Search

Your search keyword '"Chen, Xiheng"' showing total 39 results
Start Over Author "Chen, Xiheng"
39 results on '"Chen, Xiheng"'

10. The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis

Author

Li, Runting, Lin, Fa, Chen, Yu, Lu, Junlin, Yang, Jun, Han, Heze, Yuan, Kexin, Wang, Ke, Yan, Debin, Li, Ruinan, He, Shihao, Li, Zhipeng, Zhang, Haibin, Chen, Xiheng, Ma, Li, Zhao, Yahui, Hao, Qiang, Ye, Xun, Wang, Hao, Li, Hongliang, Zhang, Linlin, Shi, Guangzhi, Zhou, Jianxin, Li, Youxiang, Wang, Shuo, Chen, Xiaolin, and Zhao, Yuanli

Published
2022
Full Text
View/download PDF

11. Diagnosis of intracranial aneurysms by computed tomography angiography using deep learning-based detection and segmentation

Author

You, Wei, Feng, Junqiang, Lu, Jing, Chen, Ting, Liu, Xinke, Wu, Zhenzhou, Gong, Guoyang, Sui, Yutong, Wang, Yanwen, Zhang, Yifan, Ye, Wanxing, Chen, Xiheng, Lv, Jian, Wei, Dachao, Tang, Yudi, Deng, Dingwei, Gui, Siming, Lin, Jun, Chen, Peike, Wang, Ziyao, Gong, Wentao, Wang, Yang, Zhu, Chengcheng, Zhang, Yue, Saloner, David A, Mitsouras, Dimitrios, Guan, Sheng, Li, Youxiang, Jiang, Yuhua, and Wang, Yan

Abstract

BackgroundDetecting and segmenting intracranial aneurysms (IAs) from angiographic images is a laborious task.ObjectiveTo evaluates a novel deep-learning algorithm, named vessel attention (VA)-Unet, for the efficient detection and segmentation of IAs.MethodsThis retrospective study was conducted using head CT angiography (CTA) examinations depicting IAs from two hospitals in China between 2010 and 2021. Training included cases with subarachnoid hemorrhage (SAH) and arterial stenosis, common accompanying vascular abnormalities. Testing was performed in cohorts with reference-standard digital subtraction angiography (cohort 1), with SAH (cohort 2), acquired outside the time interval of training data (cohort 3), and an external dataset (cohort 4). The algorithm’s performance was evaluated using sensitivity, recall, false positives per case (FPs/case), and Dice coefficient, with manual segmentation as the reference standard.ResultsThe study included 3190 CTA scans with 4124 IAs. Sensitivity, recall, and FPs/case for detection of IAs were, respectively, 98.58%, 96.17%, and 2.08 in cohort 1; 95.00%, 88.8%, and 3.62 in cohort 2; 96.00%, 93.77%, and 2.60 in cohort 3; and, 96.17%, 94.05%, and 3.60 in external cohort 4. The segmentation accuracy, as measured by the Dice coefficient, was 0.78, 0.71, 0.71, and 0.66 for cohorts 1–4, respectively. VA-Unet detection recall and FPs/case and segmentation accuracy were affected by several clinical factors, including aneurysm size, bifurcation aneurysms, and the presence of arterial stenosis and SAH.ConclusionsVA-Unet accurately detected and segmented IAs in head CTA comparably to expert interpretation. The proposed algorithm has significant potential to assist radiologists in efficiently detecting and segmenting IAs from CTA images.

Published
2025
Full Text
View/download PDF

12. Diagnosis of intracranial aneurysms by computed tomography angiography using deep learning-based detection and segmentation

Author

You, Wei, primary, Feng, Junqiang, additional, Lu, Jing, additional, Chen, Ting, additional, Liu, Xinke, additional, Wu, Zhenzhou, additional, Gong, Guoyang, additional, Sui, Yutong, additional, Wang, Yanwen, additional, Zhang, Yifan, additional, Ye, Wanxing, additional, Chen, Xiheng, additional, Lv, Jian, additional, Wei, Dachao, additional, Tang, Yudi, additional, Deng, Dingwei, additional, Gui, Siming, additional, Lin, Jun, additional, Chen, Peike, additional, Wang, Ziyao, additional, Gong, Wentao, additional, Wang, Yang, additional, Zhu, Chengcheng, additional, Zhang, Yue, additional, Saloner, David A, additional, Mitsouras, Dimitrios, additional, Guan, Sheng, additional, Li, Youxiang, additional, Jiang, Yuhua, additional, and Wang, Yan, additional

