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2. Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

Author

Liu, Chung-Hsiang, Tsai, Chon-Haw, Huang, Wei-Shih, Lu, Chung-Ta, Tsai, Tzung-Chang, Tseng, Chun-Hung, Lin, Kang-Hsu, Shyu, Woei-Cherng, Yang, Yu-Wan, Liu, Yen-Liang, Cho, Der-Yang, Chen, Chun-Chung, Jeng, Jiann-Shing, Tang, Sung-Chun, Tsai, Li-Kai, Yeh, Shin-Joe, Chen, Chih-Hao, Tsai, Hsin-Hsi, Li, Jie-Yuan, Chen, Han-Jung, Lu, Kan, Hsu, Shih-Pin, Kuo, Hung-Chang, Tsou, Jung-Chi, Wang, Yan-Tang, Tai, Yi-Cheng, Hsieh, Meng-Tsang, Liliang, Po-Chao, Liang, Cheng-Loong, Wang, Hao-Kuang, Tsai, Yu-Tun, Wang, Kuo-Wei, Chen, Jui-Sheng, Chen, Po-Yuan, Wang, Yi-Ching, Chen, Chih-Hung, Sung, Pi-Shan, Hsieh, Han-Chieh, Su, Hui-Chen, Chiu, Hou-Chang, Lien, Li-Ming, Chen, Wei-Hung, Bai, Chyi-Huey, Huang, Tzu-Hsuan, Lau, Chi-Ieong, Wu, Ya-Ying, Yeh, Hsu-Ling, Chang, Anna, Lin, Ching-Huang, Yen, Cheng-Chang, Lin, Ruey-Tay, Chen, Chun-Hung, Khor, Gim-Thean, Chao, A-Ching, Lin, Hsiu-Fen, Huang, Poyin, Lin, Huey-Juan, Ke, Der-Shin, Chang, Chia-Yu, Yeh, Poh-Shiow, Lin, Kao-Chang, Cheng, Tain-Junn, Chou, Chih-Ho, Yang, Chun-Ming, Shen, Hsiu-Chu, Chen, An-Chih, Tsai, Shih-Jei, Lu, Tsong-Ming, Kung, Sheng-Ling, Lee, Mei-Ju, Chou, Hsi-Hsien, Chang, Wei-Lun, Chiu, Pai-Yi, Hsu, Min-Hsien, Chan, Po-Chi, Pan, Chau-Hsiung, Shoung, Hai-Ming, Lo, Yi-Chen, Wang, Fu-Hwa, Chang, Wei-Chieh, Lai, Ta-Chang, Yin, Jiu-Haw, Wang, Chung-Jen, Wang, Kai-Chen, Chen, Li-Mei, Denq, Jong-Chyou, Sun, Yu, Lu, Chien-Jung, Lin, Cheng-Huai, Huang, Chieh-Cheng, Liu, Chang-Hsiu, Chan, Hoi-Fong, Lee, Siu-Pak, Sun, Ming-Hui, Ke, Li-Ying, Chen, Po-Lin, Lee, Yu-Shan, Sung, Sheng-Feng, Ong, Cheung-Ter, Wu, Chi-Shun, Hsu, Yung-Chu, Su, Yu-Hsiang, Hung, Ling-Chien, Lee, Jiunn-Tay, Lin, Jiann-Chyun, Hsu, Yaw-Don, Peng, Giia-Sheun, Hsu, Chang-Hung, Lin, Chun-Chieh, Yen, Che-Hung, Cheng, Chun-An, Sung, Yueh-Feng, Chen, Yuan-Liang, Lien, Ming-Tung, Chou, Chung-Hsing, Liu, Chia-Chen, Yang, Fu-Chi, Wu, Yi-Chung, Tso, An-Chen, Lai, Yu- Hua, Chiang, Chun-I., Tsai, Chia-Kuang, Liu, Meng-Ta, Lin, Ying-Che, Hsu, Yu-Chuan, Chiang, Tsuey-Ru, Huang, Pai-Hao, Liao, Pin-Wen, Lee, Mei-Ching, Chen, Jen-Tse, Lie, Sian-King, Sun, Mu-Chien, Hsiao, Pi-Ju, Chen, Wei-Liang, Chen, Ta-Cheng, Chang, Chen-Shu, Lai, Chien-Hsu, Chuang, Chieh-Sen, Chen, Yen-Yu, Lin, Shinn-Kuang, Su, Yu-Chin, Shiao, Jen-Lun, Yang, Fu-Yi, Liu, Chih-Yang, Chiang, Han-Lin, Chen, Guei-Chiuan, Hsu, Po-Jen, Chang, Chun-Yuan, Lin, I.-sheng, Chien, Chung-Hsien, Chang, Yang-Chuang, Chen, Ping-Kun, Hsiao, Yu-Jen, Fang, Chen-Wen, Chen, Yu-Wei, Lee, Kuo-Ying, Lin, Yun-Yu, Li, Chen-Hua, Tsai, Hui-Fen, Hsieh, Chuan-Fa, Yang, Chih-Dong, Liaw, Shiumn-Jen, Liao, How-Chin, Yeh, Shoou-Jeng, Wu, Ling-Li, Hsieh, Liang-Po, Lee, Yong-Hui, Chen, Chung-Wen, Hsu, Chih-Shan, Jhih, Ye-Jian, Zhuang, Hao-Yu, Pan, Yan-Hong, Shih, Shin-An, Chen, Chin-I., Sung, Jia-Ying, Weng, Hsing-Yu, Teng, Hao-Wen, Lee, Jing-Er, Huang, Chih-Shan, Chao, Shu-Ping, Yuan, Rey-Yue, Sheu, Jau-Jiuan, Yu, Jia-Ming, Ho, Chun-Sum, Lin, Ting-Chun, Yu, Shih-Chieh, Chen, Jiunn-Rong, Tsai, Song-Yen, Wei, Cheng-Yu, Hung, Chao-Hsien, Lee, Chia Fang, Yang, Sheng-Kung, Chen, Chih-Lin, Lin, Wei, Tseng, Hung-Pin, Liu, Chin-Hsiung, Lin, Chun-Liang, Lin, Hung-Chih, Chen, Pi-Tzu, Hu, Chaur-Jong, Chan, Lung, Chi, Nai-Fang, Chern, Chang-Ming, Lin, Chun-Jen, Wang, Shuu-Jiun, Hsu, Li-Chi, Wong, Wen-Jang, Lee, I-Hui, Yen, Der-Jen, Tsai, Ching-Piao, Kwan, Shang-Yeong, Soong, Bing-Wen, Chen, Shih-Pin, Liao, Kwong-Kum, Lin, Kung-Ping, Chen, Chien, Shan, Din-E., Fuh, Jong-Ling, Wang, Pei-Ning, Lee, Yi-Chung, Yu, Yu-Hsiang, Huang, Hui-Chi, Tsai, Jui-Yao, Wu, Ming-Hsiu, Chiang, Szu-Yi, Wang, Chiung-Yao, Hsu, Ming-Chin, Chen, Chien-Chung, Yeh, Po-Yen, Tsai, Yu-Tai, Wang, Ko-Yi, Chen, Tsang-Shan, Hsieh, Cheng-Yang, Chen, Wei-Fen, Yip, Ping-Keung, Wang, Vinchi, Wang, Kaw-Chen, Tsai, Chung-Fen, Chen, Chao-Ching, Liu, Yi-Chien, Chen, Shao-Yuan, Zhao, Zi-Hao, Wei, Zhi-Peng, Wu, Shey-Lin, Liu, Ching-Kuan, Lin, Ryh-Huei, Chu, Ching-Hua, Yan, Sui-Hing, Lin, Yi-Chun, Chen, Pei-Yun, Hsiao, Sheng-Huang, Yip, Bak-Sau, Tsai, Pei-Chun, Chou, Ping-Chen, Kuo, Tsam-Ming, Lee, Yi-Chen, Chiu, Yi-Pin, Tsai, Kun-Chang, Liao, Yi-Sheng, Tsai, Ming-Jun, Kao, Hsin-Yi, Wang, I-Kuan, Yen, Tzung-Hai, Tsai, I-Ju, Sung, Fung-Chang, and Hsu, Chung Y.

