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40 results on '"Chen, Ying-Hsiang"'

1. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Author

Howson, Joanna MM, Zhao, Wei, Barnes, Daniel R, Ho, Weang-Kee, Young, Robin, Paul, Dirk S, Waite, Lindsay L, Freitag, Daniel F, Fauman, Eric B, Salfati, Elias L, Sun, Benjamin B, Eicher, John D, Johnson, Andrew D, Sheu, Wayne HH, Nielsen, Sune F, Lin, Wei-Yu, Surendran, Praveen, Malarstig, Anders, Wilk, Jemma B, Tybjærg-Hansen, Anne, Rasmussen, Katrine L, Kamstrup, Pia R, Deloukas, Panos, Erdmann, Jeanette, Kathiresan, Sekar, Samani, Nilesh J, Schunkert, Heribert, Watkins, Hugh, Do, Ron, Rader, Daniel J, Johnson, Julie A, Hazen, Stanley L, Quyyumi, Arshed A, Spertus, John A, Pepine, Carl J, Franceschini, Nora, Justice, Anne, Reiner, Alex P, Buyske, Steven, Hindorff, Lucia A, Carty, Cara L, North, Kari E, Kooperberg, Charles, Boerwinkle, Eric, Young, Kristin, Graff, Mariaelisa, Peters, Ulrike, Absher, Devin, Hsiung, Chao A, Lee, Wen-Jane, Taylor, Kent D, Chen, Ying-Hsiang, Lee, I-Te, Guo, Xiuqing, Chung, Ren-Hua, Hung, Yi-Jen, Rotter, Jerome I, Juang, Jyh-Ming J, Quertermous, Thomas, Wang, Tzung-Dau, Rasheed, Asif, Frossard, Philippe, Alam, Dewan S, Majumder, Abdulla al Shafi, Di Angelantonio, Emanuele, Chowdhury, Rajiv, Chen, Yii-Der Ida, Nordestgaard, Børge G, Assimes, Themistocles L, Danesh, John, Butterworth, Adam S, and Saleheen, Danish

Subjects
Biological Sciences, Genetics, Clinical Research, Aging, Heart Disease, Cardiovascular, Atherosclerosis, Human Genome, Heart Disease - Coronary Heart Disease, 2.1 Biological and endogenous factors, Arteries, Cell Adhesion, Chemotaxis, Leukocyte, Coronary Artery Disease, Energy Metabolism, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Histone Code, Humans, Male, Muscle, Smooth, Vascular, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors, CARDIoGRAMplusC4D, EPIC-CVD, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 × 10-8, in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanisms.

Published
2017

2. Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia

Author

Blechter, Batel, Wong, Jason Y.Y., Agnes Hsiung, Chao, Hosgood, H.Dean, Yin, Zhihua, Shu, Xiao-Ou, Zhang, Han, Shi, Jianxin, Song, Lei, Song, Minsun, Zheng, Wei, Wang, Zhaoming, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Teresa Landi, Maria, Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chien, Li-Hsin, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Jie Seow, Wei, Bassig, Bryan A., Hu, Wei, Ji, Bu-Tian, Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Pik Wong, Maria, Lu, Daru, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, Chatterjee, Nilanjan, and Lan, Qing

Published
2021
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3. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Tobacco, Clinical Research, Urologic Diseases, Lung, Genetics, Rare Diseases, Lung Cancer, Human Genome, Hematology, Cancer, Tobacco Smoke and Health, Prevention, Lymphoma, Adult, Aged, Asian People, Bone Neoplasms, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Kidney Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lung Neoplasms, Lymphoma, Large B-Cell, Diffuse, Male, Middle Aged, Neoplasms, Osteosarcoma, Polymorphism, Single Nucleotide, Smoking, Testicular Neoplasms, Tissue Array Analysis, Urinary Bladder Neoplasms, White People, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

4. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Author

Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, De Vivo, Immaculata, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John KC, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, and Davis, Faith G

Subjects
Humans, Neoplasms, Osteosarcoma, Bone Neoplasms, Testicular Neoplasms, Lung Neoplasms, Kidney Neoplasms, Genetic Predisposition to Disease, Tissue Array Analysis, Smoking, Polymorphism, Single Nucleotide, Adult, Aged, Middle Aged, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Urinary Bladder Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Oncology And Carcinogenesis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundStudies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.MethodsBetween 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.ResultsGWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.ConclusionOur results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

5. Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)

Author

Hosgood, III, H. Dean, Song, Minsun, Hsiung, Chao Agnes, Yin, Zhihua, Shu, Xiao-Ou, Wang, Zhaoming, Chatterjee, Nilanjan, Zheng, Wei, Caporaso, Neil, Burdette, Laurie, Yeager, Meredith, Berndt, Sonja I., Landi, Maria Teresa, Chen, Chien-Jen, Chang, Gee-Chen, Hsiao, Chin-Fu, Tsai, Ying-Huang, Chien, Li-Hsin, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Chen, Chung-Hsing, Yang, Tsung-Ying, Wang, Chih-Liang, Hung, Jen-Yu, Lin, Chien-Chung, Perng, Reury-Perng, Chen, Chih-Yi, Chen, Kun-Chieh, Li, Yao-Jen, Yu, Chong-Jen, Chen, Yi-Song, Chen, Ying-Hsiang, Tsai, Fang-Yu, Kim, Christopher, Seow, Wei Jie, Bassig, Bryan A., Wu, Wei, Guan, Peng, He, Qincheng, Gao, Yu-Tang, Cai, Qiuyin, Chow, Wong-Ho, Xiang, Yong-Bing, Lin, Dongxin, Wu, Chen, Wu, Yi-Long, Shin, Min-Ho, Hong, Yun-Chul, Matsuo, Keitaro, Chen, Kexin, Wong, Maria Pik, Lu, Dara, Jin, Li, Wang, Jiu-Cun, Seow, Adeline, Wu, Tangchun, Shen, Hongbing, Fraumeni, Jr, Joseph F., Yang, Pan-Chyr, Chang, I-Shou, Zhou, Baosen, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2015
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6. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Author

Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, III, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E., Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao-Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu-Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y.Y., Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu-Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K.C., Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Jr, Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A., Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L., Laird-Offringa, Ite A., Marconett, Crystal N., Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., and Lan, Qing

Published
2017
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7. Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women

