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26 results on '"Chen, Wuhe"'

1. Repeat corneal transplantation in Southern China: Indications, surgical technique, outcomes, and risk factors for repeat keratoplasty failure

Author

Zheng, Qiaolan, Zheng, Qinxiang, Chen, Wuhe, Li, Jinyang, Zhao, Zelin, Wang, Haiou, Jiang, Dan, and Chen, Wei

Subjects
Corneal diseases -- Diagnosis -- Care and treatment, Cornea -- Transplantation
Abstract

Purpose: To report the indications, surgical techniques, and outcomes of repeat keratoplasty and evaluate the risk factors for graft failure in the Chinese population. Methods: The medical records of 216 patients (243 cases) who underwent at least two keratoplasties at a leading eye hospital in southern China between 2011 and 2020 were retrospectively reviewed. Indications and surgical procedures for repeat corneal transplantation were analyzed. Kaplan-Meier survival analysis was used to determine the graft survival rate after repeat keratoplasty. A multivariable survival model was used to assess the risk factors. Results: Repeated keratoplasties increased continuously from 2011 to 2020 (P = 0.002). The most common primary indication was infectious keratitis (38.7%), and the most common reason for repeat keratoplasty was graft rejection (30.04%). Regraft techniques included penetrating keratoplasty (PK) in 165 cases (67.9%), deep lamellar keratoplasty (DALK) in 52 cases (21.40%), and endothelial keratoplasty (EK) in 26 cases (10.7%). Median survival was 5.3, 6.8, and 6.4 years for PK, DALK, and EK, respectively. The 5-year survival rate was 53.5%, 66.6%, and 69.8% for PK, DALK, and EK, respectively. The median LogMAR visual acuity was 1.4 for PK, 0.75 for DALK, and 1.2 for EK at the end of the follow-up. Multivariate analysis revealed that graft rejection is a risk factor for repeat keratoplasty failure (P = 0.002). Conclusions: DALK and EK may provide better outcomes than PK in treating graft failure. Preventing and treating postoperative graft rejection may be key to improving regraft survival. These findings will aid in the management of failed corneal grafts. Keywords: Graft survival, repeat keratoplasty, risk factors for graft failure, visual outcome, Author(s): Qiaolan Zheng [1]; Qinxiang Zheng [1]; Wuhe Chen [1]; Jinyang Li [1]; Zelin Zhao [1]; Haiou Wang [1]; Dan Jiang [1]; Wei Chen (corresponding author) [1] Corneal blindness can [...]

Published
2024
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8. Macular Microvasculature Density Changes in Anisometropic Amblyopic Eyes after Successful Treatment

Author

Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Chen, Wuhe, Thorn, Frank, Deng, Ruzhi, Li, Xiaoman, Lou, Jiangtao, Wang, Yingjie, Yu, Xinping, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Chen, Wuhe, Thorn, Frank, Deng, Ruzhi, Li, Xiaoman, Lou, Jiangtao, Wang, Yingjie, and Yu, Xinping

Abstract

Purpose. To determine if the abnormal macular microvasculature in hyperopic anisometropic amblyopia changes after occlusion therapy, and to discover if the macular microvasculature influences the efficacy of amblyopic treatment. Materials and Methods. Twenty-two children with hyperopic anisometropic amblyopia (median, 8 years old) were enrolled along with 66 healthy controls of similar age and gender distribution. Best-corrected visual acuity (BCVA) was determined, and macular vessel density in the superficial and deep capillary plexuses (SCPs and DCPs, respectively) was measured by optical coherence tomography angiography before and after refractive correction and occlusion therapy. Changes in BCVA and macular SCP and DCP vessel density were measured after amblyopia treatment of 7.5 ± 4.4 months. Results. The amblyopic baseline BCVA, logMAR 0.42 ± 0.27, improved to logMAR 0.18 ± 0.18 in 14 patients (64%) after amblyopia treatment (). In 8 patients (36%), there was no improvement in the BCVA. In amblyopic eyes with improved BCVA, the SCP density tended to increase in each parafoveal quadrant, while it tended to decrease in all quadrants of the fellow eyes. For patients in whom BCVA did not improve, the macular SCP vessel density tended to decrease in all quadrants of the amblyopic and fellow eyes. The posttreatment difference in SCP vessel density between amblyopic and fellow eyes was not significant. Multiple linear regression analysis showed that older age and greater foveal SCP vessel density were negatively correlated with BCVA improvement ( and , respectively). Conclusions. Macular vessel density tends to increase in anisometropic amblyopic eyes after successful treatment. Younger age and lower SCP macular density are predictive of a greater therapeutic effect of occlusion therapy.

Published
2021

9. Myopia progression and stabilization in school‐aged children with single‐vision lenses.

Author

Qin, Zhuoer, Peng, Tingting, Zhang, Zicheng, Lou, Jiangtao, Wang, Chunxiao, Deng, Ruzhi, Xu, Meiping, Yu, Xinping, and Chen, Wuhe

Subjects
SCHOOL children, MYOPIA, GIRLS, MEDICAL records
Abstract

Purpose: To investigate the longitudinal changes in myopia from onset to stabilization in school‐aged children with single‐vison lenses (SVLs). Methods: The medical records of patients wearing SVLs with long‐term follow‐up data between 2006 and 2016 were retrospectively reviewed. The patients who were 6–10 years old at the initial visit and 16 years old at the last assessment were included and analysed. The periods of progression and stabilization of myopia were evaluated by plotting fitted curves of the changes in spherical equivalent (SE). Results: Seven hundred and seventy‐three patients (median initial age 9 years) were accessed over an average of 7 years (IQR, 6–7 years). The initial mean SE was −1.92 ± 1.57 D and increased to −6.05 ± 2.14 D at 16 years old. The average age at myopia stabilization was 14.6 years, and girls slightly stabilized earlier than boys. 73.7% of the 6‐year‐olds and 85.7% of the 7‐year‐olds had high myopia at 16 years old, and the risk decreased each year from 7 to 10 years old. Children who had SE greater than −4 D up to 10 years had 89.0% risk of high myopia at 16 years old. Children with SE between −0.5 D and −2 D still had 34% risk of developing high myopia at 16 years old. Conclusion: This study provides a comprehensive picture of myopia progression from onset to stabilization in school‐aged children with SVLs in China. All children who have myopia onset below 10 years of age were at risk for high myopia, and children who have myopia onset below 8 years of age require more attention. [ABSTRACT FROM AUTHOR]

Published
2022
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18. Atmospheric refractive turbulence effect on diffraction-limited infrared coherent lidar

Author

Chen Wuhe, Situ Da, and Zhong Xubin

Subjects
Diffraction, Optimal design, Physics, Atmospheric Science, Turbulence, Infrared, business.industry, Nonlinear system, Optics, Lidar, Atmospheric turbulence, Astrophysics::Earth and Planetary Astrophysics, business, Physics::Atmospheric and Oceanic Physics, Gaussian beam, Remote sensing
Abstract

This paper, based on the Kavaya-Suni format, discusses the signal-to-noise ratio equation of the diffraction-limited coherent CO2 lidar in detail, which is applied to atmospheric turbulence. The cumulative SNR and relative SNR, which are all affected by the nonlinear effects of the diffraction-limited Gaussian beam, atmospheric molecule and atmospheric turbulence, are simulated by microcomputer. Six instructions for the optimal design of IR CO2 Coherent Lidar System, are provided.

Published
1998
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