Published
2018
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3. Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients

Author

Liu, Chung-Hsiang, Tsai, Chon-Haw, Huang, Wei-Shih, Lu, Chung-Ta, Tsai, Tzung-Chang, Tseng, Chun-Hung, Lin, Kang-Hsu, Shyn, Woei-Cherng, Yang, Yu-Wan, Liu, Yen-Liang, Cho, Der-Yang, Chen, Chun-Chung, Jeng, Jiann-Shing, Tang, Sung-Chun, Tsai, Li-Kai, Yeh, Shin-Joe, Hsu, Shih-Pin, Chen, Han-Jung, Chang, Cheng-Sen, Kuo, Hung-Chang, Lee, Lian-Hui, Tsui, Huan-Wen, Tsou, Jung-Chi, Wang, Yan-Tang, Tai, Yi-Cheng, Tsai, Kun-Chang, Chen, Yen-Wen, Lu, Kan, Liliang, Po-Chao, Tsai, Yu-Tun, Liang, Cheng-Loong, Wang, Kuo-Wei, Wang, Hao-Kuang, Chen, Jui-Sheng, Chen, Po-Yuan, Chye, Cien-Leong, Tzeng, Wei-Jie, Wu, Pei-Hua, Chen, Chih-Hung, Sung, Pi-Shan, Hsieh, Han-Chieh, Su, Hui-Chen, Chiu, Hou-Chang, Lien, Li-Ming, Chen, Wei-Hung, Bai, Chyi-Huey, Huang, Tzu-Hsuan, Lau, Chi-Ieong, Wu, Ya-Ying, Yeh, Hsu-Ling, Chang, Anna, Lin, Ching-Huang, Yen, Cheng-Chang, Lin, Ruey-Tay, Chen, Chun-Hung, Khor, Gim-Thean, Chao, A-Ching, Lin, Hsiu-Fen, Huang, Poyin, Lin, Huey-Juan, Ke, Der-Shin, Chang, Chia-Yu, Yeh, Poh-Shiow, Lin, Kao-Chang, Cheng, Tain-Junn, Chou, Chih-Ho, Yang, Chun-Ming, Shen, Hsiu-Chu, Chen, An-Chih, Tsai, Shih-Jei, Lu, Tsong-Ming, Kung, Sheng-Ling, Lee, Mei-Ju, Chou, Hsi-Hsien, Chi, Hsin-Yi, Pan, Chou-Hsiung, Chan, Po-Chi, Hsu, Min-Hsien, Chang, Wei-Lun, Huang, Zhi-Zang, Shoung, Hai-Ming, Lo, Yi-Chen, Wang, Fu-Hwa, Lai, Ta-Chang, Yin, Jiu-Haw, Wang, Chung-Jen, Wang, Kai-Chen, Chen, Li-Mei, Denq, Jong-Chyou, Sun, Yu, Lu, Chien-Jung, Lin, Cheng-Huai, Huang, Chieh-Cheng, Liu, Chang-Hsiu, Chan, Hoi-Fong, Lee, Siu-Pak, Sun, Ming-Hui, Ke, Li-Ying, Chen, Po-Lin, Lee, Yu-Shan, Sung, Sheng-Feng, Ong, Cheung-Ter, Wu, Chi-Shun, Hsu, Yung-Chu, Su, Yu-Hsiang, Hung, Ling-Chien, Lee, Jiunn-Tay, Lin, Jiann-Chyun, Hsu, Yaw-Don, Peng, Giia-Sheun, Hsu, Chang-Hung, Lin, Chun-Chieh, Yen, Che-Hung, Cheng, Chun-An, Sung, Yueh-Feng, Chen, Yuan-Liang, Lien, Ming-Tung, Chou, Chung-Hsing, Liu, Chia-Chen, Yang, Fu-Chi, Wu, Yi-Chung, Tso, An-Chen, Lai, Yu-Hua, Chiang, Chun-I, Tsai, Chia-Kuang, Liu, Meng-Ta, Lin, Ying-Che, Hsu, Yu-Chuan, Chiang, Tsuey-Ru, Lee, Mei-Ching, Huang, Pai-Hao, Lie, Sian-King, Liao, Pin-Wen, Chen, Jen-Tse, Sun, Mu-Chien, Lai, Tien-Pao, Chen, Wei-Liang, Chen, Yen-Chun, Chen, Ta-Cheng, Wang, Wen-Fu, Lee, Kwo-Whei, Chang, Chen-Shu, Lai, Chien-Hsu, Shih, Siao-Ya, Chuang, Chieh-Sen, Chen, Yen-Yu, Chen, Chien-Min, Lin, Shinn-Kuang, Su, Yu-Chin, Hsiao, Cheng-Lun, Yang, Fu-Yi, Liu, Chih-Yang, Chiang, Han-Lin, Chang, Chun-Yuan, Lin, I-sheng, Chien, Chung-Hsien, Chang, Yang-Chuang, Chen, Ping-Kun, Chiu, Pai-Yi, Hsiao, Yu-Jen, Fang, Chen-Wen, Chen, Yu-Wei, Lee, Kuo-Ying, Lin, Yun-Yu, Li, Chen-Hua, Tsai, Hui-Fen, Hsieh, Chuan-Fa, Yang, Chih-Dong, Liaw, Shiumn-Jen, Liao, How-Chin, Yeh, Shoou-Jeng, Wu, Ling-Li, Hsieh, Liang-Po, Lee, Yong-Hui, Chen, Chung-Wen, Hsu, Chih-Shan, Jhih, Ye-Jian, Zhuang, Hao-Yu, Pan, Yan-Hong, Shih, Shin-An, Chen, Chin-I, Sung, Jia-Ying, Weng, Hsing-Yu, Teng, Hao-Wen, Lee, Jing-Er, Huang, Chih-Shan, Chao, Shu-Ping, Yuan, Rey-Yue, Sheu, Jau- Jiuan, Yu, Jia-Ming, Ho, Chun-Sum, Lin, Ting-Chun, Yu, Shih-Chieh, Chen, Jiunn-Rong, Tsai, Song-Yen, Wei, Cheng-Yu, Yang, Chao-Nan, Hung, Chao-Hsien, Shih, Ian, Tseng, Hung-Pin, Liu, Chin-Hsiung, Lin, Chun-Liang, Lin, Hung-Chih, Chen, Pi-Tzu, Hu, Chaur-Jong, Chi, Nai-Fang, Chan, Lung, Chern, Chang-Ming, Lin, Chun-Jen, Wang, Shuu-Jiun, Hsu, Li-Chi, Wong, Wen-Jang, Lee, I-Hui, Yen, Der-Jen, Tsai, Ching-Piao, Kwan, Shang-Yeong, Soong, Bing-Wen, Chen, Shih-Pin, Liao, Kwong-Kum, Lin, Kung-Ping, Chen, Chien, Shan, Din-E, Fuh, Jong-Ling, Wang, Pei-Ning, Lee, Yi-Chung, Yu, Yu-Hsiang, Huang, Hui-Chi, Tsai, Jui-Yao, Wu, Ming-Hsiu, Chen, Shi-Cheng, Chiang, Szu-Yi, Wang, Chiung-Yao, Hsu, Ming-Chin, Chen, Chien-Chung, Yeh, Po-Yen, Tsai, Yu-Tai, Wang, Ko-Yi, Chen, Tsang-Shan, Yip, Ping-Keung, Wang, Vinchi, Wang, Kaw-Chen, Tsai, Chung-Fen, Chen, Chao-Ching, Chen, Chih-Hao, Liu, Yi-Chien, Chen, Shao-Yuan, Zhao, Zi-Hao, Wei, Zhi-Peng, Wu, Shey-Lin, Liu, Ching-Kuan, Lin, Ryh-Huei, Chu, Ching-Hua, Yan, Sui-Hing, Lin, Yi-Chun, Chen, Pei-Yun, Hsiao, Sheng-Huang, Yip, Bak-Sau, Tsai, Pei-Chun, Chou, Ping-Chen, Kuo, Tsam-Ming, Lee, Yi-Chen, Chiu, Yi-Pin, Liao, Yi-Sheng, Tsai, Ming-Jun, Kao, Hsin-Yi, Wang, I.-Kuan, Yen, Tzung-Hai, Muo, Chih-Hsin, Ma, Henry, Wen, Chi-Pang, Sung, Fung-Chang, and Hsu, Chung Y.

