232 results on '"Chen, Yu-Yu"'
Search Results
2. Fully implantable and bioresorbable cardiac pacemakers without leads or batteries.
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Choi, Yeon, Yin, Rose, Pfenniger, Anna, Koo, Jahyun, Avila, Raudel, Benjamin Lee, K, Chen, Sheena, Lee, Geumbee, Li, Gang, Qiao, Yun, Murillo-Berlioz, Alejandro, Kiss, Alexi, Han, Shuling, Lee, Seung, Li, Chenhang, Xie, Zhaoqian, Chen, Yu-Yu, Burrell, Amy, Geist, Beth, Kim, Joohee, Yoon, Hong-Joon, Banks, Anthony, Kang, Seung-Kyun, Zhang, Zheng, Haney, Chad, Sahakian, Alan, Johnson, David, Efimova, Tatiana, Huang, Yonggang, Trachiotis, Gregory, Knight, Bradley, Arora, Rishi, Efimov, Igor, Rogers, John, and Jeong, Hyoyoung
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Absorbable Implants ,Animals ,Atrioventricular Block ,Disease Models ,Animal ,Dogs ,Equipment Design ,Humans ,Mice ,Pacemaker ,Artificial ,Rabbits ,Rats ,Wireless Technology - Abstract
Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.
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- 2021
3. A Functional Magnetic Resonance Imaging Study Using Dynamic Amplitude of Low-Frequency Fluctuation to Assess Brain Activity in Patients with Moyamoya Disease.
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Qian Wei, Xiao-Yu Wang, Li-Juan Zhang, Chen-Yu Yu, Hui-Ye Shu, Xu-Lin Liao, San-Hua Xu, Ting Su, Min Kang, and Yi Shao
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- 2023
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4. A programmable encapsulation system improves delivery of therapeutic bacteria in mice
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Harimoto, Tetsuhiro, Hahn, Jaeseung, Chen, Yu-Yu, Im, Jongwon, Zhang, Joanna, Hou, Nicholas, Li, Fangda, Coker, Courtney, Gray, Kelsey, Harr, Nicole, Chowdhury, Sreyan, Pu, Kelly, Nimura, Clare, Arpaia, Nicholas, Leong, Kam W., and Danino, Tal
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- 2022
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5. Catalytic Asymmetric Diastereodivergent Synthesis of 2-Alkenylindoles Bearing both Axial and Central Chirality
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Yang, Shuang, primary, Huang, Jia-Bo, additional, Wang, Da-Hua, additional, Wang, Ning-Yi, additional, Chen, Yu-Yu, additional, Ke, Xin-Yan, additional, Chen, Hao, additional, Ni, Shao-Fei, additional, Zhang, Yu-Chen, additional, and Shi, Feng, additional
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- 2024
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6. Detection of Fe3+ and Hg2+ ions through photoluminescence quenching of carbon dots derived from urea and bitter tea oil residue
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Hu, Chechia, Wang, Ke-Hsuan, Chen, Yu-Yu, Maniwa, Motoki, Andrew Lin, Kun-Yi, Kawai, Takeshi, and Chen, Wei
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- 2022
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7. Synergistic Photoredox and Electrochemical Catalysis in Organic Synthesis and Late‐Stage Functionalizations.
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Sun, Ci‐Yang, Lin, Ting‐Jun, Chen, Yu‐Yu, Li, Hung‐Li, and Chiang, Chien‐Wei
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ORGANIC synthesis ,CATALYSIS ,EXCITED states ,VISIBLE spectra ,PHOTOCATALYSTS - Abstract
This review delves into the innovative field of interfacial photoelectrochemical (iPEC) and photoelectrochemical (PEC) catalysis, the dynamic synthesis methodologies that seamlessly integrates electrochemical and photoredox catalysis for efficient and environmentally friendly reactions. Utilizing minute quantities of photocatalysts, visible light becomes a powerful tool, generating transient excited states to catalyze a spectrum of reactions through single‐electron oxidation or reduction events. The review categorizes recent advancements, highlighting applications in organic synthesis, late‐stage modifications, and the distinctive features of photoelectrochemical methodology. Despite being in its early stages, this synergistic approach holds great promise for propelling organic synthesis forward, with potential applications in large‐scale synthesis and diverse late‐stage functionalizations, including asymmetric catalysis and bioconjugation strategies for biomolecule modifications. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Research progress in imaging research of amblyopia
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Qiu-Yu Li, Chen-Yu Yu, and Yi Shao
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amblyopia ,imaging ,functional magnetic resonance imaging ,optical coherence tomography ,Ophthalmology ,RE1-994 - Abstract
Ophthalmology is a subject that mainly applying the imaging examination to diagnose. With the development of modern medicine, the study in clinical imaging of ophthalmology has made a great progress recently. Amblyopia is one of the common eye diseases, which usually result in devastating loss of vision. Sum of imaging technologies such as magnetic resonance imaging, functional magnetic resonance imaging, optical coherence tomography and optical coherence tomography angiography have been extensively used in the field of amblyopia. Then that contributed to stimulate the development of the related imaging studies. In this article, we summarized and overviewed the rencent progress of clinical imaging studies in various types of amblyopia.
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- 2021
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9. Neuroimaging Markers of Chronic Eye Diseases and Their Application Values
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Chen-Yu Yu, Rong Huang, Shi-Qi Li, and Yi Shao
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magnetic resonance imaging ,chronic eye diseases ,markers ,neurology ,application ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
In recent years, the impact of various chronic eye diseases on quality of life has become increasingly apparent. Therefore, it is particularly important to control the progress of chronic diseases at an early stage. Many studies have used neuroimaging methods to explore the effects of chronic eye diseases on the brain, and to identify changes in brain function that may act as markers for early diagnosis and treatment. This article reviews the clinical application of different techniques of functional magnetic resonance imaging in chronic eye diseases.
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- 2022
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10. Research advancement of bone marrow and adipose-derived mesenchymal stem cells in the treatment of eye diseases
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Chen-Yu Yu, Rong-Bin Liang, and Yi Shao
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mesenchymal stem cells ,dry eye disease ,retinopathy ,cornea injury ,Ophthalmology ,RE1-994 - Abstract
Mesenchymal stem cells(MSCs)are multipotent cells with high proliferation ability that can differentiate into a variety of cell types. Thus great plasticity was provided for the regeneration of somatic cells in animal individual growth. Recently, MSCs have been applied to the treatment of traumatic and degenerative diseases on account of its distinct biologic peculiarity. The cells have tremendous potential in the clinical application. This article reviewed clinical treatment of ophthalmic diseases, administration route, methods of acquiring and security about two of MSCs derived from bone marrow and adipose tissue(BMSCs and ADSCs).
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- 2021
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11. Finding new addictive QTL for yield traits based on a high-density genetic map in hybrid rice
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Zhang, Miao, Zhou, Zheng-ping, Chen, Yu-yu, Cao, Yong-run, Deng, Chen-wei, Xue, Pao, Zhan, Xiao-deng, Cheng, Shi-hua, Cao, Li-yong, and Zhang, Ying-xin
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- 2021
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12. Development of a Low Cost 15-Gsps Analog-to-Digital Converter Board by using a Field Programmable Gate Array Mezzanine Card Connector for FPGA-Based Backends.
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Homin Jiang, Chen-Yu Yu, Mark Chen, and Miter Liu
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- 2019
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13. 411 Programming immunogenicity of bacterial cancer therapy with biosensor-driven encapsulation systems
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Hahn, Jaeseung, primary, Harimoto, Tetsuhiro, additional, Chen, Yu-Yu, additional, Liguori, Filippo, additional, and Danino, Tal, additional
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- 2023
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14. An Intelligent Water Monitoring IoT System for Ecological Environment and Smart Cities
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Chen, Shih-Lun, primary, Chou, He-Sheng, additional, Huang, Chun-Hsiang, additional, Chen, Chih-Yun, additional, Li, Liang-Yu, additional, Huang, Ching-Hui, additional, Chen, Yu-Yu, additional, Tang, Jyh-Haw, additional, Chang, Wen-Hui, additional, and Huang, Je-Sheng, additional
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- 2023
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15. An Ontology-Based Herb Therapy Recommendation for Respiration System
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Chien, Hung-Yu, Chen, Jian-Fan, Chen, Yu-Yu, Lin, Pei-Syuan, Chang, Yi-Ting, Chen, Rong-Chung, Howlett, Robert James, Series editor, Jain, Lakhmi C., Series editor, Pan, Jeng-Shyang, editor, Tsai, Pei-Wei, editor, and Watada, Junzo, editor
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- 2018
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16. A ring-like accretion structure in M87 connecting its black hole and jet
