphoinositide 3-kinase (PI3K)/AKT signaling pathway plays a pivotal role in controlling cell growth and tumorigenesis. We hypothesized that genetic variants within this pathway may affect the clinical outcomes of patients undergoing ADT for prostate cancer. Methods: We genotyped 399 single-nucleotide polymorphisms (SNPs) across 28 core PI3K/AKT pathway genes in a cohort of 630 patients with prostate cancer undergoing ADT. We assessed the potential association of the SNPs with patient survival. Functional analyses of the implicated genes were also performed to evaluate their effects on prostate cancer. Results: After multivariate Cox regression analysis and multiple testing correction, GABRB3 rs12591845 exhibited the most significant association with both overall and cancer-specific survivals (P < 0.003). A comprehensive pooled analysis of 16 independent gene expression datasets revealed elevated expression of GABRB3 in prostate cancer tissues compared to that in normal tissues (P < 0.001). Furthermore, gene set enrichment analysis unveiled differential enrichment of pathways such as myogenesis, interferon γ and α responses, and the MYC proto-oncogene pathway in tumors with elevated GABRB3 expression, implying a role for GABRB3 in prostate cancer. Conclusion: Our results suggest that rs12591845 could potentially serve as a valuable prognostic indicator for patients undergoing ADT. The potential role of GABRB3 in promoting prostate tumorigenesis is also highlighted. [ABSTRACT FROM AUTHOR]

A strip‐typed antenna with the advantages of simple structure and easy fabrication is first proposed. When the antenna is mounted on a planar circuit board, it has the same radiation characteristics as a traditional microstrip antenna operated in the fundamental mode; however, the proposed antenna only occupies a space of a linear length for the surface of the circuit board. Then, A 1 × 4 array with ± 45° polarizations is realized using the strip‐typed antenna as a radiating element. The dual‐polarized array is excited with a pair of coplanar corporate feed networks. Simulated results show that the gains of the radiating element and array are up to 8 and 13 dBi, respectively; in addition, the isolation between the two input ports of the array is higher than 27 dB within an impedance bandwidth of around 11%. Experiments are also carried out, and they validate the simulated results. Details of the designs are presented. [ABSTRACT FROM AUTHOR]

A design for reconfigurable circularly polarized (CP) microstrip antennas with frequency agility is described. The main radiating element of the antenna is a suspended patch, and it is connected with two vertical feed probes. When one feed probe is used as a signal input port, the other probe can serve as a perturbation element of the microstrip antenna resonant at the fundamental mode, and consequently a CP radiation is generated. Because the dual probes are arranged in an orthogonal fashion, the antenna can be operated in right‐handed and left‐handed circular polarization modes. To vary the CP operation frequency, four varactors are mounted on the ring slot embedded on the radiating patch. Simulated results indicate that the CP frequency can be continuously tuned from 1.2 to 1.9 GHz with decreasing the capacitance of the varactors. A prototype is also fabricated, and only one DC bias is required to realize the reconfigurable antenna. The design concept of the proposed antenna is shown, and CP performances at different frequencies are also presented. [ABSTRACT FROM AUTHOR]

With the development of network, a single controller cannot meet the control needs of a large number of switches, which needs to be handed by multiple controllers. This paper uses the improved k-means++ algorithm to divide the topological graph into an undirected graph and the shortest path problem of the undirected graph. The graph is divided by the weight of the edge, and the weight is weighted by link bandwidth and transmission delay. The load balance and cost of the two methods are compared to obtain the mutt-controller deployment strategy. Subsequently, by adopting a traffic balance in strategy for multiple paths in the network, the data is reasonably distributed on different paths, so that the network traffic is distributed more evenly and the network performance is higher. Experimental verification shows that when multiple paths are available for data packets, the transmission path can be selected reasonably to balance the load of each path in the network. [ABSTRACT FROM AUTHOR]

In the present work we undertook the complete mitochondrial genome sequencing of an important glioma model inbred rat strain for the first time. The total length of the mitogenome was 16,308 bp. It harbored 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes and 1 non-coding control region (D-loop region). The mutation events were also reported. [ABSTRACT FROM PUBLISHER]