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36 results on '"Chen, NaiBin"'

15. Efficacy and cost‐effectiveness analysis of pretreatment percutaneous endoscopic gastrostomy in unresectable locally advanced esophageal cancer patients treated with concurrent chemoradiotherapy (GASTO 1059)

Author

Ai, XinLei, primary, Zhang, PengXin, additional, Xie, XinMin, additional, Qiu, Bo, additional, Zhu, YuJia, additional, Zhao, Lei, additional, Xi, Mian, additional, Wu, YingJia, additional, Guo, SuPing, additional, Guo, JinYu, additional, Liu, FangJie, additional, Wang, DaQuan, additional, Chen, NaiBin, additional, He, QianWen, additional, Hu, YongHong, additional, Liu, MengZhong, additional, Ding, ZhaoXia, additional, and Liu, Hui, additional

Published
2023
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16. Moderately hypo-fractionated radiotherapy combined with S-1 in inoperable locally advanced esophageal squamous cell carcinoma: A prospective, single-arm phase II study (GASTO-1045)

Author

Zhou, Rui, primary, Luo, Guangyu, additional, Guo, Suping, additional, Wu, Yingjia, additional, Luo, Qiaoting, additional, Wang, Daquan, additional, Chen, Naibin, additional, Liu, Fangjie, additional, Guo, Jinyu, additional, Ye, Wenfeng, additional, Qiu, Bo, additional, and Liu, Hui, additional

Published
2023
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18. Patlak-Ki derived from ultra-high sensitivity dynamic total body [18F]FDG PET/CT correlates with the response to induction immuno-chemotherapy in locally advanced non-small cell lung cancer patients.

Author

Wang, DaQuan, Qiu, Bo, Liu, QianWen, Xia, LiangPing, Liu, SongRan, Zheng, ChaoJie, Liu, Hui, Mo, YiWen, Zhang, Xu, Hu, YingYing, Zheng, ShiYang, Zhou, Yin, Fu, Jia, Chen, NaiBin, Liu, FangJie, Zhou, Rui, Guo, JinYu, and Fan, Wei

Subjects
NON-small-cell lung carcinoma, URODYNAMICS, NUCLEOTIDE sequencing, CANCER patients, MANN Whitney U Test, INDUCED labor (Obstetrics)
Abstract

Purpose: This study aimed to investigate the predictive value of metabolic features in response to induction immuno-chemotherapy in patients with locally advanced non-small cell cancer (LA-NSCLC), using ultra-high sensitivity dynamic total body [18F]FDG PET/CT. Methods: The study analyzed LA-NSCLC patients who received two cycles of induction immuno-chemotherapy and underwent a 60-min dynamic total body [18F]FDG PET/CT scan before treatment. The primary tumors (PTs) were manually delineated, and their metabolic features, including the Patlak-Ki, Patlak-Intercept, maximum SUV (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were evaluated. The overall response rate (ORR) to induction immuno-chemotherapy was evaluated according to RECIST 1.1 criteria. The Patlak-Ki of PTs was calculated from the 20–60 min frames using the Patlak graphical analysis. The best feature was selected using Laplacian feature importance scores, and an unsupervised K-Means method was applied to cluster patients. ROC curve was used to examine the effect of selected metabolic feature in predicting tumor response to treatment. The targeted next generation sequencing on 1021 genes was conducted. The expressions of CD68, CD86, CD163, CD206, CD33, CD34, Ki67 and VEGFA were assayed through immunohistochemistry. The independent samples t test and the Mann–Whitney U test were applied in the intergroup comparison. Statistical significance was considered at P < 0.05. Results: Thirty-seven LA-NSCLC patients were analyzed between September 2020 and November 2021. All patients received two cycles of induction chemotherapy combined with Nivolumab/ Camrelizumab. The Laplacian scores showed that the Patlak-Ki of PTs had the highest importance for patient clustering, and the unsupervised K-Means derived decision boundary of Patlak-Ki was 2.779 ml/min/100 g. Patients were categorized into two groups based on their Patlak-Ki values: high FDG Patlak-Ki (H-FDG-Ki, Patlak-Ki > 2.779 ml/min/100 g) group (n = 23) and low FDG Patlak-Ki (L-FDG-Ki, Patlak-Ki ≤ 2.779 ml/min/100 g) group (n = 14). The ORR to induction immuno-chemotherapy was 67.6% (25/37) in the whole cohort, with 87% (20/23) in H-FDG-Ki group and 35.7% (5/14) in L-FDG-Ki group (P = 0.001). The sensitivity and specificity of Patlak-Ki in predicting the treatment response were 80% and 75%, respectively [AUC = 0.775 (95%CI 0.605–0.945)]. The expression of CD3+/CD8+ T cells and CD86+/CD163+/CD206+ macrophages were higher in the H-FDG-Ki group, while Ki67, CD33+ myeloid cells, CD34+ micro-vessel density (MVD) and tumor mutation burden (TMB) were comparable between the two groups. Conclusions: The total body [18F]FDG PET/CT scanner performed a dynamic acquisition of the entire body and clustered LA-NSCLC patients into H-FDG-Ki and L-FDG-Ki groups based on the Patlak-Ki. Patients with H-FDG-Ki demonstrated better response to induction immuno-chemotherapy and higher levels of immune cell infiltration in the PTs compared to those with L-FDG-Ki. Further studies with a larger patient cohort are required to validate these findings. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Hypofractionated concurrent chemoradiotherapy related lymphopenia and its association with survival in locally advanced non-small cell lung cancer patients