Published
2024
Full Text
View/download PDF

15. Towards an integrated environmental permit in China: a legal study based on EU regulatory experiences

Author

Chen, Xiheng and Chen, Xiheng

Abstract

Different approaches to controlling emissions into the air, water, or soil separately bear the risk of being ineffective to combat the pollution as a whole. In order to combat the hydra-headed ogre of pollution, the legal framework that attempts to implement integrated pollution prevention and control using the permit instrument was adopted in 1996 at the EU level and in 2020 in China. This research examines to what extent the new regulatory design of the emissions permit system in China, considering the EU regulatory experiences towards integration and seen from the perspective of the specific Chinese situation, provides possibilities for or barriers to the implementation of integrated pollution prevention and control. It was found that China’s emissions permit system presents regulatory possibilities for controlling emissions into the air, water, and land in an integrated manner, but some challenges still exist, particularly in view of environmental effectiveness and environmental trade-offs.

Published
2023

19. Alcohol flushing syndrome is significantly associated with intracranial aneurysm rupture in the Chinese Han population

Author

Chen, Xiheng, Gui, Siming, Deng, Dingwei, Dong, Linggen, Zhang, Longhui, Wei, Dachao, Jiang, Jia, Ge, Huijian, Liu, Peng, Lv, Ming, and Li, Youxiang

Subjects
Neurology, Neurology (clinical)
Abstract

ObjectiveAlthough alcohol flushing syndrome (AFS) has been associated with various diseases, its association with intracranial aneurysm rupture (IAR) is unclear. We aimed to examine this association in the Chinese Han population.MethodsWe retrospectively reviewed Chinese Han patients with intracranial aneurysms who were evaluated and treated at our institution between January 2020 and December 2021. AFS was determined using a semi-structured telephone interview. Clinical data and aneurysm characteristics were assessed. Univariate and multivariate logistic regression were conducted to determine independent factors associated with aneurysmal rupture.ResultsA total of 1,170 patients with 1,059 unruptured and 236 ruptured aneurysms were included. The incidence of aneurysm rupture was significantly higher in patients without AFS (p p ConclusionAlcohol flushing syndrome may be a novel clinical marker to assess the risk of IAR. The association between AFS and IAR exists independently of alcohol consumption. Further single nucleotide polymorphism testing and molecular biology studies are warranted.

Published
2023
Full Text
View/download PDF

20. Long-term outcomes and dynamic changes of in-stent stenosis after Pipeline embolization device treatment of intracranial aneurysms

Author

Gui, Siming, primary, Chen, Xiheng, additional, Wei, Dachao, additional, Deng, Dingwei, additional, You, Wei, additional, Meng, Xiangyu, additional, Lv, Jian, additional, Feng, Junqiang, additional, Tang, Yudi, additional, Yang, Shu, additional, Chen, Ting, additional, Liu, Peng, additional, Ge, Huijian, additional, Jin, Hengwei, additional, Liu, Xinke, additional, Jiang, Yuhua, additional, Feng, Wei, additional, and LI, Youxiang, additional

Published
2023
Full Text
View/download PDF

21. Integrated metagenomic and metabolomic analysis reveals distinctive stage-specific gut-microbiome-derived metabolites in intracranial aneurysms

Author

Sun, Haitao, Sun, Kaijian, Tian, Hao, Chen, Xiheng, Su, Shixing, Tu, Yi, Chen, Shilan, Wang, Jiaxuan, Peng, Meichang, Zeng, Meiqin, Li, Xin, Luo, Yunhao, Xie, Yugu, Feng, Xin, Li, Zhuang, Zhang, Xin, Li, Xifeng, Liu, Yanchao, Ye, Wei, Chen, Zhengrui, Zhu, Zhaohua, Li, Youxiang, Xia, Fangbo, Zhou, Hongwei, and Duan, Chuanzhi