Author

Wang, Zhaoming, Seow, Wei Jie, Shiraishi, Kouya, Hsiung, Chao A., Matsuo, Keitaro, Liu, Jie, Chen, Kexin, Yamji, Taiki, Yang, Yang, Chang, I-Shou, Wu, Chen, Hong, Yun-Chul, Burdett, Laurie, Wyatt, Kathleen, Chung, Charles C., Li, Shengchao A., Yeager, Meredith, Hutchinson, Amy, Hu, Wei, Caporaso, Neil, Landi, Maria T., Chatterjee, Nilanjan, Song, Minsun, Fraumeni, Joseph F., Jr, Kohno, Takashi, Yokota, Jun, Kunitoh, Hideo, Ashikawa, Kyota, Momozawa, Yukihide, Daigo, Yataro, Mitsudomi, Tetsuya, Yatabe, Yasushi, Hida, Toyoaki, Hu, Zhibin, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Yin, Zhihua, Li, Xuelian, Ren, Yangwu, Guan, Peng, Chang, Jiang, Tan, Wen, Chen, Chien-Jen, Chang, Gee-Chen, Tsai, Ying-Huang, Su, Wu-Chou, Chen, Kuan-Yu, Huang, Ming-Shyan, Chen, Yuh-Min, Zheng, Hong, Li, Haixin, Cui, Ping, Guo, Huan, Xu, Ping, Liu, Li, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Park, Jae Yong, Kim, Yeul Hong, Sung, Jae Sook, Park, Kyong Hwa, Kim, Young Tae, Jung, Yoo Jin, Kang, Chang Hyun, Park, In Kyu, Kim, Hee Nam, Jeon, Hyo-Sung, Choi, Jin Eun, Choi, Yi Young, Kim, Jin Hee, Oh, In-Jae, Kim, Young-Chul, Sung, Sook Whan, Kim, Jun Suk, Yoon, Ho-Il, Kweon, Sun-Seog, Shin, Min-Ho, Seow, Adeline, Chen, Ying, Lim, Wei-Yen, Liu, Jianjun, Wong, Maria Pik, Lee, Victor Ho Fun, Bassig, Bryan A., Tucker, Margaret, Berndt, Sonja I., Chow, Wong-Ho, Ji, Bu-Tian, Wang, Junwen, Xu, Jun, Sihoe, Alan Dart Loon, Ho, James C.M., Chan, John K.C., Wang, Jiu-Cun, Lu, Daru, Zhao, Xueying, Zhao, Zhenhong, Wu, Junjie, Chen, Hongyan, Jin, Li, Wei, Fusheng, Wu, Guoping, An, She-Juan, Zhang, Xu-Chao, Su, Jian, Wu, Yi-Long, Gao, Yu-Tang, Xiang, Yong-Bing, He, Xingzhou, Li, Jihua, Zheng, Wei, Shu, Xiao-Ou, Cai, Qiuyin, Klein, Robert, Pao, William, Lawrence, Charles, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Chien, Li-Hsin, Chen, Ying-Hsiang, Chen, Chung-Hsing, Wang, Wen-Chang, Chen, Chih-Yi, Wang, Chih-Liang, Yu, Chong-Jen, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Li, Yao-Jen, Yang, Tsung-Ying, Lin, Chien-Chung, Yang, Pan-Chyr, Wu, Tangchun, Lin, Dongxin, Zhou, Baosen, Yu, Jinming, Shen, Hongbing, Kubo, Michiaki, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2016
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8. Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort)†

Author

Juang, Jyh-Ming Jimmy, Chen, Ching-Yu Julius, Chen, Ying-Hsiang, Wu, I-Chien, Hsu, Chih-Cheng, Chen, Lei-Na, Tang, Feng-Cheng, Wang, Chi-Chung, Juan, Chung-Chou, Chiu, Hou-Chang, Lo, Huey-Ming, Chang, I-Shou, Hwang, Juey-Jen, Lai, Ling-Ping, Chiang, Fu-Tien, Lin, Jiunn-Lee, and Hsiung, Chao Agnes

Published
2015
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9. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J., Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, Dean H., III, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E., Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A., Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J., Chung, Charles C., Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I., Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C.H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K. C., Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F., Jr., Zheng, Wei, Lin, Dongxin, Chanock, Stephen J., Rothman, Nathaniel, and Lan, Qing

Published
2015
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10. Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Author

Hosgood, III, H. Dean, Wang, Wen-Chang, Hong, Yun-Chul, Wang, Jiu-Cun, Chen, Kexin, Chang, I-Shou, Chen, Chien-Jen, Lu, Daru, Yin, Zhihua, Wu, Chen, Zheng, Wei, Qian, Biyun, Park, Jae Yong, Kim, Yeul Hong, Chatterjee, Nilanjan, Chen, Ying, Chang, Gee-Chen, Hsiao, Chin-Fu, Yeager, Meredith, Tsai, Ying-Huang, Wei, Hu, Kim, Young Tae, Wu, Wei, Zhao, Zhenhong, Chow, Wong-Ho, Zhu, Xiaoling, Lo, Yen-Li, Sung, Sook Whan, Chen, Kuan-Yu, Yuenger, Jeff, Kim, Joo Hyun, Huang, Liming, Chen, Ying-Hsiang, Gao, Yu-Tang, Kim, Jin Hee, Huang, Ming-Shyan, Jung, Tae Hoon, Caporaso, Neil, Zhao, Xueying, Huan, Zhang, Yu, Dianke, Kim, Chang Ho, Su, Wu-Chou, Shu, Xiao-Ou, Kim, In-San, Bassig, Bryan, Chen, Yuh-Min, Cha, Sung Ick, Tan, Wen, Chen, Hongyan, Yang, Tsung-Ying, Sung, Jae Sook, Wang, Chih-Liang, Li, Xuelian, Park, Kyong Hwa, Yu, Chong-Jen, Ryu, Jeong-Seon, Xiang, Yongbing, Hutchinson, Amy, Kim, Jun Suk, Cai, Qiuyin, Landi, Maria Teresa, Lee, Kyoung-Mu, Hung, Jen-Yu, Park, Ju-Yeon, Tucker, Margaret, Lin, Chien-Chung, Ren, Yangwu, Perng, Reury-Perng, Chen, Chih-Yi, Jin, Li, Chen, Kun-Chieh, Li, Yao-Jen, Chiu, Yu-Fang, Tsai, Fang-Yu, Yang, Pan-Chyr, Fraumeni, Jr., Joseph F., Seow, Adeline, Lin, Dongxin, Zhou, Baosen, Chanock, Stephen, Hsiung, Chao Agnes, Rothman, Nathaniel, and Lan, Qing

Published
2012
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11. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Author

Howson, Joanna M.M., Zhao, Wei, Barnes, Daniel R., Ho, Weang-Kee, Young, Robin, Paul, Dirk S., Waite, Lindsay L., Freitag, Daniel F., Fauman, Eric B., Salfati, Elias L., Sun, Benjamin B., Eicher, John D., Johnson, Andrew D., Sheu, Wayne H.H., Nielsen, Sune F., Lin, Wei-Yu, Surendran, Praveen, Malarstig, Anders, Wilk, Jemma B., Tybjærg-Hansen, Anne, Rasmussen, Katrine L., Kamstrup, Pia R., Deloukas, Panos, Erdmann, Jeanette, Kathiresan, Sekar, Samani, Nilesh J., Schunkert, Heribert, Watkins, Hugh, Do, Ron, Rader, Daniel J., Johnson, Julie A., Hazen, Stanley L., Quyyumi, Arshed A., Spertus, John A., Pepine, Carl J., Franceschini, Nora, Justice, Anne, Reiner, Alex P., Buyske, Steven, Hindorff, Lucia A., Carty, Cara L., North, Kari E., Kooperberg, Charles, Boerwinkle, Eric, Young, Kristin, Graff, Mariaelisa, Peters, Ulrike, Absher, Devin, Hsiung, Chao A., Lee, Wen-Jane, Taylor, Kent D., Chen, Ying-Hsiang, Lee, I-Te, Guo, Xiuqing, Chung, Ren-Hua, Hung, Yi-Jen, Rotter, Jerome I., Juang, Jyh-Ming J., Quertermous, Thomas, Wang, Tzung-Dau, Rasheed, Asif, Frossard, Philippe, Alam, Dewan S., Majumder, Abdulla Al Shafi, Di Angelantonio, Emanuele, Chowdhury, Rajiv, Chen, Yii-Der Ida, Nordestgaard, Børge G., Assimes, Themistocles L., Danesh, John, Butterworth, Adam S., and Saleheen, Danish

Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 × 10(-8), in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanisms.

