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292 results on '"Chen, Shih-Shih"'

2. The DLEU2/miR-15a/miR-16-1 cluster shapes the immune microenvironment of chronic lymphocytic leukemia

Author

Zhang, Ronghua, Khare, Priyanka, Banerjee, Priyanka, Ivan, Cristina, Schneider, Sarah, Barbaglio, Federica, Clise-Dwyer, Karen, Jensen, Vanessa Behrana, Thompson, Erika, Mendoza, Marisela, Chiorazzi, Nicholas, Chen, Shih-Shih, Yan, Xiao-Jie Joy, Jain, Nitin, Ghia, Paolo, Caligaris-Cappio, Federico, Mendonsa, Rima, Kasimsetty, Sashi, Swoboda, Ryan, Bayraktar, Recep, Wierda, William, Gandhi, Varsha, Calin, George A., Keating, Michael J., and Bertilaccio, Maria Teresa Sabrina

Published
2024
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3. Mutation-specific CAR T cells as precision therapy for IGLV3-21R110 expressing high-risk chronic lymphocytic leukemia

Author

Märkl, Florian, Schultheiß, Christoph, Ali, Murtaza, Chen, Shih-Shih, Zintchenko, Marina, Egli, Lukas, Mietz, Juliane, Chijioke, Obinna, Paschold, Lisa, Spajic, Sebastijan, Holtermann, Anne, Dörr, Janina, Stock, Sophia, Zingg, Andreas, Läubli, Heinz, Piseddu, Ignazio, Anz, David, Minden, Marcus Dühren-von, Zhang, Tianjiao, Nerreter, Thomas, Hudecek, Michael, Minguet, Susana, Chiorazzi, Nicholas, Kobold, Sebastian, and Binder, Mascha

Published
2024
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5. Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL

Author

Ferrer, Gerardo, Jung, Byeongho, Chiu, Pui Yan, Aslam, Rukhsana, Palacios, Florencia, Mazzarello, Andrea Nicola, Vergani, Stefano, Bagnara, Davide, Chen, Shih-Shih, Yancopoulos, Sophia, Xochelli, Aliki, Yan, Xiao-Jie, Burger, Jan A., Barrientos, Jacqueline C., Kolitz, Jonathan E., Allen, Steven L., Stamatopoulos, Kostas, Rai, Kanti R., Sherry, Barbara, and Chiorazzi, Nicholas

Published
2021
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6. Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib.

Author

Burger, Jan, Li, Kelvin, Keating, Michael, Sivina, Mariela, Amer, Ahmed, Garg, Naveen, Ferrajoli, Alessandra, Huang, Xuelin, Kantarjian, Hagop, Wierda, William, Hellerstein, Marc, Turner, Scott, Emson, Claire, Chen, Shih-Shih, Yan, Xiao-Jie, Wodarz, Dominik, Chiorazzi, Nicholas, and OBrien, Susan

Subjects
Adenine, Agammaglobulinaemia Tyrosine Kinase, Aged, Cell Death, Cell Proliferation, Deuterium Oxide, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Middle Aged, Pilot Projects, Piperidines, Protein Kinase Inhibitors, Pyrazoles, Pyrimidines
Abstract

BACKGROUND. Ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL) that inhibits Brutons tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. METHODS. We used stable isotopic labeling with deuterated water (2H2O) to measure directly the effects of ibrutinib on leukemia cell proliferation and death in 30 patients with CLL. RESULTS. The measured average CLL cell proliferation (birth) rate before ibrutinib therapy was 0.39% of the clone per day (range 0.17%-1.04%); this decreased to 0.05% per day (range 0%-0.36%) with treatment. Death rates of blood CLL cells increased from 0.18% per day (average, range 0%-0.7%) prior to treatment to 1.5% per day (range 0%-3.0%) during ibrutinib therapy, and they were even higher in tissue compartments. CONCLUSIONS. This study provides the first direct in vivo measurements to our knowledge of ibrutinibs antileukemia actions, demonstrating profound and immediate inhibition of CLL cell proliferation and promotion of high rates of CLL cell death. TRIAL REGISTRATION. This trial was registered at clinicaltrials.gov (NCT01752426). FUNDING. This study was supported by a Cancer Center Support Grant (National Cancer Institute grant P30 CA016672), an NIH grant (CA081554) from the National Cancer Institute, MD Andersons Moon Shots Program in CLL, and Pharmacyclics, an AbbVie company.

