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27 results on '"Chen, Wei-Chiao"'

12. A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

Author

Kuo, Ho-Chang, primary, Hsu, Yu-Wen, additional, Wu, Chung-Min, additional, Chen, Shawn Hsiang-Yin, additional, Hung, Kuo-Sheng, additional, Chang, Wei-Pin, additional, Yang, Kuender D., additional, Hsieh, Kai-Sheng, additional, Chen, Wei-Chiao, additional, Onouchi, Yoshihiro, additional, and Chang, Wei-Chiao, additional

Published
2013
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13. ORAI1 Genetic Polymorphisms Associated with the Susceptibility of Atopic Dermatitis in Japanese and Taiwanese Populations

Author

Chang, Wei-Chiao, primary, Lee, Chih-Hung, additional, Hirota, Tomomitsu, additional, Wang, Li-Fang, additional, Doi, Satoru, additional, Miyatake, Akihiko, additional, Enomoto, Tadao, additional, Tomita, Kaori, additional, Sakashita, Masafumi, additional, Yamada, Takechiyo, additional, Fujieda, Shigeharu, additional, Ebe, Koji, additional, Saeki, Hidehisa, additional, Takeuchi, Satoshi, additional, Furue, Masutaka, additional, Chen, Wei-Chiao, additional, Chiu, Yi-Ching, additional, Chang, Wei Pin, additional, Hong, Chien-Hui, additional, Hsi, Edward, additional, Juo, Suh-Hang Hank, additional, Yu, Hsin-Su, additional, Nakamura, Yusuke, additional, and Tamari, Mayumi, additional

Published
2012
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16. Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells

Author

Hou, Ming-Feng, primary, Kuo, Ho-Chang, additional, Li, Jih-Heng, additional, Wang, Yu-Shiuan, additional, Chang, Chen-Chia, additional, Chen, Ku-Chung, additional, Chen, Wei-Chiao, additional, Chiu, Chien-Chih, additional, Yang, Shengyu, additional, and Chang, Wei-Chiao, additional

Published
2011
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17. Polymorphisms of transforming growth factor-β signaling pathway and Kawasaki disease in the Taiwanese population

Author

Kuo, Ho-Chang, primary, Onouchi, Yoshihiro, additional, Hsu, Yu-Wen, additional, Chen, Wei-Chiao, additional, Huang, Jin-Ding, additional, Huang, Ying-Hsien, additional, Yang, Ya-Ling, additional, Chao, Mei-Chyn, additional, Yu, Hong-Ren, additional, Juan, Yung-Shun, additional, Kuo, Chiu-Ming, additional, Yang, Kuender D, additional, Huang, Jung-San, additional, and Chang, Wei-Chiao, additional

Published
2011
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18. A Genetic Polymorphism (rs17251221) in the Calcium-Sensing Receptor Gene (CASR) Is Associated with Stone Multiplicity in Calcium Nephrolithiasis

Author

Chou, Yii-Her, primary, Woon, Peng Yeong, additional, Chen, Wei-Chiao, additional, Hsu, Yu-Wen, additional, Chang, Jer-Ming, additional, Hwang, Daw-Yang, additional, Chiu, Yi-Ching, additional, Kuo, Ho-Chang, additional, Chang, Wei-Pin, additional, Hou, Ming-Feng, additional, Liu, Mu-En, additional, Chang, Jan-Gowth, additional, and Chang, Wei-Chiao, additional

Published
2011
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20. Association of ORAI1 Haplotypes with the Risk of HLA-B27 Positive Ankylosing Spondylitis

Author

Wei, James Cheng-Chung, primary, Yen, Jeng-Hsien, additional, Juo, Suh-Hang Hank, additional, Chen, Wei-Chiao, additional, Wang, Yu-Shiuan, additional, Chiu, Yi-Ching, additional, Hsieh, Tusty-Jiuan, additional, Guo, Yuh-Cherng, additional, Huang, Chun-Huang, additional, Wong, Ruey-Hong, additional, Wang, Hui-Po, additional, Tsai, Ke-Li, additional, Wu, Yang-Chang, additional, Chang, Hsueh-Wei, additional, Hsi, Edward, additional, Chang, Wei-Pin, additional, and Chang, Wei-Chiao, additional