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Ru-Sen Lu, Keiichi Asada, Thomas P. Krichbaum, Jongho Park, Fumie Tazaki, Hung-Yi Pu, Masanori Nakamura, Andrei Lobanov, Kazuhiro Hada, Kazunori Akiyama, Jae-Young Kim, Ivan Marti-Vidal, José L. Gómez, Tomohisa Kawashima, Feng Yuan, Eduardo Ros, Walter Alef, Silke Britzen, Michael Bremer, Avery E. Broderick, Akihiro Doi, Gabriele Giovannini, Marcello Giroletti, Paul T. P. Ho, Mareki Honma, David H. Hughes, Makoto Inoue, Wu Jiang, Motoki Kino, Shoko Koyama, Michael Lindqvist, Jun Liu, Alan P. Marscher, Satoki Matsushita, Hiroshi Nagai, Helge Rottmann, Tuomas Savolainen, Karl-Friedrich Schuster, Zhi-Qiang Shen, Pablo de Vicente, R. Craig Walker, Hai Yang, J. Anton Zensus, Juan Carlos Algaba, Alexander Allardi, Uwe Bach, Ryan Berthold, Dan Bintley, Do-Young Byun, Carolina Casadio, Shu-Hao Chang, Chih-Cheng Chang, Song-Chu Chang, Chung-Chen Chen, Ming-Tang Chen, Ryan Chilson, Tim C. Chuter, John Conway, Geoffrey B. Crew, Jessica T. Dempsey, Sven Dornbusch, Aaron Faber, Per Friberg, Javier González García, Miguel Gómez Garrido, Chih-Chiang Han, Kuo-Chang Han, Yutaka Hasegawa, Ruben Herrero-Illana, Yau-De Huang, Chih-Wei L. Huang, Violette Impellizzeri, Homin Jiang, Hao Jinchi, Taehyun Jung, Juha Kallunki, Petri Kirves, Kimihiro Kimura, Jun Yi Koay, Patrick M. Koch, Carsten Kramer, Alex Kraus, Derek Kubo, Cheng-Yu Kuo, Chao-Te Li, Lupin Chun-Che Lin, Ching-Tang Liu, Kuan-Yu Liu, Wen-Ping Lo, Li-Ming Lu, Nicholas MacDonald, Pierre Martin-Cocher, Hugo Messias, Zheng Meyer-Zhao, Anthony Minter, Dhanya G. Nair, Hiroaki Nishioka, Timothy J. Norton, George Nystrom, Hideo Ogawa, Peter Oshiro, Nimesh A. Patel, Ue-Li Pen, Yurii Pidopryhora, Nicolas Pradel, Philippe A. Raffin, Ramprasad Rao, Ignacio Ruiz, Salvador Sanchez, Paul Shaw, William Snow, T. K. Sridharan, Ranjani Srinivasan, Belén Tercero, Pablo Torne, Efthalia Traianou, Jan Wagner, Craig Walther, Ta-Shun Wei, Jun Yang, Chen-Yu Yu, CAS - Shanghai Astronomical Observatory, Academia Sinica - Institute of Astronomy and Astrophysics, Max Planck Institute for Radio Astronomy, National Astronomical Observatory of Japan, Harvard University, Universidad de Valencia, CSIC - Institute of Astrophysics of Andalusia, The University of Tokyo, Institut de Radio Astronomie Millimétrique, University of Waterloo, JAXA Institute of Space and Astronautical Science, Universita di Bologna, INAF Istituto di Radioastronomia, Instituto Nacional de Astrofisica Optica y Electronica, Kogakuin University, Chalmers University of Technology, Boston University, The Graduate University for Advanced Studies, Department of Electronics and Nanoengineering, National Radio Astronomy Observatory Socorro, University of Malaya, University of Vermont, East Asian Observatory, Korea Astronomy and Space Science Institute, Foundation for Research and Technology - Hellas, National Chung-Shan Institute of Science and Technology, Massachusetts Institute of Technology, Western University, European Southern Observatory Santiago, Leiden University, Metsähovi Radio Observatory, Japan Aerospace Exploration Agency, National Sun Yat-sen University, National Cheng Kung University, Universidad de Concepción, National Radio Astronomy Observatory, IGN Yebes, Aalto-yliopisto, and Aalto University
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High Energy Astrophysical Phenomena (astro-ph.HE) ,Multidisciplinary ,Astrophysics of Galaxies (astro-ph.GA) ,FOS: Physical sciences ,General Relativity and Quantum Cosmology (gr-qc) ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies ,General Relativity and Quantum Cosmology - Abstract
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation^{1,2}. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure, which was interpreted as gravitationally lensed emission around a central black hole^3. Here we report images of M87 obtained in 2018, at a wavelength of 3.5 mm, showing that the compact radio core is spatially resolved. High-resolution imaging shows a ring-like structure of 8.4_{-1.1}^{+0.5} Schwarzschild radii in diameter, approximately 50% larger than that seen at 1.3 mm. The outer edge at 3.5 mm is also larger than that at 1.3 mm. This larger and thicker ring indicates a substantial contribution from the accretion flow with absorption effects in addition to the gravitationally lensed ring-like emission. The images show that the edge-brightened jet connects to the accretion flow of the black hole. Close to the black hole, the emission profile of the jet-launching region is wider than the expected profile of a black-hole-driven jet, suggesting the possible presence of a wind associated with the accretion flow., 50 pages, 18 figures, 3 tables, author's version of the paper published in Nature
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- 2023
17. A distance-based weighting framework for boosting the performance of dynamic ensemble selection
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Zhang, Zhong-Liang, Chen, Yu-Yu, Li, Jing, and Luo, Xing-Gang
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- 2019
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18. Metal microparticle – Polymer composites as printable, bio/ecoresorbable conductive inks
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Lee, Seungae, Koo, Jahyun, Kang, Seung-Kyun, Park, Gayoung, Lee, Yung Jong, Chen, Yu-Yu, Lim, Seon Ah, Lee, Kyung-Mi, and Rogers, John A.
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- 2018
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19. Localization of electromagnetic waves in two-dimensional random dielectric systems
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Gupta, Bikash C., Chen, Yu-Yu, and Ye, Zhen
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Condensed Matter - Disordered Systems and Neural Networks - Abstract
We rigorously calculate the propagation and scattering of electromagnetic waves by rectangular and random arrays of dielectric cylinders in a uniform medium. For regular arrays, the band structures are computed and complete bandgaps are discovered. For random arrays, the phenomenon of wave localization is investigated and compared in two scenarios: (1) wave propagating through the array of cylinders; this is the scenario which has been commonly considered in the literature, and (2) wave transmitted from a source located inside the ensemble. We show that within complete band gaps, results from the two scenarios are similar. Outside the gaps, however, there is a distinct difference, that is, waves can be blocked from propagation by disorders in the first scenario, but such an inhibition may not lead to inhibition or wave localization in the second scenario. The study suggests that the traditional method may be ambiguous in discerning localization effects., Comment: 5 pages, 5 figures
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- 2002
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20. Wireless bioresorbable electronic system enables sustained nonpharmacological neuroregenerative therapy
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Koo, Jahyun, MacEwan, Matthew R., Kang, Seung-Kyun, Won, Sang Min, Stephen, Manu, Gamble, Paul, Xie, Zhaoqian, Yan, Ying, Chen, Yu-Yu, Shin, Jiho, Birenbaum, Nathan, Chung, Sangjin, Kim, Sung Bong, Khalifeh, Jawad, Harburg, Daniel V., Bean, Kelsey, Paskett, Michael, Kim, Jeonghyun, Zohny, Zohny S., Lee, Seung Min, Zhang, Ruoyao, Luo, Kaijing, Ji, Bowen, Banks, Anthony, Lee, Hyuck Mo, Huang, Younggang, Ray, Wilson Z., and Rogers, John A.
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- 2018
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21. Propagation inhibition and wave localization in a 2D random liquid medium
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Chen, Yu-Yu and Ye, Zhen
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Condensed Matter - Disordered Systems and Neural Networks - Abstract
Acoustic propagation and scattering in water containing many parallel air-filled cylinders is studied. Two situations are considered and compared: (1) wave propagating through the array of cylinders, imitating a traditional experimental setup, and (2) wave transmitted from a source located inside the ensemble. We show that waves can be blocked from propagation by disorders in the first scenario, but the inhibition does not necessarily imply wave localization. Furthermore, the results reveal the phenomenon of wave localization in a range of frequencies., Comment: Typos in Fiures are corrected
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- 2001
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22. Nonconventional Fluorescent Hyperbranched Polymer Dots as Skin Nanocarriers Constructed from an Olefinic Aliphatic AB2-Type Monomer
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Chang, Chang-Cheng, primary, Chen, Yu-Yu, additional, Chiang, Hsiu-Mei, additional, Shen, Yu-Fang, additional, Wang, Jian-Cheng, additional, Ma, Kang-Chiao, additional, Lin, Ching-Hsuan, additional, and Juang, Tzong-Yuan, additional
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- 2022
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23. Investigating Why Sulfurization Can Greatly Improve Ethanol Selectivity for Carbon Dioxide Electroreduction
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Wang, Qian-Yu, primary, Li, Yu-Hang, additional, Zhao, Yu, additional, Chen, Yu-Yu, additional, Geng, Bi-Jun, additional, Ye, Rong-Kai, additional, Liu, Qiong, additional, Liu, Xiao-Qing, additional, Tong, Ye-Xiang, additional, Zhang, Yue-Jiao, additional, Cheng, Jun, additional, Fang, Ping-Ping, additional, Hu, Jian-Qiang, additional, Li, Jian-Feng, additional, and Tian, Zhong-Qun, additional
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- 2022
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24. Effects of Thickness of a Low-Temperature Buffer and Impurity Incorporation on the Characteristics of Nitrogen-polar GaN
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Yang, Fann-Wei, Chen, Yu-Yu, Feng, Shih-Wei, Sun, Qian, and Han, Jung
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- 2016
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25. Investigation of changes in activity and function in acute unilateral open globe injury–associated brain regions based on percent amplitude of fluctuation method: a resting-state functional MRI study
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Yi Shao, Chen-Yu Yu, Yi-Cong Pan, Chu-Qi Li, Hui-Ye Shu, Fan Yao, and Li-Juan Zhang
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Male ,medicine.medical_specialty ,Brain activity and meditation ,Hospital Anxiety and Depression Scale ,Amygdala ,Cerebellum ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Depression (differential diagnoses) ,Brain Mapping ,Radiological and Ultrasound Technology ,Resting state fMRI ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Brain ,General Medicine ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,ROC Curve ,Disease Progression ,Cardiology ,Anxiety ,Female ,medicine.symptom ,Functional magnetic resonance imaging ,business - Abstract
Background Open globe injury (OGI) is a serious condition that can lead to visual impairment and lifelong sequelae, brain activity of some brain regions would change in patients with OGI. Purpose To evaluate changes in brain activity associated with unilateral OGI by resting-state functional magnetic resonance imaging (rs-fMRI) and analysis of percentage amplitude of fluctuation (PerAF). Material and Methods A total of 22 patients with OGI (12 men, 10 women) and 22 healthy controls (HCs) matched for sex, age, and body weight were enrolled. All patients underwent rs-fMRI scans. Brain activity in the relevant brain regions was assessed with the PerAF method. The ability of PerAF to distinguish patients with OGI from HCs was assessed by receiver operating characteristic (ROC) curve analysis. We also examined the relationship between Hospital Anxiety and Depression Scale (HADS) scores and PerAF signals by Pearson’s correlation analysis. Results PerAF values in amygdala_R and Frontal_Inf_Orb_L/Frontal_Inf_Oper_L were increased whereas that in Cerebellum Anterior Lobe/Cerebelum_8_L was decreased in patients with OGI compared to HCs. The areas under the ROC curve showed that these brain regions could distinguish between patients with OGI and HCs. The PerAF value of amygdala_R was positively correlated with HADS scores. Conclusion Changes in PerAF in the amygdala_R, Frontal_inferior_Orb_L/Frontal_Inf_Oper_L, and Cerebellum Anterior Lobe/Cerebelum_8_L in patients with OGI may be related to an increased risk of developing psychiatric disorders such as anxiety and depression. PerAF can be used to investigate the neural basis of complications associated with OGI and monitor disease progression.
