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443 results on '"Chen, M.H."'

7. Assessment of ketamine uropathy

Author

Jang, M.Y., Wu, W.J., Ruan, Y.S., Li, S.Y., Wu, J.S., Chung, Y.C., Li, W.J., Li, Y.H., Tang, Y.C., Shen, K.H., Lin, W.Y., Chen, J.S., Lee, M.H., Chen, M.H., Zou, J.L., Jhang, J.S., Syu, J.S., Yang, S.S., Chang, S.J., Lin, A.T.L., Fan, Y.H., Meng, E., Syu, Y.J., Yu, H.J., Guo, Y.C., Ye, J.S., Wang, Y.J., Jhang, J.F., Jiang, Y.H., Kuo, H.C., Yang, Stephen S., Wu, Chun-Hsien, Chen, Judy Yi-Ju, and Chang, Shang-Jen

Published
2015
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9. Cross-ancestry investigation of venousc genomic predictors

Author

Thibord, F., Klarin, D., Brody, J.A., Chen, M.H., Levin, M.G., Chasman, D.I., Goode, E.L., Hveem, K., Teder-Laving, M., Martinez-Perez, A., Aissi, D., Daian-Bacq, D., Ito, K., Natarajan, P., Lutsey, P.L., Nadkarni, G.N., Vries, P.S. de, Cuellar-Partida, G., Wolford, B.N., Pattee, J.W., Kooperberg, C., Braekkan, S.K., Li-Gao, R.F., Saut, N., Sept, C., Germain, M., Judy, R.L., Wiggins, K.L., Ko, D., O'Donnell, C.J., Taylor, K.D., Giulianini, F., Andrade, M. de, Nost, T.H., Boland, A., Empana, J.P., Koyama, S., Gilliland, T., R. do, Huffman, J.E., Wang, X., Zhou, W., Soria, J.M., Souto, J.C., Pankratz, N., Haessler, J., Hindberg, K., Rosendaal, F.R., Turman, C., Olaso, R., Kember, R.L., Bartz, T.M., Lynch, J.A., Heckbert, S.R., Armasu, S.M., Brumpton, B., Smadja, D.M., Jouven, X., Komuro, I., Clapham, K.R., Loos, R.J.F., Willer, C.J., Sabater-Lleal, M., Pankow, J.S., Reiner, A.P., Morelli, V.M., Ridker, P.M., Vlieg, A.V., Deleuze, J.F., Kraft, P., Rader, D.J., Lee, K.M., Psaty, B.M., Skogholt, A.H., Emmerich, J., Suchon, P., Rich, S.S., Vy, H.T., Tang, W.H., Jackson, R.D., Hansen, J.B., Morange, P.E., Kabrhel, C., Tregouet, D.A., Damrauer, S.M., Johnson, A.D., and Smith, N.L.

Subjects
meta-analysis, genome-wide association study, venous thromboembolism, genetics, venous thrombosis
Abstract

Background: Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand discovery of new genetic loci associated with VTE by using cross-ancestry genomic resources. Methods: We present new cross-ancestry meta-analyzed GWAS results involving up to 81 669 VTE cases from 30 studies, with replication of novel loci in independent populations and loci characterization through in silico genomic interrogations. Results: In our genetic discovery effort that included 55 330 participants with VTE (47 822 European, 6320 African, and 1188 Hispanic ancestry), we identified 48 novel associations, of which 34 were replicated after correction for multiple testing. In our combined discovery-replication analysis (81 669 VTE participants) and ancestry-stratified meta-analyses (European, African, and Hispanic), we identified another 44 novel associations, which are new candidate VTE-associated loci requiring replication. In total, across all GWAS meta-analyses, we identified 135 independent genomic loci significantly associated with VTE risk. A genetic risk score of the significantly associated loci in Europeans identified a 6-fold increase in risk for those in the top 1% of scores compared with those with average scores. We also identified 31 novel transcript associations in transcriptome-wide association studies and 8 novel candidate genes with protein quantitative-trait locus Mendelian randomization analyses. In silico interrogations of hemostasis and hematology traits and a large phenome-wide association analysis of the 135 GWAS loci provided insights to biological pathways contributing to VTE, with some loci contributing to VTE through well-characterized coagulation pathways and others providing new data on the role of hematology traits, particularly platelet function. Many of the replicated loci are outside of known or currently hypothesized pathways to thrombosis. Conclusions: Our cross-ancestry GWAS meta-analyses identified new loci associated with VTE. These findings highlight new pathways to thrombosis and provide novel molecules that may be useful in the development of improved antithrombosis treatments.