Published
2017

14. Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study

Author

Chen, Ching-Yu Julius, primary, Juang, Jyh-Ming Jimmy, additional, Chen, Ying-Hsiang, additional, Wu, I-Chien, additional, Hsu, Chih-Cheng, additional, Wu, Ray-Chin, additional, Chen, Kwo-Ching, additional, Liaw, Wen-Jin, additional, Tsai, Tsung-Lung, additional, Lin, Lian-Yu, additional, Hwang, Juey-Jen, additional, Ho, Li-Ting, additional, Yu, Chih-Chien, additional, Lee, Jen-Kuang, additional, Wu, Cho-Kai, additional, Yeh, Shih-Fan Sherri, additional, Yang, Dun-Hui, additional, Chang, I-Shou, additional, Lai, Ling-Ping, additional, Chiang, Fu-Tien, additional, Lin, Jiunn-Lee, additional, and Hsiung, Chao Agnes, additional

Published
2017
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15. Analysis of heritability and shared heritability based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., de Sanjose, Silvia, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan

Subjects
Adult, Asian Continental Ancestry Group, Male, Lung Neoplasms, DATABASE, European Continental Ancestry Group, RELATIVES, Bone Neoplasms, Polymorphism, Single Nucleotide, Article, LUNG-CANCER, Testicular Neoplasms, Neoplasms, SWEDEN, LYMPHOMA, Humans, Genetic Predisposition to Disease, FAMILIAL RISK, Oncology & Carcinogenesis, Aged, Osteosarcoma, Science & Technology, MUTATIONS, Smoking, Middle Aged, Leukemia, Lymphocytic, Chronic, B-Cell, PANCREATIC-CANCER, Kidney Neoplasms, MULTIPLE SUSCEPTIBILITY LOCI, INDIVIDUALS, Oncology, Urinary Bladder Neoplasms, Tissue Array Analysis, Female, Lymphoma, Large B-Cell, Diffuse, Life Sciences & Biomedicine, 1112 Oncology And Carcinogenesis, Genome-Wide Association Study
Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common SNPs for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49,492 cancer cases and 34,131 controls. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl2, on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% CI = 14% - 37%) and 7% (4% - 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ=0.73, SE=0.28), Diffuse Large B-Cell Lymphoma (DLBCL) and pediatric osteosarcoma (ρ=0.53, SE=0.21), DLBCL and Chronic Lymphocytic Leukemia (CLL) (ρ=0.51, SE=0.18), and bladder and lung (ρ=0.35, SE=0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a non-smoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

16. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Author

LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E, Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y Y, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L, Laird-Offringa, Ite A, Marconett, Crystal N, Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., Lan, Qing, LS IRAS EEPI GRA (Gezh.risico-analyse), dIRAS RA-2, Seow, Wei Jie, Matsuo, Keitaro, Hsiung, Chao Agnes, Shiraishi, Kouya, Song, Minsun, Kim, Hee Nam, Wong, Maria Pik, Hong, Yun-Chul, Hosgood, H. Dean, Wang, Zhaoming, Chang, I-Shou, Wang, Jiu-Cun, Chatterjee, Nilanjan, Tucker, Margaret, Wei, Hu, Mitsudomi, Tetsuya, Zheng, Wei, Kim, Jin Hee, Zhou, Baosen, Caporaso, Neil E, Albanes, Demetrius, Shin, Min-Ho, Chung, Lap Ping, An, She-Juan, Wang, Ping, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young Tae, Shu, Xiao Ou, Kim, Young-Chul, Bassig, Bryan A., Chang, Jiang, Ho, James Chung Man, Ji, Bu Tian, Kubo, Michiaki, Daigo, Yataro, Ito, Hidemi, Momozawa, Yukihide, Ashikawa, Kyota, Kamatani, Yoichiro, Honda, Takayuki, Sakamoto, Hiromi, Kunitoh, Hideo, Tsuta, Koji, Watanabe, Shun-Ichi, Nokihara, Hiroshi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Tsuboi, Masahiro, Goto, Koichi, Yin, Zhihua, Shi, Jianxin, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Shimizu, Kimihiro, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Wong, Jason Y Y, Matsuda, Fumihiko, Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Song, Fengju, Lee, Victor Ho Fun, Su, Wu-Chou, Chen, Yuh-Min, Chang, Gee-Chen, Chen, Kuan-Yu, Huang, Ming-Shyan, Yang, Pan-Chyr, Lin, Hsien-Chih, Xiang, Yong-Bing, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Chien-Jen, Li, Haixin, Gao, Yu Tang, Wu, Chen, Qian, Biyun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Wang, Wen-Chang, Chung, Charles C., Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Jacobs, Kevin B., Hutchinson, Amy, Berndt, Sonja I., He, Xingzhou, Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Wang, Chih-Liang, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Chen, Chih-Yi, Vermeulen, Roel, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Li, Jihua, Chen, Hongyan, Yu, Chong-Jen, Jin, Li, Lo, Yen-Li, Chen, Ying-Hsiang, Fraumeni, Joseph F., Liu, Jie, Yamaji, Taiki, Yang, Yang, Hicks, Belynda, Wyatt, Kathleen, Li, Shengchao A, Dai, Juncheng, Ma, Hongxia, Jin, Guangfu, Song, Bao, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Cui, Ping, Iwasaki, Motoki, Shimazu, Taichi, Tsugane, Shoichiro, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chien, Li-Hsin, Chen, Hui-Ling, Su, Yu-Chun, Tsai, Fang-Yu, Chen, Yi-Song, Yu, Jinming, Stevens, Victoria L, Laird-Offringa, Ite A, Marconett, Crystal N, Lin, Dongxin, Chen, Kexin, Wu, Yi-Long, Landi, Maria Teresa, Shen, Hongbing, Rothman, Nathaniel, Kohno, Takashi, Chanock, Stephen J., and Lan, Qing