Author

Liu, FangJie, primary, Wu, YingJia, additional, Shao, JianHui, additional, Qiu, Bo, additional, Guo, SuPing, additional, Luo, QiaoTing, additional, Guo, JinYu, additional, Wang, DaQuan, additional, Chu, Chu, additional, Zhou, Rui, additional, Chen, NaiBin, additional, Ai, XinLei, additional, and Liu, Hui, additional

Published
2022
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20. Evaluation of the efficacy and feasibility of concurrent weekly docetaxel-nedaplatin and hypo-fractionated radiotherapy in atypical histologic subtypes of primary and metastatic mediastinal malignancies

Author

Meng, FanJun, primary, Ai, XinLei, additional, Wang, Bin, additional, Zhou, Yin, additional, Li, Su, additional, Wang, DaQuan, additional, Liu, FangJie, additional, Chen, NaiBin, additional, Zhou, Rui, additional, Guo, JinYu, additional, Huang, XiaoYan, additional, Yin, ShaoHan, additional, Qiu, Bo, additional, and Liu, Hui, additional

Published
2022
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21. Comparison and quantification of different concurrent chemotherapy regimens with radiotherapy in locally advanced non-small cell lung cancer: Clinical outcomes and theoretical results from an extended LQ and TCP model

Author

Ai, XinLei, primary, Qiu, Bo, additional, Zhou, Yin, additional, Li, Su, additional, Li, QiWen, additional, Huan, Jian, additional, Li, JiBin, additional, Hu, Nan, additional, Chen, NaiBin, additional, Liu, FangJie, additional, Wang, DaQuan, additional, Chu, Chu, additional, Wang, Bin, additional, Chen, Li, additional, Jiang, HaiHang, additional, Huang, ShiYu, additional, Huang, XiaoYan, additional, Bi, Nan, additional, and Liu, Hui, additional

Published
2022
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22. Assessing dynamic metabolic heterogeneity in non-small cell lung cancer patients via ultra-high sensitivity total-body [18F]FDG PET/CT imaging: quantitative analysis of [18F]FDG uptake in primary tumors and metastatic lymph nodes.

Author

Wang, DaQuan, Zhang, Xu, Liu, Hui, Qiu, Bo, Liu, SongRan, Zheng, ChaoJie, Fu, Jia, Mo, YiWen, Chen, NaiBin, Zhou, Rui, Chu, Chu, Liu, FangJie, Guo, JinYu, Zhou, Yin, Zhou, Yun, and Fan, Wei

Subjects
NON-small-cell lung carcinoma, METABOLISM, LYMPH node cancer, CANCER treatment, CANCER immunotherapy
Abstract