Abstract

ObjectiveOur study aimed to explore the influence of gut microbiota and their metabolites on intracranial aneurysms (IA) progression and pinpoint-related metabolic biomarkers derived from the gut microbiome.DesignWe recruited 358 patients with unruptured IA (UIA) and 161 with ruptured IA (RIA) from two distinct geographical regions for conducting an integrated analysis of plasma metabolomics and faecal metagenomics. Machine learning algorithms were employed to develop a classifier model, subsequently validated in an independent cohort. Mouse models of IA were established to verify the potential role of the specific metabolite identified.ResultsDistinct shifts in taxonomic and functional profiles of gut microbiota and their related metabolites were observed in different IA stages. Notably, tryptophan metabolites, particularly indoxyl sulfate (IS), were significantly higher in plasma of RIA. Meanwhile, upregulated tryptophanase expression and indole-producing microbiota were observed in gut microbiome of RIA. A model harnessing gut-microbiome-derived tryptophan metabolites demonstrated remarkable efficacy in distinguishing RIA from UIA patients in the validation cohort (AUC=0.97). Gut microbiota depletion by antibiotics decreased plasma IS concentration, reduced IA formation and rupture in mice, and downregulated matrix metalloproteinase-9 expression in aneurysmal walls with elastin degradation reduction. Supplement of IS reversed the effect of gut microbiota depletion.ConclusionOur investigation highlights the potential of gut-microbiome-derived tryptophan metabolites as biomarkers for distinguishing RIA from UIA patients. The findings suggest a novel pathogenic role for gut-microbiome-derived IS in elastin degradation in the IA wall leading to the rupture of IA.

Published
2024
Full Text
View/download PDF

28. Protocol and Preliminary Results of the Establishment of Intracranial Aneurysm Database for Artificial Intelligence Application Based on CTA Images

Author

You, Wei, primary, Sun, Yong, additional, Feng, Junqiang, additional, Wang, Zhiliang, additional, Li, Lin, additional, Chen, Xiheng, additional, Lv, Jian, additional, Tang, Yudi, additional, Deng, Dingwei, additional, Wei, Dachao, additional, Gui, Siming, additional, Liu, Xinke, additional, Liu, Peng, additional, Jin, Hengwei, additional, Ge, Huijian, additional, and Zhang, Yanling, additional

Published
2022
Full Text
View/download PDF

29. UHF RFID Indoor Localization Based on Phase Difference.

Author

Zeng, Yanhan, Liao, Yuxing, Chen, Xiheng, and Tan, Hong-zhou

Subjects
INDOOR positioning systems, RADIO frequency identification systems, PATTERN matching, MACHINE learning
Abstract

An indoor positioning system, with ultra-high frequency radio frequency identification based on phase difference (PD), is presented in this paper. Several groups of phases are obtained by setting reader's different transmitting frequency to reduce the phase ambiguity. Two positioning algorithms are proposed with rough PDs, which are pattern matching based on PD correction and machine learning based on without PD correction. The experiments of two methods, in which machine learning gets a better positioning precision of 0.43 m, are also presented and discussed. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. UHF RFID Indoor Positioning System With Phase Interference Model Based on Double Tag Array

Author

Hong-Zhou Tan, Yanhan Zeng, Ruguo Li, and Chen Xiheng

Subjects
0209 industrial biotechnology, General Computer Science, Indoor positioning, Computer science, Phase (waves), 02 engineering and technology, Interference (wave propagation), 020901 industrial engineering & automation, Phase offset, Indoor positioning system, Genetic algorithm, 0202 electrical engineering, electronic engineering, information engineering, UHF RFID, General Materials Science, Phase difference, interference model, business.industry, 020208 electrical & electronic engineering, General Engineering, Computer Science::Computation and Language (Computational Linguistics and Natural Language and Speech Processing), phase difference, Identification (information), Ultra high frequency, lcsh:Electrical engineering. Electronics. Nuclear engineering, business, double tag array, lcsh:TK1-9971, Computer hardware
Abstract