Published
2011
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21. ITPKC Single Nucleotide Polymorphism Associated with the Kawasaki Disease in a Taiwanese Population

Author

Kuo, Ho-Chang, primary, Yang, Kuender D., additional, Juo, Suh-Hang Hank, additional, Liang, Chi-Di, additional, Chen, Wei-Chiao, additional, Wang, Yu-Shiuan, additional, Lee, Chih-Hung, additional, Hsi, Edward, additional, Yu, Hong-Ren, additional, Woon, Peng-Yeong, additional, Lin, I-Chun, additional, Huang, Chien-Fu, additional, Hwang, Daw-Yang, additional, Lee, Chiu-Ping, additional, Lin, Li-Yan, additional, Chang, Wei-Pin, additional, and Chang, Wei-Chiao, additional

Published
2011
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22. CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children

Author

Kuo, Ho-Chang, primary, Yu, Hong-Ren, additional, Juo, Suh-Hang Hank, additional, Yang, Kuender D, additional, Wang, Yu-Shiuan, additional, Liang, Chi-Di, additional, Chen, Wei-Chiao, additional, Chang, Wei-Pin, additional, Huang, Chien-Fu, additional, Lee, Chiu-Ping, additional, Lin, Li-Yan, additional, Liu, Yu-Chen, additional, Guo, Yuh-Cherng, additional, Chiu, Chien-Chih, additional, and Chang, Wei-Chiao, additional

Published
2010
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23. A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease.

Author

Kuo, Ho-Chang, Hsu, Yu-Wen, Wu, Chung-Min, Chen, Shawn Hsiang-Yin, Hung, Kuo-Sheng, Chang, Wei-Pin, Yang, Kuender D., Hsieh, Kai-Sheng, Chen, Wei-Chiao, Onouchi, Yoshihiro, and Chang, Wei-Chiao

Subjects
SINGLE nucleotide polymorphisms, LOCUS (Genetics), CORONARY disease, MUCOCUTANEOUS lymph node syndrome, COMPUTATIONAL biology, GENETIC polymorphisms, POPULATION biology
Abstract

Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients’ risk for CAL formation and IVIG responsiveness in a Taiwanese population. [ABSTRACT FROM AUTHOR]

Published
2013
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24. CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children.

Author

Kuo, Ho-Chang, Yu, Hong-Ren, Juo, Suh-Hang Hank, Yang, Kuender D, Wang, Yu-Shiuan, Liang, Chi-Di, Chen, Wei-Chiao, Chang, Wei-Pin, Huang, Chien-Fu, Lee, Chiu-Ping, Lin, Li-Yan, Liu, Yu-Chen, Guo, Yuh-Cherng, Chiu, Chien-Chih, and Chang, Wei-Chiao

Subjects
GENETIC polymorphisms, MUCOCUTANEOUS lymph node syndrome, PEDIATRICS, HUMAN genetics, NUCLEOTIDES, VASCULITIS, ETIOLOGY of diseases
Abstract

Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. A study from Japan reported that G to A substitution of a single-nucleotide polymorphism (SNP) located in the 5′-untranslated region of caspase 3 (CASP3) (rs72689236), which was associated with nuclear factor of activated T cell-mediated T-cell activation, is responsible for susceptibility to KD. This study was conducted to investigate whether the polymorphism of CASP3 is responsible for susceptibility and coronary artery lesion (CAL) formation in KD in the Taiwanese population. A total of 1092 subjects (341 KD patients and 751 controls) were investigated to identify an SNP of rs72689236 using Invader assays (Third Wave Technologies). Our data provided a borderline significant association between the genotypes and allele frequency of rs72689236 in control subjects and KD patients (P=0.0535 under the dominant model; P=0.0575 under the allelic model). The A allele of rs72689236 in KD patients and in patients with CAL and intravenous immunoglobulin resistance was seen in a higher frequency. Importantly, a significant association was obtained between rs72689236 and KD patients with aneurysm formation (P=0.009, under the recessive model). The A allele of rs72689236 is very likely to be a risk allele in the development of aneurysm in patients with KD. [ABSTRACT FROM AUTHOR]