Published
2017

17. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and Freedman, Neal D. Freeman, Laura E. Beane Fuchs, Charles and Gago-Dominguez, Manuela Gallinger, Steven Gao, Yu-Tang and Gapstur, Susan M. Garcia-Closas, Montserrat Garcia-Closas, Reina and Gascoyne, Randy D. Gastier-Foster, Julie Gaudet, Mia M. and Gaziano, J. Michael Giffen, Carol Giles, Graham G. and Giovannucci, Edward Glimelius, Bengt Goggins, Michael and Gokgoz, Nalan Goldstein, Alisa M. Gorlick, Richard Gross, Myron Grubb, III, Robert Gu, Jian Guan, Peng Gunter, Marc Guo, Huan Habermann, Thomas M. Haiman, Christopher A. and Halai, Dina Hallmans, Goran Hassan, Manal Hattinger, Claudia He, Qincheng He, Xingzhou Helzlsouer, Kathy and Henderson, Brian Henriksson, Roger Hjalgrim, Henrik and Hoffman-Bolton, Judith Hohensee, Chancellor Holford, Theodore R. and Holly, Elizabeth A. Hong, Yun-Chul Hoover, Robert N. and Horn-Ross, Pamela L. Hosain, G. M. Monawar Hosgood, III, H. Dean and Hsiao, Chin-Fu Hu, Nan Hu, Wei Hu, Zhibin Huang, Ming-Shyan Huerta, Jose-Maria Hung, Jen-Yu Hutchinson, Amy and Inskip, Peter D. Jackson, Rebecca D. Jacobs, Eric J. and Jenab, Mazda Jeon, Hyo-Sung Ji, Bu-Tian Jin, Guangfu and Jin, Li Johansen, Christoffer Johnson, Alison Jung, Yoo Jin and Kaaks, Rudolph Kamineni, Aruna Kane, Eleanor Kang, Chang Hyun Karagas, Margaret R. Kelly, Rachel S. Khaw, Kay-Tee and Kim, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk and Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kitahara, Cari M. Klein, Alison P. Klein, Robert J. Kogevinas, Manolis and Kohno, Takashi Kolonel, Laurence N. Kooperberg, Charles and Kricker, Anne Krogh, Vittorio Kunitoh, Hideo Kurtz, Robert C. Kweon, Sun-Seog LaCroix, Andrea Lawrence, Charles and Lecanda, Fernando Lee, Victor Ho Fun Li, Donghui Li, Haixin and Li, Jihua Li, Yao-Jen Li, Yuqing Liao, Linda M. and Liebow, Mark Lightfoot, Tracy Lim, Wei-Yen Lin, Chien-Chung and Lin, Dongxin Lindstrom, Sara Linet, Martha S. Link, Brian K. Liu, Chenwei Liu, Jianjun Liu, Li Ljungberg, Boerje Lloreta, Josep Di Lollo, Simonetta Lu, Daru Lund, Eiluv Malats, Nuria Mannisto, Satu Le Marchand, Loic and Marina, Neyssa Masala, Giovanna Mastrangelo, Giuseppe and Matsuo, Keitaro Maynadie, Marc Mckay, James McKean-Cowdin, Roberta Melbye, Mads Melin, Beatrice S. Michaud, Dominique S. Mitsudomi, Tetsuya Monnereau, Alain Montalvan, Rebecca and Moore, Lee E. Mortensen, Lotte Maxild Nieters, Alexandra and North, Kari E. Novak, Anne J. Oberg, Ann L. Offit, Kenneth and Oh, In-Jae Olson, Sara H. Palli, Domenico Pao, William and Park, In Kyu Park, Jae Yong Park, Kyong Hwa and Patino-Garcia, Ana Pavanello, Sofia Peeters, Petra H. M. and Perng, Reury-Perng Peters, Ulrike Petersen, Gloria M. Picci, Piero Pike, Malcolm C. Porru, Stefano Prescott, Jennifer and Prokunina-Olsson, Ludmila Qian, Biyun Qiao, You-Lin Rais, Marco Riboli, Elio Riby, Jacques Risch, Harvey A. and Rizzato, Cosmeri Rodabough, Rebecca Roman, Eve Roupret, Morgan Ruder, Avima M. de Sanjose, Silvia Scelo, Ghislaine and Schned, Alan Schumacher, Fredrick Schwartz, Kendra and Schwenn, Molly Scotlandi, Katia Seow, Adeline Serra, Consol and Serra, Massimo Sesso, Howard D. Setiawan, Veronica Wendy and Severi, Gianluca Severson, Richard K. Shanafelt, Tait D. and Shen, Hongbing Shen, Wei Shin, Min-Ho Shiraishi, Kouya and Shu, Xiao-Ou Siddiq, Afshan Sierrasesumaga, Luis Sihoe, Alan Dart Loon Skibola, Christine F. Smith, Alex Smith, Martyn T. and Southey, Melissa C. Spinelli, John J. Staines, Anthony and Stampfer, Meir Stern, Marianna C. Stevens, Victoria L. and Stolzenberg-Solomon, Rachael S. Su, Jian Su, Wu-Chou Sund, Malin Sung, Jae Sook Sung, Sook Whan Tan, Wen Tang, Wei and Tardon, Adonina Thomas, David Thompson, Carrie A. and Tinker, Lesley F. Tirabosco, Roberto Tjonneland, Anne and Travis, Ruth C. Trichopoulos, Dimitrios Tsai, Fang-Yu Tsai, Ying-Huang Tucker, Margaret Turner, Jenny Vajdic, Claire M. and Vermeulen, Roel C. H. Villano, Danylo J. Vineis, Paolo and Virtamo, Jarmo Visvanathan, Kala Wactawski-Wende, Jean Wang, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wei, Fusheng Weiderpass, Elisabete Weiner, George J. Weinstein, Stephanie Wentzensen, Nicolas White, Emily Witzig, Thomas E. and Wolpin, Brian M. Wong, Maria Pik Wu, Chen Wu, Guoping and Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wunder, Jay S. Xiang, Yong-Bing Xu, Jun Xu, Ping and Yang, Pan-Chyr Yang, Tsung-Ying Ye, Yuanqing Yin, Zhihua and Yokota, Jun Yoon, Ho-Il Yu, Chong-Jen Yu, Herbert and Yu, Kai Yuan, Jian-Min Zelenetz, Andrew Zeleniuch-Jacquotte, Anne Zhang, Xu-Chao Zhang, Yawei Zhao, Xueying Zhao, Zhenhong Zheng, Hong Zheng, Tongzhang Zheng, Wei Zhou, Baosen Zhu, Meng Zucca, Mariagrazia Boca, Simina M. and Cerhan, James R. Ferri, Giovanni M. Hartge, Patricia Hsiung, Chao Agnes Magnani, Corrado Miligi, Lucia Morton, Lindsay M. and Smedby, Karin E. Teras, Lauren R. Vijai, Joseph Wang, Sophia S. Brennan, Paul Caporaso, Neil E. Hunter, David J. and Kraft, Peter Rothman, Nathaniel Silverman, Debra T. and Slager, Susan L. Chanock, Stephen J. Chatterjee, Nilanjan

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusion: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

18. Association between GWAS-identified lung adenocarcinoma susceptibility loci andEGFRmutations in never-smoking Asian women, and comparison with findings from Western populations

Author

Seow, Wei Jie, primary, Matsuo, Keitaro, additional, Hsiung, Chao Agnes, additional, Shiraishi, Kouya, additional, Song, Minsun, additional, Kim, Hee Nam, additional, Wong, Maria Pik, additional, Hong, Yun-Chul, additional, Hosgood, H. Dean, additional, Wang, Zhaoming, additional, Chang, I-Shou, additional, Wang, Jiu-Cun, additional, Chatterjee, Nilanjan, additional, Tucker, Margaret, additional, Wei, Hu, additional, Mitsudomi, Tetsuya, additional, Zheng, Wei, additional, Kim, Jin Hee, additional, Zhou, Baosen, additional, Caporaso, Neil E., additional, Albanes, Demetrius, additional, Shin, Min-Ho, additional, Chung, Lap Ping, additional, An, She-Juan, additional, Wang, Ping, additional, Zheng, Hong, additional, Yatabe, Yasushi, additional, Zhang, Xu-Chao, additional, Kim, Young Tae, additional, Shu, Xiao-Ou, additional, Kim, Young-Chul, additional, Bassig, Bryan A., additional, Chang, Jiang, additional, Ho, James Chung Man, additional, Ji, Bu-Tian, additional, Kubo, Michiaki, additional, Daigo, Yataro, additional, Ito, Hidemi, additional, Momozawa, Yukihide, additional, Ashikawa, Kyota, additional, Kamatani, Yoichiro, additional, Honda, Takayuki, additional, Sakamoto, Hiromi, additional, Kunitoh, Hideo, additional, Tsuta, Koji, additional, Watanabe, Shun-Ichi, additional, Nokihara, Hiroshi, additional, Miyagi, Yohei, additional, Nakayama, Haruhiko, additional, Matsumoto, Shingo, additional, Tsuboi, Masahiro, additional, Goto, Koichi, additional, Yin, Zhihua, additional, Shi, Jianxin, additional, Takahashi, Atsushi, additional, Goto, Akiteru, additional, Minamiya, Yoshihiro, additional, Shimizu, Kimihiro, additional, Tanaka, Kazumi, additional, Wu, Tangchun, additional, Wei, Fusheng, additional, Wong, Jason Y.Y., additional, Matsuda, Fumihiko, additional, Su, Jian, additional, Kim, Yeul Hong, additional, Oh, In-Jae, additional, Song, Fengju, additional, Lee, Victor Ho Fun, additional, Su, Wu-Chou, additional, Chen, Yuh-Min, additional, Chang, Gee-Chen, additional, Chen, Kuan-Yu, additional, Huang, Ming-Shyan, additional, Yang, Pan-Chyr, additional, Lin, Hsien-Chih, additional, Xiang, Yong-Bing, additional, Seow, Adeline, additional, Park, Jae Yong, additional, Kweon, Sun-Seog, additional, Chen, Chien-Jen, additional, Li, Haixin, additional, Gao, Yu-Tang, additional, Wu, Chen, additional, Qian, Biyun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Wang, Wen-Chang, additional, Chung, Charles C., additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Jacobs, Kevin B., additional, Hutchinson, Amy, additional, Berndt, Sonja I., additional, He, Xingzhou, additional, Wu, Wei, additional, Wang, Junwen, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Wang, Chih-Liang, additional, Sihoe, Alan Dart Loon, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chan, John K.C., additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Li, Jihua, additional, Chen, Hongyan, additional, Yu, Chong-Jen, additional, Jin, Li, additional, Lo, Yen-Li, additional, Chen, Ying-Hsiang, additional, Fraumeni, Joseph F., additional, Liu, Jie, additional, Yamaji, Taiki, additional, Yang, Yang, additional, Hicks, Belynda, additional, Wyatt, Kathleen, additional, Li, Shengchao A., additional, Dai, Juncheng, additional, Ma, Hongxia, additional, Jin, Guangfu, additional, Song, Bao, additional, Wang, Zhehai, additional, Cheng, Sensen, additional, Li, Xuelian, additional, Ren, Yangwu, additional, Cui, Ping, additional, Iwasaki, Motoki, additional, Shimazu, Taichi, additional, Tsugane, Shoichiro, additional, Zhu, Junjie, additional, Jiang, Gening, additional, Fei, Ke, additional, Wu, Guoping, additional, Chien, Li-Hsin, additional, Chen, Hui-Ling, additional, Su, Yu-Chun, additional, Tsai, Fang-Yu, additional, Chen, Yi-Song, additional, Yu, Jinming, additional, Stevens, Victoria L., additional, Laird-Offringa, Ite A., additional, Marconett, Crystal N., additional, Lin, Dongxin, additional, Chen, Kexin, additional, Wu, Yi-Long, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Rothman, Nathaniel, additional, Kohno, Takashi, additional, Chanock, Stephen J., additional, and Lan, Qing, additional

