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Your search keyword '"Chen, Yanxun"' showing total 9 results
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9 results on '"Chen, Yanxun"'

8. A study on the acoustical problem of stereo cinema

Author

Chen Yanxun

Subjects
Engineering, Acoustics and Ultrasonics, Point (typography), Multimedia, business.industry, Design elements and principles, computer.software_genre, GeneralLiterature_MISCELLANEOUS, law.invention, Stereophonic sound, Movie theater, Architectural acoustics, Hardware_GENERAL, law, Computer graphics (images), ComputerSystemsOrganization_SPECIAL-PURPOSEANDAPPLICATION-BASEDSYSTEMS, business, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), computer
Abstract

This note presents the method and principles of design of a stereo sound cinema from the point of view of psycho- and electro-acoustics as well as architectural acoustics. In this note, the acoustical design and measurement data refer to a six-channel Dolby stereo cinema.

Published
1994

9. Knockdown of deoxythymidylate kinase suppresses progression and epithelial-mesenchymal-transition of lung adenocarcinoma via STAT3 signaling.

Author

Yu F, Chen Y, Qiu R, Lin N, Yin Y, Zhuo Y, Lin J, and Lai F

Subjects
Humans, Thymidine Monophosphate pharmacology, Signal Transduction, Lung pathology, Cell Proliferation, Cell Movement, Gene Expression Regulation, Neoplastic, STAT3 Transcription Factor genetics, STAT3 Transcription Factor metabolism, STAT3 Transcription Factor pharmacology, Adenocarcinoma of Lung genetics, Adenocarcinoma of Lung metabolism, Adenocarcinoma of Lung pathology, Lung Neoplasms genetics, Lung Neoplasms metabolism, Lung Neoplasms pathology
Abstract

Current research has shown that inhibiting deoxythymidylate kinase (DTYMK) can significantly reduce development of lung cancer without liver kinase B1. However, its underlying regulatory mechanism is still unclear. We therefore aimed to investigate whether DTYMK inhibitors could suppress lung adenocarcinoma (LUAD) progression. In this study, human tissues, A549 cells, and xenograft tumors were used to explore the regulation and mechanism of DTYMK on LUAD cell proliferation and migration. Meanwhile, YMU1 (a DTYMK inhibitor) was applied to A549 cells and xenograft tumors to investigate its potential as a drug for LUAD. DTYMK was overexpressed in LUAD tissues and correlated with tumor stage. Knockdown of DTYMK suppressed cell viability, migration, and invasion. In addition, the activation of signal transducers and activators of transcription 3 (STAT3) was repressed upon DTYMK inhibition. YMU1 showed the same effect as DTYMK knockdown in vivo and in vitro. DTYMK plays an important role in progression of LUAD through the STAT3 signaling pathway. YMU1 may have the potential to inhibit the development of LUAD. NEW & NOTEWORTHY DTYMK plays an important role in progression of LUAD through the STAT3 signaling pathway. YMU1 may serve as a novel drug to suppress the development of LUAD.

Published
2023
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