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- 2021
26. Mapping of qTGW1.1, a Quantitative Trait Locus for 1000-Grain Weight in Rice (Oryza sativa L.)
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ZHANG Hong-wei, CHEN Yu-yu, CHEN Jun-yu, ZHU Yu-jun, HUANG De-run, FAN Ye-yang, and ZHUANG Jie-yun
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1000-grain weight ,minor effect ,quantitative trait locus ,rice (Oryza sativa L.) ,Plant culture ,SB1-1110 - Abstract
1000-grain weight (TGW) is one of the three component traits of the grain yield in rice (Oryza sativa L). This study was conducted to validate and fine-map qTGW1.1, a minor QTL for TGW which was previously located in a 3.7-Mb region on the long arm of rice chromosome 1. Five sets of near isogenic lines (NILs) were developed from two BC2F4 populations of the indica rice cross Zhenshan 973/Milyang 46. The NIL sets consisted of two homozygous genotypic groups differing in the regions RM11448−RM11522, RM11448−RM11549, RM1232−RM11615, RM11543−RM11554 and RM11569−RM11621, respectively. Four traits, including TGW, grain length, grain width and heading date, were measured. Phenotypic difference between the two genotypic groups in each NIL population was analyzed using SAS procedure GLM. Significant QTL effects were detected on TGW with the Zhenshan 97 allele increasing grain weight by 0.12 g to 0.14 g and explaining 8.30% to 15.19% of the phenotypic variance. Significant effects were also observed for grain length and width, whereas no significant effect was found for heading date. Based on comparison among the five NILs on the segregating regions and the results of QTL analysis, qTGW1.1 was delimited to a 376.9-kb region flanked by DNA markers Wn28382 and RM11554. Our results indicate that the effects of minor QTLs could be steadily detected in a highly isogenic background and suggest that such QTLs could be utilized in the breeding of high-yielding rice varieties.
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- 2015
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27. Evaluation of Physiological Coping Strategies and Quality Substances in Purple SweetPotato under Different Salinity Levels
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Wang, Xin, primary, Dai, Wei-Wei, additional, Liu, Chong, additional, Zhang, Guang-Xi, additional, Song, Wei-Han, additional, Li, Chen, additional, Yangchen, Yuenden-Ci, additional, Gao, Run-Fei, additional, Chen, Yu-Yu, additional, Yan, Hui, additional, Tang, Wei, additional, Kou, Meng, additional, Zhang, Yun-Gang, additional, Yuan, Bo, additional, and Li, Qiang, additional
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- 2022
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28. Fractional amplitude of low-frequency fluctuation in patients with neovascular glaucoma: a resting-state functional magnetic resonance imaging study
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Si-Wen Tan, Qiong Zhou, Yu-Qing Zhang, Shi-Nan Wu, Meng-Ying Peng, Si-Yi Chen, Chen-Yu Yu, and Yi Shao
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medicine.medical_specialty ,Visual acuity ,genetic structures ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Brain activity and meditation ,Neovascular glaucoma ,Hospital Anxiety and Depression Scale ,030227 psychiatry ,Correlation ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cardiology ,Medicine ,Original Article ,Radiology, Nuclear Medicine and imaging ,In patient ,medicine.symptom ,business ,Functional magnetic resonance imaging ,030217 neurology & neurosurgery - Abstract
BACKGROUND: Neovascular glaucoma (NVG) is a secondary refractory disease with a poor prognosis, and there are few advanced studies on its pathogenesis and treatment. In this research, the fractional amplitude of low-frequency fluctuation (fALFF) technology was used in resting-state functional magnetic resonance imaging (rsfMRI) to investigate intrinsic neuron activity in the patient’s brain with NVG. METHODS: Sixteen patients with NVG (eight males and eight females) and 16 healthy controls (HCs) of similar age and sex were included. All patients and controls received rsfMRI scans, and the differences between the two groups in fALFF values were compared by independent sample t-test. Receiver operating characteristic (ROC) curves were used to compare fALFF values in the brain regions of NVG patients and HCs and assess accuracy. Finally, Pearson linear correlation analysis assessed the correlation between fALFF signals in brain regions and the clinical evaluation indicators of patients with NVG. RESULTS: In patients with NVG, fALFF signal values in the right Rolandic operculum, left anterior cingulate and paracingulate gyri, and right caudate were significantly decreased. In contrast, fALFF signal values in the left precuneus were significantly higher than those recorded in the HCs. Analysis of the ROC curve for each brain region showed that the area under the ROC curve of NVG patients was large (close to 1), and the accuracy was good. In the NVG group, the hospital anxiety and depression scale (r=−0.952, P
- Published
- 2021
29. An Ontology-Based Herb Therapy Recommendation for Respiration System
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Chien, Hung-Yu, primary, Chen, Jian-Fan, additional, Chen, Yu-Yu, additional, Lin, Pei-Syuan, additional, Chang, Yi-Ting, additional, and Chen, Rong-Chung, additional
- Published
- 2017
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30. Cellular membrane-targeting ruthenium complexes as efficient photosensitizers for broad-spectrum antibacterial activity.
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Wang, Yi, Hu, Ya-Tao, Zhang, Hai-Lin, Chen, Yu-Yu, Shi, Hong-Dong, Liu, Jin-Gang, and Zhang, Qian-Ling
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ANTIBACTERIAL agents ,RUTHENIUM compounds ,ELECTROSTATIC interaction ,PHOTOSENSITIZERS ,PHOTODYNAMIC therapy ,CELL membranes - Abstract
A ruthenium complex [Ru(phen)
2 (phen-5-amine)-C14] (Ru-C14) with broad-spectrum antibacterial activity was designed and synthesized; positively charged Ru-C14 could target bacteria via electrostatic interactions and showed high binding effectiveness to cell membranes. In addition, Ru-C14 could act as a photosensitizer. Under 465 nm light irradiation, Ru-C14 could generate1 O2 , thus disrupting the bacterial intracellular redox balance and leading to bacterial death. Ru-C14 also exhibited minimum inhibitory concentration values of 6.25 μM against Escherichia coli and 3.125 μM against Staphylococcus aureus; these values are lower than those of streptomycin and methicillin. This work combined the merits of cell membrane targeting and photodynamic therapy for antibacterial activity. The findings might open up a new avenue for effective anti-infection treatment and other medical applications. [ABSTRACT FROM AUTHOR]- Published
- 2023
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31. First Sagittarius A* Event Horizon Telescope Results. I. The Shadow of the Supermassive Black Hole in the Center of the Milky Way
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null Event Horizon Telescope Collaboration, Kazunori Akiyama, Antxon Alberdi, Walter Alef, Juan Carlos Algaba, Richard Anantua, Keiichi Asada, Rebecca Azulay, Uwe Bach, Anne-Kathrin Baczko, David Ball, Mislav Baloković, John Barrett, Michi Bauböck, Bradford A. Benson, Dan Bintley, Lindy Blackburn, Raymond Blundell, Katherine L. Bouman, Geoffrey C. Bower, Hope Boyce, Michael Bremer, Christiaan D. Brinkerink, Roger Brissenden, Silke Britzen, Avery E. Broderick, Dominique Broguiere, Thomas Bronzwaer, Sandra Bustamante, Do-Young Byun, John E. Carlstrom, Chiara Ceccobello, Andrew Chael, Chi-kwan Chan, Koushik Chatterjee, Shami Chatterjee, Ming-Tang Chen, Yongjun Chen, Xiaopeng Cheng, Ilje Cho, Pierre Christian, Nicholas S. Conroy, John E. Conway, James M. Cordes, Thomas M. Crawford, Geoffrey B. Crew, Alejandro Cruz-Osorio, Yuzhu Cui, Jordy Davelaar, Mariafelicia De Laurentis, Roger Deane, Jessica Dempsey, Gregory Desvignes, Jason Dexter, Vedant Dhruv, Sheperd S. Doeleman, Sean Dougal, Sergio A. Dzib, Ralph P. Eatough, Razieh Emami, Heino Falcke, Joseph Farah, Vincent L. Fish, Ed Fomalont, H. Alyson Ford, Raquel Fraga-Encinas, William T. Freeman, Per Friberg, Christian M. Fromm, Antonio Fuentes, Peter Galison, Charles F. Gammie, Roberto García, Olivier Gentaz, Boris Georgiev, Ciriaco Goddi, Roman Gold, Arturo I. Gómez-Ruiz, José L. Gómez, Minfeng Gu, Mark Gurwell, Kazuhiro Hada, Daryl Haggard, Kari Haworth, Michael H. Hecht, Ronald Hesper, Dirk Heumann, Luis C. Ho, Paul Ho, Mareki Honma, Chih-Wei L. Huang, Lei Huang, David H. Hughes, Shiro Ikeda, C. M. Violette Impellizzeri, Makoto Inoue, Sara Issaoun, David J. James, Buell T. Jannuzi, Michael Janssen, Britton Jeter, Wu Jiang, Alejandra Jiménez-Rosales, Michael D. Johnson, Svetlana Jorstad, Abhishek V. Joshi, Taehyun Jung, Mansour Karami, Ramesh