Published
2011
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25. Lack of Association between CLEC5A Gene Single-Nucleotide Polymorphisms and Kawasaki Disease in Taiwanese Children

Author

Yang, Ya-Ling, Chang, Wei-Pin, Hsu, Yu-Wen, Chen, Wei-Chiao, Yu, Hong-Ren, Liang, Chi-Di, Tsai, Yao-Ting, Huang, Ying-Hsien, D. Yang, Kuender, Kuo, Ho-Chang, and Chang, Wei-Chiao

Abstract

Background. Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD. Methods. A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test. Results. No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response. Conclusions. This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.

Published
2012
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26. Involvement of intracellular calcium mobilization in IL-8 activation in human retinal pigment epithelial cells.

Author

Yang IH, Wong JH, Chang CM, Chen BK, Tsai YT, Chen WC, Wang ET, Hsu WL, and Chang WC

Subjects
Blotting, Western, Calcium Signaling, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Humans, Interleukin-8 biosynthesis, Macular Degeneration pathology, RNA metabolism, Real-Time Polymerase Chain Reaction, Retinal Pigment Epithelium pathology, Calcium metabolism, Gene Expression Regulation, Interleukin-8 genetics, Macular Degeneration metabolism, RNA genetics, Retinal Pigment Epithelium metabolism
Abstract

Purpose: Calcium signaling is an important intracellular pathway. Increased intracellular calcium is associated with cytokine regulation and inflammatory signals secretion. The purpose of this study is to understand the molecular mechanisms by which calcium signaling controls IL-8 activation in human RPE cells., Methods: Fluorescence-based calcium imaging and different mutants of IL-8 plasmids were used in this study. The IL-8 promoter activation, gene expression, and secretion were detected by using luciferase reporter assay, quantitative real-time PCR (Q-PCR), and ELISA, respectively. In addition, pharmacological inhibitors and small interfering RNA (siRNA) were applied to clarify the mechanisms of IL-8 activation., Results: Our study reported that intracellular calcium mobilization activated IL-8 gene expression and secretion. Application of pharmacological inhibitor BAY 11-7082, siRNA, and plasmids of the nuclear factor κ light chain enhancer of activated B cells (NF-κB) binding site, we identified that NF-κB is the main transcription factor involved in intracellular calcium mobilization-mediated IL-8 activation in human RPE cells., Conclusions: Collectively, our findings highlight the important role of intracellular calcium mobilization in the activation of IL-8. These findings may be helpful for the clinical applications in the age-related macular degeneration (AMD) prevention and treatment., (Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.)

Published
2015
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27. Lack of association between CLEC5A gene single-nucleotide polymorphisms and Kawasaki disease in Taiwanese children.

Author

Yang YL, Chang WP, Hsu YW, Chen WC, Yu HR, Liang CD, Tsai YT, Huang YH, Yang KD, Kuo HC, and Chang WC

Subjects
Case-Control Studies, Chi-Square Distribution, Child, Child, Preschool, Female, Gene Frequency, Genetic Predisposition to Disease, Haplotypes, Humans, Infant, Male, Polymorphism, Single Nucleotide, Taiwan, Lectins, C-Type genetics, Mucocutaneous Lymph Node Syndrome genetics, Receptors, Cell Surface genetics
Abstract

Background: Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD., Methods: A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test., Results: No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response., Conclusions: This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.

Published
2012
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