Published
2017
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5. Derivation and Validation of a Discharge Disposition Predicting Model after Acute Stroke

Author

Jeng, Jiann-Shing, Yeh, Shin-Joe, Tsai, Li-Kai, Chiu, Hou-Chang, Lien, Li-Ming, Chen, Wei-Hung, Bai, Chyi-Huey, Huang, Tzu-Hsuan, Lau, Chi-Ieong, Wu, Ya-Ying, Yuan, Rey-Yue, Hu, Chaur-Jong, Sheu, Jau-Jiuan, Yu, Jia-Ming, Ho, Chun-Sum, Chung, Wen-Ting, Sung, Jia-Ying, Chen, Chin-I, Weng, Hsing-Yu, Han, Yu-Hsuan, Huang, Chun-Ping, Lin, Huey-Juan, Ke, Der-Shin, Chang, Chia-Yu, Yeh, Poh-Shiow, Lin, Kao-Chang, Cheng, Tain-Junn, Chou, Chih-Ho, Yang, Chun-Ming, Lo, Yuk-Keung, Lin, Yu-Te, Lin, Ching-Hwung, Lin, Jiann-Chyun, Hsu, Yaw-Don, Denq, Jong-Chyou, Peng, Giia-Sheun, Lee, Jiunn-Tay, Hsu, Chang-Hung, Lin, Chun-Chieh, Yen, Che-Hung, Cheng, Chun-An, Sung, Yueh-Feng, Chen, Yuan-Liang, Lien, Ming-Tung, Chou, Chung-Hsing, Liu, Chia-Chen, Yang, Fu-Chi, Wu, Yi-Chung, Tso, An-Chen, Lai, Yu-Hua, Chiang, Chun-I, Tsai, Chia-Kuang, Liu, Meng-Ta, Lin, Ying-Che, Hsu, Yu-Chuan, Liu, Chung-Hsiang, Tsai, Chon-Haw, Huang, Wei-Shih, Lu, Chung-Ta, Tsai, Tzung-Chang, Tseng, Chun-Hung, Lin, Kang-Hsu, Shyn, Woei-Cherng, Yang, Yu-Wan, Liu, Yen-Liang, Cho, Der-Yang, Chen, Chun-Chung, Sun, Ming-Hui, Yu, Shih-Chieh, Ke, Li-Ying, Lai, Ming-Liang, Chen, Chih-Hung, Chen, Jiunn-Rong, Tsai, Song-Yen, Chiang, Tsuey-Ru, Lee, Mei-Ching, Lin, Shinn-Kuang, Tseng, Yuan-Fu, Lee, Jing-Er, Hsiao, Cheng-Lun, Liang, Jen-Feng, Chen, Chiu-Mei, Wu, Chao-Hsin, Chen, Yu-Wei, Lee, Kuo-Ying, Lin, Yun-Yu, Li, Chen-Hua, Smith, Eric E., Tsai, Hui-Fen, Hsieh, Chuan-Fa, Yang, Chih-Dong, Liaw, Shiumn-Jen, Liao, How-Chin, Hu, Han-Hwa, Wong, Wen-Jang, Luk, Yun-On, Chern, Chang-Ming, Hsu, Li-Chi, Chung, Chih-Ping, Sun, Mu-Chien, Wu, Shey-Lin, Tseng, Hung-Pin, Liu, Chin-Hsiung, Lin, Chun-Liang, Lin, Hung-Chih, Lai, Ta-Chang, Yin, Jiu-Haw, Wang, Chung-Jen, Wang, Kai-Chen, Chen, Li-Mei, Chan, Lung, Lee, Siu-Pak, Sun, Yu, Huang, Chieh-Cheng, Liu, Chang-Hsiu, Lin, Cheng-Huai, Lu, Chien-Jung, Yeh, Shoou-Jeng, Wu, Ling-Li, Hsieh, Liang-Po, Lee, Yong-Hui, Chen, Chung-Wen, Chen, Po-Lin, Lee, Yu-Shan, Chen, Shu-Yi, Chen, Han-Jung, Hsu, Shih-Pin, Chang, Cheng-Sen, Kuo, Hung-Chang, Wu, Shu-Lung, Tsui, Huan-Wen, Tsou, Jung-Chi, Chou, Feng-Hsiung, Lin, Pei-Jung, Tung, Chin-Sung, Lu, Kan, Liliang, Po-Chou, Tsai, Yu-Duan, Liang, Cheng-Loong, Wang, Kuo-Wei, Wang, Hao-Kuang, Chen, Te-Yuan, Hsin, Yue-Loong, Lin, Chih-Yuan, Yip, Bak-Sau, Tsai, Pei-Chun, Chou, Ping-Chen, Kuo, Tsam-Ming, Lee, Yi-Chen, Chiu, Yi-Pin, Tsai, Kun-Chang, Lin, Ruey-Tay, Chen, Chun-Hung, Khor, Gim-Thean, Chao, A-Ching, Lin, Hsiu-Fen, Lin, I-Sheng, Yan, Sui-Hing, Lin, Yi-Chun, Chen, Pei-Yun, Hsiao, Sheng-Huang, Po, Helen L., Lin, Ya-Ju, Tu, Hao-Chieh, Tang, Sung-Chun, Lin, Fu-Yu, Chen, Ping-Kun, Chiu, Pai-Yi, Yip, Ping-Keung, Wang, Vin-Chi, Wang, Kaw-Chen, Tsai, Chung-Fen, Chen, Chao-Ching, Chen, Chih-Hao, Liu, Yi-Chien, Yeh, Chung-Hsin, Pan, Chou-Hsiung, Jih, Shin-Yi, Chan, Po-Chi, Hsu, Min-Hsien, Shoung, Hai-Ming, Lo, Yi-Chen, Wang, Fu-Hwa, Wei, Cheng-Yu, Lee, Jun-Yu, Lin, Ryh-Huei, Chu, Ching-Hua, Hsu, Ming-Chin, Lin, Feng-Jenq, Chen, Pi-Tzu, Mou, Chih-Hsin, Chang, Chun-Yuan, Chen, An-Chih, Hsiao, Yu-Jen, Lin, Ching-Huang, Hsu, Chung-Y., and Sung, Fung-Chang

Published
2015
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9. Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia

Author

Lin, Chieh-Hsin, Chen, Ping-Kun, Wang, Shi-Heng, and Lane, Hsien-Yuan

Subjects
Psychiatry, Aged, 80 and over, Male, Research, Drug Administration Schedule, Online Only, Cognition, Sex Factors, Double-Blind Method, Alzheimer Disease, Sodium Benzoate, Humans, Female, Original Investigation, Aged
Abstract

Key Points Question Is there a gender difference in the effectiveness of benzoate treatment for dementia with behavioral and psychological symptoms? Findings In this post hoc secondary analysis of a randomized, double-masked, 6-week trial that included 97 patients with behavioral and psychological symptoms, benzoate significantly surpassed placebo in cognitive performance in women but not in men on 1 of 2 assessment measures. Benzoate also increased estradiol to follicle-stimulating hormone ratios among women. Meaning These findings suggest that benzoate may improve cognitive function in women with later-phase dementia., This secondary analysis of a randomized, 6-week clinical trial examines gender differences in the effectiveness of sodium benzoate in treating the behavioral and psychological symptoms of dementia., Importance Female gender is a major risk factor for dementia; however, gender has not yet been adequately addressed by clinical trials. A recent study demonstrated that sodium benzoate, a D-amino acid oxidase inhibitor, improved cognitive function in early-phase Alzheimer disease. Objective To examine the potential gender difference in the effects of benzoate treatment on the behavioral and psychological symptoms of dementia (BPSD). Design, Setting, and Participants This post hoc secondary analysis used data from a randomized, double-masked, placebo-controlled trial conducted in 3 major medical centers in Taiwan and enrolled 97 patients with BPSD. Data were analyzed between February 2014 and November 2017. Interventions Six weeks of treatment of 250 to 1500 mg/d of sodium benzoate or placebo. Main Outcomes and Measures The primary outcome measures were Alzheimer disease assessment scale–cognitive subscale (ADAS-cog) and Behavioral Pathology in Alzheimer Disease Rating Scale (BEHAVE-AD) scores. Results Among 97 total participants (62 [64%] women; mean [SD] age, 75.4 [7.7] years), 49 patients (30 women and 19 men) were randomized to sodium benzoate, and 48 (32 women and 16 men) were randomized to placebo. Among 62 women, 6-week benzoate treatment significantly surpassed placebo in the effects on ADAS-cog performance (mean [SD] difference in score between baseline and end point, −3.1 [6.4] points vs 0 [4.5] points; Cohen d = 0.56; P = .04) but not BEHAVE-AD performance. In contrast, among 35 men, the 2 treatment groups did not differ significantly in both ADAS-cog and BEHAVE-AD scores. Compared with placebo, benzoate treatment also increased estradiol to follicle-stimulating hormone ratios among women (mean [SD] difference between baseline and end point, 0 [0.2] vs −0.1 [0.3]; P = .03). Conclusions and Relevance These findings suggest that benzoate treatment may improve cognitive function in women with later-phase dementia. In the future, longer dose-finding trials are warranted to further clarify the efficacy of benzoate for later-phase dementia and investigate the role of sex hormones and other factors in the pathogenesis of dementia. Trial Registration ClinicalTrials.gov Identifier: NCT02103673

Published
2021

12. Association between restless legs syndrome and migraine

Author

Chen, Ping-Kun, Fuh, Jong-Ling, Chen, Shih-Pin, and Wang, Shuu-Jiun

Subjects
Restless legs syndrome -- Development and progression, Restless legs syndrome -- Research, Migraine -- Development and progression, Migraine -- Research, Comorbidity -- Research, Health, Psychology and mental health
Published
2010

18. Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke

Author

Wang, I-Kuan, primary, Liu, Chung-Hsiang, additional, Yen, Tzung-Hai, additional, Jeng, Jiann-Shing, additional, Sung, Sheng-Feng, additional, Huang, Pai-Hao, additional, Li, Jie-Yuan, additional, Sun, Yu, additional, Wei, Cheng-Yu, additional, Lien, Li-Ming, additional, Tsai, I-Ju, additional, Sung, Fung-Chang, additional, Hsu, Chung Y., additional, Tsai, Chon-Haw, additional, Huang, Wei-Shih, additional, Lu, Chung-Ta, additional, Tsai, Tzung-Chang, additional, Tseng, Chun-Hung, additional, Lin, Kang-Hsu, additional, Shyu, Woei-Cherng, additional, Yang, Yu-Wan, additional, Liu, Yen-Liang, additional, Cho, Der-Yang, additional, Chen, Chun-Chung, additional, Tang, Sung-Chun, additional, Tsai, Li-Kai, additional, Yeh, Shin-Joe, additional, Chen, Chih-Hao, additional, Tsai, Hsin-Hsi, additional, Chen, Han-Jung, additional, Lu, Kan, additional, Hsu, Shih-Pin, additional, Kuo, Hung-Chang, additional, Tsou, Jung-Chi, additional, Wang, Yan-Tang, additional, Tai, Yi-Cheng, additional, Hsieh, Meng-Tsang, additional, Liliang, Po-Chao, additional, Liang, Cheng-Loong, additional, Wang, Hao-Kuang, additional, Tsai, Yu-Tun, additional, Wang, Kuo-Wei, additional, Chen, Jui-Sheng, additional, Chen, Po-Yuan, additional, Wang, Yi-Ching, additional, Chen, Chih-Hung, additional, Sung, Pi-Shan, additional, Hsieh, Han-Chieh, additional, Su, Hui-Chen, additional, Chiu, Hou-Chang, additional, Chen, Wei-Hung, additional, Bai, Chyi-Huey, additional, Huang, Tzu-Hsuan, additional, Lau, Chi-Ieong, additional, Wu, Ya-Ying, additional, Yeh, Hsu-Ling, additional, Chang, Anna, additional, Lin, Ching-Huang, additional, Yen, Cheng-Chang, additional, Lin, Ruey-Tay, additional, Chen, Chun-Hung, additional, Khor, Gim-Thean, additional, Chao, A-Ching, additional, Lin, Hsiu-Fen, additional, Huang, Poyin, additional, Lin, Huey-Juan, additional, Ke, Der-Shin, additional, Chang, Chia-Yu, additional, Yeh, Poh-Shiow, additional, Lin, Kao-Chang, additional, Cheng, Tain-Junn, additional, Chou, Chih-Ho, additional, Yang, Chun-Ming, additional, Shen, Hsiu-Chu, additional, Chen, An-Chih, additional, Tsai, Shih-Jei, additional, Lu, Tsong-Ming, additional, Kung, Sheng-Ling, additional, Lee, Mei-Ju, additional, Chou, Hsi-Hsien, additional, Chang, Wei-Lun, additional, Chiu, Pai-Yi, additional, Hsu, Min-Hsien, additional, Chan, Po-Chi, additional, Pan, Chau-Hsiung, additional, Shoung, Hai-Ming, additional, Lo, Yi-Chen, additional, Wang, Fu-Hwa, additional, Chang, Wei-Chieh, additional, Lai, Ta-Chang, additional, Yin, Jiu-Haw, additional, Wang, Chung-Jen, additional, Wang, Kai-Chen, additional, Chen, Li-Mei, additional, Denq, Jong-Chyou, additional, Lu, Chien-Jung, additional, Lin, Cheng-Huai, additional, Huang, Chieh-Cheng, additional, Liu, Chang-Hsiu, additional, Chan, Hoi-Fong, additional, Lee, Siu-Pak, additional, Sun, Ming-Hui, additional, Ke, Li-Ying, additional, Chen, Po-Lin, additional, Lee, Yu-Shan, additional, Ong, Cheung-Ter, additional, Wu, Chi-Shun, additional, Hsu, Yung-Chu, additional, Su, Yu-Hsiang, additional, Hung, Ling-Chien, additional, Lee, Jiunn-Tay, additional, Lin, Jiann-Chyun, additional, Hsu, Yaw-Don, additional, Peng, Giia-Sheun, additional, Hsu, Chang-Hung, additional, Lin, Chun-Chieh, additional, Yen, Che-Hung, additional, Cheng, Chun-An, additional, Sung, Yueh-Feng, additional, Chen, Yuan-Liang, additional, Lien, Ming-Tung, additional, Chou, Chung-Hsing, additional, Liu, Chia-Chen, additional, Yang, Fu-Chi, additional, Wu, Yi-Chung, additional, Tso, An-Chen, additional, Lai, Yu- Hua, additional, Chiang, Chun-I., additional, Tsai, Chia-Kuang, additional, Liu, Meng-Ta, additional, Lin, Ying-Che, additional, Hsu, Yu-Chuan, additional, Chiang, Tsuey-Ru, additional, Liao, Pin-Wen, additional, Lee, Mei-Ching, additional, Chen, Jen-Tse, additional, Lie, Sian-King, additional, Sun, Mu-Chien, additional, Hsiao, Pi-Ju, additional, Chen, Wei-Liang, additional, Chen, Ta-Cheng, additional, Chang, Chen-Shu, additional, Lai, Chien-Hsu, additional, Chuang, Chieh-Sen, additional, Chen, Yen-Yu, additional, Lin, Shinn-Kuang, additional, Su, Yu-Chin, additional, Shiao, Jen-Lun, additional, Yang, Fu-Yi, additional, Liu, Chih-Yang, additional, Chiang, Han-Lin, additional, Chen, Guei-Chiuan, additional, Hsu, Po-Jen, additional, Chang, Chun-Yuan, additional, Lin, I.-sheng, additional, Chien, Chung-Hsien, additional, Chang, Yang-Chuang, additional, Chen, Ping-Kun, additional, Hsiao, Yu-Jen, additional, Fang, Chen-Wen, additional, Chen, Yu-Wei, additional, Lee, Kuo-Ying, additional, Lin, Yun-Yu, additional, Li, Chen-Hua, additional, Tsai, Hui-Fen, additional, Hsieh, Chuan-Fa, additional, Yang, Chih-Dong, additional, Liaw, Shiumn-Jen, additional, Liao, How-Chin, additional, Yeh, Shoou-Jeng, additional, Wu, Ling-Li, additional, Hsieh, Liang-Po, additional, Lee, Yong-Hui, additional, Chen, Chung-Wen, additional, Hsu, Chih-Shan, additional, Jhih, Ye-Jian, additional, Zhuang, Hao-Yu, additional, Pan, Yan-Hong, additional, Shih, Shin-An, additional, Chen, Chin-I., additional, Sung, Jia-Ying, additional, Weng, Hsing-Yu, additional, Teng, Hao-Wen, additional, Lee, Jing-Er, additional, Huang, Chih-Shan, additional, Chao, Shu-Ping, additional, Yuan, Rey-Yue, additional, Sheu, Jau-Jiuan, additional, Yu, Jia-Ming, additional, Ho, Chun-Sum, additional, Lin, Ting-Chun, additional, Yu, Shih-Chieh, additional, Chen, Jiunn-Rong, additional, Tsai, Song-Yen, additional, Hung, Chao-Hsien, additional, Lee, Chia Fang, additional, Yang, Sheng-Kung, additional, Chen, Chih-Lin, additional, Lin, Wei, additional, Tseng, Hung-Pin, additional, Liu, Chin-Hsiung, additional, Lin, Chun-Liang, additional, Lin, Hung-Chih, additional, Chen, Pi-Tzu, additional, Hu, Chaur-Jong, additional, Chan, Lung, additional, Chi, Nai-Fang, additional, Chern, Chang-Ming, additional, Lin, Chun-Jen, additional, Wang, Shuu-Jiun, additional, Hsu, Li-Chi, additional, Wong, Wen-Jang, additional, Lee, I-Hui, additional, Yen, Der-Jen, additional, Tsai, Ching-Piao, additional, Kwan, Shang-Yeong, additional, Soong, Bing-Wen, additional, Chen, Shih-Pin, additional, Liao, Kwong-Kum, additional, Lin, Kung-Ping, additional, Chen, Chien, additional, Shan, Din-E., additional, Fuh, Jong-Ling, additional, Wang, Pei-Ning, additional, Lee, Yi-Chung, additional, Yu, Yu-Hsiang, additional, Huang, Hui-Chi, additional, Tsai, Jui-Yao, additional, Wu, Ming-Hsiu, additional, Chiang, Szu-Yi, additional, Wang, Chiung-Yao, additional, Hsu, Ming-Chin, additional, Chen, Chien-Chung, additional, Yeh, Po-Yen, additional, Tsai, Yu-Tai, additional, Wang, Ko-Yi, additional, Chen, Tsang-Shan, additional, Hsieh, Cheng-Yang, additional, Chen, Wei-Fen, additional, Yip, Ping-Keung, additional, Wang, Vinchi, additional, Wang, Kaw-Chen, additional, Tsai, Chung-Fen, additional, Chen, Chao-Ching, additional, Liu, Yi-Chien, additional, Chen, Shao-Yuan, additional, Zhao, Zi-Hao, additional, Wei, Zhi-Peng, additional, Wu, Shey-Lin, additional, Liu, Ching-Kuan, additional, Lin, Ryh-Huei, additional, Chu, Ching-Hua, additional, Yan, Sui-Hing, additional, Lin, Yi-Chun, additional, Chen, Pei-Yun, additional, Hsiao, Sheng-Huang, additional, Yip, Bak-Sau, additional, Tsai, Pei-Chun, additional, Chou, Ping-Chen, additional, Kuo, Tsam-Ming, additional, Lee, Yi-Chen, additional, Chiu, Yi-Pin, additional, Tsai, Kun-Chang, additional, Liao, Yi-Sheng, additional, Tsai, Ming-Jun, additional, and Kao, Hsin-Yi, additional