Karuppusamy, Tomohisa Kawashima, Garrett K. Keating, Mark Kettenis, Dong-Jin Kim, Jae-Young Kim, Jongsoo Kim, Junhan Kim, Motoki Kino, Jun Yi Koay, Prashant Kocherlakota, Yutaro Kofuji, Patrick M. Koch, Shoko Koyama, Carsten Kramer, Michael Kramer, Thomas P. Krichbaum, Cheng-Yu Kuo, Noemi La Bella, Tod R. Lauer, Daeyoung Lee, Sang-Sung Lee, Po Kin Leung, Aviad Levis, Zhiyuan Li, Rocco Lico, Greg Lindahl, Michael Lindqvist, Mikhail Lisakov, Jun Liu, Kuo Liu, Elisabetta Liuzzo, Wen-Ping Lo, Andrei P. Lobanov, Laurent Loinard, Colin J. Lonsdale, Ru-Sen Lu, Jirong Mao, Nicola Marchili, Sera Markoff, Daniel P. Marrone, Alan P. Marscher, Iván Martí-Vidal, Satoki Matsushita, Lynn D. Matthews, Lia Medeiros, Karl M. Menten, Daniel Michalik, Izumi Mizuno, Yosuke Mizuno, James M. Moran, Kotaro Moriyama, Monika Moscibrodzka, Cornelia Müller, Alejandro Mus, Gibwa Musoke, Ioannis Myserlis, Andrew Nadolski, Hiroshi Nagai, Neil M. Nagar, Masanori Nakamura, Ramesh Narayan, Gopal Narayanan, Iniyan Natarajan, Antonios Nathanail, Santiago Navarro Fuentes, Joey Neilsen, Roberto Neri, Chunchong Ni, Aristeidis Noutsos, Michael A. Nowak, Junghwan Oh, Hiroki Okino, Héctor Olivares, Gisela N. Ortiz-León, Tomoaki Oyama, Feryal Özel, Daniel C. M. Palumbo, Georgios Filippos Paraschos, Jongho Park, Harriet Parsons, Nimesh Patel, Ue-Li Pen, Dominic W. Pesce, Vincent Piétu, Richard Plambeck, Aleksandar PopStefanija, Oliver Porth, Felix M. Pötzl, Ben Prather, Jorge A. Preciado-López, Dimitrios Psaltis, Hung-Yi Pu, Venkatessh Ramakrishnan, Ramprasad Rao, Mark G. Rawlings, Alexander W. Raymond, Luciano Rezzolla, Angelo Ricarte, Bart Ripperda, Freek Roelofs, Alan Rogers, Eduardo Ros, Cristina Romero-Cañizales, Arash Roshanineshat, Helge Rottmann, Alan L. Roy, Ignacio Ruiz, Chet Ruszczyk, Kazi L. J. Rygl, Salvador Sánchez, David Sánchez-Argüelles, Miguel Sánchez-Portal, Mahito Sasada, Kaushik Satapathy, Tuomas Savolainen, F. Peter Schloerb, Jonathan Schonfeld, Karl-Friedrich Schuster, Lijing Shao, Zhiqiang Shen, Des Small, Bong Won Sohn, Jason SooHoo, Kamal Souccar, He Sun, Fumie Tazaki, Alexandra J. Tetarenko, Paul Tiede, Remo P. J. Tilanus, Michael Titus, Pablo Torne, Efthalia Traianou, Tyler Trent, Sascha Trippe, Matthew Turk, Ilse van Bemmel, Huib Jan van Langevelde, Daniel R. van Rossum, Jesse Vos, Jan Wagner, Derek Ward-Thompson, John Wardle, Jonathan Weintroub, Norbert Wex, Robert Wharton, Maciek Wielgus, Kaj Wiik, Gunther Witzel, Michael F. Wondrak, George N. Wong, Qingwen Wu, Paul Yamaguchi, Doosoo Yoon, André Young, Ken Young, Ziri Younsi, Feng Yuan, Ye-Fei Yuan, J. Anton Zensus, Shuo Zhang, Guang-Yao Zhao, Shan-Shan Zhao, Claudio Agurto, Alexander Allardi, Rodrigo Amestica, Juan Pablo Araneda, Oriel Arriagada, Jennie L. Berghuis, Alessandra Bertarini, Ryan Berthold, Jay Blanchard, Ken Brown, Mauricio Cárdenas, Michael Cantzler, Patricio Caro, Edgar Castillo-Domínguez, Tin Lok Chan, Chih-Cheng Chang, Dominic O. Chang, Shu-Hao Chang, Song-Chu Chang, Chung-Chen Chen, Ryan Chilson, Tim C. Chuter, Miroslaw Ciechanowicz, Edgar Colin-Beltran, Iain M. Coulson, Joseph Crowley, Nathalie Degenaar, Sven Dornbusch, Carlos A. Durán, Wendeline B. Everett, Aaron Faber, Karl Forster, Miriam M. Fuchs, David M. Gale, Gertie Geertsema, Edouard González, Dave Graham, Frédéric Gueth, Nils W. Halverson, Chih-Chiang Han, Kuo-Chang Han, Yutaka Hasegawa, José Luis Hernández-Rebollar, Cristian Herrera, Ruben Herrero-Illana, Stefan Heyminck, Akihiko Hirota, James Hoge, Shelbi R. Hostler Schimpf, Ryan E. Howie, Yau-De Huang, Homin Jiang, Hao Jinchi, David John, Kimihiro Kimura, Thomas Klein, Derek Kubo, John Kuroda, Caleb Kwon, Richard Lacasse, Robert Laing, Erik M. Leitch, Chao-Te Li, Ching-Tang Liu, Kuan-Yu Liu, Lupin C.-C. Lin, Li-Ming Lu, Felipe Mac-Auliffe, Pierre Martin-Cocher, Callie Matulonis, John K. Maute, Hugo Messias, Zheng Meyer-Zhao, Alfredo Montaña, Francisco Montenegro-Montes, William Montgomerie, Marcos Emir Moreno Nolasco, Dirk Muders, Hiroaki Nishioka, Timothy J. Norton, George Nystrom, Hideo Ogawa, Rodrigo Olivares, Peter Oshiro, Juan Pablo Pérez-Beaupuits, Rodrigo Parra, Neil M. Phillips, Michael Poirier, Nicolas Pradel, Richard Qiu, Philippe A. Raffin, Alexandra S. Rahlin, Jorge Ramírez, Sean Ressler, Mark Reynolds, Iván Rodríguez-Montoya, Alejandro F. Saez-Madain, Jorge Santana, Paul Shaw, Leslie E. Shirkey, Kevin M. Silva, William Snow, Don Sousa, T. K. Sridharan, William Stahm, Anthony A. Stark, John Test, Karl Torstensson, Paulina Venegas, Craig Walther, Ta-Shun Wei, Chris White, Gundolf Wieching, Rudy Wijnands, Jan G. A. Wouterloot, Chen-Yu Yu, Wei Yu (于威), Milagros Zeballos, High Energy Astrophys. & Astropart. Phys (API, FNWI), Akiyama, K., Alberdi, A., Alef, W., Algaba, J. 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[0000-0001-6920-662X], Nakamura, Masanori [0000-0001-6081-2420], Narayan, Ramesh [0000-0002-1919-2730], Narayanan, Gopal [0000-0002-4723-6569], Natarajan, Iniyan [0000-0001-8242-4373], Neilsen, Joey [0000-0002-8247-786X], Neri, Roberto [0000-0002-7176-4046], Ni, Chunchong [0000-0003-1361-5699], Noutsos, Aristeidis [0000-0002-4151-3860], Nowak, Michael A. [0000-0001-6923-1315], Oh, Junghwan [0000-0002-4991-9638], Okino, Hiroki [0000-0003-3779-2016], Olivares, Héctor [0000-0001-6833-7580], Ortiz-León, Gisela N. [0000-0002-2863-676X], Oyama, Tomoaki [0000-0003-4046-2923], Özel, Feryal [0000-0003-4413-1523], Palumbo, Daniel C. M. [0000-0002-7179-3816], Paraschos, Georgios Filippos [0000-0001-6757-3098], Park, Jongho [0000-0001-6558-9053], Parsons, Harriet [0000-0002-6327-3423], Patel, Nimesh [0000-0002-6021-9421], Pen, Ue-Li [0000-0003-2155-9578], Pesce, Dominic W. [0000-0002-5278-9221], Plambeck, Richard [0000-0001-6765-9609], Porth, Oliver [0000-0002-4584-2557], Pötzl, Felix M. 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[0000-0003-4146-9043], Sánchez, Salvador [0000-0002-8042-5951], Sánchez-Argüelles, David [0000-0002-7344-9920], Sánchez-Portal, Miguel [0000-0003-0981-9664], Sasada, Mahito [0000-0001-5946-9960], Satapathy, Kaushik [0000-0003-0433-3585], Savolainen, Tuomas [0000-0001-6214-1085], Schonfeld, Jonathan [0000-0002-8909-2401], Schuster, Karl-Friedrich [0000-0003-2890-9454], Shao, Lijing [0000-0002-1334-8853], Shen, Zhiqiang [0000-0003-3540-8746], Small, Des [0000-0003-3723-5404], Sohn, Bong Won [0000-0002-4148-8378], SooHoo, Jason [0000-0003-1938-0720], Souccar, Kamal [0000-0001-7915-5272], Sun, He [0000-0003-1526-6787], Tazaki, Fumie [0000-0003-0236-0600], Tetarenko, Alexandra J. [0000-0003-3906-4354], Tiede, Paul [0000-0003-3826-5648], Tilanus, Remo P. J. [0000-0002-6514-553X], Titus, Michael [0000-0001-9001-3275], Torne, Pablo [0000-0001-8700-6058], Traianou, Efthalia [0000-0002-1209-6500], Trippe, Sascha [0000-0003-0465-1559], Turk, Matthew [0000-0002-5294-0198], van Bemmel, Ilse [0000-0001-5473-2950], van Langevelde, Huib Jan [0000-0002-0230-5946], van Rossum, Daniel R. [0000-0001-7772-6131], Vos, Jesse [0000-0003-3349-7394], Wagner, Jan [0000-0003-1105-6109], Ward-Thompson, Derek [0000-0003-1140-2761], Wardle, John [0000-0002-8960-2942], Weintroub, Jonathan [0000-0002-4603-5204], Wex, Norbert [0000-0003-4058-2837], Wharton, Robert [0000-0002-7416-5209], Wielgus, Maciek [0000-0002-8635-4242], Wiik, Kaj [0000-0002-0862-3398], Witzel, Gunther [0000-0003-2618-797X], Wondrak, Michael F. [0000-0002-6894-1072], Wong, George N. [0000-0001-6952-2147], Wu, Qingwen [0000-0003-4773-4987], Yamaguchi, Paul [0000-0002-6017-8199], Yoon, Doosoo [0000-0001-8694-8166], Young, André [0000-0003-0000-2682], Young, Ken [0000-0002-3666-4920], Younsi, Ziri [0000-0001-9283-1191], Yuan, Feng [0000-0003-3564-6437], Yuan, Ye-Fei [0000-0002-7330-4756], Zensus, J. Anton [0000-0001-7470-3321], Zhang, Shuo [0000-0002-2967-790X], Zhao, Guang-Yao [0000-0002-4417-1659], Zhao, Shan-Shan [0000-0002-9774-3606], Berghuis, Jennie L. [0000-0003-2287-158X], Blanchard, Jay [0000-0002-2756-395X], Chan, Tin Lok [0000-0001-9197-932X], Coulson, Iain M. [0000-0002-7316-4626], Degenaar, Nathalie [0000-0002-0092-3548], Durán, Carlos A. [0000-0001-7622-3890], Everett, Wendeline B. [0000-0002-5370-6651], Forster, Karl [0000-0001-5800-5531], Halverson, Nils W. [0000-0003-2606-9340], Herrero-Illana, Ruben [0000-0002-7758-8717], Hirota, Akihiko [0000-0002-0465-5421], Howie, Ryan E. [0000-0002-5451-3624], Kwon, Caleb [0000-0001-9006-7345], Laing, Robert [0000-0001-6786-3087], Leitch, Erik M. [0000-0001-8553-9336], Lin, Lupin C.-C. [0000-0003-4083-9567], Maute, John K. [0000-0002-5744-4249], Messias, Hugo [0000-0002-2985-7994], Montenegro-Montes, Francisco [0000-0002-7430-3771], Muders, Dirk [0000-0002-2315-2571], Pérez-Beaupuits, Juan Pablo [0000-0003-3536-2274], Poirier, Michael [0000-0001-6641-0959], Qiu, Richard [0000-0003-3462-0817], Rahlin, Alexandra S. [0000-0003-3953-1776], Ressler, Sean [0000-0003-0220-5723], Reynolds, Mark [0000-0003-1621-9392], Saez-Madain, Alejandro F. [0000-0002-0804-3414], Sousa, Don [0000-0002-2625-2607], Stark, Anthony A. [0000-0002-2718-9996], White, Chris [0000-0001-7448-4253], Wijnands, Rudy [0000-0002-3516-2152], Wouterloot, Jan G. A. [0000-0002-4694-6905], Yu (于威), Wei [0000-0002-5168-6052], Apollo - University of Cambridge Repository, Ministerio de Ciencia e Innovación (España), European Commission, European Research Council, Science and Technology Facilities Council (UK), Astronomy, Metsähovi Radio Observatory, Department of Electronics and Nanoengineering, Science Support Office, Aalto-yliopisto, and Aalto University