Purpose: This study aimed to quantitatively assess [18F]FDG uptake in primary tumor (PT) and metastatic lymph node (mLN) in newly diagnosed non-small cell lung cancer (NSCLC) using the total-body [18F]FDG PET/CT and to characterize the dynamic metabolic heterogeneity of NSCLC. Methods: The 60-min dynamic total-body [18F]FDG PET/CT was performed before treatment. The PTs and mLNs were manually delineated. An unsupervised K-means classification method was used to cluster patients based on the imaging features of PTs. The metabolic features, including Patlak-Ki, Patlak-Intercept, SUVmean, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and textural features, were extracted from PTs and mLNs. The targeted next-generation sequencing of tumor-associated genes was performed. The expression of Ki67, CD3, CD8, CD34, CD68, and CD163 in PTs was determined by immunohistochemistry. Results: A total of 30 patients with stage IIIA–IV NSCLC were enrolled. Patients were divided into fast dynamic FDG metabolic group (F-DFM) and slow dynamic FDG metabolic group (S-DFM) by the unsupervised K-means classification of PTs. The F-DFM group showed significantly higher Patlak-Ki (P < 0.001) and SUVmean (P < 0.001) of PTs compared with the S-DFM group, while no significant difference was observed in Patlak-Ki and SUVmean of mLNs between the two groups. The texture analysis indicated that PTs in the S-DFM group were more heterogeneous in FDG uptake than those in the F-DFM group. Higher T cells (CD3+/CD8+) and macrophages (CD68+/CD163+) infiltration in the PTs were observed in the F-DFM group. No significant difference was observed in tumor mutational burden between the two groups. Conclusion: The dynamic total-body [18F]FDG PET/CT stratified NSCLC patients into the F-DFM and S-DFM groups, based on Patlak-Ki and SUVmean of PTs. PTs in the F-DFM group seemed to be more homogenous in terms of [18F]FDG uptake than those in the S-DFM group. The higher infiltrations of T cells and macrophages were observed in the F-DFM group, which suggested a potential benefit from immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2022
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24. A Prospective Phase II Study of Simultaneous Modulated Accelerated Radiotherapy Concurrently With CDDP/S1 for Esophageal Squamous Cell Carcinoma in the Elderly

Author

Guo, SuPing, primary, Liu, FangJie, additional, Liu, Hui, additional, Wu, YingJia, additional, Zhang, XuHui, additional, Ye, WenFeng, additional, Luo, GuangYu, additional, Li, QiWen, additional, Chen, NaiBin, additional, Hu, Nan, additional, Wang, Bin, additional, Zhang, Jun, additional, Lin, MaoSheng, additional, Feng, HuiXia, additional, and Qiu, Bo, additional

Published
2021
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26. Hypo-fractionated radiotherapy with concurrent chemotherapy for locoregional recurrence of non-small cell lung cancer after complete resection: A prospective, single-arm, phase II study (GASTO-1017)

Author

Chen, NaiBin, primary, Li, QiWen, additional, Wang, SiYu, additional, Xiong, Mai, additional, Luo, YiFeng, additional, Wang, Bin, additional, Chen, Li, additional, Lin, MaoSheng, additional, Jiang, XiaoBo, additional, Fang, JianLan, additional, Guo, SuPing, additional, Guo, JinYu, additional, Hu, Nan, additional, Ai, XinLei, additional, Wang, DaQuan, additional, Chu, Chu, additional, Liu, FangJie, additional, Long, Hao, additional, Wang, JunYe, additional, Qiu, Bo, additional, and Liu, Hui, additional

Published
2021
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27. Dynamic 18F-FDG Total body PET Imaging as a predictive marker of induction chemo-immunotherapy response in locally advanced non-small cell lung cancer.

Author

Liu, Hui, primary, Qiu, Bo, additional, Wang, DaQuan, additional, Zhang, Xu, additional, Liu, Hui, additional, Zhou, Yin, additional, Li, QiWen, additional, Chu, Chu, additional, Liu, FangJie, additional, Chen, NaiBin, additional, Hu, Nan, additional, Ai, XinLei, additional, Guo, JinYu, additional, and Fan, Wei, additional

Published
2021
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28. Assessing tumor metabolic heterogeneity of non-small cell lung cancer with total body PET-CT imaging on the uExplorer: Analysis of dynamic changes of 18F-FDG uptake.