Published
2016
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19. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author

Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and F and Sampson, Joshua N. Wheeler, William A. Yeager, Meredith and Panagiotou, Orestis Wang, Zhaoming Berndt, Sonja I. Lan, Qing Abnet, Christian C. Amundadottir, Laufey T. Figueroa, Jonine D. Landi, Maria Teresa Mirabello, Lisa Savage, Sharon A. Taylor, Philip R. De Vivo, Immaculata McGlynn, Katherine A. Purdue, Mark P. Rajaraman, Preetha Adami, Hans-Olov and Ahlbom, Anders Albanes, Demetrius Amary, Maria Fernanda An, She-Juan Andersson, Ulrika Andriole, Jr., Gerald Andrulis, Irene L. Angelucci, Emanuele Ansell, Stephen M. Arici, Cecilia Armstrong, Bruce K. Arslan, Alan A. Austin, Melissa A. Baris, Dalsu Barkauskas, Donald A. Bassig, Bryan A. and Becker, Nikolaus Benavente, Yolanda Benhamou, Simone Berg, Christine Van Den Berg, David Bernstein, Leslie Bertrand, Kimberly A. Birmann, Brenda M. Black, Amanda Boeing, Heiner and Boffetta, Paolo Boutron-Ruault, Marie-Christine Bracci, Paige M. Brinton, Louise Brooks-Wilson, Angela R. and Bueno-de-Mesquita, H. Bas Burdett, Laurie Buring, Julie and Butler, Mary Ann Cai, Qiuyin Cancel-Tassin, Geraldine and Canzian, Federico Carrato, Alfredo Carreon, Tania Carta, Angela Chan, John K. C. Chang, Ellen T. Chang, Gee-Chen and Chang, I-Shou Chang, Jiang Chang-Claude, Jenny Chen, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing and Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu and Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song and Chen, Yuh-Min Chien, Li-Hsin Chirlaque, Maria-Dolores and Choi, Jin Eun Choi, Yi Young Chow, Wong-Ho Chung, Charles C. and Clavel, Jacqueline Clavel-Chapelon, Franoise Cocco, Pierluigi Colt, Joanne S. Comperat, Eva Conde, Lucia and Connors, Joseph M. Conti, David Cortessis, Victoria K. and Cotterchio, Michelle Cozen, Wendy Crouch, Simon Crous-Bou, Marta Cussenot, Olivier Davis, Faith G. Ding, Ti Diver, W. Ryan Dorronsoro, Miren Dossus, Laure Duell, Eric J. and Ennas, Maria Grazia Erickson, Ralph L. Feychting, Maria and Flanagan, Adrienne M. Foretova, Lenka Fraumeni, Jr., Joseph F. and F

Abstract

Background: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Methods: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers. Results: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, h(l)(2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (rho = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (rho = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (rho = 0.51, SE = 0.18), and bladder and lung (rho = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures. Conclusio

Published
2015

20. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J, Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, H Dean, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E, Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A, Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J, Chung, Charles C, Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I, Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F, Zheng, Wei, Lin, Dongxin, Chanock, Stephen J, Rothman, Nathaniel, Lan, Qing, Machiela, Mitchell J, Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, H Dean, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E, Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A, Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J, Chung, Charles C, Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I, Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F, Zheng, Wei, Lin, Dongxin, Chanock, Stephen J, Rothman, Nathaniel, and Lan, Qing

Abstract

Recent evidence from several relatively small nested case-control studies in prospective cohorts shows an association between longer telomere length measured phenotypically in peripheral white blood cell (WBC) DNA and increased lung cancer risk. We sought to further explore this relationship by examining a panel of seven telomere-length associated genetic variants in a large study of 5,457 never-smoking female Asian lung cancer cases and 4,493 never-smoking female Asian controls using data from a previously reported genome-wide association study. Using a group of 1,536 individuals with phenotypically measured telomere length in WBCs in the prospective Shanghai Women's Health study, we demonstrated the utility of a genetic risk score (GRS) of seven telomere-length associated variants to predict telomere length in an Asian population. We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. Stratified analyses suggested the effect of the telomere-associated GRS is strongest among younger individuals. We found no difference in GRS effect between adenocarcinoma and squamous cell subtypes. Our results indicate that a genetic background that favors longer telomere length may increase lung cancer risk, which is consistent with earlier prospective studies relating longer telomere length with increased lung cancer risk.

Published
2015

21. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Risk Assessment, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan

Published
2015

22. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Machiela, Mitchell J, Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, H Dean, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E, Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A, Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J, Chung, Charles C, Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I, Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F, Zheng, Wei, Lin, Dongxin, Chanock, Stephen J, Rothman, Nathaniel, Lan, Qing, Risk Assessment, Infection & Immunity, dIRAS RA-2, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), Machiela, Mitchell J, Hsiung, Chao Agnes, Shu, Xiao-Ou, Seow, Wei Jie, Wang, Zhaoming, Matsuo, Keitaro, Hong, Yun-Chul, Seow, Adeline, Wu, Chen, Hosgood, H Dean, Chen, Kexin, Wang, Jiu-Cun, Wen, Wanqing, Cawthon, Richard, Chatterjee, Nilanjan, Hu, Wei, Caporaso, Neil E, Park, Jae Yong, Chen, Chien-Jen, Kim, Yeul Hong, Kim, Young Tae, Landi, Maria Teresa, Shen, Hongbing, Lawrence, Charles, Burdett, Laurie, Yeager, Meredith, Chang, I-Shou, Mitsudomi, Tetsuya, Kim, Hee Nam, Chang, Gee-Chen, Bassig, Bryan A, Tucker, Margaret, Wei, Fusheng, Yin, Zhihua, An, She-Juan, Qian, Biyun, Lee, Victor Ho Fun, Lu, Daru, Liu, Jianjun, Jeon, Hyo-Sung, Hsiao, Chin-Fu, Sung, Jae Sook, Kim, Jin Hee, Gao, Yu-Tang, Tsai, Ying-Huang, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Hutchinson, Amy, Wang, Wen-Chang, Klein, Robert J, Chung, Charles C, Oh, In-Jae, Chen, Kuan-Yu, Berndt, Sonja I, Wu, Wei, Chang, Jiang, Zhang, Xu-Chao, Huang, Ming-Shyan, Zheng, Hong, Wang, Junwen, Zhao, Xueying, Li, Yuqing, Choi, Jin Eun, Su, Wu-Chou, Park, Kyong Hwa, Sung, Sook Whan, Chen, Yuh-Min, Liu, Li, Kang, Chang Hyun, Hu, Lingmin, Chen, Chung-Hsing, Pao, William, Kim, Young-Chul, Yang, Tsung-Ying, Xu, Jun, Guan, Peng, Tan, Wen, Su, Jian, Wang, Chih-Liang, Li, Haixin, Sihoe, Alan Dart Loon, Zhao, Zhenhong, Chen, Ying, Choi, Yi Young, Hung, Jen-Yu, Kim, Jun Suk, Yoon, Ho-Il, Cai, Qiuyin, Lin, Chien-Chung, Park, In Kyu, Xu, Ping, Dong, Jing, Kim, Christopher, He, Qincheng, Perng, Reury-Perng, Kohno, Takashi, Kweon, Sun-Seog, Chen, Chih-Yi, Vermeulen, Roel C H, Wu, Junjie, Lim, Wei-Yen, Chen, Kun-Chieh, Chow, Wong-Ho, Ji, Bu-Tian, Chan, John K C, Chu, Minjie, Li, Yao-Jen, Yokota, Jun, Li, Jihua, Chen, Hongyan, Xiang, Yong-Bing, Yu, Chong-Jen, Kunitoh, Hideo, Wu, Guoping, Jin, Li, Lo, Yen-Li, Shiraishi, Kouya, Chen, Ying-Hsiang, Lin, Hsien-Chih, Wu, Tangchun, Wong, Maria Pik, Wu, Yi-Long, Yang, Pan-Chyr, Zhou, Baosen, Shin, Min-Ho, Fraumeni, Joseph F, Zheng, Wei, Lin, Dongxin, Chanock, Stephen J, Rothman, Nathaniel, and Lan, Qing

Published
2015

23. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, Chatterjee, Nilanjan, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Sampson, Joshua N, Wheeler, William A, Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I, Lan, Qing, Abnet, Christian C, Amundadottir, Laufey T, Figueroa, Jonine D, Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A, Taylor, Philip R, Vivo, Immaculata De, McGlynn, Katherine A, Purdue, Mark P, Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Andrulis, Irene L, Angelucci, Emanuele, Ansell, Stephen M, Arici, Cecilia, Armstrong, Bruce K, Arslan, Alan A, Austin, Melissa A, Baris, Dalsu, Barkauskas, Donald A, Bassig, Bryan A, Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A, Birmann, Brenda M, Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Brinton, Louise, Brooks-Wilson, Angela R, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K C, Chang, Ellen T, Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C, Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S, Comperat, Eva, Conde, Lucia, Connors, Joseph M, Conti, David, Cortessis, Victoria K, Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G, Ding, Ti, Diver, W Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J, Ennas, Maria Grazia, Erickson, Ralph L, Feychting, Maria, Flanagan, Adrienne M, Foretova, Lenka, Fraumeni, Joseph F, Freedman, Neal D, Beane Freeman, Laura E, Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D, Gastier-Foster, Julie, Gaudet, Mia M, Gaziano, J Michael, Giffen, Carol, Giles, Graham G, Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M, Gorlick, Richard, Gross, Myron, Grubb, Robert, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M, Haiman, Christopher A, Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Horn-Ross, Pamela L, Hosain, G M Monawar, Hosgood, H Dean, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D, Jackson, Rebecca D, Jacobs, Eric J, Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R, Kelly, Rachel S, Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M, Klein, Alison P, Klein, Robert J, Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N, Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C, Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M, Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S, Link, Brian K, Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S, Michaud, Dominique S, Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E, Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E, Novak, Anne J, Oberg, Ann L, Offit, Kenneth, Oh, In-Jae, Olson, Sara H, Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H M, Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M, Picci, Piero, Pike, Malcolm C, Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A, Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M, Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D, Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K, Shanafelt, Tait D, Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F, Smith, Alex, Smith, Martyn T, Southey, Melissa C, Spinelli, John J, Staines, Anthony, Stampfer, Meir, Stern, Marianna C, Stevens, Victoria L, Stolzenberg-Solomon, Rachael S, Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A, Tinker, Lesley F, Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C, Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M, Vermeulen, Roel C H, Villano, Danylo J, Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J, Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E, Wolpin, Brian M, Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S, Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M, Cerhan, James R, Ferri, Giovanni M, Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M, Smedby, Karin E, Teras, Lauren R, Vijai, Joseph, Wang, Sophia S, Brennan, Paul, Caporaso, Neil E, Hunter, David J, Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T, Slager, Susan L, Chanock, Stephen J, and Chatterjee, Nilanjan

Published
2015

25. Comparisons of clinical impacts on individuals with Brugada electrocardiographic patterns defined by ISHNE criteria or EHRA/HRS/APHRS criteria: a nationwide community-based study.

Author

Chen, Ching-Yu Julius, Juang, Jyh-Ming Jimmy, Chen, Ying-Hsiang, Wu, I-Chien, Hsu, Chih-Cheng, Wu, Ray-Chin, Chen, Kwo-Ching, Liaw, Wen-Jin, Tsai, Tsung-Lung, Lin, Lian-Yu, Hwang, Juey-Jen, Ho, Li-Ting, Yu, Chih-Chien, Lee, Jen-Kuang, Wu, Cho-Kai, Yeh, Shih-Fan Sherri, Yang, Dun-Hui, Chang, I-Shou, Lai, Ling-Ping, and Chiang, Fu-Tien

Abstract

Introduction: Identifying Brugada electrocardiographic pattern (BrP) early is crucial to prevent sudden cardiac death. Two different diagnostic criteria proposed by International Society for Holter and Noninvasive Electrocardiography (ISHNE) and Heart Rhythm Society/European Heart Rhythm Association/Asia-Pacific Heart Rhythm Society (HRS/EHRA/APHRS) were widely used in clinical practice. The difference in prevalence and prognosis of BrP by applying the two different criteria was never studied before. Methods: This study was prospectively conducted in a nationwide large-scale stratified random sampling community-based cohort (HALST) from Han Chinese population in Taiwan from December 2008 to December 2012. We compared the prevalence and prognosis of BrP defined by the two diagnostic criteria. Results: A total of 5214 adults were enrolled (2530 men) with mean age of 69.3 years. Four had spontaneous type 1 BrP (0.077%). By the HRS/EHRA/APHRS criteria, 68 individuals have type 2 BrP (1.30%) and 101 have type 3 BrP (1.94%) whereas by the ISHNE criteria, 46 individuals exhibited type 2 BrP (0.88%). When applying the ISHNE criteria, the number of individuals with BrP decreased by 71%. However, all-cause mortality and cardiovascular mortality were not different between individuals with or without BrP, irrespective of the criteria used. Conclusions: The two different criteria may impact the diagnostic yield of individuals with BrP, but do not affect the prognosis of the individuals with BrP. [ABSTRACT FROM AUTHOR]

Published
2018
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26. Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never-smoking women in Asia: a report from the female lung cancer consortium in Asia