- Subjects
Black holes ,F520 ,Astrophysics::High Energy Astrophysical Phenomena ,Astronomy ,F521 ,Astronomy and Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,5109 Space Sciences ,Heterodyne interferometry ,Galactic center ,General Relativity and Quantum Cosmology ,Space and Planetary Science ,5101 Astronomical Sciences ,Kerr black holes ,Rotating black holes ,51 Physical Sciences ,Astrophysics::Galaxy Astrophysics ,Mathematics - Abstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Full list of authors: Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Algaba, Juan Carlos; Anantua, Richard; Asada, Keiichi; Azulay, Rebecca; Bach, Uwe; Baczko, Anne-Kathrin; Ball, David; Balokovic, Mislav; Barrett, John; Baubock, Michi; Benson, Bradford A.; Bintley, Dan; Blackburn, Lindy; Blundell, Raymond; Bouman, Katherine L.; Bower, Geoffrey C.; Boyce, Hope; Bremer, Michael; Brinkerink, Christiaan D.; Brissenden, Roger; Britzen, Silke; Broderick, Avery E.; Broguiere, Dominique; Bronzwaer, Thomas; Bustamante, Sandra; Byun, Do-Young; Carlstrom, John E.; Ceccobello, Chiara; Chael, Andrew; Chan, Chi-kwan; Chatterjee, Koushik; Chatterjee, Shami; Chen, Ming-Tang; Chen, Yongjun; Cheng, Xiaopeng; Cho, Ilje; Christian, Pierre; Conroy, Nicholas S.; Conway, John E.; Cordes, James M.; Crawford, Thomas M.; Crew, Geoffrey B.; Cruz-Osorio, Alejandro; Cui, Yuzhu; Davelaar, Jordy; De Laurentis, Mariafelicia; Deane, Roger; Dempsey, Jessica; Desvignes, Gregory; Dexter, Jason; Dhruv, Vedant; Doeleman, Sheperd S.; Dougal, Sean; Dzib, Sergio A.; Eatough, Ralph P.; Emami, Razieh; Falcke, Heino; Farah, Joseph; Fish, Vincent L.; Fomalont, Ed; Ford, H. Alyson; Fraga-Encinas, Raquel; Freeman, William T.; Friberg, Per; Fromm, Christian M.; Fuentes, Antonio; Galison, Peter; Gammie, Charles F.; Garcia, Roberto; Gentaz, Olivier; Georgiev, Boris; Goddi, Ciriaco; Gold, Roman; Gomez-Ruiz, Arturo, I; Gomez, Jose L.; Gu, Minfeng; Gurwell, Mark; Hada, Kazuhiro; Haggard, Daryl; Haworth, Kari; Hecht, Michael H.; Hesper, Ronald; Heumann, Dirk; Ho, Luis C.; Ho, Paul; Honma, Mareki; Huang, Chih-Wei L.; Huang, Lei; Hughes, David H.; Ikeda, Shiro; Impellizzeri, C. M. Violette; Inoue, Makoto; Issaoun, Sara; James, David J.; Jannuzi, Buell T.; Janssen, Michael; Jeter, Britton; Jiang, Wu; Jimenez-Rosales, Alejandra; Johnson, Michael D.; Jorstad, Svetlana; Joshi, Abhishek, V; Jung, Taehyun; Karami, Mansour; Karuppusamy, Ramesh; Kawashima, Tomohisa; Keating, Garrett K.; Kettenis, Mark; Kim, Dong-Jin; Kim, Jae-Young; Kim, Jongsoo; Kim, Junhan; Kino, Motoki; Koay, Jun Yi; Kocherlakota, Prashant; Kofuji, Yutaro; Koch, Patrick M.; Koyama, Shoko; Kramer, Carsten; Kramer, Michael; Krichbaum, Thomas P.; Kuo, Cheng-Yu; La Bella, Noemi; Lauer, Tod R.; Lee, Daeyoung; Lee, Sang-Sung; Leung, Po Kin; Levis, Aviad; Li, Zhiyuan; Lico, Rocco; Lindahl, Greg; Lindqvist, Michael; Lisakov, Mikhail; Liu, Jun; Liu, Kuo; Liuzzo, Elisabetta; Lo, Wen-Ping; Lobanov, Andrei P.; Loinard, Laurent; Lonsdale, Colin J.; Lu, Ru-Sen; Mao, Jirong; Marchili, Nicola; Markoff, Sera; Marrone, Daniel P.; Marscher, Alan P.; Marti-Vidal, Ivan; Matsushita, Satoki; Matthews, Lynn D.; Medeiros, Lia; Menten, Karl M.; Michalik, Daniel; Mizuno, Izumi; Mizuno, Yosuke; Moran, James M.; Moriyama, Kotaro; Moscibrodzka, Monika; Muller, Cornelia; Mus, Alejandro; Musoke, Gibwa; Myserlis, Ioannis; Nadolski, Andrew; Nagai, Hiroshi; Nagar, Neil M.; Nakamura, Masanori; Narayan, Ramesh; Narayanan, Gopal; Natarajan, Iniyan; Nathanail, Antonios; Fuentes, Santiago Navarro; Neilsen, Joey; Neri, Roberto; Ni, Chunchong; Noutsos, Aristeidis; Nowak, Michael A.; Oh, Junghwan; Okino, Hiroki; Olivares, Hector; Ortiz-Leon, Gisela N.; Oyama, Tomoaki; Palumbo, Daniel C. M.; Paraschos, Georgios Filippos; Park, Jongho; Parsons, Harriet; Patel, Nimesh; Pen, Ue-Li; Pesce, Dominic W.; Pietu, Vincent; Plambeck, Richard; PopStefanija, Aleksandar; Porth, Oliver; Potzl, Felix M.; Prather, Ben; Preciado-Lopez, Jorge A.; Pu, Hung-Yi; Ramakrishnan, Venkatessh; Rao, Ramprasad; Rawlings, Mark G.; Raymond, Alexander W.; Rezzolla, Luciano; Ricarte, Angelo; Ripperda, Bart; Roelofs, Freek; Rogers, Alan; Ros, Eduardo; Romero-Canizales, Cristina; Roshanineshat, Arash; Rottmann, Helge; Roy, Alan L.; Ruiz, Ignacio; Ruszczyk, Chet; Rygl, Kazi L. J.; Sanchez, Salvador; Sanchez-Arguelles, David; Sanchez-Portal, Miguel; Sasada, Mahito; Satapathy, Kaushik; Savolainen, Tuomas; Schloerb, F. Peter; Schonfeld, Jonathan; Schuster, Karl-Friedrich; Shao, Lijing; Shen, Zhiqiang; Small, Des; Sohn, Bong Won; SooHoo, Jason; Souccar, Kamal; Sun, He; Tazaki, Fumie; Tetarenko, Alexandra J.; Tiede, Paul; Tilanus, Remo P. J.; Titus, Michael; Torne, Pablo; Traianou, Efthalia; Trent, Tyler; Trippe, Sascha; Turk, Matthew; van Bemmel, Ilse; van Langevelde, Huib Jan; van Rossum, Daniel R.; Vos, Jesse; Wagner, Jan; Ward-Thompson, Derek; Wardle, John; Weintroub, Jonathan; Wex, Norbert; Wharton, Robert; Wielgus, Maciek; Wiik, Kaj; Witzel, Gunther; Wondrak, Michael F.; Wong, George N.; Wu, Qingwen; Yamaguchi, Paul; Yoon, Doosoo; Young, Andre; Young, Ken; Younsi, Ziri; Yuan, Feng; Yuan, Ye-Fei; Zensus, J. Anton; Zhang, Shuo; Zhao, Guang-Yao; Zhao, Shan-Shan; Ozel, Feryal; Agurto, Claudio; Allardi, Alexander; Amestica, Rodrigo; Araneda, Juan Pablo; Arriagada, Oriel; Berghuis, Jennie L.; Bertarini, Alessandra; Berthold, Ryan; Blanchard, Jay; Brown, Ken; Cardenas, Mauricio; Cantzler, Michael; Caro, Patricio; Castillo-Dominguez, Edgar; Chan, Tin Lok; Chang, Chih-Cheng; Chang, Dominic O.; Chang, Shu-Hao; Chang, Song-Chu; Chen, Chung-Chen; Chilson, Ryan; Chuter, Tim C.; Ciechanowicz, Miroslaw; Colin-Beltran, Edgar; Coulson, Iain M.; Crowley, Joseph; Degenaar, Nathalie; Dornbusch, Sven; Duran, Carlos A.; Everett, Wendeline B.; Faber, Aaron; Forster, Karl; Fuchs, Miriam M.; Gale, David M.; Geertsema, Gertie; Gonzalez, Edouard; Graham, Dave; Gueth, Frederic; Halverson, Nils W.; Han, Chih-Chiang; Han, Kuo-Chang; Hasegawa, Yutaka; Hernandez-Rebollar, Jose Luis; Herrera, Cristian; Herrero-Illana, Ruben; Heyminck, Stefan; Hirota, Akihiko; Hoge, James; Schimpf, Shelbi R. Hostler; Howie, Ryan E.; Huang, Yau-De; Jiang, Homin; Jinchi, Hao; John, David; Kimura, Kimihiro; Klein, Thomas; Kubo, Derek; Kuroda, John; Kwon, Caleb; Lacasse, Richard; Laing, Robert; Leitch, Erik M.; Li, Chao-Te; Liu, Ching-Tang; Liu, Kuan-Yu; Lin, Lupin C-C; Lu, Li-Ming; Mac-Auliffe, Felipe; Martin-Cocher, Pierre; Matulonis, Callie; Maute, John K.; Messias, Hugo; Meyer-Zhao, Zheng; Montana, Alfredo; Montenegro-Montes, Francisco; Montgomerie, William; Nolasco, Marcos Emir Moreno; Muders, Dirk; Nishioka, Hiroaki; Norton, Timothy J.; Nystrom, George; Ogawa, Hideo; Olivares, Rodrigo; Oshiro, Peter; Perez-Beaupuits, Juan Pablo; Parra, Rodrigo; Phillips, Neil M.; Poirier, Michael; Pradel, Nicolas; Qiu, Richard; Raffin, Philippe A.; Rahlin, Alexandra S.; Ramirez, Jorge; Ressler, Sean; Reynolds, Mark; Rodriguez-Montoya, Ivan; Saez-Madain, Alejandro F.; Santana, Jorge; Shaw, Paul; Shirkey, Leslie E., Jr.; Silva, Kevin M.; Snow, William; Sousa, Don; Sridharan, T. K.; Stahm, William; Stark, Anthony A.; Test, John; Torstensson, Karl; Venegas, Paulina; Walther, Craig; Wei, Ta-Shun; White, Chris; Wieching, Gundolf; Wijnands, Rudy; Wouterloot, Jan G. A.; Yu, Chen-Yu; Yu, Wei; Zeballos, Milagros; Event Horizon Telescope Collaboration., We present the first Event Horizon Telescope (EHT) observations of Sagittarius A* (Sgr A*), the Galactic center source associated with a supermassive black hole. These observations were conducted in 2017 using a global interferometric array of eight telescopes operating at a wavelength of λ = 1.3 mm. The EHT data resolve a compact emission region with intrahour variability. A variety of imaging and modeling analyses all support an image that is dominated by a bright, thick ring with a diameter of 51.8 ± 2.3 μas (68% credible interval). The ring has modest azimuthal brightness asymmetry and a comparatively dim interior. Using a large suite of numerical simulations, we demonstrate that the EHT images of Sgr A* are consistent with the expected appearance of a Kerr black hole with mass ∼4 × 106 M⊙, which is inferred to exist at this location based on previous infrared observations of individual stellar orbits, as well as maser proper-motion studies. Our model comparisons disfavor scenarios where the black hole is viewed at high inclination (i > 50°), as well as nonspinning black holes and those with retrograde accretion disks. Our