Published
2018
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19. Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients

Author

Wang, I.-Kuan, primary, Liu, Chung-Hsiang, additional, Yen, Tzung-Hai, additional, Jeng, Jiann-Shing, additional, Hsu, Shih-Pin, additional, Chen, Chih-Hung, additional, Lien, Li-Ming, additional, Lin, Ruey-Tay, additional, Chen, An-Chih, additional, Lin, Huey-Juan, additional, Chi, Hsin-Yi, additional, Lai, Ta-Chang, additional, Sun, Yu, additional, Lee, Siu-Pak, additional, Sung, Sheng-Feng, additional, Chen, Po-Lin, additional, Lee, Jiunn-Tay, additional, Chiang, Tsuey-Ru, additional, Lin, Shinn-Kuang, additional, Muo, Chih-Hsin, additional, Ma, Henry, additional, Wen, Chi-Pang, additional, Sung, Fung-Chang, additional, Hsu, Chung Y., additional, Tsai, Chon-Haw, additional, Huang, Wei-Shih, additional, Lu, Chung-Ta, additional, Tsai, Tzung-Chang, additional, Tseng, Chun-Hung, additional, Lin, Kang-Hsu, additional, Shyn, Woei-Cherng, additional, Yang, Yu-Wan, additional, Liu, Yen-Liang, additional, Cho, Der-Yang, additional, Chen, Chun-Chung, additional, Tang, Sung-Chun, additional, Tsai, Li-Kai, additional, Yeh, Shin-Joe, additional, Chen, Han-Jung, additional, Chang, Cheng-Sen, additional, Kuo, Hung-Chang, additional, Lee, Lian-Hui, additional, Tsui, Huan-Wen, additional, Tsou, Jung-Chi, additional, Wang, Yan-Tang, additional, Tai, Yi-Cheng, additional, Tsai, Kun-Chang, additional, Chen, Yen-Wen, additional, Lu, Kan, additional, Liliang, Po-Chao, additional, Tsai, Yu-Tun, additional, Liang, Cheng-Loong, additional, Wang, Kuo-Wei, additional, Wang, Hao-Kuang, additional, Chen, Jui-Sheng, additional, Chen, Po-Yuan, additional, Chye, Cien-Leong, additional, Tzeng, Wei-Jie, additional, Wu, Pei-Hua, additional, Sung, Pi-Shan, additional, Hsieh, Han-Chieh, additional, Su, Hui-Chen, additional, Chiu, Hou-Chang, additional, Chen, Wei-Hung, additional, Bai, Chyi-Huey, additional, Huang, Tzu-Hsuan, additional, Lau, Chi-Ieong, additional, Wu, Ya-Ying, additional, Yeh, Hsu-Ling, additional, Chang, Anna, additional, Lin, Ching-Huang, additional, Yen, Cheng-Chang, additional, Chen, Chun-Hung, additional, Khor, Gim-Thean, additional, Chao, A-Ching, additional, Lin, Hsiu-Fen, additional, Huang, Poyin, additional, Ke, Der-Shin, additional, Chang, Chia-Yu, additional, Yeh, Poh-Shiow, additional, Lin, Kao-Chang, additional, Cheng, Tain-Junn, additional, Chou, Chih-Ho, additional, Yang, Chun-Ming, additional, Shen, Hsiu-Chu, additional, Tsai, Shih-Jei, additional, Lu, Tsong-Ming, additional, Kung, Sheng-Ling, additional, Lee, Mei-Ju, additional, Chou, Hsi-Hsien, additional, Pan, Chou-Hsiung, additional, Chan, Po-Chi, additional, Hsu, Min-Hsien, additional, Chang, Wei-Lun, additional, Huang, Zhi-Zang, additional, Shoung, Hai-Ming, additional, Lo, Yi-Chen, additional, Wang, Fu-Hwa, additional, Yin, Jiu-Haw, additional, Wang, Chung-Jen, additional, Wang, Kai-Chen, additional, Chen, Li-Mei, additional, Denq, Jong-Chyou, additional, Lu, Chien-Jung, additional, Lin, Cheng-Huai, additional, Huang, Chieh-Cheng, additional, Liu, Chang-Hsiu, additional, Chan, Hoi-Fong, additional, Sun, Ming-Hui, additional, Ke, Li-Ying, additional, Lee, Yu-Shan, additional, Ong, Cheung-Ter, additional, Wu, Chi-Shun, additional, Hsu, Yung-Chu, additional, Su, Yu-Hsiang, additional, Hung, Ling-Chien, additional, Lin, Jiann-Chyun, additional, Hsu, Yaw-Don, additional, Peng, Giia-Sheun, additional, Hsu, Chang-Hung, additional, Lin, Chun-Chieh, additional, Yen, Che-Hung, additional, Cheng, Chun-An, additional, Sung, Yueh-Feng, additional, Chen, Yuan-Liang, additional, Lien, Ming-Tung, additional, Chou, Chung-Hsing, additional, Liu, Chia-Chen, additional, Yang, Fu-Chi, additional, Wu, Yi-Chung, additional, Tso, An-Chen, additional, Lai, Yu-Hua, additional, Chiang, Chun-I, additional, Tsai, Chia-Kuang, additional, Liu, Meng-Ta, additional, Lin, Ying-Che, additional, Hsu, Yu-Chuan, additional, Lee, Mei-Ching, additional, Huang, Pai-Hao, additional, Lie, Sian-King, additional, Liao, Pin-Wen, additional, Chen, Jen-Tse, additional, Sun, Mu-Chien, additional, Lai, Tien-Pao, additional, Chen, Wei-Liang, additional, Chen, Yen-Chun, additional, Chen, Ta-Cheng, additional, Wang, Wen-Fu, additional, Lee, Kwo-Whei, additional, Chang, Chen-Shu, additional, Lai, Chien-Hsu, additional, Shih, Siao-Ya, additional, Chuang, Chieh-Sen, additional, Chen, Yen-Yu, additional, Chen, Chien-Min, additional, Su, Yu-Chin, additional, Hsiao, Cheng-Lun, additional, Yang, Fu-Yi, additional, Liu, Chih-Yang, additional, Chiang, Han-Lin, additional, Chang, Chun-Yuan, additional, Lin, I-sheng, additional, Chien, Chung-Hsien, additional, Chang, Yang-Chuang, additional, Chen, Ping-Kun, additional, Chiu, Pai-Yi, additional, Hsiao, Yu-Jen, additional, Fang, Chen-Wen, additional, Chen, Yu-Wei, additional, Lee, Kuo-Ying, additional, Lin, Yun-Yu, additional, Li, Chen-Hua, additional, Tsai, Hui-Fen, additional, Hsieh, Chuan-Fa, additional, Yang, Chih-Dong, additional, Liaw, Shiumn-Jen, additional, Liao, How-Chin, additional, Yeh, Shoou-Jeng, additional, Wu, Ling-Li, additional, Hsieh, Liang-Po, additional, Lee, Yong-Hui, additional, Chen, Chung-Wen, additional, Hsu, Chih-Shan, additional, Jhih, Ye-Jian, additional, Zhuang, Hao-Yu, additional, Pan, Yan-Hong, additional, Shih, Shin-An, additional, Chen, Chin-I, additional, Sung, Jia-Ying, additional, Weng, Hsing-Yu, additional, Teng, Hao-Wen, additional, Lee, Jing-Er, additional, Huang, Chih-Shan, additional, Chao, Shu-Ping, additional, Yuan, Rey-Yue, additional, Sheu, Jau- Jiuan, additional, Yu, Jia-Ming, additional, Ho, Chun-Sum, additional, Lin, Ting-Chun, additional, Yu, Shih-Chieh, additional, Chen, Jiunn-Rong, additional, Tsai, Song-Yen, additional, Wei, Cheng-Yu, additional, Yang, Chao-Nan, additional, Hung, Chao-Hsien, additional, Shih, Ian, additional, Tseng, Hung-Pin, additional, Liu, Chin-Hsiung, additional, Lin, Chun-Liang, additional, Lin, Hung-Chih, additional, Chen, Pi-Tzu, additional, Hu, Chaur-Jong, additional, Chi, Nai-Fang, additional, Chan, Lung, additional, Chern, Chang-Ming, additional, Lin, Chun-Jen, additional, Wang, Shuu-Jiun, additional, Hsu, Li-Chi, additional, Wong, Wen-Jang, additional, Lee, I-Hui, additional, Yen, Der-Jen, additional, Tsai, Ching-Piao, additional, Kwan, Shang-Yeong, additional, Soong, Bing-Wen, additional, Chen, Shih-Pin, additional, Liao, Kwong-Kum, additional, Lin, Kung-Ping, additional, Chen, Chien, additional, Shan, Din-E, additional, Fuh, Jong-Ling, additional, Wang, Pei-Ning, additional, Lee, Yi-Chung, additional, Yu, Yu-Hsiang, additional, Huang, Hui-Chi, additional, Tsai, Jui-Yao, additional, Wu, Ming-Hsiu, additional, Chen, Shi-Cheng, additional, Chiang, Szu-Yi, additional, Wang, Chiung-Yao, additional, Hsu, Ming-Chin, additional, Chen, Chien-Chung, additional, Yeh, Po-Yen, additional, Tsai, Yu-Tai, additional, Wang, Ko-Yi, additional, Chen, Tsang-Shan, additional, Yip, Ping-Keung, additional, Wang, Vinchi, additional, Wang, Kaw-Chen, additional, Tsai, Chung-Fen, additional, Chen, Chao-Ching, additional, Chen, Chih-Hao, additional, Liu, Yi-Chien, additional, Chen, Shao-Yuan, additional, Zhao, Zi-Hao, additional, Wei, Zhi-Peng, additional, Wu, Shey-Lin, additional, Liu, Ching-Kuan, additional, Lin, Ryh-Huei, additional, Chu, Ching-Hua, additional, Yan, Sui-Hing, additional, Lin, Yi-Chun, additional, Chen, Pei-Yun, additional, Hsiao, Sheng-Huang, additional, Yip, Bak-Sau, additional, Tsai, Pei-Chun, additional, Chou, Ping-Chen, additional, Kuo, Tsam-Ming, additional, Lee, Yi-Chen, additional, Chiu, Yi-Pin, additional, Liao, Yi-Sheng, additional, Tsai, Ming-Jun, additional, and Kao, Hsin-Yi, additional