Published
2022

10. Machine Learning for the Prediction of Distant Metastases Following Postprostatectomy Salvage Radiation Therapy

Author

Sabbagh, A., primary, Tilki, D., additional, Feng, J., additional, Hong, J.C., additional, Chen, M.H., additional, Wu, J., additional, Huland, H., additional, Graefen, M., additional, Wiegel, T., additional, Böhmer, D., additional, Washington, S., additional, Cowan, J., additional, Cooperberg, M.R., additional, Feng, F.Y., additional, Carroll, P., additional, Trock, B., additional, Partin, A.W., additional, DAmico, A.V., additional, and Mohamad, O., additional

Published
2022
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12. Machine Learning for the Prediction of Lymph Node Metastasis in Patients with Prostate Cancer

Author

Sabbagh, A., primary, III, S. Washington, additional, Tilki, D., additional, Hong, J.C., additional, Feng, J., additional, Chen, M.H., additional, Wu, J., additional, Huland, H., additional, Graefen, M., additional, Wiegel, T., additional, Böhmer, D., additional, Cowan, J., additional, Cooperberg, M.R., additional, Feng, F.Y., additional, Trock, B., additional, Partin, A.W., additional, DAmico, A.V., additional, Carroll, P., additional, and Mohamad, O., additional

Published
2022
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15. Testing a Family Supportive End of Life Care Intervention in a Chinese Neonatal Intensive Care Unit: A Quasi-experimental Study With a Non-randomized Controlled Trial Design

Author

Zhang, R., Tang, Q., Zhu, L.H., Peng, X.M., Zhang, N., Xiong, Y.E.E., Chen, M.H., Chen, K.L., Luo, D., Li, X., Latour, Jos, Zhang, R., Tang, Q., Zhu, L.H., Peng, X.M., Zhang, N., Xiong, Y.E.E., Chen, M.H., Chen, K.L., Luo, D., Li, X., and Latour, Jos

Abstract

Background: Neonatal death often occurs in tertiary Neonatal Intensive Care Units (NICUs). In China, end-of-life-care (EOLC) does not always involve parents. Aim: The aim of this study is to evaluate a parent support intervention to integrate parents at the end of life of their infant in the NICU. Methods: A quasi-experimental study using a non-randomized clinical trial design was conducted between May 2020 and September 2021. Participants were infants in an EOLC pathway in the NICU and their parents. Parents were allocated into a family supportive EOLC intervention group or a standard EOLC group based on their wishes. The primary outcomes depression (Edinburgh Postnatal Depression Scale for mothers; Hamilton Depression rating scale for fathers) and Satisfaction with Care were measured 1 week after infants' death. Student t-test for continuous variables and the Chi-square test categorical variables were used in the statistical analysis. Results: In the study period, 62 infants died and 45 infants and 90 parents were enrolled; intervention group 20 infants, standard EOLC group 25 infants. The most common causes of death in both groups were congenital abnormalities (n = 20, 44%). Mean gestational age of infants between the family supportive EOLC group and standard EOLC group was 31.45 vs. 33.8 weeks (p = 0.234). Parents between both groups did not differ in terms of age, delivery of infant, and economic status. In the family support group, higher education levels were observed among mother (p = 0.026) and fathers (p = 0.020). Both mothers and fathers in the family supportive EOLC group had less depression compared to the standard EOLC groups; mothers (mean 6.90 vs. 7.56; p = 0.017) and fathers (mean 20.7 vs. 23.1; p < 0.001). Parents reported higher satisfaction in the family supportive EOLC group (mean 88.9 vs. 86.6; p < 0.001). Conclusions: Supporting parents in EOLC in Chinese NICUs might decreased their depression and increase satisfaction after the death of their

Published
2022

24. Hyperfine quenching of the metastable 4s4p ³[P.sub.0] and ³[P.sub.2] states of Zn-like ions

Author

Chen, M.H. and Cheng, K.T.