Published
2017

10. IGF1R as druggable target mediating PI3K-δ inhibitor resistance in a murine model of chronic lymphocytic leukemia

Author

Scheffold, Annika, Jebaraj, Billy Michael Chelliah, Tausch, Eugen, Bloehdorn, Johannes, Ghia, Paolo, Yahiaoui, Anella, Dolnik, Anna, Blätte, Tamara Jacqueline, Bullinger, Lars, Dheenadayalan, Rashmi Priyadharshini, Li, Li, Schneider, Christof, Chen, Shih-Shih, Chiorazzi, Nicholas, Dietrich, Sascha, Seiffert, Martina, Tannheimer, Stacey, Döhner, Hartmut, Mertens, Daniel, and Stilgenbauer, Stephan

Published
2019
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13. Mutation-specific CAR T cells as precision therapy for IGLV3-21R110expressing high-risk chronic lymphocytic leukemia

Author

Märkl, Florian, primary, Schultheiß, Christoph, additional, Ali, Murtaza, additional, Chen, Shih-Shih, additional, Egli, Lukas, additional, Mietz, Juliane, additional, Chijioke, Obinna, additional, Paschold, Lisa, additional, Spajic, Sebastijan, additional, Holtermann, Anne, additional, Dörr, Janina, additional, Stock, Sophia, additional, Piseddu, Ignazio, additional, Anz, David, additional, Minden, Marcus Dühren-von, additional, Zhang, Tianjiao, additional, Nerreter, Thomas, additional, Hudecek, Michael, additional, Chiorazzi, Nicholas, additional, Kobold, Sebastian, additional, and Binder, Mascha, additional

Published
2023
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14. Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations.

Author

Smiraglia, Dominic J, Kazhiyur-Mannar, Ramakrishnan, Oakes, Christopher C, Wu, Yue-Zhong, Liang, Ping, Ansari, Tahmina, Su, Jian, Rush, Laura J, Smith, Laura T, Yu, Li, Liu, Chunhui, Dai, Zunyan, Chen, Shih-Shih, Wang, Shu-Huei, Costello, Joseph, Ioshikhes, Ilya, Dawson, David W, Hong, Jason S, Teitell, Michael A, Szafranek, Angela, Camoriano, Marta, Song, Fei, Elliott, Rosemary, Held, William, Trasler, Jacquetta M, Plass, Christoph, and Wenger, Rephael

Subjects
Intestinal Mucosa, Liver, Animals, Humans, Mice, DNA Restriction Enzymes, Electrophoresis, Gel, Two-Dimensional, Restriction Mapping, Computational Biology, Genomics, Organ Specificity, DNA Methylation, CpG Islands, Genome, Genome, Human, Electrophoresis, Gel, Two-Dimensional, Human, Intestines, Biological Sciences, Information and Computing Sciences, Medical and Health Sciences, Bioinformatics
Abstract

BackgroundRestriction landmark genomic scanning (RLGS) is one of the most successfully applied methods for the identification of aberrant CpG island hypermethylation in cancer, as well as the identification of tissue specific methylation of CpG islands. However, a limitation to the utility of this method has been the ability to assign specific genomic sequences to RLGS spots, a process commonly referred to as "RLGS spot cloning."ResultsWe report the development of a virtual RLGS method (vRLGS) that allows for RLGS spot identification in any sequenced genome and with any enzyme combination. We report significant improvements in predicting DNA fragment migration patterns by incorporating sequence information into the migration models, and demonstrate a median Euclidian distance between actual and predicted spot migration of 0.18 centimeters for the most complex human RLGS pattern. We report the confirmed identification of 795 human and 530 mouse RLGS spots for the most commonly used enzyme combinations. We also developed a method to filter the virtual spots to reduce the number of extra spots seen on a virtual profile for both the mouse and human genomes. We demonstrate use of this filter to simplify spot cloning and to assist in the identification of spots exhibiting tissue-specific methylation.ConclusionThe new vRLGS system reported here is highly robust for the identification of novel RLGS spots. The migration models developed are not specific to the genome being studied or the enzyme combination being used, making this tool broadly applicable. The identification of hundreds of mouse and human RLGS spot loci confirms the strong bias of RLGS studies to focus on CpG islands and provides a valuable resource to rapidly study their methylation.