Published
2017
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20. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan

Author

Chen, Shih-Pin, primary, Fuh, Jong-Ling, additional, Chung, Ming-Yi, additional, Lin, Ying-Chao, additional, Liao, Yi-Chu, additional, Wang, Yen-Feng, additional, Hsu, Chia-Lin, additional, Yang, Ueng-Cheng, additional, Lin, Ming-Wei, additional, Chiou, Jen-Jie, additional, Wang, Po-Jen, additional, Chen, Ping-Kun, additional, Fan, Pi-Chuan, additional, Wu, Jer-Yuan, additional, Chen, Yuan-Tsong, additional, Kao, Lung-Sen, additional, Shen-Jang Fann, Cathy, additional, and Wang, Shuu-Jiun, additional

Published
2017
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21. Susceptible genes of restless legs syndrome in migraine

Author

Fuh, Jong-Ling, primary, Chung, Ming-Yi, additional, Yao, Shu-Chih, additional, Chen, Ping-Kun, additional, Liao, Yi-Chu, additional, Hsu, Chia-Lin, additional, Wang, Po-Jen, additional, Wang, Yen-Feng, additional, Chen, Shih-Pin, additional, Fann, Cathy S-J, additional, Kao, Lung-Sen, additional, and Wang, Shuu-Jiun, additional

Published
2016
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24. Derivation and Validation of a Discharge Disposition Predicting Model after Acute Stroke

Author

Tseng, Hung-Pin, primary, Lin, Feng-Jenq, additional, Chen, Pi-Tzu, additional, Mou, Chih-Hsin, additional, Lee, Siu-Pak, additional, Chang, Chun-Yuan, additional, Chen, An-Chih, additional, Liu, Chung-Hsiang, additional, Yeh, Chung-Hsin, additional, Tsai, Song-Yen, additional, Hsiao, Yu-Jen, additional, Lin, Ching-Huang, additional, Hsu, Shih-Pin, additional, Yu, Shih-Chieh, additional, Hsu, Chung-Y., additional, Sung, Fung-Chang, additional, Jeng, Jiann-Shing, additional, Yeh, Shin-Joe, additional, Tsai, Li-Kai, additional, Chiu, Hou-Chang, additional, Lien, Li-Ming, additional, Chen, Wei-Hung, additional, Bai, Chyi-Huey, additional, Huang, Tzu-Hsuan, additional, Lau, Chi-Ieong, additional, Wu, Ya-Ying, additional, Yuan, Rey-Yue, additional, Hu, Chaur-Jong, additional, Sheu, Jau-Jiuan, additional, Yu, Jia-Ming, additional, Ho, Chun-Sum, additional, Chung, Wen-Ting, additional, Sung, Jia-Ying, additional, Chen, Chin-I, additional, Weng, Hsing-Yu, additional, Han, Yu-Hsuan, additional, Huang, Chun-Ping, additional, Lin, Huey-Juan, additional, Ke, Der-Shin, additional, Chang, Chia-Yu, additional, Yeh, Poh-Shiow, additional, Lin, Kao-Chang, additional, Cheng, Tain-Junn, additional, Chou, Chih-Ho, additional, Yang, Chun-Ming, additional, Lo, Yuk-Keung, additional, Lin, Yu-Te, additional, Lin, Ching-Hwung, additional, Lin, Jiann-Chyun, additional, Hsu, Yaw-Don, additional, Denq, Jong-Chyou, additional, Peng, Giia-Sheun, additional, Lee, Jiunn-Tay, additional, Hsu, Chang-Hung, additional, Lin, Chun-Chieh, additional, Yen, Che-Hung, additional, Cheng, Chun-An, additional, Sung, Yueh-Feng, additional, Chen, Yuan-Liang, additional, Lien, Ming-Tung, additional, Chou, Chung-Hsing, additional, Liu, Chia-Chen, additional, Yang, Fu-Chi, additional, Wu, Yi-Chung, additional, Tso, An-Chen, additional, Lai, Yu-Hua, additional, Chiang, Chun-I, additional, Tsai, Chia-Kuang, additional, Liu, Meng-Ta, additional, Lin, Ying-Che, additional, Hsu, Yu-Chuan, additional, Tsai, Chon-Haw, additional, Huang, Wei-Shih, additional, Lu, Chung-Ta, additional, Tsai, Tzung-Chang, additional, Tseng, Chun-Hung, additional, Lin, Kang-Hsu, additional, Shyn, Woei-Cherng, additional, Yang, Yu-Wan, additional, Liu, Yen-Liang, additional, Cho, Der-Yang, additional, Chen, Chun-Chung, additional, Sun, Ming-Hui, additional, Ke, Li-Ying, additional, Lai, Ming-Liang, additional, Chen, Chih-Hung, additional, Chen, Jiunn-Rong, additional, Chiang, Tsuey-Ru, additional, Lee, Mei-Ching, additional, Lin, Shinn-Kuang, additional, Tseng, Yuan-Fu, additional, Lee, Jing-Er, additional, Hsiao, Cheng-Lun, additional, Liang, Jen-Feng, additional, Chen, Chiu-Mei, additional, Wu, Chao-Hsin, additional, Chen, Yu-Wei, additional, Lee, Kuo-Ying, additional, Lin, Yun-Yu, additional, Li, Chen-Hua, additional, Smith, Eric E., additional, Tsai, Hui-Fen, additional, Hsieh, Chuan-Fa, additional, Yang, Chih-Dong, additional, Liaw, Shiumn-Jen, additional, Liao, How-Chin, additional, Hu, Han-Hwa, additional, Wong, Wen-Jang, additional, Luk, Yun-On, additional, Chern, Chang-Ming, additional, Hsu, Li-Chi, additional, Chung, Chih-Ping, additional, Sun, Mu-Chien, additional, Wu, Shey-Lin, additional, Tseng, Hung-Pin, additional, Liu, Chin-Hsiung, additional, Lin, Chun-Liang, additional, Lin, Hung-Chih, additional, Lai, Ta-Chang, additional, Yin, Jiu-Haw, additional, Wang, Chung-Jen, additional, Wang, Kai-Chen, additional, Chen, Li-Mei, additional, Chan, Lung, additional, Sun, Yu, additional, Huang, Chieh-Cheng, additional, Liu, Chang-Hsiu, additional, Lin, Cheng-Huai, additional, Lu, Chien-Jung, additional, Yeh, Shoou-Jeng, additional, Wu, Ling-Li, additional, Hsieh, Liang-Po, additional, Lee, Yong-Hui, additional, Chen, Chung-Wen, additional, Chen, Po-Lin, additional, Lee, Yu-Shan, additional, Chen, Shu-Yi, additional, Chen, Han-Jung, additional, Chang, Cheng-Sen, additional, Kuo, Hung-Chang, additional, Wu, Shu-Lung, additional, Tsui, Huan-Wen, additional, Tsou, Jung-Chi, additional, Chou, Feng-Hsiung, additional, Lin, Pei-Jung, additional, Tung, Chin-Sung, additional, Lu, Kan, additional, Liliang, Po-Chou, additional, Tsai, Yu-Duan, additional, Liang, Cheng-Loong, additional, Wang, Kuo-Wei, additional, Wang, Hao-Kuang, additional, Chen, Te-Yuan, additional, Hsin, Yue-Loong, additional, Lin, Chih-Yuan, additional, Yip, Bak-Sau, additional, Tsai, Pei-Chun, additional, Chou, Ping-Chen, additional, Kuo, Tsam-Ming, additional, Lee, Yi-Chen, additional, Chiu, Yi-Pin, additional, Tsai, Kun-Chang, additional, Lin, Ruey-Tay, additional, Chen, Chun-Hung, additional, Khor, Gim-Thean, additional, Chao, A-Ching, additional, Lin, Hsiu-Fen, additional, Lin, I-Sheng, additional, Yan, Sui-Hing, additional, Lin, Yi-Chun, additional, Chen, Pei-Yun, additional, Hsiao, Sheng-Huang, additional, Po, Helen L., additional, Lin, Ya-Ju, additional, Tu, Hao-Chieh, additional, Tang, Sung-Chun, additional, Lin, Fu-Yu, additional, Chen, Ping-Kun, additional, Chiu, Pai-Yi, additional, Yip, Ping-Keung, additional, Wang, Vin-Chi, additional, Wang, Kaw-Chen, additional, Tsai, Chung-Fen, additional, Chen, Chao-Ching, additional, Chen, Chih-Hao, additional, Liu, Yi-Chien, additional, Pan, Chou-Hsiung, additional, Jih, Shin-Yi, additional, Chan, Po-Chi, additional, Hsu, Min-Hsien, additional, Shoung, Hai-Ming, additional, Lo, Yi-Chen, additional, Wang, Fu-Hwa, additional, Wei, Cheng-Yu, additional, Lee, Jun-Yu, additional, Lin, Ryh-Huei, additional, Chu, Ching-Hua, additional, and Hsu, Ming-Chin, additional