Subjects
Phase transformations (Statistical physics) -- Research, Metal ions -- Atomic properties -- Composition -- Chemical properties, Zinc -- Atomic properties -- Chemical properties, Physics
Abstract

The hyperfine-induced 4s4p ³[P.sub.0,2]-4[s.sup.2] ¹[S.sup.0] transition rates for Zn-like ions with Z = 30-66 are calculated using a large scale relativistic configuration-interaction method. Comparisons are made between different approaches to hyperfine quenching studies, and discussions are given to the significance of various contributions. For the ³[P.sup.0] state, the effect of the ¹[P.sub.1] state on hyperfine quenching is found to be quite substantial and cannot be ignored in spite of the large energy separation. For the ³[P.sub.2] state, hyperfine quenching leads to different decay rates to the ground state for different hyperfine levels and the induced decays can dominated over the unperturbed M2 transition. The present results are compared with the other theoretical predictions, and reasons for the discrepancies are discussed. PACS Nos: 31.30.Gs, 32.10.Fn, 31.15.aj, 31.15.am Utilisant une methode d'interaction de configuration relativiste a grande echelle, nous avons calcule les taux de transition hyperfine induits 4s4p ³[P.sub.0,2]-4[s.sup.2] ¹[S.sup.0] dans les ions de type Zn, avec Z = 30-66. Nous comparons avec les resultats de differentes approches a l'extinction hyperfine et discutons la signification des differentes contributions. Pour l'etat ³[P.sub.0], nous trouvons que l'effet de l'etat ¹[P.sub.1] sur l'extinction hyperfine est tres significative et ne peut etre ignoree, en depit de l'importante separation en energie. Pour l'etat ³[P.sub.2],l'extinction hyperfine mene a differents taux de desintegration vers le fondamental pour differents niveaux hyperfins et les desintegrations induites peuvent dominer la transition M2 sans perturbation. Nous comparons nos resultats avec d' autres predictions theoriques et analysons les desaccords. [Traduit par la Redaction], 1. Introduction The properties of metastable states are important in pure and applied atomic physics. In astrophysical and laboratory-produced plasmas, forbidden lines can be used to determine the density and [...]

Published
2011
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25. High-precision relativistic atomic structure calculations and the EBIT: tests of quantum electrodynamics in highly charged ions (1)

Author

Cheng, K.T., Chen, M.H., Johnson, W.R., and Sapirstein, J.

Subjects
Electronic structure -- Evaluation -- Research, Atomic structure -- Evaluation -- Research, Perturbation (Mathematics) -- Research, Quantum electrodynamics -- Research, Electron beams -- Properties -- Research, Ions -- Properties -- Research, Physics
Abstract

Abstract: High-precision relativistic atomic-structure calculations based on the relativistic many-body perturbation theory and the relativistic configuration-interaction method are shown to provide stringent tests of strong-field quantum electrodynamic (QED) corrections when [...]

Published
2008

28. PSA failure following definitive treatment of Prostrate cancer having Biopsy Gleason score 7 with tertiary grade 5

Author

Patel A.A., Chen, M.H., Renshaw, A.A., and D'Amico, A.V.

Subjects
Prostate cancer -- Diagnosis, Prostate cancer -- Care and treatment, Prostate-specific antigen -- Patient outcomes
Abstract

The study to examine the PSA failure following treatment of prostrate cancer is presented. Results conclude that men with Biopsy Gleason score 7 prostrate cancer and tertiary grade 5 disease may have a risk of PSA failure following definitive therapy.