A UHF radio-frequency identification (RFID) indoor positioning system based on phase difference is presented in this paper. An additional auxiliary tag and the target tag make up a double tag array to eliminate the phase ambiguity. To quantify the phase offset caused by the interference between tags, a mathematical model is built. Based on the double tag array and the interference model, a hyperbolic positioning algorithm, combining the genetic algorithm, is implemented to improve the positioning accuracy. Compared with other RFID positioning systems, the proposed system achieves a better positioning accuracy of 0.2217 m.

Published
2019

38. Spontaneous delayed migration or shortening after pipeline embolization device treatment of intracranial aneurysm: incidence, management, and risk factors.

Author

Dong L, Wang C, Wei D, Peng Q, Wu X, Chen X, Li M, Li T, Liu H, Zhao Y, Duan R, Jin W, Zhang Y, Wang Y, and Lv M

Abstract

Background: Studies reporting spontaneous delayed migration or shortening (SDMS) after treatment with the Pipeline Embolization Device (PED) are limited. This study aimed to evaluate the incidence of SDMS after PED treatment, propose management strategies, and identify the risk factors contributing to its occurrence., Methods: We retrospectively reviewed consecutive patients with an intracranial aneurysm (IA) treated with PEDs at three institutions. SDMS was classified as type I or II based on whether the PED covered the aneurysm neck., Results: The total cohort comprised 790 patients. SDMS was identified in 24 (3.04%) patients. Eighteen of the 24 patients had type I SDMS and did not require retreatment, while the remaining six patients had type II SDMS and all received retreatment. Multivariate logistic regression showed that the difference between the proximal and distal parent artery diameters (DPAD) (adjusted OR 2.977; 95% CI 1.054 to 8.405; P=0.039) and device tortuosity index (DTI) (adjusted OR 8.059; 95% CI 2.867 to 23.428; P<0.001) were independent predictors of SDMS after PED treatment, while the difference in length (DL) (adjusted OR 0.841; 95% CI 0.738 to 0.958; P=0.009) and PED plus coiling (adjusted OR 0.288; 95% CI 0.106 to 0.785; P=0.015) were protective factors., Conclusion: The incidence of SDMS after PED treatment of IA was 3.04%. For patients with type I SDMS with incomplete aneurysm occlusion we recommend continuous imaging follow-up while, for patients with type II SDMS, we recommend aggressive retreatment. The DPAD and DTI were independent risk predictors of SDMS after PED treatment, while the DL and PED plus coiling were protective factors., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2025
Full Text
View/download PDF

39. Causal relationships between human blood metabolites and intracranial aneurysm and aneurysmal subarachnoid hemorrhage: a Mendelian randomization study.

Author

Jiang J, Gui S, Wei D, Chen X, Tang Y, Lv J, You W, Chen T, Yang S, Ge H, and Li Y

Abstract

Objective: The aim of this study was to assess the causal relationships between blood metabolites and intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm., Methods: Our exposure sample consisted of 7,824 individuals from a genome-wide association study of human blood metabolites. Our outcome sample consisted of 79,429 individuals (7,495 cases and 71,934 controls) from the International Stroke Genetics Consortium, which conducted a genome-wide association study of intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm. We identified blood metabolites with a potential causal effect on intracranial aneurysms and conducted sensitivity analyses to validate our findings., Results: After rigorous screening and Mendelian randomization tests, we found four, two, and three serum metabolites causally associated with intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm, respectively (all P < 0.05). Sensitivity analyses confirmed the robustness of these associations., Conclusions: Our Mendelian randomization analysis demonstrated causal relationships between human blood metabolites and intracranial aneurysm, aneurysmal subarachnoid hemorrhage, and unruptured intracranial aneurysm. Further research is required to explore the potential of targeting these metabolites in the management of intracranial aneurysm., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Jiang, Gui, Wei, Chen, Tang, Lv, You, Chen, Yang, Ge and Li.)

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results