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The Fengyun-4B (FY-4B) satellite is currently the primary operational geostationary meteorological satellite in China, replacing the previous FY-4A satellite. The advanced geostationary radiation imager (AGRI) aboard the FY-4B satellite provides an operational sea surface temperature (SST) product with a high observation frequency of 15 min. This paper conducts the first data quality assessment of operational SST products from the FY-4B/AGRI using quality-controlled measured SSTs from the in situ SST quality monitor dataset and foundation SSTs produced by the operational sea surface temperature and sea ice analysis (OSTIA) system from July 2023 to January 2024. The FY-4B/AGRI SST product provides a data quality level flag on a pixel-by-pixel basis. Accuracy evaluations are conducted on the FY-4B/AGRI SST product with different data quality levels. The results indicate that the FY-4B/AGRI operational SST generally has a negative mean bias compared to in situ SST and OSTIA SST, and that the accuracy of the FY-4B/AGRI SST, with an excellent quality level, can meet the needs of practical applications. The FY-4B/AGRI SST with an excellent quality level demonstrates a strong correlation with in situ SST and OSTIA SST, with a correlation coefficient R exceeding 0.99. Compared with in situ SST, the bias, root mean square error (RMSE), and unbiased RMSE (ubRMSE) of the FY-4B/AGRI SST with an excellent quality level are −0.19, 0.66, and 0.63 °C in daytime, and −0.15, 0.70, and 0.68 °C at night, respectively. Compared with OSTIA SST, the bias, RMSE, and ubRMSE of the FY-4B/AGRI SST with an excellent data quality level are −0.10, 0.64, and 0.63 °C in daytime, and −0.13, 0.68, and 0.67 °C at night. The FY-4B/AGRI SST tends to underestimate the sea water temperature in mid–low-latitude regions, while it tends to overestimate sea water temperature in high-latitude regions and near the edges of the full disk. The time-varying validation of FY-4B/AGRI SST accuracy shows weak fluctuations with a period of 3–4 months. Hourly accuracy verification shows that the difference between the FY-4B/AGRI SST and OSTIA SST reflects a diurnal effect. However, FY-4B/AGRI SST products need to be used with caution around midnight to avoid an abnormal accuracy. This paper also discusses the relationships between the FY-4B/AGRI SST and satellite zenith angle, water vapor content, wind speed, and in situ SST, which have an undeniable impact on the underestimation of the FY-4B/AGRI operational SST. The accuracy of the FY-4B/AGRI operational SST retrieval algorithm still needs to be further improved in the future. [ABSTRACT FROM AUTHOR]

Objective: To observe the changes of ocular biometric parameters in childrenwith low to moderate myopia after wearing orthokeratology lenses. Methods: A total of 80 children with low to moderate myopia at the Ophthalmology Department of Ruijin Hospital were enrolled. Children were randomly divided into 2 groups: orthokeratology lens group (n=40) and spectacles (n=40) group. Axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), and lens thickness (LT) of children in the 2 groups were measured by Lenstar 900 at baseline, 6 months and 12 months after wearing orthokeratology lenses or spectacles, and differences in data between the 2 groups were analyzed with independent t tests. Results: There were no statistically significant differences in AL, CCT, ACD, and LT between the 2 groups at baseline. The incremental AL in the orthokeratology group was lower than that in the spectacles group at both 6 months [(0.08±0.08) mm vs (0.16±0.13) mm, t=-4.859, P

Immunotherapy is a therapeutic modality designed to elicit or augment an immune response against malignancies. Despite the immune system's ability to detect and eradicate neoplastic cells, certain neoplastic cells can elude immune surveillance and elimination through diverse mechanisms. Therefore, antitumor immunotherapy has emerged as a propitious strategy. Pyroptosis, a type of programmed cell death (PCD) regulated by Gasdermin (GSDM), is associated with cytomembrane rupture due to continuous cell expansion, which results in the release of cellular contents that can trigger robust inflammatory and immune responses. The field of nanomedicine has made promising progress, enabling the application of nanotechnology to enhance the effectiveness and specificity of cancer therapy by potentiating, enabling, or augmenting pyroptosis. In this review, we comprehensively examine the paradigms underlying antitumor immunity, particularly paradigms related to nanotherapeutics combined with pyroptosis; these treatments include chemotherapy (CT), hyperthermia therapy, photodynamic therapy (PDT), chemodynamic therapy (CDT), ion-interference therapy (IIT), biomimetic therapy, and combination therapy. Furthermore, we thoroughly discuss the coordinated mechanisms that regulate these paradigms. This review is expected to enhance the understanding of the interplay between pyroptosis and antitumor immunotherapy, broaden the utilization of diverse nanomaterials in pyroptosis-based antitumor immunotherapy, and facilitate advancements in clinical tumor therapy. [ABSTRACT FROM AUTHOR]