results provide direct evidence for the presence of a supermassive black hole at the center of the Milky Way, and for the first time we connect the predictions from dynamical measurements of stellar orbits on scales of 103–105 gravitational radii to event-horizon-scale images and variability. Furthermore, a comparison with the EHT results for the supermassive black hole M87* shows consistency with the predictions of general relativity spanning over three orders of magnitude in central mass. © 2022. The Author(s). Published by the American Astronomical Society., The Event Horizon Telescope Collaboration thanks the following organizations and programs: the Academia Sinica; the Academy of Finland (projects 274477, 284495, 312496, 315721); the Agencia Nacional de Investigación y Desarrollo (ANID), Chile via NCN19_058 (TITANs) and Fondecyt 1221421, the Alexander von Humboldt Stiftung; an Alfred P. Sloan Research Fellowship; Allegro, the European ALMA Regional Centre node in the Netherlands, the NL astronomy research network NOVA and the astronomy institutes of the University of Amsterdam, Leiden University and Radboud University; the ALMA North America Development Fund; the Black Hole Initiative, which is funded by grants from the John Templeton Foundation and the Gordon and Betty Moore Foundation (although the opinions expressed in this work are those of the author(s) and do not necessarily reflect the views of these Foundations); Chandra DD7-18089X and TM6-17006X; the China Scholarship Council; China Postdoctoral Science Foundation fellowship (2020M671266); Consejo Nacional de Ciencia y Tecnología (CONACYT, Mexico, projects U0004-246083, U0004-259839, F0003-272050, M0037-279006, F0003-281692, 104497, 275201, 263356); the Consejería de Economía, Conocimiento, Empresas y Universidad of the Junta de Andalucía (grant P18-FR-1769), the Consejo Superior de Investigaciones Científicas (grant 2019AEP112); the Delaney Family via the Delaney Family John A. Wheeler Chair at Perimeter Institute; Dirección General de Asuntos del Personal Académico-Universidad Nacional Autónoma de México (DGAPA-UNAM, projects IN112417 and IN112820); the Dutch Organization for Scientific Research (NWO) VICI award (grant 639.043.513) and grant OCENW.KLEIN.113; the Dutch National Supercomputers, Cartesius and Snellius (NWO Grant 2021.013); the EACOA Fellowship awarded by the East Asia Core Observatories Association, which consists of the Academia Sinica Institute of Astronomy and Astrophysics, the National Astronomical Observatory of Japan, Center for Astronomical Mega-Science, Chinese Academy of Sciences, and the Korea Astronomy and Space Science Institute; the European Research Council (ERC) Synergy Grant "BlackHoleCam: Imaging the Event Horizon of Black Holes" (grant 610058); the European Union Horizon 2020 research and innovation programme under grant agreements RadioNet (No 730562) and M2FINDERS (No 101018682); the Generalitat Valenciana postdoctoral grant APOSTD/2018/177 and GenT Program (project CIDEGENT/2018/021); MICINN Research Project PID2019-108995GB-C22; the European Research Council for advanced grant "JETSET: Launching, propagation and emission of relativistic jets from binary mergers and across mass scales" (Grant No. 884631); the Institute for Advanced Study; the Istituto Nazionale di Fisica Nucleare (INFN) sezione di Napoli, iniziative specifiche TEONGRAV; the International Max Planck Research School for Astronomy and Astrophysics at the Universities of Bonn and Cologne; DFG research grant "Jet physics on horizon scales and beyond" (Grant No. FR 4069/2-1); Joint Princeton/Flatiron and Joint Columbia/Flatiron Postdoctoral Fellowships, research at the Flatiron Institute is supported by the Simons Foundation; the Japan Ministry of Education, Culture, Sports, Science and Technology (MEXT; grant JPMXP1020200109); the Japanese Government (Monbukagakusho: MEXT) Scholarship; the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for JSPS Research Fellowship (JP17J08829); the Joint Institute for Computational Fundamental Science, Japan; the Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS, grants QYZDJ-SSW-SLH057, QYZDJSSW-SYS008, ZDBS-LY-SLH011); the Leverhulme Trust Early Career Research Fellowship; the Max-Planck-Gesellschaft (MPG); the Max Planck Partner Group of the MPG and the CAS; the MEXT/JSPS KAKENHI (grants 18KK0090, JP21H01137, JP18H03721, JP18K13594, 18K03709, JP19K14761, 18H01245, 25120007); the Malaysian Fundamental Research Grant Scheme (FRGS) FRGS/1/2019/STG02/UM/02/6; the MIT International Science and Technology Initiatives (MISTI) Funds; the Ministry of Science and Technology (MOST) of Taiwan (103-2119-M-001-010-MY2, 105-2112-M-001-025-MY3, 105-2119-M-001-042, 106-2112-M-001-011, 106-2119-M-001-013, 106-2119-M-001-027, 106-2923-M-001-005, 107-2119-M-001-017, 107-2119-M-001-020, 107-2119-M-001-041, 107-2119-M-110-005, 107-2923-M-001-009, 108-2112-M-001-048, 108-2112-M-001-051, 108-2923-M-001-002, 109-2112-M-001-025, 109-2124-M-001-005, 109-2923-M-001-001, 110-2112-M-003-007-MY2, 110-2112-M-001-033, 110-2124-M-001-007, and 110-2923-M-001-001); the Ministry of Education (MoE) of Taiwan Yushan Young Scholar Program; the Physics Division, National Center for Theoretical Sciences of Taiwan; the National Aeronautics and Space Administration (NASA, Fermi Guest Investigator grant 80NSSC20K1567, NASA Astrophysics Theory Program grant 80NSSC20K0527, NASA NuSTAR award 80NSSC20K0645); NASA Hubble Fellowship grant HST-HF2-51431.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555; the National Institute of Natural Sciences (NINS) of Japan; the National Key Research and Development Program of China (grant 2016YFA0400704, 2017YFA0402703, 2016YFA0400702); the National Science Foundation (NSF, grants AST-0096454, AST-0352953, AST-0521233, AST-0705062, AST-0905844, AST-0922984, AST-1126433, AST-1140030, DGE-1144085, AST-1207704, AST-1207730, AST-1207752, MRI-1228509, OPP-1248097, AST-1310896, AST-1440254, AST-1555365, AST-1614868, AST-1615796, AST-1715061, AST-1716327, AST-1716536, OISE-1743747, AST-1816420, AST-1935980, AST-2034306); NSF Astronomy and Astrophysics Postdoctoral Fellowship (AST-1903847); the Natural Science Foundation of China (grants 11650110427, 10625314, 11721303, 11725312, 11873028, 11933007, 11991052, 11991053, 12192220, 12192223); the Natural Sciences and Engineering Research Council of Canada (NSERC, including a Discovery Grant and the NSERC Alexander Graham Bell Canada Graduate Scholarships-Doctoral Program); the National Youth Thousand Talents Program of China; the National Research Foundation of Korea (the Global PhD Fellowship Grant: grants NRF-2015H1A2A1033752, the Korea Research Fellowship Program: NRF-2015H1D3A1066561, Brain Pool Program: 2019H1D3A1A01102564, Basic Research Support Grant 2019R1F1A1059721, 2021R1A6A3A01086420, 2022R1C1C1005255); Netherlands Research School for Astronomy (NOVA) Virtual Institute of Accretion (VIA) postdoctoral fellowships; Onsala Space Observatory (OSO) national infrastructure, for the provisioning of its facilities/observational support (OSO receives funding through the Swedish Research Council under grant 2017-00648); the Perimeter Institute for Theoretical Physics (research at Perimeter Institute is supported by the Government of Canada through the Department of Innovation, Science and Economic Development and by the Province of Ontario through the Ministry of Research, Innovation and Science); the Spanish Ministerio de Ciencia e Innovación (grants PGC2018-098915-B-C21, AYA2016-80889-P, PID2019-108995GB-C21, PID2020-117404GB-C21); the University of Pretoria for financial aid in the provision of the new Cluster Server nodes and SuperMicro (USA) for a SEEDING GRANT approved towards these nodes in 2020; the Shanghai Pilot Program for Basic Research, Chinese Academy of Science, Shanghai Branch (JCYJ-SHFY-2021-013); the State Agency for Research of the Spanish MCIU through the "Center of Excellence Severo Ochoa" award for the Instituto de Astrofísica de Andalucía (SEV-2017- 0709); the Spinoza Prize SPI 78-409; the South African Research Chairs Initiative, through the South African Radio Astronomy Observatory (SARAO, grant ID 77948), which is a facility of the National Research Foundation (NRF), an agency of the Department of Science and Innovation (DSI) of South Africa; the Toray Science Foundation; Swedish Research Council (VR); the US Department of Energy (USDOE) through the Los Alamos National Laboratory (operated by Triad National Security, LLC, for the National Nuclear Security Administration of the USDOE (Contract 89233218CNA000001); and the YCAA Prize Postdoctoral Fellowship. APEX is a collaboration between the Max-Planck-Institut für Radioastronomie (Germany), ESO, and the Onsala Space Observatory (Sweden). The SMA is a joint project between the SAO and ASIAA and is funded by the Smithsonian Institution and the Academia Sinica. The JCMT is operated by the East Asian