Published
2015
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25. Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: Results from Taiwan Stroke Registry.

Author

Chen, Yu-Wei, Li, Chen-Hua, Yang, Chih-Dong, Liu, Chung-Hsiang, Chen, Chih-Hung, Sheu, Jau-Jiuan, Lin, Shinn-Kuang, Chen, An-Chih, Chen, Ping-Kun, Chen, Po-Lin, Yeh, Chung-Hsin, Chen, Jiunn-Rong, Hsiao, Yu-Jen, Lin, Ching-Huang, Hsu, Shih-Pin, Chen, Tsang-Shan, Sung, Sheng-Feng, Yu, Shih-Chieh, Muo, Chih-Hsin, and Wen, Chi Pang

Subjects
CEREBRAL hemorrhage treatment, PHYSIOLOGICAL effects of cholesterol, HEALTH outcome assessment, NEUROLOGY
Abstract

The relationship between cholesterol level and hemorrhagic stroke is inconclusive. We hypothesized that low cholesterol levels may have association with intracerebral hemorrhage (ICH) severity at admission and 3-month outcomes. This study used data obtained from a multi-center stroke registry program in Taiwan. We categorized acute spontaneous ICH patients, based on their baseline levels of total cholesterol (TC) measured at admission, into 3 groups with <160, 160–200 and >200 mg/dL of TC. We evaluated risk of having initial stroke severity, with National Institutes of Health Stroke Scale (NIHSS) >15 and unfavorable outcomes (modified Rankin Scale [mRS] score >2, 3-month mortality) after ICH by the TC group. A total of 2444 ICH patients (mean age 62.5±14.2 years; 64.2% men) were included in this study and 854 (34.9%) of them had baseline TC <160 mg/dL. Patients with TC <160 mg/dL presented more often severe neurological deficit (NIHSS >15), with an adjusted odds ratio [aOR] of 1.80; 95% confidence interval [CI], 1.41–2.30), and 3-month mRS >2 (aOR, 1.41; 95% CI, 1.11–1.78) using patients with TC >200 mg/dL as reference. Those with TC >160 mg/dL and body mass index (BMI) <22 kg/m2 had higher risk of 3-month mortality (aOR 3.94, 95% CI 1.76–8.80). Prior use of lipid-lowering drugs (2.8% of the ICH population) was not associated with initial severity and 3-month outcomes. A total cholesterol level lower than 160 mg/dL was common in patients with acute ICH and was associated with greater neurological severity on presentation and poor 3-month outcomes, especially with lower BMI. [ABSTRACT FROM AUTHOR]

Published
2017
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27. Bidirectional triggering association between migraine and restless legs syndrome: A diary study.

Author

Chen, Ping-Kun, Fuh, Jong-Ling, and Wang, Shuu-Jiun

Subjects
*MIGRAINE, *COMORBIDITY, *RESTLESS legs syndrome, *MIGRAINE diagnosis, *RANDOM effects model, *THERAPEUTICS, *DISEASE risk factors, *MEDICAL records, *DISEASE complications, MIGRAINE complications
Abstract

Objective: Migraine is comorbid with restless legs syndrome (RLS). However, the temporal association between these two episodic disorders remains elusive. The current study investigated the temporal relationship between migraine and RLS attacks.Methods: Migraine patients with RLS were recruited from a headache clinic. Patients with symptomatic RLS, RLS mimics, daily headaches, or daily RLS attacks were excluded. The patients recorded their headaches and RLS attacks for two weeks in a diary. The severity of each headache or RLS attack was rated on a four-point (0-3) Likert scale. Logit-normal, random-effects models were employed to estimate the odds ratios (ORs) for the temporal association between migraine and RLS attacks.Results: Thirty migraine patients with RLS (28 F/2 M, mean age 35.5 ± 9.0 years) completed the study. On the basis of 420 daily diary records, migraine attacks were associated with subsequent RLS attacks occurring on the same and next nights (OR = 6.94, 95% confidence interval (CI) = 4.39-11.0 and OR = 3.00, CI = 1.92-4.68; both ITALIC! p < 0.001). RLS attacks were associated with subsequent migraine attacks only on Day 1 (OR = 1.97 (CI = 1.3-2.98; ITALIC! p = 0.01). Overall, the frequencies of migraine and RLS attacks in two weeks were correlated (Spearman's correlation = 0.56, ITALIC! p = 0.001).Conclusions: Our study results showed a bidirectional triggering association between migraine and RLS attacks. The association was stronger and lasted longer for migraine triggering subsequent RLS than that for vice versa. [ABSTRACT FROM AUTHOR]

Published
2016
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34. Response to Dr. Ambrosetto.

Author

Chen, Ping-Kun and Wang, Shuu-Jiun

Subjects
*INFLAMMATION, *MIGRAINE
Abstract

A letter to the editor in presented in response to an editorial on chronic inflammation on ophthalmoplegic migraine (OM).

Published
2013
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35. Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan.

Author

Chen, Shih-Pin, Fuh, Jong-Ling, Chung, Ming-Yi, Lin, Ying-Chao, Liao, Yi-Chu, Wang, Yen-Feng, Hsu, Chia-Lin, Yang, Ueng-Cheng, Lin, Ming-Wei, Chiou, Jen-Jie, Wang, Po-Jen, Chen, Ping-Kun, Fan, Pi-Chuan, Wu, Jer-Yuan, Chen, Yuan-Tsong, Kao, Lung-Sen, Shen-Jang Fann, Cathy, and Wang, Shuu-Jiun

Subjects
*MIGRAINE aura, *MIGRAINE, *NEURAL transmission, *GLIAL cell line-derived neurotrophic factor, *PATIENTS, *GENETICS
Abstract

