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18 results on '"Chen, Zhaoni"'

1. Preventive effect of tilapia skin collagen hydrolysates on ulcerative colitis mice based on metabonomic and 16 S rRNA gene sequencing

Author

Chen, Zhaoni, primary, Nong, Yunyuan, additional, Wang, Qianyi, additional, Feng, Linlin, additional, He, Ying, additional, Guo, Bingjian, additional, Qin, Yuelian, additional, Zhong, Xinyu, additional, Qin, Jinghua, additional, Wei, Jinbin, additional, Dong, Min, additional, Pan, Shihan, additional, and Su, Zhiheng, additional

Published
2023
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2. Combining 1H-NMR-based metabonomics and network pharmacology to dissect the mechanism of antidepression effect of Milletia speciosa Champ on mouse with chronic unpredictable mild stress-induced depression

Author

Su, Zhiheng, primary, Ruan, Junxiang, additional, Liu, Xi, additional, Zheng, Hua, additional, Ruan, Jingzhou, additional, Lu, Yuying, additional, Cheng, Bang, additional, Wu, Fang, additional, Wu, Jinxia, additional, Liu, Xuwen, additional, Song, Fangming, additional, Chen, Zhaoni, additional, Song, Hui, additional, Liang, Yonghong, additional, and Guo, Hongwei, additional

Published
2021
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6. Serum metabolomics reveals the intervention mechanism and compatible regularity of Chaihu Shu Gan San on chronic unpredictable mild stress-induced depression rat model

Author

Zhang, Hongye, primary, Huang, Huimin, additional, Song, Hui, additional, Chin, Bonnie, additional, Zheng, Hua, additional, Ruan, Junxiang, additional, Wu, Fang, additional, Cheng, Bang, additional, Wu, Jinxia, additional, Liu, Xuwen, additional, Liang, Yonghong, additional, Song, Fangming, additional, Chen, Zhaoni, additional, Tang, Chaoling, additional, Lu, Shiyin, additional, Guo, Hongwei, additional, Zou, Zhongmei, additional, and Su, Zhiheng, additional

Published
2020
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8. Metabolomics analysis of Danggui Sini decoction on treatment of collagen-induced arthritis in rats

Author

Cheng, Bang, primary, Zheng, Hua, additional, Wu, Fang, additional, Wu, Jinxia, additional, Liu, Xuwen, additional, Tang, Chaoling, additional, Lu, Shiyin, additional, Chen, Zhaoni, additional, Song, Fangming, additional, Ruan, Junxiang, additional, Zhang, Hongye, additional, Song, Hui, additional, Liu, Wei, additional, Guo, Hongwei, additional, Liang, Yonghong, additional, and Su, Zhiheng, additional

Published
2017
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16. Hepatoprotective Effects of the Polysaccharide Isolated from Tarphochlamys affinis (Acanthaceae) against CCl4-Induced Hepatic Injury

Author

Lin, Xing, primary, Liu, Xi, additional, Huang, Quanfang, additional, Zhang, Shijun, additional, Zheng, Li, additional, Wei, Ling, additional, He, Min, additional, Jiao, Yang, additional, Huang, Jianchun, additional, Fu, Shujie, additional, Chen, Zhaoni, additional, Li, Yongwen, additional, Zhuo, Lang, additional, and Huang, Renbin, additional

Published
2012
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18. Protective effect of Fufang-Liu-Yue-Qing, a traditional Chinese herbal formula, on CCl4 induced liver fibrosis in rats

Author

Lin, Xing, Zhang, Shijun, Huang, Quanfang, Wei, Ling, Zheng, Li, Chen, Zhaoni, Jiao, Yang, Huang, Jianchun, Fu, Shujie, and Huang, Renbin

Subjects
*ENZYME analysis, *LIVER disease prevention, *FIBROSIS, *ALTERNATIVE medicine, *ANIMAL experimentation, *ANTIOXIDANTS, *APOPTOSIS, *BIOPHYSICS, *COLLAGEN, *COMPARATIVE studies, *INTERLEUKINS, *LONGITUDINAL method, *RESEARCH methodology, *MEDICINAL plants, *BOTANIC medicine, *CHINESE medicine, *LIPID peroxidation (Biology), *RATS, *TUMOR necrosis factors, *DESCRIPTIVE statistics, *PREVENTION
Abstract

Abstract: Ethnopharmacological relevance: Chinese prescription Fufang-Liu-Yue-Qing (FLYQ) has long been employed clinically to treat chronic hepatitis B, and we have reported its beneficial effects on liver fibrosis in vitro. The present study was investigated to verify protective effects of FLYQ on liver fibrosis in a rat model and to investigate the underlying mechanisms which have not been explored yet. Materials and methods: Liver fibrosis was established by intragastric administration of 2ml/kg CCl4 twice a week for 12 weeks. During the experiment, the model group received CCl4 only, and the normal control group received an equal volume of saline. Treatment groups received not only CCl4 for 12 weeks, but also the corresponding drugs, colchicine (1.00mg/kg/day) or FLYQ (300, 150, 75mg/kg/day) from 5 to 12 weeks. Results: Analysis experiments showed that FLYQ could significantly alleviate liver injury, as indicated by decreasing levels of ALT, AST, ALP, GGT, IL-6 and TNF-α. Moreover, FLYQ could effectively inhibit collagen deposition and reduce the pathological tissue damage. Research on mechanism showed that FLYQ was able to markedly reduce lipid peroxidation, recruit the anti-oxidative defense system, promote ECM degradation by modulating the levels of TIMP-1 and MMP-2, and induce HSC apoptosis by down-regulating bcl-2 mRNA, as well as inhibit the expressions of α-SMA and TGF-β1 proteins. Conclusions: Our results show that FLYQ is effective in attenuating hepatic injury and fibrosis in the CCl4-induced rat model, which should be developed as a new drug for treatment of liver fibrosis and even cirrhosis. [Copyright &y& Elsevier]

Published
2012
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