Published
2007

18. Supplementary Figure S2 from Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline C., primary, Ferrer, Gerardo, primary, King-Richards, Morgan, primary, Chen, Yu-Ju, primary, Ravichandran, Priyadarshini, primary, Ibrahim, Michael, primary, Kieso, Yasmine, primary, Waters, Sheila, primary, Kutok, Jeffery L., primary, Peluso, Marisa, primary, Sharma, Sujata, primary, Weaver, David T., primary, Pachter, Jonathan A., primary, Rai, Kanti R., primary, and Chiorazzi, Nicholas, primary

Published
2023
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19. Data from Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline C., primary, Ferrer, Gerardo, primary, King-Richards, Morgan, primary, Chen, Yu-Ju, primary, Ravichandran, Priyadarshini, primary, Ibrahim, Michael, primary, Kieso, Yasmine, primary, Waters, Sheila, primary, Kutok, Jeffery L., primary, Peluso, Marisa, primary, Sharma, Sujata, primary, Weaver, David T., primary, Pachter, Jonathan A., primary, Rai, Kanti R., primary, and Chiorazzi, Nicholas, primary

Published
2023
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20. Supplementary Table S1 from Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline C., primary, Ferrer, Gerardo, primary, King-Richards, Morgan, primary, Chen, Yu-Ju, primary, Ravichandran, Priyadarshini, primary, Ibrahim, Michael, primary, Kieso, Yasmine, primary, Waters, Sheila, primary, Kutok, Jeffery L., primary, Peluso, Marisa, primary, Sharma, Sujata, primary, Weaver, David T., primary, Pachter, Jonathan A., primary, Rai, Kanti R., primary, and Chiorazzi, Nicholas, primary

Published
2023
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21. Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in a Xenograft Model

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline C., additional, Ferrer, Gerardo, additional, King-Richards, Morgan, additional, Chen, Yu-Ju, additional, Ravichandran, Priyadarshini, additional, Ibrahim, Michael, additional, Kieso, Yasmine, additional, Waters, Sheila, additional, Kutok, Jeffery L., additional, Peluso, Marisa, additional, Sharma, Sujata, additional, Weaver, David T., additional, Pachter, Jonathan A., additional, Rai, Kanti R., additional, and Chiorazzi, Nicholas, additional

Published
2023
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22. Supplementary Tables and Figures from SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, primary, ten Hacken, Elisa, primary, Chen, Shih-Shih, primary, Bhan, Atul K., primary, Suarez-Fueyo, Abel, primary, Katsuyama, Eri, primary, Tsokos, George C., primary, Chiorazzi, Nicholas, primary, Wu, Catherine J., primary, Burger, Jan A., primary, Herzog, Roland W., primary, Engel, Pablo, primary, and Terhorst, Cox, primary

Published
2023
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23. Data from SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, primary, ten Hacken, Elisa, primary, Chen, Shih-Shih, primary, Bhan, Atul K., primary, Suarez-Fueyo, Abel, primary, Katsuyama, Eri, primary, Tsokos, George C., primary, Chiorazzi, Nicholas, primary, Wu, Catherine J., primary, Burger, Jan A., primary, Herzog, Roland W., primary, Engel, Pablo, primary, and Terhorst, Cox, primary

Published
2023
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24. Abstract 4933: Duvelisib eliminates CLL B Cells, impairs CLL-supporting cells, and overcomes ibrutinib resistance in a patient-derived xenograft model

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline C., additional, Ferrer, Gerardo, additional, Ravichandran, Priyadarshini, additional, Ibrahim, Michael, additional, Kieso, Yasmine, additional, Kutok, Jeffery L., additional, Peluso, Marisa, additional, Sharma, Sujata, additional, Weaver, David T., additional, Pachter, Jonathan A., additional, Rai, Kanti R., additional, and Chiorazzi, Nicholas, additional

Published
2023
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25. Supplementary Legends from SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, primary, ten Hacken, Elisa, primary, Chen, Shih-Shih, primary, Bhan, Atul K., primary, Suarez-Fueyo, Abel, primary, Katsuyama, Eri, primary, Tsokos, George C., primary, Chiorazzi, Nicholas, primary, Wu, Catherine J., primary, Burger, Jan A., primary, Herzog, Roland W., primary, Engel, Pablo, primary, and Terhorst, Cox, primary

Published
2023
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26. Supplementary Figures from Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model

Author

Niemann, Carsten U., primary, Mora-Jensen, Helena I., primary, Dadashian, Eman L., primary, Krantz, Fanny, primary, Covey, Todd, primary, Chen, Shih-Shih, primary, Chiorazzi, Nicholas, primary, Izumi, Raquel, primary, Ulrich, Roger, primary, Lannutti, Brian J., primary, Wiestner, Adrian, primary, and Herman, Sarah E.M., primary