Observatory on behalf of the NAOJ, ASIAA, and KASI, as well as the Ministry of Finance of China, Chinese Academy of Sciences, and the National Key Research and Development Program (No. 2017YFA0402700) of China and Natural Science Foundation of China grant 11873028. Additional funding support for the JCMT is provided by the Science and Technologies Facility Council (UK) and participating universities in the UK and Canada. The LMT is a project operated by the Instituto Nacional de Astrófisica, Óptica, y Electrónica (Mexico) and the University of Massachusetts at Amherst (USA). The IRAM 30-m telescope on Pico Veleta, Spain is operated by IRAM and supported by CNRS (Centre National de la Recherche Scientifique, France), MPG (Max-Planck-Gesellschaft, Germany) and IGN (Instituto Geográfico Nacional, Spain). The SMT is operated by the Arizona Radio Observatory, a part of the Steward Observatory of the University of Arizona, with financial support of operations from the State of Arizona and financial support for instrumentation development from the NSF. Support for SPT participation in the EHT is provided by the National Science Foundation through award OPP-1852617 to the University of Chicago. Partial support is also provided by the Kavli Institute of Cosmological Physics at the University of Chicago. The SPT hydrogen maser was provided on loan from the GLT, courtesy of ASIAA. This work used the Extreme Science and Engineering Discovery Environment (XSEDE), supported by NSF grant ACI-1548562, and CyVerse, supported by NSF grants DBI-0735191, DBI-1265383, and DBI-1743442. XSEDE Stampede2 resource at TACC was allocated through TG-AST170024 and TG-AST080026N. XSEDE JetStream resource at PTI and TACC was allocated through AST170028. This research is part of the Frontera computing project at the Texas Advanced Computing Center through the Frontera Large-Scale Community Partnerships allocation AST20023. Frontera is made possible by National Science Foundation award OAC-1818253. This research was carried out using resources provided by the Open Science Grid, which is supported by the National Science Foundation and the U.S. Department of Energy Office of Science. Additional work used ABACUS2.0, which is part of the eScience center at Southern Denmark University. Simulations were also performed on the SuperMUC cluster at the LRZ in Garching, on the LOEWE cluster in CSC in Frankfurt, on the HazelHen cluster at the HLRS in Stuttgart, and on the Pi2.0 and Siyuan Mark-I at Shanghai Jiao Tong University. The computer resources of the Finnish IT Center for Science (CSC) and the Finnish Computing Competence Infrastructure (FCCI) project are acknowledged. This research was enabled in part by support provided by Compute Ontario (http://computeontario.ca), Calcul Quebec (http://www.calculquebec.ca) and Compute Canada (http://www.computecanada.ca).
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- 2022
32. Mobility model extraction for surface roughness of SiGe along (110) and (100) Orientations in HKMG bulk FinFET devices
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Chen, Chien-Hung, Li, Yiming, Chen, Chieh-Yang, Chen, Yu-Yu, Hsu, Sheng-Chia, Huang, Wen-Tsung, and Chu, Sheng-Yuan
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- 2013
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33. The intrinsic parameter fluctuation on high-κ/metal gate bulk FinFET devices
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Li, Yiming, Su, Hsin-Wen, Chen, Yu-Yu, Hsu, Sheng-Chia, and Huang, Wen-Tsung
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- 2013
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34. Electrochemical detection of fucosidase activity in human serum
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Chwan Bor Fuh, Hweiyan Tsai, Chen Yu Yu, and Chien‐Hong Chen
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Biochemistry ,Chemistry ,medicine ,Fucosidase activity ,General Chemistry ,Electrochemical detection ,Liver cancer ,medicine.disease - Published
- 2020
35. Altered White Matter Integrity in Patients with Retinal Vein Occlusion: A Diffusion Tensor Imaging and Tract-Based Spatial Statistics Study
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Mou-Xin Zhang, Min-Jie Chen, Li-Ying Tang, Chen-Yu Yu, Yu-Ling Xu, San-Hua Xu, Ping Ying, Min Kang, Li-Juan Zhang, and Yi Shao
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Male ,Models, Statistical ,Article Subject ,Biochemistry (medical) ,Clinical Biochemistry ,Brain ,General Medicine ,Middle Aged ,White Matter ,Diffusion Tensor Imaging ,Retinal Vein Occlusion ,Image Processing, Computer-Assisted ,Genetics ,Anisotropy ,Humans ,Female ,Molecular Biology - Abstract
Background. To investigate microstructural alterations of white matter in retinal vein occlusion (RVO) patients by tract-based spatial statistics (TBSS) and diffusion tensor imaging (DTI). Material/Methods. DTI was performed on 14 RVO patients and 14 normal controls (HCs). We measured and recorded fractional anisotropy (FA) and radial diffusivity (RD) of white matter fibers and classified them through the receiver operating characteristic (ROC) curve and correlation analysis, respectively. Results. The mean FA value of white matter in RVO patients is lower than the HCs, and the mean RD value in RVO patients increased, especially in the bilateral posterior thalamic, bilateral sagittal stratum, body of corpus callosum, cingulum, and fornix. The ROC curve of different brain regions showed high accuracy. Moreover, the mean FA and RD values were significantly correlated with visual and psychological disorders. Conclusion. TBSS could be regarded as an important method to reveal the alterations of white matter in RVO patients, indicating the underlying neurological mechanism of the RVO.
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- 2022
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36. Dissection of qTGW1.2 to three QTLs for grain weight and grain size in rice (Oryza sativa L.)
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Wang, Lin-Lin, Chen, Yu-Yu, Guo, Liang, Zhang, Hong-Wei, Fan, Ye-Yang, and Zhuang, Jie-Yun
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- 2015
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37. Dissection of Closely Linked Quantitative Trait Locis Controlling Grain Size in Rice
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Xue, Pao, primary, Chen, Yu-yu, additional, Wen, Xiao-xia, additional, Wang, Bei-fang, additional, Yang, Qin-qin, additional, Gong, Ke, additional, Kang, Yi-wei, additional, Sun, Lian-ping, additional, Yu, Ping, additional, Cao, Li-yong, additional, Zhang, Ying-xin, additional, Zhan, Xiao-deng, additional, and Cheng, Shi-hua, additional
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- 2022
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38. Fine mapping of qHd1, a minor heading date QTL with pleiotropism for yield traits in rice (Oryza sativa L.)
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Chen, Jun-Yu, Guo, Liang, Ma, Huan, Chen, Yu-Yu, Zhang, Hong-Wei, Ying, Jie-Zheng, and Zhuang, Jie-Yun
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- 2014
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39. Effects of GS3 and GL3.1 for Grain Size Editing by CRISPR/Cas9 in Rice
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Cao Yongrun, Cheng ShiHua, Shah Liaqat, Wang Beifang, Cao LiYong, Zhu Aike, Chen Yu-yu, Zhang Yingxin, Wen Xiaoxia, Zhang Yue, and Xue Pao
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0106 biological sciences ,0301 basic medicine ,grain quality ,Plant Science ,lcsh:Plant culture ,Biology ,Quantitative trait locus ,01 natural sciences ,03 medical and health sciences ,Grain quality ,CRISPR ,lcsh:SB1-1110 ,Leaf size ,grain size ,rice ,grain yield ,Grain number ,Grain size ,Japonica rice ,GL3.1 ,030104 developmental biology ,Agronomy ,Grain yield ,GS3 ,Agronomy and Crop Science ,010606 plant biology & botany ,Biotechnology - Abstract
Grain size is one of key agronomic traits associated with grain yield and grain quality. Both major quantitative trait loci GS3 and GL3.1 play a predominant role in negative regulation of grain size. In this study, a CRISPR/Cas9-mediated multiplex genome editing system was used to simultaneously edit GS3 and GL3.1 in a typical japonica rice Nipponbare. In T1 generation, we found that gs3 formed slender grain with lower chalkiness percentage, while gs3gl3.1 produced larger grain with higher chalkiness percentage. In terms of other agronomic traits, flag leaf size, grain number and grain yield of both gs3 and gs3gl3.1 mutants were affected. It is noteworthy that gs3 and gs3gl3.1 mutants both led to dramatical reduction of grain number, thereby decreased grain yield. In conclusion, these results indicated that knockout of GS3 and GL3.1 could rapidly improve grain size, but probably have some negative influences on grain quality and grain yield.