Author

Machiela, Mitchell J., primary, Hsiung, Chao Agnes, additional, Shu, Xiao-Ou, additional, Seow, Wei Jie, additional, Wang, Zhaoming, additional, Matsuo, Keitaro, additional, Hong, Yun-Chul, additional, Seow, Adeline, additional, Wu, Chen, additional, Hosgood, H. Dean, additional, Chen, Kexin, additional, Wang, Jiu-Cun, additional, Wen, Wanqing, additional, Cawthon, Richard, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Caporaso, Neil E., additional, Park, Jae Yong, additional, Chen, Chien-Jen, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Chang, I-Shou, additional, Mitsudomi, Tetsuya, additional, Kim, Hee Nam, additional, Chang, Gee-Chen, additional, Bassig, Bryan A., additional, Tucker, Margaret, additional, Wei, Fusheng, additional, Yin, Zhihua, additional, An, She-Juan, additional, Qian, Biyun, additional, Lee, Victor Ho Fun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Kim, Jin Hee, additional, Gao, Yu-Tang, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Hutchinson, Amy, additional, Wang, Wen-Chang, additional, Klein, Robert J., additional, Chung, Charles C., additional, Oh, In-Jae, additional, Chen, Kuan-Yu, additional, Berndt, Sonja I., additional, Wu, Wei, additional, Chang, Jiang, additional, Zhang, Xu-Chao, additional, Huang, Ming-Shyan, additional, Zheng, Hong, additional, Wang, Junwen, additional, Zhao, Xueying, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Su, Wu-Chou, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Chen, Yuh-Min, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Pao, William, additional, Kim, Young-Chul, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Su, Jian, additional, Wang, Chih-Liang, additional, Li, Haixin, additional, Sihoe, Alan Dart Loon, additional, Zhao, Zhenhong, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Kohno, Takashi, additional, Kweon, Sun-Seog, additional, Chen, Chih-Yi, additional, Vermeulen, Roel C.H, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chow, Wong-Ho, additional, Ji, Bu-Tian, additional, Chan, John K. C., additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Yokota, Jun, additional, Li, Jihua, additional, Chen, Hongyan, additional, Xiang, Yong-Bing, additional, Yu, Chong-Jen, additional, Kunitoh, Hideo, additional, Wu, Guoping, additional, Jin, Li, additional, Lo, Yen-Li, additional, Shiraishi, Kouya, additional, Chen, Ying-Hsiang, additional, Lin, Hsien-Chih, additional, Wu, Tangchun, additional, Wong, Maria Pik, additional, Wu, Yi-Long, additional, Yang, Pan-Chyr, additional, Zhou, Baosen, additional, Shin, Min-Ho, additional, Fraumeni, Joseph F., additional, Zheng, Wei, additional, Lin, Dongxin, additional, Chanock, Stephen J., additional, Rothman, Nathaniel, additional, and Lan, Qing, additional

Published
2014
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28. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

Author

Lan, Qing, primary, Hsiung, Chao A, additional, Matsuo, Keitaro, additional, Hong, Yun-Chul, additional, Seow, Adeline, additional, Wang, Zhaoming, additional, Hosgood, H Dean, additional, Chen, Kexin, additional, Wang, Jiu-Cun, additional, Chatterjee, Nilanjan, additional, Hu, Wei, additional, Wong, Maria Pik, additional, Zheng, Wei, additional, Caporaso, Neil, additional, Park, Jae Yong, additional, Chen, Chien-Jen, additional, Kim, Yeul Hong, additional, Kim, Young Tae, additional, Landi, Maria Teresa, additional, Shen, Hongbing, additional, Lawrence, Charles, additional, Burdett, Laurie, additional, Yeager, Meredith, additional, Yuenger, Jeffrey, additional, Jacobs, Kevin B, additional, Chang, I-Shou, additional, Mitsudomi, Tetsuya, additional, Kim, Hee Nam, additional, Chang, Gee-Chen, additional, Bassig, Bryan A, additional, Tucker, Margaret, additional, Wei, Fusheng, additional, Yin, Zhihua, additional, Wu, Chen, additional, An, She-Juan, additional, Qian, Biyun, additional, Lee, Victor Ho Fun, additional, Lu, Daru, additional, Liu, Jianjun, additional, Jeon, Hyo-Sung, additional, Hsiao, Chin-Fu, additional, Sung, Jae Sook, additional, Kim, Jin Hee, additional, Gao, Yu-Tang, additional, Tsai, Ying-Huang, additional, Jung, Yoo Jin, additional, Guo, Huan, additional, Hu, Zhibin, additional, Hutchinson, Amy, additional, Wang, Wen-Chang, additional, Klein, Robert, additional, Chung, Charles C, additional, Oh, In-Jae, additional, Chen, Kuan-Yu, additional, Berndt, Sonja I, additional, He, Xingzhou, additional, Wu, Wei, additional, Chang, Jiang, additional, Zhang, Xu-Chao, additional, Huang, Ming-Shyan, additional, Zheng, Hong, additional, Wang, Junwen, additional, Zhao, Xueying, additional, Li, Yuqing, additional, Choi, Jin Eun, additional, Su, Wu-Chou, additional, Park, Kyong Hwa, additional, Sung, Sook Whan, additional, Shu, Xiao-Ou, additional, Chen, Yuh-Min, additional, Liu, Li, additional, Kang, Chang Hyun, additional, Hu, Lingmin, additional, Chen, Chung-Hsing, additional, Pao, William, additional, Kim, Young-Chul, additional, Yang, Tsung-Ying, additional, Xu, Jun, additional, Guan, Peng, additional, Tan, Wen, additional, Su, Jian, additional, Wang, Chih-Liang, additional, Li, Haixin, additional, Sihoe, Alan Dart Loon, additional, Zhao, Zhenhong, additional, Chen, Ying, additional, Choi, Yi Young, additional, Hung, Jen-Yu, additional, Kim, Jun Suk, additional, Yoon, Ho-Il, additional, Cai, Qiuyin, additional, Lin, Chien-Chung, additional, Park, In Kyu, additional, Xu, Ping, additional, Dong, Jing, additional, Kim, Christopher, additional, He, Qincheng, additional, Perng, Reury-Perng, additional, Kohno, Takashi, additional, Kweon, Sun-Seog, additional, Chen, Chih-Yi, additional, Vermeulen, Roel, additional, Wu, Junjie, additional, Lim, Wei-Yen, additional, Chen, Kun-Chieh, additional, Chow, Wong-Ho, additional, Ji, Bu-Tian, additional, Chan, John K C, additional, Chu, Minjie, additional, Li, Yao-Jen, additional, Yokota, Jun, additional, Li, Jihua, additional, Chen, Hongyan, additional, Xiang, Yong-Bing, additional, Yu, Chong-Jen, additional, Kunitoh, Hideo, additional, Wu, Guoping, additional, Jin, Li, additional, Lo, Yen-Li, additional, Shiraishi, Kouya, additional, Chen, Ying-Hsiang, additional, Lin, Hsien-Chih, additional, Wu, Tangchun, additional, Wu, Yi-Long, additional, Yang, Pan-Chyr, additional, Zhou, Baosen, additional, Shin, Min-Ho, additional, Fraumeni, Joseph F, additional, Lin, Dongxin, additional, Chanock, Stephen J, additional, and Rothman, Nathaniel, additional

Published
2012
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34. Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort).