Published
2023
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27. Supplementary methods and figure legends from Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model

Author

Niemann, Carsten U., primary, Mora-Jensen, Helena I., primary, Dadashian, Eman L., primary, Krantz, Fanny, primary, Covey, Todd, primary, Chen, Shih-Shih, primary, Chiorazzi, Nicholas, primary, Izumi, Raquel, primary, Ulrich, Roger, primary, Lannutti, Brian J., primary, Wiestner, Adrian, primary, and Herman, Sarah E.M., primary

Published
2023
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28. Data from Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model

Author

Niemann, Carsten U., primary, Mora-Jensen, Helena I., primary, Dadashian, Eman L., primary, Krantz, Fanny, primary, Covey, Todd, primary, Chen, Shih-Shih, primary, Chiorazzi, Nicholas, primary, Izumi, Raquel, primary, Ulrich, Roger, primary, Lannutti, Brian J., primary, Wiestner, Adrian, primary, and Herman, Sarah E.M., primary

Published
2023
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31. Data from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Author

Hackanson, Björn, primary, Bennett, Kristi L., primary, Brena, Romulo M., primary, Jiang, Jinmai, primary, Claus, Rainer, primary, Chen, Shih-Shih, primary, Blagitko-Dorfs, Nadya, primary, Maharry, Katie, primary, Whitman, Susan P., primary, Schmittgen, Thomas D., primary, Lübbert, Michael, primary, Marcucci, Guido, primary, Bloomfield, Clara D., primary, and Plass, Christoph, primary

Published
2023
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32. Supplementary Table 1 from Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia

Author

Hackanson, Björn, primary, Bennett, Kristi L., primary, Brena, Romulo M., primary, Jiang, Jinmai, primary, Claus, Rainer, primary, Chen, Shih-Shih, primary, Blagitko-Dorfs, Nadya, primary, Maharry, Katie, primary, Whitman, Susan P., primary, Schmittgen, Thomas D., primary, Lübbert, Michael, primary, Marcucci, Guido, primary, Bloomfield, Clara D., primary, and Plass, Christoph, primary

Published
2023
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34. Integrin Signaling Pathway Is Crucial for the Recently Divided Fraction of CLL Cells and Facilitates Cell Migration in a Disease Progressive Manner

Author

Yan, Xiao J., primary, Palacios, Florencia, additional, Chen, Shih-Shih, additional, Li, Wentian, additional, Rhodes, Joanna M., additional, Barrientos, Jacqueline C., additional, Allen, Steven L, additional, Kolitz, Jonathan E., additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2022
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35. CLECL1+ CLL Cells: A Key Subset That Drives CLL Survival and Proliferation and Shapes a Th2-Biased Tumor Microenvironment

Author

Chen, Shih-Shih, primary, Yan, Xiao-Jie, additional, Cardillo, Martina, additional, Ng, Anita, additional, Shih, Andrew, additional, Blanco, Gonzalo, additional, King-Richards, Morgan, additional, Chen, Yu-Ju, additional, Kieso, Yasmine, additional, Rhodes, Joanna M., additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2022
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39. Epigenetic Changes during Disease Progression in a Murine Model of Human Chronic Lymphocytic Leukemia

Author

Chen, Shih-Shih, Raval, Aparna, Johnson, Amy J., Hertlein, Erin, Liu, Te-Hui, Jin, Victor X., Sherman, Mara H., Liu, Shu-Jun, Dawson, David W., Williams, Katie E., Lanasa, Mark, Liyanarachchi, Sandya, Lin, Thomas S., Marcucci, Guido, Pekarsky, Yuri, Davuluri, Ramana, Croce, Carlo M., Guttridge, Denis C., Teitell, Michael A., Byrd, John C., Plass, Christoph, and de la Chapelle, Albert

Published
2009
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41. Efficacy of Ibrutinib Monotherapy in Pre-Clinical Mouse Models of Richter Transformation: Ibrutinib Effectively Reduces the Incidence of Richter Transformation but Fails in Treating Transformed Lymphoma, Especially in Primary Lymphoid Tissue

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline, additional, Yan, Xiao-Jie, additional, Wirtz, Uwe, additional, Szafer-Glusman, Edith, additional, Rai, Kanti R, additional, and Chiorazzi, Nicholas, additional