Background Susceptibility genes for migraine, despite it being a highly prevalent and disabling neurological disorder, have not been analyzed in Asians by genome-wide association study (GWAS). Methods We conducted a two-stage case-control GWAS to identify susceptibility genes for migraine without aura in Han Chinese residing in Taiwan. In the discovery stage, we genotyped 1005 clinic-based Taiwanese migraine patients and 1053 population-based sex-matched controls using Axiom Genome-Wide CHB Array. In the replication stage, we genotyped 27 single-nucleotide polymorphisms with p < 10-4 in 1120 clinic-based migraine patients and 604 sex-matched normal controls by using Sequenom. Variants at LRP1, TRPM8, and PRDM, which have been replicated in Caucasians, were also genotyped. Results We identified a novel susceptibility locus (rs655484 in DLG2) that reached GWAS significance level for migraine risk in Han Chinese ( p = 1.45 × 10-12, odds ratio [OR] = 2.42), and also another locus (rs3781545in GFRA1) with suggestive significance ( p = 1.27 × 10-7, OR = 1.38). In addition, we observed positive association signals with a similar trend to the associations identified in Caucasian GWASs for rs10166942 in TRPM8 (OR = 1.33, 95% confidence interval [CI] = 1.14-1.54, Ppermutation = 9.99 × 10-5; risk allele: T) and rs1172113 in LRP1 (OR = 1.23, 95% CI = 1.04-1.45, Ppermutation = 2.9 × 10-2; risk allele: T). Conclusion The present study is the first migraine GWAS conducted in Han-Chinese and Asians. The newly identified susceptibility genes have potential implications in migraine pathogenesis. DLG2 is involved in glutamatergic neurotransmission, and GFRA1 encodes GDNF receptors that are abundant in CGRP-containing trigeminal neurons. Furthermore, positive association signals for TRPM8 and LRP1 suggest the possibility for common genetic contributions across ethnicities. [ABSTRACT FROM AUTHOR]

Published
2018
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36. Susceptible genes of restless legs syndrome in migraine.

Author

Jong-Ling Fuh, Ming-Yi Chung, Shu-Chih Yao, Ping-Kun Chen, Yi-Chu Liao, Chia-Lin Hsu, Po-Jen Wang, Yen-Feng Wang, Shih-Pin Chen, Cathy S-J Fann, Lung-Sen Kao, Shuu-Jiun Wang, Fuh, Jong-Ling, Chung, Ming-Yi, Yao, Shu-Chih, Chen, Ping-Kun, Liao, Yi-Chu, Hsu, Chia-Lin, Wang, Po-Jen, and Wang, Yen-Feng

Subjects
*RESTLESS legs syndrome, *SINGLE nucleotide polymorphisms, *RESTLESS legs syndrome treatment, *HEADACHE treatment, *MIGRAINE, *REGRESSION analysis, *GENETICS
Abstract

Objective Several genetic variants have been found to increase the risk of restless legs syndrome (RLS). The aim of the present study was to determine if these genetic variants were also associated with the comorbidity of RLS and migraine in patients. Methods Thirteen single-nucleotide polymorphisms (SNPs) at six RLS risk loci ( MEIS1, BTBD9, MAP2K5, PTPRD, TOX3, and an intergenic region on chromosome 2p14) were genotyped in 211 migraine patients with RLS and 781 migraine patients without RLS. Association analyses were performed for the overall cohort, as well as for the subgroups of patients who experienced migraines with and without aura and episodic migraines (EMs) vs. chronic migraines (CMs). In order to verify which genetic markers were potentially related to the incidence of RLS in migraine patients, multivariate regression analyses were also performed. Results Among the six tested loci, only MEIS1 was significantly associated with RLS. The most significant SNP of MEIS1, rs2300478, increased the risk of RLS by 1.42-fold in the overall cohort ( p = 0.0047). In the subgroup analyses, MEIS1 augmented the risk of RLS only in the patients who experienced EMs (odds ratio (OR) = 1.99, p = 0.0004) and not those experiencing CMs. Multivariate regression analyses further showed that rs2300478 in MEIS1 (OR = 1.39, p = 0.018), a CM diagnosis (OR = 1.52, p = 0.022), and depression (OR = 1.86, p = 0.005) were independent predictors of RLS in migraine. Conclusions MEIS1 variants were associated with an increased risk of RLS in migraine patients. It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines. [ABSTRACT FROM AUTHOR]

Published
2016
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37. [Treatment guidelines for acute and preventive treatment of cluster headache].

Author

Chen PK, Chen HM, Chen WH, Chen YY, Fuh JL, Lee LH, Liao YC, Lin KC, Tseng HP, Tsai JJ, Wang PJ, Wang SJ, Yang CP, Yiu CH, and Wu ZA

Subjects
Acute Disease, Cluster Headache prevention & control, Humans, Practice Guidelines as Topic, Cluster Headache drug therapy
Abstract

The Treatment Guideline Subcommittee of the Taiwan Headache Society evaluated both the acute and the preventive treatments for cluster headache now being used in Taiwan, based on the principles of evidence- based medicine. We assessed the quality of clinical trials and levels of evidence, and referred to other treatment guidelines proposed by other countries. Throughout several panel discussions, we merged opinions from the subcommittee members and proposed a consensus on the major roles, recommended levels, clinical efficacy, adverse events and cautions of clinical practice regarding acute and preventive treatments of cluster headache. The majority of Taiwanese patients have episodic cluster headaches, because chronic clusters are very rare. Cluster headache is characterized by severe and excruciating pain which develops within a short time and is associated with ipsilateral autonomic symptoms. Therefore, emergency treatment for a cluster headache attack is extremely important. Within the group of acute medications currently available in Taiwan, the subcommittee determined that high-flow oxygen inhalation has the best evidence of effectiveness, followed by intranasal triptans. Both are recommended as first-line medical treatments for acute attacks. Oral triptans were determined to be second-line medications. For transitional prophylaxis, oral corticosteroids are recommended as the first-line medication, and ergotamine as the second-line choice. As for maintenance prophylaxis, verapamil has the best evidence and is recommended as the first-line medication. Lithium, melatonin, valproic acid, topiramate and gabapentin are suggested as the second-line preventive medications. Surgical interventions, including occipital nerve stimulation, deep brain stimulation, radiofrequency block of the sphenopalatine ganglion, percutaneous radiofrequency rhizotomy and trigeminal nerve section, are invasive and their long-term efficacy and adverse events are still not clear in Taiwanese patients; therefore, they are not recommended currently by the subcommittee. The transitional and maintenance prophylactic medications can be used together to attain treatment efficacy. Once the maintenance prophylaxis achieves efficacy, the transitional prophylactic medications can be tapered gradually. We suggest the corticosteroids be used within two weeks, if possible. The duration of maintenance treatment depends on the individual patient's clinical condition, and the medications can be tapered off when the cluster period is over.

Published
2011

38. Comorbidities of migraine.

Author

Wang SJ, Chen PK, and Fuh JL

Abstract

Migraine is a common neurological disorder and can be severely disabling during attacks. The highest prevalence occurs between the ages of 25 and 55 years, potentially the most productive period of life. Migraine leads to a burden not only for the individual, but also for the family and society in general. Prior studies have found that migraine occurs together with other illnesses at a greater coincidental rate than is seen in the general population. These occurrences are called "comorbidities," which means that these disorders are interrelated with migraine. To delineate the comorbidities of migraine is important, because it can help improve treatment strategies and the understanding of the possible pathophysiology of migraine. The comorbid illnesses in patients with migraine include stroke, sub-clinical vascular brain lesions, coronary heart disease, hypertension, patent foramen ovale, psychiatric diseases (depression, anxiety, bipolar disorder, panic disorder, and suicide), restless legs syndrome, epilepsy and asthma. In this paper, we review the existing epidemiological and hospital-based studies, and illustrate the connections between these illnesses and migraine.

Published
2010
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39. Confusion or delirium in patients with posterior cerebral arterial infarction.

Author

Shih HT, Huang WS, Liu CH, Tsai TC, Lu CT, Lu MK, Chen PK, Tseng CH, Jou SB, Tsai CH, and Lee CC

Subjects
Adult, Aged, Aged, 80 and over, Echocardiography, Transesophageal, Electrocardiography, Female, Humans, Male, Middle Aged, Risk Factors, Confusion etiology, Delirium etiology, Infarction, Posterior Cerebral Artery psychology
Abstract

Objective: To identify the possible anatomic sites and risk factors for the development of confusion or delirium in patients with posterior cerebral arterial (PCA) infarction., Materials and Methods: Twenty-nine patients aged 34-86 years with PCA infarction were divided into two groups: one with and the other without perturbed mentation. The clinical and laboratory data, including neuroimages, were retrospectively reviewed. Student-t, chi-square and Fisher's exact tests were performed for data analysis., Results: Confusion or delirium tended to develop in the left (10/13) or bilateral (5/5) PCA infarction as compared to the right PCA infarction (3/15) (P< 0.05) and medial occipital-temporal gyri involvement was crucial for its development (P< 0.05). The results were also noted in the patients with first-ever stroke. Diabetes mellitus was the sole biochemical factor to be associated with confusion or delirium (P< 0.01)., Conclusions: The involvement of the medial occipito-temporal gyri, especially on the left side was the pivotal factor for the development of confusion or delirium in patients with PCA infarction. Higher prevalence of diabetes mellitus was also observed in the group with mental perturbation.

Published
2007

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