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13. Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve.

Author

Li, Yuanyuan, Xu, Ruoyao, Chen, Muyan, Zheng, Kaige, Nie, Huimin, Yin, Chengyu, Liu, Boyu, Tai, Yan, Du, Junying, Wang, Jie, Fang, Jianqiao, and Liu, Boyi

Subjects
PERIPHERAL neuropathy, CHEMOKINES, FLOW cytometry, SCIATIC nerve, MACROPHAGES, RESEARCH funding, NEURONS, DESCRIPTIVE statistics, IN vivo studies, ELECTROACUPUNCTURE, MICE, HYPERALGESIA, SENSORY ganglia, ANIMAL experimentation, ACUPUNCTURE points, PACLITAXEL, STAINS & staining (Microscopy), SENSORY receptors, ALLODYNIA
Abstract

Background: Paclitaxel-induced peripheral neuropathy (PIPN) is prevalent among patients receiving paclitaxel chemotherapy, which results in sensory abnormality as well as neuropathic pain. Conventional medications lack effectiveness on PIPN. Clinical trials identified beneficial effects of acupuncture on PIPN among patients receiving chemotherapy. Here we explored the mechanisms underlying how acupuncture might alleviate PIPN. Methods: A mouse model of PIPN was established by repeated paclitaxel application. Electroacupuncture (EA) was applied at ST36 and BL60 acupoints of model mice. Immunostaining, flow cytometry, behavioral assay, in vivo imaging were utilized for effects determination and mechanism exploration. Results: EA ameliorated mechanical and cold pain hypersensitivities, reduced sensory neuron damage and improved loss in intra-epidermal nerve fibers (IENFs) in model mice. Macrophages infiltration were detected in DRG and sciatic nerve of model mice, which was reduced by EA. EA affected M1-like pro-inflammatory macrophage infiltration in DRG, whereas it did not affect M2-like macrophages. DRG neurons released chemoattractant CCL2 that recruited macrophages via CCR2 to DRG. EA reduced CCL2 overproduction by DRG neurons and reduced macrophage infiltration. Blocking CCR2 mimicked EA's anti-allodynic effect, whereas exogenously applying recombinant CCL2 reversed the ameliorative effect of EA on macrophage infiltration and abolished EA's anti-allodynia on model mice. EA ameliorated other signs of PIPN, including sensory neuron damage, sciatic nerve morphology impairment and IENFs loss. In mice inoculated with breast cancer cells, EA didn't affect paclitaxel-induced antitumor effect. Conclusions: These findings suggest EA alleviates PIPN by reducing CCL2/CCR2 mediated-pro-inflammatory macrophage infiltration into sensory ganglia as well as the sciatic nerve. Our study supports EA could be used as a potential non-pharmacological therapy for PIPN. [ABSTRACT FROM AUTHOR]

Published
2025
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16. Electroacupuncture Alleviates Paclitaxel-induced Peripheral Neuropathy by Reducing CCL2-mediated Macrophage Infiltration in Sensory Ganglia and Sciatic Nerve

Author

Li, Yuanyuan, primary, Xu, Ruoyao, additional, Chen, Muyan, additional, Zheng, Kaige, additional, Nie, Huimin, additional, Yin, Chengyu, additional, Liu, Boyu, additional, Tai, Yan, additional, Du, Junying, additional, Wang, Jie, additional, Fang, Jianqiao, additional, and Liu, Boyi, additional

Published
2024
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33. Comparison of intestinal microbiota and activities of digestive and immune-related enzymes of sea cucumber Apostichopus japonicusin two habitats

Author

Wang, Qi, Zhang, Xiumei, Chen, Muyan, Li, Wentao, and Zhang, Peidong

Abstract

Sea cucumber Apostichopus japonicusstock enhancement by releasing hatchery-produced seeds is a management tool used to recover its population under natural environmental conditions. To assess the suitability of releasing sites, we examined the microbiota of the gut contents of A. japonicusfrom two populations (one in sandy-muddy seagrass beds and one in rocky intertidal reefs) and the microbiota in their surrounding sediments. The activities of digestive and immune-related enzymes in the A. japonicuswere also examined. The results indicated that higher bacterial richness and Shannon diversity index were observed in all the seagrass-bed samples. There were significant differences in intestinal and sediment microorganisms between the two habitats, with a 2.87 times higher abundance of Firmicutes in the seagrass bed sediments than that in the reefs. Meanwhile, Bacteroidetes and Actinobacteria were significantly higher abundant in the gut content of A. japonicusfrom seagrass bed than those from the reefs. In addition, the seagrass-bed samples exhibited a relatively higher abundance of potential probiotics. Principal coordinates analysis and heatmap showed the bacterial communities were classified into two groups corresponding to the two habitat types. Moreover, compared to A. japonicusobtained from rocky intertidal habitat, those obtained from the seagrass bed showed higher lysozyme, superoxide dismutase and protease activities. Our results suggest that bacterial communities present in seagrass beds might enhance the digestive function and immunity of A. japonicus. Therefore, compared with the rocky intertidal reef, seagrass bed seems to be more beneficial for the survival of A. japonicus.

Published
2024
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42. Index

Author

Chen, Muyang

Published
2024

43. Notes

Author

Chen, Muyang

Published
2024

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