Published
2021
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42. Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in Preclinical Models

Author

Chen, Shih-Shih, primary, Barrientos, Jacqueline, additional, Ferrer, Gerardo, additional, Ravichandran, Priyadarshini, additional, Ibrahim, Michael, additional, Kieso, Yasmine, additional, Kutok, Jeff, additional, Peluso, Marisa, additional, Sharma, Sujata, additional, Weaver, David, additional, Pachter, Jonathan, additional, Rai, Kanti, additional, and Chiorazzi, Nicholas, additional

Published
2021
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43. Downregulation of Death-Associated Protein Kinase 1 (DAPK1) in Chronic Lymphocytic Leukemia

Author

Raval, Aparna, Tanner, Stephan M., Byrd, John C., Angerman, Elizabeth B., Perko, James D., Chen, Shih-Shih, Hackanson, Björn, Grever, Michael R., Lucas, David M., Matkovic, Jennifer J., Lin, Thomas S., Kipps, Thomas J., Murray, Fiona, Weisenburger, Dennis, Sanger, Warren, Lynch, Jane, Watson, Patrice, Jansen, Mary, Yoshinaga, Yuko, Rosenquist, Richard, de Jong, Pieter J., Coggill, Penny, Beck, Stephan, Lynch, Henry, de la Chapelle, Albert, and Plass, Christoph

Published
2007
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44. A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Author

Patten, Piers E. M., primary, Ferrer, Gerardo, additional, Chen, Shih-Shih, additional, Kolitz, Jonathan E., additional, Rai, Kanti R., additional, Allen, Steven L., additional, Barrientos, Jacqueline C., additional, Ioannou, Nikolaos, additional, Ramsay, Alan G., additional, and Chiorazzi, Nicholas, additional

Published
2021
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45. CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia

Author

Sivina, Mariela, primary, Xiao, Lianchun, additional, Kim, Ekaterina, additional, Vaca, Alicia, additional, Chen, Shih-Shih, additional, Keating, Michael J., additional, Ferrajoli, Alessandra, additional, Estrov, Zeev, additional, Jain, Nitin, additional, Wierda, William G., additional, Huang, Xuelin, additional, Chiorazzi, Nicholas, additional, and Burger, Jan A., additional

Published
2020
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46. A Galileo analysis of organizational climate

Author

Fink, Edward L. and Chen, Shih-Shih

Subjects
Human behavior -- Research, Organizational behavior -- Research, Communication -- Research, Psychology and mental health
Abstract

This article attempts to (a) establish a conceptual framework for climate research, (b) develop a research scheme based on this conceptual ground, and (c) examine the relationship between communication and the convergence of views regarding organizational climate. University faculty members comprise the sample for this study (N = 105). Using the Galileo multidimensional scaling model, a description of the faculty climate at a university is presented, as well as comparisons between the climates of groups of faculty. There is a substantial correlation between a person's attitude and his or her perception of the relation of others toward those same concepts. Faculty members who communicate more with their colleagues report less psychological distance between themselves and the university. In addition, an individual's climate space becomes more similar to the space of the group with whom he or she maintains denser communication ties as compared with the space of the group with whom he or she maintains less dense ties.

Published
1995

49. CLL B Cells Develop Resistance to Ibrutinib By Reinvigorating the IL-4R - IL-4 Axis Blocked By Bruton's Tyrosine Kinase Inhibitors Including Acalabrutinib and Zanubrutinib

Author

Chen, Shih-Shih, primary, Tam, Constantine S., primary, Ramsay, Alan G., primary, Ravichandran, Priyadarshini, primary, Couto-Francisco, Natalia C., primary, Ibrahim, Michael, primary, Ferrer, Gerardo, primary, Kolitz, Jonathan E., primary, Allen, Steven L., primary, Zhou, He, primary, Barrientos, Jacqueline C, primary, Rai, Kanti R, primary, and Chiorazzi, Nicholas, primary

Published
2019
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50. SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer

Author

Yigit, Burcu, primary, Wang, Ninghai, additional, ten Hacken, Elisa, additional, Chen, Shih-Shih, additional, Bhan, Atul K., additional, Suarez-Fueyo, Abel, additional, Katsuyama, Eri, additional, Tsokos, George C., additional, Chiorazzi, Nicholas, additional, Wu, Catherine J., additional, Burger, Jan A., additional, Herzog, Roland W., additional, Engel, Pablo, additional, and Terhorst, Cox, additional

Published
2019
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