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- 2020
40. A method for predicting the airworthiness of emergency repair UAVs based on real-time environmental data
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CHEN, Yu-Yu, primary, XIA, Peng-Fei, additional, and ZHANG, Zhong-Liang, additional
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- 2021
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41. Non-Conventional Fluorescence and Cytotoxicity of Two Aliphatic Hyperbranched Polymer Dots Having Poly(amic acid) Structures: Implications for Labeling Nanodrug Carriers
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Chen, Yu-Yu, primary, Fan, Siao-Cian, additional, Chang, Chang-Cheng, additional, Wang, Jian-Cheng, additional, Chiang, Hsiu-Mei, additional, and Juang, Tzong-Yuan, additional
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- 2021
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42. Instantly Detecting Catalysts’ Hot Spots Temperature In Situ during Photocatalysis by Operando Raman Spectroscopy
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Wang, Qian-Yu, primary, Chen, Yu-Yu, additional, Ye, Rong-Kai, additional, Liu, Qiong, additional, Chen, Huan-Yu, additional, Yang, Hao, additional, Li, Ming-Yang, additional, Hu, Jian-Qiang, additional, and Fang, Ping-Ping, additional
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- 2021
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43. Serum markers change for intraocular metastasis in renal cell carcinoma
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Chen-Yu Yu, Yi-Cong Pan, Hui-Ye Shu, Qian-Min Ge, Yi Shao, Tie Sun, Biao Li, Jing Tang, and Li-Juan Zhang
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Adult ,Male ,renal cell carcinoma ,medicine.medical_specialty ,education ,Enolase ,Biophysics ,intraocular metastasis ,Risk Assessment ,Biochemistry ,Gastroenterology ,Metastasis ,NSE ,Predictive Value of Tests ,Risk Factors ,Renal cell carcinoma ,Internal medicine ,Chemical Biology ,Biomarkers, Tumor ,medicine ,Humans ,Risk factor ,Carcinoma, Renal Cell ,Molecular Biology ,health care economics and organizations ,Research Articles ,Aged ,Retrospective Studies ,Cancer ,Receiver operating characteristic ,business.industry ,Eye Neoplasms ,digestive, oral, and skin physiology ,Area under the curve ,Reproducibility of Results ,Cell Biology ,Middle Aged ,Prognosis ,medicine.disease ,Kidney Neoplasms ,Phosphopyruvate Hydratase ,Enzymology ,Female ,business ,Serum markers - Abstract
Objective: Renal cell carcinoma is prone to early metastasis. In general, intraocular metastasis (IOM) is not common. In the present study, we studied the relationship between different biochemical indicators and the occurrence of IOM in renal cancer patients, and identified the potential risk factors. Methods: A retrospective analysis of the clinical data of 214 patients with renal cell carcinoma from October 2001 to August 2016 was carried out. The difference and correlation of various indicators between the two groups with or without IOM was analyzed, and binary logistic regression analysis was used to explore the risk factors of IOM in renal cancer patients. The diagnostic value of each independent related factor was calculated according to the receiver operating curve (ROC). Results: The level of neuron-specific enolase (NSE) in renal cell carcinoma patients with IOM was significantly higher than that in patients without IOM (P0.05). Binary logistic regression analysis showed that NSE was an independent risk factor for IOM in renal cell carcinoma patients (P Conclusion: NSE concentration is a risk factor for IOM in patients with renal cell cancer. If the concentration of NSE in the patient’s body is ≥49.5 U/l, disease monitoring and eye scans should be strengthened.
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- 2021
44. Smartphone Traffic Engineering for Energy Efficient Communications: Design and Experimental Evaluation
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Hsieh, Chang-Hung, Chao, Shih-Lung, Chen, Yu-Yu, Yang, Chih-Chieh, and Wei, Hung-Yu
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- 2014
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45. Nonconventional Fluorescent Hyperbranched Polymer Dots as Skin Nanocarriers Constructed from an Olefinic Aliphatic AB2‑Type Monomer.
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Chang, Chang-Cheng, Chen, Yu-Yu, Chiang, Hsiu-Mei, Shen, Yu-Fang, Wang, Jian-Cheng, Ma, Kang-Chiao, Lin, Ching-Hsuan, and Juang, Tzong-Yuan
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- 2022
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46. Abnormal Fractional Amplitude of Low-frequency Fluctuation Changes in Patients With Diabetic Optic Neuropathy: a Functional MRI Study
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Qiu-Yu Li, Li-Juan Zhang, Qian-Min Ge, Yi-Cong Pan, Chen-Yu Yu, Wenfeng Liu, Hui-Ye Shu, Yi Shao, and Rong-Bin Liang
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Optic neuropathy ,medicine.medical_specialty ,Text mining ,Amplitude ,business.industry ,Internal medicine ,medicine ,Cardiology ,In patient ,Low frequency ,business ,medicine.disease - Abstract
The present study was to assess the spontaneous changes in brain activity in patients with DON using functional magnetic resonance imaging (fMRI). 14 DON patients and 14 healthy controls (HCs) were enrolled. All participants underwent resting-state fMRI (rs-fMRI). The fractional amplitude of low-frequency fluctuation (fALFF) method was applied to evaluate neural activity changes. The Hospital Anxiety and Depression Scale (HADS) was used to assess the anxiety and depression status of participants. The independent sample t test and chi-squared test were applied to analyze demographics of DON patients and HCs. Receiver operating characteristic (ROC) curves were applied to analyze the variation in mean fALFF values between DON patients and HCs. The relationships between the fALFF values of brain regions and clinical behaviors in the DON group were analyzed using Pearson’s correlation analysis. In contrast to HCs, the fALFF value of DON patients was significantly higher in the right precentral gyrus (RPCG). However, the fALFF values in right anterior cingulate gyrus (RACG) and left middle cingulate gyrus (LMCG) were markedly decreased in DON patients. The area under the curve (AUC) of ROCs for each brain region showed high accuracy. Pearson's correlation analysis showed that fALFF values of the right anterior cingulate gyrus and left middle cingulate gyrus were negatively correlated with HADS scores, while fALFF values of the left middle cingulate gyrus were negatively correlated with DON disease duration. To sum up, we found abnormal spontaneous brain activities in regions related to cognitive and emotional dysfunction, eye movement disorder, and vision loss in patients with DON. These results may indicate the underlying neuropathological mechanisms of DON, and show that fALFF may be an effective method by which to distinguish patients with DON from healthy individuals.
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- 2021
47. A programmable probiotic encapsulation system enhances therapeutic delivery in vivo
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Harimoto, Tetsuhiro, primary, Hahn, Jaeseung, additional, Chen, Yu-Yu, additional, Im, Jongwon, additional, Zhang, Joanna, additional, Hou, Nicholas, additional, Li, Fangda, additional, Coker, Courtney, additional, Gray, Kelsey, additional, Harr, Nicole, additional, Chowdhury, Sreyan, additional, Pu, Kelly, additional, Nimura, Clare, additional, Arpaia, Nicholas, additional, Leong, Kam, additional, and Danino, Tal, additional
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- 2021
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48. Dissection of Closely Linked QTLs Controlling Grain Size in Rice
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Xue, Pao, primary, Chen, Yu-yu, additional, Wen, Xiao-xia, additional, Wang, Bei-fang, additional, Yang, Qin-qin, additional, Gong, Ke, additional, Kang, Yi-wei, additional, Sun, Lian-ping, additional, Yu, Ping, additional, Cao, Li-yong, additional, Zhang, Ying-xin, additional, Zhan, Xiao-deng, additional, and Cheng, Shi-hua, additional
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- 2021
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49. The mechanism of optical chirality enhancement in vertical-cut slant-gap antenna
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Chen, Yu-Yu, primary, Lin, Chia-Yi, additional, and Chang, Shih-Hui Gilbert, additional
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- 2021
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50. Prognostic value of miR-142 in solid tumors: a meta-analysis
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Wen-Qing Shi, Shiyang Zheng, Yi Shao, Chen-Yu Yu, Zhiwei Ye, Kang Yu, Qian-Min Ge, Ya-Jie Yu, and Rongqiang Liu
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0301 basic medicine ,Oncology ,medicine.medical_specialty ,Biophysics ,Value (computer science) ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Neoplasms ,Internal medicine ,Chemical Biology ,medicine ,Overall survival ,Humans ,Prospective cohort study ,Molecular Biology ,Research Articles ,Cancer ,Molecular Interactions ,business.industry ,Hazard ratio ,Cell Biology ,medicine.disease ,Confidence interval ,meta-analysis ,MicroRNAs ,miR-142 ,030104 developmental biology ,030220 oncology & carcinogenesis ,Meta-analysis ,prognosis ,business - Abstract
Several studies on the prognostic value of microRNA 142 (miR-142) in solid tumors have reported conflicting results. Therefore, the aim of this meta-analysis was to evaluate the relationship between the miR-142 and prognosis in solid tumors. A comprehensive search for relevant studies was conducted until 10 November 2020. Studies that investigated the prognostic significance of the miR-142 in solid tumors were included. The hazard ratio and 95% confidence interval were calculated using a random-effects model. All data analyses were performed using the STATA 12.0 software (Stata Corporation, College Station, TX, U.S.A.). Twenty articles involving 2451 participants were included in the meta-analysis. The results showed that high miR-142 expression was a better predictor of overall survival (OS) (HR = 0.66, 95% CI: 0.47–0.93) and disease-free/progression-free/recurrence-free survival (DFS/PFS/RFS) (HR = 0.71, 95% CI: 0.55–0.91) compared with low miR-142 expression. MiR-142 can be used as an effective prognostic marker for patients with solid tumors. Future large prospective studies are warranted to further confirm the present findings.
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- 2021
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