Author

Liu, Hui, primary, Zhang, Xu, additional, Liu, Hui, additional, Qiu, Bo, additional, Wang, DaQuan, additional, Zhou, Yin, additional, Li, QiWen, additional, Chu, Chu, additional, Liu, FangJie, additional, Chen, NaiBin, additional, Hu, Nan, additional, Ai, XinLei, additional, Guo, JinYu, additional, and Fan, Wei, additional

Published
2021
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29. Benefit from Adjuvant TKIs Versus TKIs Plus Chemotherapy in EGFR-Mutant Stage III-pN2 Lung Adenocarcinoma

Author

Li, Qiwen, primary, Ma, Li, additional, Qiu, Bo, additional, Wen, Yuzhi, additional, Liang, Wenhua, additional, Hu, Wanming, additional, Chen, Naibin, additional, Zhang, Tian, additional, Xu, Shuangbing, additional, Chen, Lingjuan, additional, Guo, Minzhang, additional, Zhao, Yi, additional, Liu, Songran, additional, Guo, Jinyu, additional, Wang, Junye, additional, Wang, Siyu, additional, Wang, Xin, additional, Pang, Qingsong, additional, Long, Hao, additional, and Liu, Hui, additional

Published
2021
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30. The influence of hidden researcher decisions in applied microeconomics

Author

Huntington‐Klein, Nick, primary, Arenas, Andreu, additional, Beam, Emily, additional, Bertoni, Marco, additional, Bloem, Jeffrey R., additional, Burli, Pralhad, additional, Chen, Naibin, additional, Grieco, Paul, additional, Ekpe, Godwin, additional, Pugatch, Todd, additional, Saavedra, Martin, additional, and Stopnitzky, Yaniv, additional

Published
2021
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31. The Influence of Hidden Researcher Decisions in Applied Microeconomics

Author

Huntington-Klein, Nick, Arenas, Andreu, Beam, Emily A., Bertoni, Marco, Bloem, Jeffrey R., Burli, Pralhad, Chen, Naibin, Greico, Paul, Ekpe, Godwin, Pugatch, Todd, Saavedra, Martin, and Stopnitzky, Yaniv

Subjects
B41, Research, ddc:330, C81, Metascience, Replication, C10
Abstract

Researchers make hundreds of decisions about data collection, preparation, and analysis in their research. We use a many-analysts approach to measure the extent and impact of these decisions. Two published causal empirical results are replicated by seven replicators each. We find large differences in data preparation and analysis decisions, many of which would not likely be reported in a publication. No two replicators reported the same sample size. Statistical significance varied across replications, and for one of the studies the effect's sign varied as well. The standard deviation of estimates across replications was 3-4 times the typical reported standard error.

Published
2020

32. Developing and Validating an Integrated Gross Tumor Volume (GTV)-TNM&nbsp;Stratification System for Supplementing Unresectable Locally Advanced Non-small Cell Lung Cancer Treated With Concurrent Chemoradiotherapy

Author

Chen, NaiBin, primary, Li, QiWen, additional, Zhu, ZhengFei, additional, Wang, YiMing, additional, Cheng, ZhangKai, additional, Hui, ZhouGuang, additional, Guo, SuPing, additional, He, HaoQiang, additional, Wang, Bin, additional, Huang, XiaoYan, additional, Li, JiBin, additional, Guo, JinYu, additional, Hu, Nan, additional, Ai, XinLei, additional, Zhou, Yin, additional, Wang, DaQuan, additional, Liu, FangJie, additional, Xie, ChuanMiao, additional, Qiu, Bo, additional, and Liu, Hui, additional

Published
2020
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33. The Influence of Hidden Researcher Decisions in Applied Microeconomics

Author

Huntington-Klein, Nick, primary, Arenas, Andreu, additional, Beam, Emily, additional, Bertoni, Marco, additional, Bloem, Jeffrey, additional, Burli, Pralhad H, additional, Chen, Naibin, additional, Grieco, Paul L.E., additional, Ekpe, Godwin, additional, Pugatch, Todd, additional, Saavedra, Martin Hugo, additional, and Stopnitzky, Yaniv, additional

Published
2020
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36. Value of Patlak-Ki from ultra-high sensitivity dynamic total body [ 18 F]FDG PET/CT for evaluation of treatment response to induction immuno-chemotherapy in locally advanced non-small cell lung cancer (LA-NSCLC) patients.

Author

Wang, DaQuan, Qiu, Bo, Liu, Qianwen, Xia, Liangping, Songran, Liu, Zheng, ChaoJie, Liu, Hui, Mo, Yiwen, Zhang, Xu, Hu, Ying-Ying, Zheng, ShiYang, Zhou, Yin, Fu, Jia, Chen, NaiBin, Liu, FangJie, Zhou, Rui, Guo, JinYu, and Fan, Wei

Published
2023
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