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This study tested the mediating role of bullying attitudes and moderating role of school connectedness in the link between sympathy and Chinese adolescents' active defending behaviors in bullying. Participants were 808 Chinese adolescents (53.3% male, M[subscript age] = 12.40, SD = 0.50). The results showed that sympathy was significantly positively correlated with active defending behaviors through bullying attitudes. In addition, school connectedness could moderate the relationship between sympathy and active defending behaviors. Specifically, the positive correlation between sympathy and active defending behaviors was stronger for adolescents with a high level of school connectedness. These findings emphasize the importance of considering complex multiple ecological level factors when examining bullying bystander.

Although life satisfaction is critical for adolescents' emotional, social, and educational functioning and positive development, social cognitive roles in adolescents' life satisfaction and potential underlying processes are less known. The present study aimed to explore the effect of implicit theories of intelligence on adolescent life satisfaction and their potential mechanisms. A moderated mediation model was constructed to investigate the mediating role of career exploration and the moderating role of career-specific parental support. Data were collected from 443 10th grade high-school students in Sichuan, China. Results revealed that career exploration fully mediated the positive relationship between implicit theories of intelligence and life satisfaction, while career-specific parental support moderated the relationship between career exploration and life satisfaction. These findings highlight the value of exploring social-cognition and career-related factors in life satisfaction.

Background Individuals who receive allogeneic hematopoietic cell transplant (allo-HCT) are immunocompromised and at high risk of pneumococcal infections, especially in the months following transplant. This study evaluated the safety and immunogenicity of V114 (VAXNEUVANCE; Merck, Sharp & Dohme LLC, a subsidiary of Merck & Co. Inc. Rahway, NJ, USA), a 15-valent pneumococcal conjugate vaccine (PCV), when given to allo-HCT recipients. Methods Participants received 3 doses of V114 or PCV13 (Prevnar 13; Wyeth LLC) in 1-month intervals starting 3–6 months after allo-HCT. Twelve months after HCT, participants received either PNEUMOVAX 23 or a fourth dose of PCV (if they experienced chronic graft vs host disease). Safety was evaluated as the proportion of participants with adverse events (AEs). Immunogenicity was evaluated by measuring serotype-specific immunoglobulin G (IgG) geometric mean concentrations (GMCs) and opsonophagocytic activity (OPA) geometric mean titers (GMTs) for all V114 serotypes in each vaccination group. Results A total of 274 participants were enrolled and vaccinated in the study. The proportions of participants with AEs and serious AEs were generally comparable between intervention groups, and the majority of AEs in both groups were of short duration and mild-to-moderate intensity. For both IgG GMCs and OPA GMTs, V114 was generally comparable to PCV13 for the 13 shared serotypes, and higher for serotypes 22F and 33F at day 90. Conclusions V114 was well tolerated in allo-HCT recipients, with a generally comparable safety profile to PCV13. V114 induced comparable immune responses to PCV13 for the 13 shared serotypes, and was higher for V114 serotypes 22F and 33F. Study results support the use of V114 in allo-HCT recipients. Clinical Trials Registration.  clinicaltrials.gov (NCT03565900) and European Union at EudraCT 2018-000066-11. [ABSTRACT FROM AUTHOR]