Published
2007

48. Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

Author

Lindstrom, S., Wang, L., Smith, E.N., Gordon, W., Vlieg, A.V., Andrade, M. de, Brody, J.A., Pattee, J.W., Haessler, J., Brumpton, B., Chasman, D.I., Suchon, P., Chen, M.H., Turman, C., Germain, M., Wiggins, K.L., MacDonald, J., Braekkan, S.K., Armasu, S.M., Pankratz, N., Jackson, R.D., Nielsen, J.B., Giulianini, F., Puurunen, M.K., Ibrahim, M., Heckbert, S.R., Damrauer, S.M., Natarajan, P., Klarin, D., Vries, P.S. de, Sabater-Lleal, M., Huffman, J.E., Bammler, T.K., Frazer, K.A., McCauley, B.M., Taylor, K., Pankow, J.S., Reiner, A.P., Gabrielsen, M.E., Deleuze, J.F., O'Donnell, C.J., Kim, J., McKnight, B., Kraft, P., Hansen, J.B., Rosendaal, F.R., Heit, J.A., Psaty, B.M., Tang, W.H., Kooperberg, C., Hveem, K., Ridker, P.M., Morange, P.E., Johnson, A.D., Kabrhel, C., Tregouet, D.A., Smith, N.L., Busenkell, E., Judy, R., Lynch, J., Levin, M., Aragam, J.H.K., Chaffin, M., Haas, M., Assimes, T.L., Huang, J., Lee, K.M., Shao, Q., Huang, Y.F., Sun, Y.V., Vujkovic, M., Saleheen, D., Miller, D.R., Reaven, P., DuVall, S., Boden, W., Pyarajan, S., Henke, P., Gaziano, J.M., Concato, J., Rader, D.J., Cho, K., Chang, K.M., Wilson, P.W.F., Tsao, P.S., Kathiresan, S., Obi, A., Million Veteran Program, CHARGE Hemostasis Working Grp, INVENT Consortium, Program in Genetic Epidemiology and Statistical Genetics (PGESG - BOSTON), Harvard School of Public Health, University of Washington [Seattle], The Scripps Translational Science Institute and Scripps Health, Department of Thrombosis and Haemostasis, Leiden University Medical Center (LUMC), Department of Health Sciences Research [Mayo Clinic] (HSR), Mayo Clinic, University of Minnesota System, Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Brigham and Women's Hospital [Boston], Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'hématologie biologique [Hôpital de la Timone - Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), National Institutes of Health [Bethesda] (NIH), Harvard T.H. Chan School of Public Health, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Biorobotics Lab (University of Washington), University of South-Eastern Norway (USN), Department of Health Sciences Research, Ohio State University [Columbus] (OSU), Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Los Angeles Biomedical Research Institute (LA BioMed), University of Augsburg [Augsburg], Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Epidemiology, Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, University of Minnesota [Twin Cities] (UMN), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Department of Emergency Medicine, Massachusetts General Hospital [Boston], Universiteit Leiden-Universiteit Leiden, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Augsburg (UNIA), and Universiteit Leiden

Subjects
0301 basic medicine, Genetics, [SDV]Life Sciences [q-bio], Immunology, Genome-wide association study, Cell Biology, Hematology, 030204 cardiovascular system & hematology, Biology, equipment and supplies, Biochemistry, 3. Good health, Transcriptome, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Mendelian randomization, Expression quantitative trait loci, Gene expression, cardiovascular diseases, Gene, Genetic association, Whole blood
Abstract

Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To advance our understanding of the biology contributing to VTE, we conducted a genome-wide association study (GWAS) of VTE and a transcriptome-wide association study (TWAS) based on imputed gene expression from whole blood and liver. We meta-analyzed GWAS data from 18 studies for 30 234 VTE cases and 172 122 controls and assessed the association between 12 923 718 genetic variants and VTE. We generated variant prediction scores of gene expression from whole blood and liver tissue and assessed them for association with VTE. Mendelian randomization analyses were conducted for traits genetically associated with novel VTE loci. We identified 34 independent genetic signals for VTE risk from GWAS meta-analysis, of which 14 are newly reported associations. This included 11 newly associated genetic loci (C1orf198, PLEK, OSMR-AS1, NUGGC/SCARA5, GRK5, MPHOSPH9, ARID4A, PLCG2, SMG6, EIF5A, and STX10) of which 6 replicated, and 3 new independent signals in 3 known genes. Further, TWAS identified 5 additional genetic loci with imputed gene expression levels differing between cases and controls in whole blood (SH2B3, SPSB1, RP11-747H7.3, RP4-737E23.2) and in liver (ERAP1). At some GWAS loci, we found suggestive evidence that the VTE association signal for novel and previously known regions colocalized with expression quantitative trait locus signals. Mendelian randomization analyses suggested that blood traits may contribute to the underlying risk of VTE. To conclude, we identified 16 novel susceptibility loci for VTE; for some loci, the association signals are likely mediated through gene expression of nearby genes.

Published
2019

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