Author

Jyh-Ming Jimmy Juang, Ching-Yu Julius Chen, Ying-Hsiang Chen, I-Chien Wu, Chih-Cheng Hsu, Lei-Na Chen, Feng-Cheng Tang, Chi-Chung Wang, Chung-Chou Juan, Hou-Chang Chiu, Huey-Ming Lo, I-Shou Chang, Juey-Jen Hwang, Ling-Ping Lai, Fu-Tien Chiang, Jiunn-Lee Lin, Chao Agnes Hsiung, Juang, Jyh-Ming Jimmy, Chen, Ching-Yu Julius, and Chen, Ying-Hsiang

Subjects
BRUGADA syndrome diagnosis, COMPARATIVE studies, DEMOGRAPHY, ELECTROCARDIOGRAPHY, RESEARCH methodology, MEDICAL cooperation, PROGNOSIS, RESEARCH, RESEARCH evaluation, SURVIVAL, EVALUATION research, BRUGADA syndrome, DISEASE prevalence
Abstract

Aims: The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older.Methods and Results: The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively).Conclusion: The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality. [ABSTRACT FROM AUTHOR]

Published
2015
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37. Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

Author

Kooperberg, Charles, Young, Kristin, North, Kari E, Lin, Wei-Yu, Zhao, Wei, Danesh, John, Graff, Mariaelisa, Sun, Benjamin B, Butterworth, Adam S, Assimes, Themistocles L, Kamstrup, Pia R, Chung, Ren-Hua, Johnson, Andrew D, Watkins, Hugh, Deloukas, Panos, Hazen, Stanley L, Carty, Cara L, Hung, Yi-Jen, Alam, Dewan S, Nielsen, Sune F, Lee, Wen-Jane, Freitag, Daniel F, Wang, Tzung-Dau, Erdmann, Jeanette, Guo, Xiuqing, Surendran, Praveen, Hindorff, Lucia A, Kathiresan, Sekar, Chen, Yii-Der Ida, Eicher, John D, Ho, Weang-Kee, Schunkert, Heribert, Wilk, Jemma B, Pepine, Carl J, Do, Ron, Franceschini, Nora, Peters, Ulrike, Di Angelantonio, Emanuele, Quertermous, Thomas, Chowdhury, Rajiv, Malarstig, Anders, Barnes, Daniel R, Sheu, Wayne H H, Johnson, Julie A, Juang, Jyh-Ming J, Reiner, Alex P, Absher, Devin, Hsiung, Chao A, Waite, Lindsay L, Frossard, Philippe, Majumder, Abdulla Al Shafi, Samani, Nilesh J, Nordestgaard, Børge G, Rotter, Jerome I, Buyske, Steven, Justice, Anne, Rasmussen, Katrine L, Fauman, Eric B, Paul, Dirk S, Saleheen, Danish, Salfati, Elias L, Young, Robin, Chen, Ying-Hsiang, Taylor, Kent D, Spertus, John A, Boerwinkle, Eric, Rader, Daniel J, Rasheed, Asif, Howson, Joanna M M, Quyyumi, Arshed A, Tybjærg-Hansen, Anne, and Lee, I-Te

Subjects
3. Good health
Abstract

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide1,2. Although 58 genomic regions have been associated with CAD to date3–9, most of the heritability is unexplained9, indicating additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and meta-analysed results with 194,427 participants previously genotyped to give a total of 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD-associations (P < 5x10-8, in fixed effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leucocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 [p.Ser219Gly]) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell type-specific gene expression and plasma protein levels shed light on potential novel disease mechanisms.

38. Prevalence and prognosis of Brugada electrocardiogram patterns in an elderly Han Chinese population: a nation-wide community-based study (HALST cohort).

Author

Juang JM, Chen CY, Chen YH, Wu IC, Hsu CC, Chen LN, Tang FC, Wang CC, Juan CC, Chiu HC, Lo HM, Chang IS, Hwang JJ, Lai LP, Chiang FT, Lin JL, and Hsiung CA

Subjects
Age Distribution, Aged, Aged, 80 and over, China epidemiology, Female, Humans, Male, Middle Aged, Prevalence, Prognosis, Reproducibility of Results, Risk Factors, Sensitivity and Specificity, Sex Distribution, Survival Rate, Taiwan epidemiology, Brugada Syndrome diagnosis, Brugada Syndrome mortality, Electrocardiography statistics & numerical data
Abstract

Aims: The exact world-wide prevalence of Brugada electrocardiogram (ECG) pattern is still unclear, especially in adults aged 55 years and older., Methods and Results: The study was conducted as part of the Healthy Aging Longitudinal Study in Taiwan (HALST). Using a stratified random sampled method, a sample of community-dwelling subjects was recruited from seven community-based regions across Taiwan. All enrolled subjects were follow-up annually and cause of death was documented by citizen death records. A total of 5214 subjects were enrolled (male/female: 2530/2684) with a mean age of 69 ± 8 years. The overall prevalence of Brugada ECG patterns was 3.32%. Four subjects carried spontaneous Type 1 Brugada ECG pattern, 68 carried Type 2, and 101 carried Type 3. Compared with the world-wide average prevalence of Brugada ECG patterns, the prevalence of spontaneous Type 1 Brugada ECG pattern in subjects from the HALST cohort was similar (0.077 vs. 0.07%) and the combined prevalence of Types 2 and 3 Brugada ECG pattern was 10 times higher (3.24 vs. 0.28%) even the mean age of study subjects was significantly higher (69 ± 8 vs. 35 ± 8, P < 0.001). However, all-cause mortality and cardiac mortality rates were not significantly different between subjects with and without Brugada ECG patterns during the 4-year follow-up (log-rank test, P = 0.21, 0.32, respectively)., Conclusion: The prevalence of Brugada ECG pattern in adults aged 55 years and older in Taiwan was higher than the average world-wide prevalence but was not associated with increased mortality., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.)

Published
2015
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39. Subband features based on higher order statistics for ECG beat classification.

Author

Chen YH and Yu SN

Subjects
Algorithms, Arrhythmias, Cardiac diagnosis, Diagnosis, Computer-Assisted, Electrocardiography methods, Equipment Design, Fourier Analysis, Humans, Models, Statistical, Neural Networks, Computer, Reproducibility of Results, Sensitivity and Specificity, Electrocardiography instrumentation, Heart Rate, Signal Processing, Computer-Assisted
Abstract

A novel feature extraction method, which uses subband features calculated from higher order statistics, is proposed for ECG beat classification. Five levels of discrete wavelet transformation (DWT) are applied to decompose the signal into six subband signals with different frequency distribution. Higher order statistics proceeds to calculate valuable features from the three midband signals. Three RR interval-related features are added to build a feature vector of 30 features. The feature extraction paradigm cooperates with the typical feedforward backpropagation neural network (FFBNN) to discriminate seven ECG beat types. Two signal selection profiles are also proposed for different experimental design. Between them, the 2nd profile which selected different beat types from each record was determined to be more appropriate and was used as a test bench for comparing with the other methods. The proposed method demonstrates a promising accuracy of 97.53%. Comparing to the method which used higher order statistics solely to the original signal, the proposed method elevates the sensitivities of most beat types. Especially in the three beat types: RBBB, VEB, and VFW, more than 4% elevations in sensitivity are observed. This study demonstrates the effectiveness of applying higher order statistics to subband signals for characterizing ECG beats for computer-aided diagnosis of heart diseases.

Published
2007
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40. Comparison of different wavelet subband features in the classification of ECG beats using probabilistic neural network.

Author

Chen YH and Yu SN

Subjects
Humans, Models, Cardiovascular, Models, Statistical, Reproducibility of Results, Sensitivity and Specificity, Signal Processing, Computer-Assisted, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac physiopathology, Diagnosis, Computer-Assisted methods, Electrocardiography methods, Heart Rate, Neural Networks, Computer, Pattern Recognition, Automated methods
Abstract

In this paper, an electrocardiogram (ECG) beat classification system based on wavelet transformation and probabilistic neural network (PNN) is proposed to discriminate six ECG beat types. The effects of two wavelet decomposition structures, the two-stage two-band and the two-stage full binary decomposition structures, in the recognition of ECG beat types are studied. The ECG beat signals are first decomposed into components in different subbands using discrete wavelet transformation. Three statistical features of each decomposed subband signals as well as the AC power and instantaneous RR interval of the original signal are exploited to characterize the ECG signals. A PNN then follows to classify the feature vectors. The result shows that features extracted from the decomposed signals based on the two-stage two-band structure outperform the two-stage full binary structure. A promising accuracy of 99.65%, with equally well recognition rates of over 99% throughout all type of ECG beats, has been achieved using the optimal feature set. Only 11 features are needed to attain this performance. The results demonstrate the effectiveness and efficiency of the proposed method for the computer-aided diagnosis of heart diseases based on ECG signals.

Published
2006
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